Metabolic Control and Bone Health in Adolescents with Type 1 Diabetes

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  • Simmons, Jill H
    • Other Affiliation: Department of Pediatrics, Division of Endocrinology and Diabetes, Vanderbilt Children’s Hospital, Nashville, TN, USA
  • Raines, Miranda
    • Other Affiliation: Department of Pediatrics, Division of Endocrinology and Diabetes, Vanderbilt Children’s Hospital, Nashville, TN, USA
  • Ness, Kathryn D
    • Other Affiliation: Department of Pediatrics, Division of Pediatric Endocrinology, Seattle Children’s Hospital, Seattle, WA, USA
  • Hall, Randon
    • Other Affiliation: Department of Pediatrics, Division of Endocrinology and Diabetes, Vanderbilt Children’s Hospital, Nashville, TN, USA
  • Gebretsadik, Tebeb
    • Other Affiliation: Department of Biostatistics, Vanderbilt University Medical Center, Nashville, TN, USA
  • Mohan, Subburaman
    • Other Affiliation: Musculoskeletal Disease Center, Jerry L Pettis VA Medical Center, and Departments of Medicine and Biochemistry, Loma Linda University, Loma Linda, CA, USA
  • Spagnoli, Anna
    • Affiliation: School of Medicine, Department of Pediatrics
Abstract
  • Abstract Background Adults with type 1 diabetes (T1D) have decreased bone mineral density (BMD) and increased fracture risk, yet the etiologies remain elusive. Early detection of derangements in bone biomarkers during adolescence could lead to timely recognition. In adolescents with T1D, we evaluated the relationships between metabolic control, BMD, and bone anabolic and turnover markers. Methods Cross-sectional study of 57 adolescent subjects with T1D who had HbA1c consistently ≥ 9% (Poor Control, PC n = 27) or < 9% (Favorable Control, FC n = 30) for two years prior to enrollment. Subjects had T1DM for at least three years and were without diabetes complications, known celiac disease, or other chronic diseases. Results There were no differences between HbA1c groups in BMD, components of the IGF system, or 25-hydroxyvitamin D status. The prevalence of 25-hydroxyvitamin D abnormalities was similar to that seen in the general adolescent population. Few patients met the recommended dietary allowance (RDA) for vitamin D or calcium. Conclusions These data provide no evidence of association between degree of metabolic control and BMD in adolescents with T1D. Adolescents with T1D have a high prevalence of serum 25-hydroxyvitamin D abnormalities. Longitudinal studies are needed to evaluate the predictive value of vitamin D abnormalities on fracture risk.
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  • Article
Rights statement
  • In Copyright
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  • Jill H Simmons et al.; licensee BioMed Central Ltd.
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Journal title
  • International Journal of Pediatric Endocrinology
Journal volume
  • 2011
Journal issue
  • 1
Page start
  • 13
Language
  • English
Is the article or chapter peer-reviewed?
  • Yes
ISSN
  • 1687-9856
Bibliographic citation
  • International Journal of Pediatric Endocrinology. 2011 Oct 26;2011(1):13
Publisher
  • BioMed Central Ltd
Access right
  • Open Access
Date uploaded
  • August 23, 2012

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