Patients With Fibromyalgia Display Less Functional Connectivity In The Brain's Pain Inhibitory Network
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Jensen, Karin B, et al. Patients With Fibromyalgia Display Less Functional Connectivity In The Brain's Pain Inhibitory Network. BioMed Central Ltd, 2012. https://doi.org/10.17615/qn6b-wf32APA
Jensen, K., Loitoile, R., Kosek, E., Petzke, F., Carville, S., Fransson, P., Marcus, H., Williams, S., Choy, E., Mainguy, Y., Vitton, O., Gracely, R., Gollub, R., Ingvar, M., & Kong, J. (2012). Patients With Fibromyalgia Display Less Functional Connectivity In The Brain's Pain Inhibitory Network. BioMed Central Ltd. https://doi.org/10.17615/qn6b-wf32Chicago
Jensen, Karin B, Rita Loitoile, Eva Kosek, Frank Petzke, Serena Carville, Peter Fransson, Hanke Marcus et al. 2012. Patients With Fibromyalgia Display Less Functional Connectivity In The Brain's Pain Inhibitory Network. BioMed Central Ltd. https://doi.org/10.17615/qn6b-wf32- Creator
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Jensen, Karin B
- Other Affiliation: Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, USA; Athinoula A. Martinos Center for Biomedical Imaging, Boston, USA
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Loitoile, Rita
- Other Affiliation: Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, USA; Athinoula A. Martinos Center for Biomedical Imaging, Boston, USA
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Kosek, Eva
- Other Affiliation: Department of Clinical Neuroscience, Osher Center for Integrative Medicine, Karolinska Institutet, Stockholm, Sweden
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Petzke, Frank
- Other Affiliation: Pain Clinic, Centre for Anesthesiology, Emergency and Intensive care Medicine, University Medical Centre, Göttingen, Germany
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Carville, Serena
- Other Affiliation: UK Age Research Forum, London, UK
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Fransson, Peter
- Other Affiliation: Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden
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Marcus, Hanke
- Other Affiliation: Department of Anesthesiology and Postoperative Intensive Care Medicine, University Hospital of Cologne, Cologne, Germany
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Williams, Steven CR
- Other Affiliation: Centre for Neuroimaging Science, Institute of Psychiatry, King’s College London, London, UK
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Choy, Ernest
- Other Affiliation: Department of Medicine, Cardiff University School of Medicine, Cardiff, UK
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Mainguy, Yves
- Other Affiliation: Pierre Fabre Médicament, Labège, France
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Vitton, Olivier
- Other Affiliation: Pierre Fabre Médicament, Labège, France
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Gracely, Richard H.
- Affiliation: School of Medicine, Neurodevelopment Disorders Research Center, Carolina Institute for Developmental Disabilities
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Gollub, Randy
- Other Affiliation: Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, USA; Athinoula A. Martinos Center for Biomedical Imaging, Boston, USA
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Ingvar, Martin
- Other Affiliation: Department of Clinical Neuroscience, Osher Center for Integrative Medicine, Karolinska Institutet, Stockholm, Sweden
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Kong, Jian
- Other Affiliation: Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, USA; Athinoula A. Martinos Center for Biomedical Imaging, Boston, USA
- Abstract
- AbstractBackgroundThere is evidence for augmented processing of pain and impaired endogenous pain inhibition in Fibromyalgia syndrome (FM). In order to fully understand the mechanisms involved in FM pathology, there is a need for closer investigation of endogenous pain modulation. In the present study, we compared the functional connectivity of the descending pain inhibitory network in age-matched FM patients and healthy controls (HC).We performed functional magnetic resonance imaging (fMRI) in 42 subjects; 14 healthy and 28 age-matched FM patients (2 patients per HC), during randomly presented, subjectively calibrated pressure pain stimuli. A seed-based functional connectivity analysis of brain activity was performed. The seed coordinates were based on the findings from our previous study, comparing the fMRI signal during calibrated pressure pain in FM and HC: the rostral anterior cingulate cortex (rACC) and thalamus.ResultsFM patients required significantly less pressure (kPa) to reach calibrated pain at 50 mm on a 0–100 visual analogue scale (p < .001, two-tailed). During fMRI scanning, the rACC displayed significantly higher connectivity to the amygdala, hippocampus, and brainstem in healthy controls, compared to FM patients. There were no regions where FM patients showed higher rACC connectivity. Thalamus showed significantly higher connectivity to the orbitofrontal cortex in healthy controls but no regions showed higher thalamic connectivity in FM patients.ConclusionPatients with FM displayed less connectivity within the brain’s pain inhibitory network during calibrated pressure pain, compared to healthy controls. The present study provides brain-imaging evidence on how brain regions involved in homeostatic control of pain are less connected in FM patients. It is possible that the dysfunction of the descending pain modulatory network plays an important role in maintenance of FM pain and our results may translate into clinical implications by using the functional connectivity of the pain modulatory network as an objective measure of pain dysregulation.
- Date of publication
- April 26, 2012
- DOI
- Identifier
- Resource type
- Article
- Rights statement
- In Copyright
- Rights holder
- Karin B Jensen et al.; licensee BioMed Central Ltd.
- License
- Journal title
- Molecular Pain
- Journal volume
- 8
- Journal issue
- 1
- Page start
- 32
- Language
- English
- Is the article or chapter peer-reviewed?
- Yes
- ISSN
- 1744-8069
- Bibliographic citation
- Molecular Pain. 2012 Apr 26;8(1):32
- Publisher
- BioMed Central Ltd
- Access right
- Open Access
- Date uploaded
- August 23, 2012
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