A call for comparative effectiveness research to learn whether routine clinical care decisions can protect from dementia and cognitive decline

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  • Dacks, Penny A.
    • Other Affiliation: Alzheimer’s Drug Discovery Foundation, 57 West 57th St. Suite 901, New York, NY 10019, USA
  • Armstrong, Joshua J.
    • Other Affiliation: Geriatric Medicine Research Unit, Department of Medicine, Dalhousie University, Halifax, NS, Canada
  • Brannan, Stephen K.
    • Other Affiliation: Takeda Pharmaceuticals, Deerfield, IL, USA
  • Carman, Aaron J.
    • Other Affiliation: Alzheimer’s Drug Discovery Foundation, 57 West 57th St. Suite 901, New York, NY 10019, USA
  • Green, Allan M.
    • Other Affiliation: Attorney at Law, Cambridge, MA, USA
  • Kirkman, M. Sue
    • Affiliation: School of Medicine, Department of Medicine, Division of Endocrinology and Metabolism
  • Krakoff, Lawrence R.
    • Other Affiliation: Icahn School of Medicine at Mount Sinai, New York, NY, USA
  • Kuller, Lewis H.
    • Other Affiliation: Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA
  • Launer, Lenore J.
    • Other Affiliation: Intramural Research Program, National Institute on Aging, NIH, Bethesda, MD, USA
  • Lovestone, Simon
    • Other Affiliation: Department of Psychiatry, University of Oxford, Oxford, UK
  • Merikle, Elizabeth
    • Other Affiliation: Takeda Pharmaceuticals, Deerfield, IL, USA
  • Neumann, Peter J.
    • Other Affiliation: Center for the Evaluation of Value and Risk in Health, Institute for Clinical Research and Health Policy Studies, Tufts Medical Center, Boston, MA, USA
  • Rockwood, Kenneth
    • Other Affiliation: Geriatric Medicine Research Unit, Department of Medicine, Dalhousie University, Halifax, NS, Canada; DGI Clinical, Halifax, NS, Canada; Nova Scotia Health Authority, Halifax, NS, Canada
  • Shineman, Diana W.
    • Other Affiliation: Alzheimer’s Drug Discovery Foundation, 57 West 57th St. Suite 901, New York, NY 10019, USA
  • Stefanacci, Richard G.
    • Other Affiliation: Thomas Jefferson College of Population Health, The Access Group, Philadelphia, PA, USA
  • Velentgas, Priscilla
    • Other Affiliation: Scientific Affairs, Quintiles Real World Late Phase Research, Cambridge, MA, USA
  • Viswanathan, Anand
    • Other Affiliation: Representative for the American Heart Association; Hemorrhagic Stroke Research Program, Department of Neurology, Massachusetts General Hospital Stroke Research Center, Harvard Medical School, Boston, MA, USA
  • Whitmer, Rachel A.
    • Other Affiliation: Kaiser Permanente Division of Research, Population Science and Brain Aging, Oakland, CA, USA
  • Williamson, Jeff D.
    • Other Affiliation: Wake Forest University School of Medicine, Winston-Salem, NC, USA
  • Fillit, Howard M.
    • Other Affiliation: Alzheimer’s Drug Discovery Foundation, 57 West 57th St. Suite 901, New York, NY 10019, USA
Abstract
  • Abstract Common diseases like diabetes, hypertension, and atrial fibrillation are probable risk factors for dementia, suggesting that their treatments may influence the risk and rate of cognitive and functional decline. Moreover, specific therapies and medications may affect long-term brain health through mechanisms that are independent of their primary indication. While surgery, benzodiazepines, and anti-cholinergic drugs may accelerate decline or even raise the risk of dementia, other medications act directly on the brain to potentially slow the pathology that underlies Alzheimer’s and other dementia. In other words, the functional and cognitive decline in vulnerable patients may be influenced by the choice of treatments for other medical conditions. Despite the importance of these questions, very little research is available. The Alzheimer’s Drug Discovery Foundation convened an advisory panel to discuss the existing evidence and to recommend strategies to accelerate the development of comparative effectiveness research on how choices in the clinical care of common chronic diseases may protect from cognitive decline and dementia.
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  • Article
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  • In Copyright
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  • The Author(s).
Language
  • English
Bibliographic citation
  • Alzheimer's Research & Therapy. 2016 Aug 20;8(1):33
Publisher
  • BioMed Central

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