Impact of periodontal therapy on metabolic and inflammatory markers in patients with end stage renal disease
Public Deposited- Last Modified
- March 20, 2019
- Creator
-
Wehmeyer, Meggan M. H.
- Affiliation: School of Dentistry, Department of Periodontology
- Abstract
- Objective: To test whether periodontal intervention in dialysis patients with periodontal disease will result in improvement of inflammatory and metabolic markers compared to no treatment. Methods: Fifty-one dialysis patients with moderate to severe periodontal disease were recruited from six dialysis units. Twenty-five subjects were randomized to a periodontal treatment arm and twenty-six subjects were randomized to a control arm. Clinical periodontal parameters and serum were collected at baseline, 3 months and 6 months. Serum was analyzed for interleukin-6 and serum albumin. Results: Compared to untreated control, periodontal therapy was associated with a statistically significant improvement in clinical parameters of periodontal disease at 3 months, but not at 6 months and was not associated with any difference in serum interleukin-6 or serum albumin. Conclusion: Periodontal therapy was associated with improved clinical measures of periodontal disease, but not with improved interleukin-6 or serum albumin in this population. Diabetic status, plaque control and obesity should be tightly controlled in future studies of periodontal therapy in this population.
- Date of publication
- December 2010
- DOI
- Resource type
- Rights statement
- In Copyright
- Note
- "... in partial fulfillment of the requirements for the degree of Master of Science in the School of Dentistry (Periodontics)."
- Advisor
- Offenbacher, Steven
- Language
- Publisher
- Place of publication
- Chapel Hill, NC
- Access right
- Open access
- Date uploaded
- March 18, 2013
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