Polychromatic immunophenotypic characterization of T cell profiles among HIV-infected patients experiencing immune reconstitution inflammatory syndrome (IRIS)
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Murdoch, David M, et al. Polychromatic Immunophenotypic Characterization of T Cell Profiles Among Hiv-infected Patients Experiencing Immune Reconstitution Inflammatory Syndrome (iris). BioMed Central Ltd, 2009. https://doi.org/10.17615/2gvf-zf97APA
Murdoch, D., Suchard, M., Venter, W., Mhlangu, P., Ottinger, J., Feldman, C., Van Rie, A., Glencross, D., Stevens, W., & Weinhold, K. (2009). Polychromatic immunophenotypic characterization of T cell profiles among HIV-infected patients experiencing immune reconstitution inflammatory syndrome (IRIS). BioMed Central Ltd. https://doi.org/10.17615/2gvf-zf97Chicago
Murdoch, David M, Melinda S Suchard, Willem Df Venter, Patrick Mhlangu, Janet S Ottinger, Charles Feldman, Annelies Van Rie et al. 2009. Polychromatic Immunophenotypic Characterization of T Cell Profiles Among Hiv-Infected Patients Experiencing Immune Reconstitution Inflammatory Syndrome (iris). BioMed Central Ltd. https://doi.org/10.17615/2gvf-zf97- Creator
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Murdoch, David M
- Other Affiliation: Division of Pulmonary and Critical Care Medicine, Duke University Medical Center, Durham, North Carolina, USA
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Suchard, Melinda S
- Other Affiliation: Department of Molecular Medicine and Haematology, University of the Witwatersrand and National Health Laboratory Services, Johannesburg, South Africa
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Venter, Willem DF
- Other Affiliation: Reproductive Health & HIV Research Unit, University of the Witwatersrand, Johannesburg, South Africa
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Mhlangu, Patrick
- Other Affiliation: Contract Laboratory Services, Johannesburg, South Africa
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Ottinger, Janet S
- Other Affiliation: Department of Surgery and Immunology and the Duke University Center for AIDS Research (CFAR), Duke University, Durham, North Carolina, USA
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Feldman, Charles
- Other Affiliation: Division of Pulmonology, Department of Medicine, Johannesburg Hospital and University of the Witwatersrand, Johannesburg, South Africa
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Van Rie, Annelies
- Affiliation: Gillings School of Global Public Health, Department of Epidemiology
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Glencross, Deborah K
- Other Affiliation: Department of Molecular Medicine and Haematology, University of the Witwatersrand and National Health Laboratory Services, Johannesburg, South Africa; Contract Laboratory Services, Johannesburg, South Africa
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Stevens, Wendy S
- Other Affiliation: Department of Molecular Medicine and Haematology, University of the Witwatersrand and National Health Laboratory Services, Johannesburg, South Africa
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Weinhold, Kent J
- Other Affiliation: Department of Surgery and Immunology and the Duke University Center for AIDS Research (CFAR), Duke University, Durham, North Carolina, USA
- Abstract
- Abstract Objective To immunophenotype CD4+ and CD8+ T cell sub-populations in HIV-associated immune reconstitution inflammatory syndrome (IRIS). Design Nested case-control immunological study. Methods ART-naïve HIV-infected patients were prospectively observed for IRIS during the first 6 months of ART. Twenty-two IRIS cases and 22 ART-duration matched controls were sampled for T cell immunophenotyping. Results IRIS cases demonstrated significantly lower CD4 cell counts compared to controls (baseline: 79 versus 142, p = 0.02; enrollment: 183 versus 263, p = 0.05, respectively) with no differences in HIV RNA levels. Within CD4+T cells, cases exhibited more of an effector memory phenotype compared to controls (40.8 versus 27.0%, p = 0.20), while controls trended towards a central memory phenotype (43.8 versus 30.8%, p = 0.07). Within CD8+ T cells, controls exhibited more central memory (13.9 versus 7.81%, p = 0.01, respectively) and effector (13.2 versus 8.8%, p = 0.04, respectively) phenotypes compared to cases, whereas cases demonstrated more terminal effectors than controls (28.8 versus 15.1%, p = 0.05). Cases demonstrated increased activation of CD8+ T cell effector memory, terminal effector, and effector subsets than controls (p = 0.04, 0.02, and 0.02, respectively). Conclusion CD4+ and CD8+ T cell subset maturational phenotypes were heterogeneous among IRIS cases and controls. However, IRIS cases demonstrated significant increases in activation of CD8+ T cell effector subpopulations.
- Date of publication
- July 16, 2009
- DOI
- Identifier
- Resource type
- Article
- Rights statement
- In Copyright
- Rights holder
- David M Murdoch et al.; licensee BioMed Central Ltd.
- License
- Journal title
- AIDS Research and Therapy
- Journal volume
- 6
- Journal issue
- 1
- Page start
- 16
- Language
- English
- Is the article or chapter peer-reviewed?
- Yes
- ISSN
- 1742-6405
- Bibliographic citation
- AIDS Research and Therapy. 2009 Jul 16;6(1):16
- Publisher
- BioMed Central Ltd
- Access right
- Open Access
- Date uploaded
- August 23, 2012
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