Identification of 15 new psoriasis susceptibility loci highlights the role of innate immunity
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Tsoi, Lam C, et al. Identification of 15 New Psoriasis Susceptibility Loci Highlights the Role of Innate Immunity. 2012. https://doi.org/10.17615/0b5w-k988APA
Tsoi, L., Spain, S., Knight, J., Ellinghaus, E., Stuart, P., Capon, F., Ding, J., Li, Y., Tejasvi, T., Gudjonsson, J., Kang, H., Allen, M., Mc Manus, R., Novelli, G., Samuelsson, L., Schalkwijk, J., Stahle, M., Burden, A., Smith, C., Cork, M., Estivill, X., Bowcock, A., Krueger, G., Weger, W., Worthington, J., Tazi Ahnini, R., Nestle, F., Hayday, A., Hoffmann, P., Winkelmann, J., Wijmenga, C., Langford, C., Edkins, S., Andrews, R., Blackburn, H., Strange, A., Band, G., Pearson, R., Vukcevic, D., Spencer, C., Deloukas, P., Mrowietz, U., Schreiber, S., Weidinger, S., Koks, S., Kingo, K., Esko, T., Metspalu, A., Lim, H., Voorhees, J., Weichenthal, M., Wichmann, H., Chandran, V., Rosen, C., Rahman, P., Gladman, D., Griffiths, C., Reis, A., Kere, J., Association Study Of Psoriasis (Casp), C., Analysis Of Psoriasis Consortium, G., Association Genetics Extension, P., Trust Case Control Consortium 2, W., Nair, R., Franke, A., Barker, J., Abecasis, G., Elder, J., & Trembath, R. (2012). Identification of 15 new psoriasis susceptibility loci highlights the role of innate immunity. https://doi.org/10.17615/0b5w-k988Chicago
Tsoi, Lam C., Sarah L Spain, Jo Knight, Eva Ellinghaus, Philip E Stuart, Francesca Capon, Jun Ding et al. 2012. Identification of 15 New Psoriasis Susceptibility Loci Highlights the Role of Innate Immunity. https://doi.org/10.17615/0b5w-k988- Creator
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Tsoi, Lam C.
- Other Affiliation: Department of Biostatistics, Center for Statistical Genetics, University of Michigan Ann Arbor, Michigan, USA.
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Spain, Sarah L.
- Other Affiliation: Division of Genetics and Molecular Medicine, King's College London, London, UK.
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Knight, Jo
- Other Affiliation: Neuroscience Research, Centre for Addiction and Mental Health, Toronto, Ontario, Canada. National Institute for Health Research (NIHR), Biomedical Research Centre, Guy's and St. Thomas' National Health Service (NHS) Foundation Trust, London, UK.
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Ellinghaus, Eva
- Other Affiliation: Institute of Clinical Molecular Biology, Christian-Albrechts-University, Kiel, Germany.
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Stuart, Philip E.
- Other Affiliation: Department of Dermatology, University of Michigan, Ann Arbor, Michigan, USA.
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Capon, Francesca
- Other Affiliation: Division of Genetics and Molecular Medicine, King's College London, London, UK.
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Ding, Jun
- Other Affiliation: Department of Biostatistics, Center for Statistical Genetics, University of Michigan Ann Arbor, Michigan, USA.
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Li, Yanming
- Other Affiliation: Department of Biostatistics, Center for Statistical Genetics, University of Michigan Ann Arbor, Michigan, USA.
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Tejasvi, Trilokraj
- Other Affiliation: Department of Dermatology, University of Michigan, Ann Arbor, Michigan, USA.
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Gudjonsson, Johann E.
- Other Affiliation: Department of Dermatology, University of Michigan, Ann Arbor, Michigan, USA.
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Kang, Hyun M.
- Other Affiliation: Department of Biostatistics, Center for Statistical Genetics, University of Michigan Ann Arbor, Michigan, USA.
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Allen, Michael H.
- Other Affiliation: Division of Genetics and Molecular Medicine, King's College London, London, UK.
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McManus, Ross
- Other Affiliation: Department of Clinical Medicine, Trinity College Dublin, St. James's Hospital, Dublin, Ireland. Institute of Molecular Medicine, Trinity College Dublin, Dublin, Ireland.
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Novelli, Giuseppe
- Other Affiliation: National Agency for Evaluation of Universities and Research Institutes (ANVUR), Rome, Italy. Research Center San Pietro Hospital, Rome, Italy.
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Samuelsson, Lena
- Other Affiliation: Department of Medical and Clinical Genetics, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
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Schalkwijk, Joost
- Other Affiliation: Department of Dermatology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.
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Stahle, Mona
- Other Affiliation: Dermatology Unit, Department of Medicine, Karolinska Institutet, Stockholm, Sweden.
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Burden, A. David
- Other Affiliation: Department of Dermatology, Western Infirmary, Glasgow, UK.
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Smith, Catherine H.
- Other Affiliation: St. John's Institute of Dermatology, King's College London, London, UK.
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Cork, Michael J.
- Other Affiliation: Academic Unit of Dermatology Research, Department of Infection and Immunity, The University of Sheffield, Sheffield, UK.
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Estivill, Xavier
- Other Affiliation: Genes and Disease Programme, Centre for Genomic Regulation (CRG) and Pompeu Fabra University, Hospital del Mar Research Institute and Public Health and Epidemiology Network Biomedical Research Centre (CIBERESP), Barcelona, Spain.
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Bowcock, Anne M.
- Other Affiliation: Department of Genetics, Division of Human Genetics, Washington University School of Medicine, St. Louis, Missouri, USA.
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Krueger, Gerald G.
- Other Affiliation: Department of Dermatology, University of Utah, Salt Lake City, Utah, USA.
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Weger, Wolfgang
- Other Affiliation: Department of Dermatology, Medical University of Graz, Graz, Austria.
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Worthington, Jane
- Other Affiliation: Arthritis Research UK Epidemiology Unit, University of Manchester, Manchester Academic Health Science Centre, Manchester, UK.
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Tazi-Ahnini, Rachid
- Other Affiliation: Academic Unit of Dermatology Research, Department of Infection and Immunity, The University of Sheffield, Sheffield, UK.
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Nestle, Frank O.
- Other Affiliation: Division of Genetics and Molecular Medicine, King's College London, London, UK.
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Hayday, Adrian
- Other Affiliation: Division of Immunology, Infection and Inflammatory Disease, King's College London, London, UK.
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Hoffmann, Per
- Other Affiliation: Institute of Human Genetics, University of Bonn, Bonn, Germany. Department of Genomics, Life & Brain Center, University of Bonn, Bonn, Germany.
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Winkelmann, Juliane
- Other Affiliation: Department of Neurology, Technische Universität München, Munich, Germany. Institute of Human Genetics, Technische Universität München, Munich, Germany. Institute of Human Genetics, Helmholtz Zentrum Munich, German Research Center for Environmental Health, Munich, Germany.
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Wijmenga, Cisca
- Other Affiliation: Department of Genetics, University Medical Center and University of Groningen, Groningen, The Netherlands.
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Langford, Cordelia
- Other Affiliation: Wellcome Trust Sanger Institute, Hinxton, Cambridge, UK.
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Edkins, Sarah
- Other Affiliation: Wellcome Trust Sanger Institute, Hinxton, Cambridge, UK.
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Andrews, Robert
- Other Affiliation: Wellcome Trust Sanger Institute, Hinxton, Cambridge, UK.
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Blackburn, Hannah
- Other Affiliation: Wellcome Trust Sanger Institute, Hinxton, Cambridge, UK.
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Strange, Amy
- Other Affiliation: Wellcome Trust Centre for Human Genetics, Oxford, UK.
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Band, Gavin
- Other Affiliation: Wellcome Trust Centre for Human Genetics, Oxford, UK.
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Pearson, Richard D.
- Other Affiliation: Wellcome Trust Centre for Human Genetics, Oxford, UK.
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Vukcevic, Damjan
- Other Affiliation: Wellcome Trust Centre for Human Genetics, Oxford, UK.
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Spencer, Chris C.A.
- Other Affiliation: Wellcome Trust Centre for Human Genetics, Oxford, UK.
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Deloukas, Panos
- Other Affiliation: Wellcome Trust Sanger Institute, Hinxton, Cambridge, UK.
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Mrowietz, Ulrich
- Other Affiliation: Department of Dermatology, University Hospital, Schleswig-Holstein, Christian-Albrechts-University, Kiel, Germany.
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Schreiber, Stefan
- Other Affiliation: Institute of Clinical Molecular Biology, Christian-Albrechts-University, Kiel, Germany. PopGen Biobank, University Hospital Schleswig-Holstein, Kiel, Germany.
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Weidinger, Stephan
- Other Affiliation: Department of Dermatology, University Hospital, Schleswig-Holstein, Christian-Albrechts-University, Kiel, Germany.
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Koks, Sulev
- Other Affiliation: Department of Physiology, Centre of Translational Medicine and Centre for Translational Genomics, University of Tartu, Tartu, Estonia.
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Kingo, Kulli
- Other Affiliation: Department of Dermatology and Venerology, University of Tartu, Tartu, Estonia.
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Esko, Tonu
- Other Affiliation: Estonian Genome Center, University of Tartu, Tartu, Estonia.
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Metspalu, Andres
- Other Affiliation: Estonian Genome Center, University of Tartu, Tartu, Estonia.
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Lim, Henry W.
- Other Affiliation: Department of Dermatology, Henry Ford Hospital, Detroit, Michigan, USA.
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Voorhees, John J.
- Other Affiliation: Department of Dermatology, University of Michigan, Ann Arbor, Michigan, USA.
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Weichenthal, Michael
- Other Affiliation: Department of Dermatology, University Hospital, Schleswig-Holstein, Christian-Albrechts-University, Kiel, Germany.
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Wichmann, H. Erich
- Other Affiliation: Institute of Epidemiology I, Helmholtz Zentrum Munich, German Research Center for Environmental Health, Neuherberg, Germany. Institute of Medical Informatics, Biometry and Epidemiology, Ludwig-Maximilians-University, Munich, Germany. Klinikum Grosshadern, Munich, Germany.
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Chandran, Vinod
- Other Affiliation: Department of Medicine, Division of Rheumatology, University of Toronto, Toronto Western Hospital, Toronto, Ontario, Canada.
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Rosen, Cheryl F.
- Other Affiliation: Department of Medicine, Division of Dermatology, University of Toronto, Toronto Western Hospital, Toronto, Ontario, Canada.
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Rahman, Proton
- Other Affiliation: Department of Medicine, Memorial University, St. John's, Newfoundland, Canada.
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Gladman, Dafna D.
- Other Affiliation: Department of Medicine, Division of Rheumatology, University of Toronto, Toronto Western Hospital, Toronto, Ontario, Canada.
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Griffiths, Chirstopher E.M.
- Other Affiliation: Dermatological Sciences, Salford Royal NHS Foundation Trust, University of Manchester, Manchester Academic Health Science Centre, Manchester, UK.
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Reis, Andre
- Other Affiliation: Institute of Human Genetics, University of Erlangen-Nuremberg, Erlangen, Germany.
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Kere, Juha
- Other Affiliation: Department of Biosciences and Nutrition, Karolinska Institutet, Stockholm, Sweden. Folkhälsan Institute of Genetics, Helsinki, Finland. Department of Medical Genetics, University of Helsinki, Helsinki, Finland.
- Collaborative Association Study of Psoriasis (CASP)
- Genetic Analysis of Psoriasis Consortium
- Psoriasis Association Genetics Extension
- Wellcome Trust Case Control Consortium 2
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Nair, Rajan P.
- Other Affiliation: Department of Dermatology, University of Michigan, Ann Arbor, Michigan, USA.
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Franke, Andre
- Other Affiliation: Institute of Clinical Molecular Biology, Christian-Albrechts-University, Kiel, Germany.
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Barker, Jonathan N.W.N.
- Other Affiliation: Division of Genetics and Molecular Medicine, King's College London, London, UK. St. John's Institute of Dermatology, King's College London, London, UK.
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Abecasis, Goncalo R.
- Other Affiliation: Department of Biostatistics, Center for Statistical Genetics, University of Michigan Ann Arbor, Michigan, USA.
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Elder, James T.
- Other Affiliation: Department of Dermatology, University of Michigan, Ann Arbor, Michigan, USA. Ann Arbor Veterans Affairs Hospital, Ann Arbor, Michigan, USA.
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Trembath, Richard C.
- Other Affiliation: Division of Genetics and Molecular Medicine, King's College London, London, UK. Queen Mary University of London, Barts and the London School of Medicine and Dentistry, London, UK.
- Abstract
- To gain further insight into the genetic architecture of psoriasis, we conducted a meta-analysis of 3 genome-wide association studies (GWAS) and 2 independent data sets genotyped on the Immunochip, including 10,588 cases and 22,806 controls. We identified 15 new susceptibility loci, increasing to 36 the number associated with psoriasis in European individuals. We also identified, using conditional analyses, five independent signals within previously known loci. The newly identified loci shared with other autoimmune diseases include candidate genes with roles in regulating T-cell function (such as RUNX3, TAGAP and STAT3). Notably, they included candidate genes whose products are involved in innate host defense, including interferon-mediated antiviral responses (DDX58), macrophage activation (ZC3H12C) and nuclear factor (NF)-κB signaling (CARD14 and CARM1). These results portend a better understanding of shared and distinctive genetic determinants of immune-mediated inflammatory disorders and emphasize the importance of the skin in innate and acquired host defense.
- Date of publication
- 2012
- Keyword
- DOI
- Identifier
- 2-s2.0-84870512735
- https://doi.org/10.1038/ng.2467
- Related resource URL
- Resource type
- Article
- Rights statement
- In Copyright
- Journal title
- Nature Genetics
- Journal volume
- 44
- Journal issue
- 12
- Page start
- 1341
- Page end
- 1348
- Language
- English
- Version
- Postprint
- ISSN
- 1061-4036
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