ingest cdrApp 2018-06-13T15:21:37.917Z 51cd2fe2-3fd7-401f-a923-a97bc3db68a2 modifyDatastreamByValue RELS-EXT fedoraAdmin 2018-06-13T15:48:22.874Z Setting exclusive relation addDatastream MD_TECHNICAL fedoraAdmin 2018-06-13T15:48:34.348Z Adding technical metadata derived by FITS addDatastream MD_FULL_TEXT fedoraAdmin 2018-06-13T15:48:36.147Z Adding full text metadata extracted by Apache Tika modifyDatastreamByValue RELS-EXT fedoraAdmin 2018-06-13T15:48:58.264Z Setting exclusive relation modifyDatastreamByValue MD_DESCRIPTIVE cdrApp 2018-07-16T21:26:07.339Z modifyDatastreamByValue MD_DESCRIPTIVE cdrApp 2018-07-18T17:00:20.769Z modifyDatastreamByValue MD_DESCRIPTIVE cdrApp 2018-08-22T15:42:33.816Z modifyDatastreamByValue MD_DESCRIPTIVE cdrApp 2018-09-28T18:30:39.665Z modifyDatastreamByValue MD_DESCRIPTIVE cdrApp 2018-10-12T17:20:28.957Z modifyDatastreamByValue MD_DESCRIPTIVE cdrApp 2019-03-22T20:41:51.145Z Rima Janusziewicz Author Department of Chemistry College of Arts and Sciences Continuous Liquid Interface Production (CLIP) for the Fabrication of Porous Architected Structures Porous structures have long been investigated for advanced material properties however conventional fabrication methods do not have the necessary specificity to dictate void volume size, shape and distribution. Additive manufacturing (AM), or more commonly 3D printing, is a rapidly growing field in which material is selectively deposited in a layer wise manner as instructed by a computer-aided design (CAD). Therefore, AM has been seen as an attractive route for fabrication of porous structures. While many AM platforms have been investigated, the overall disadvantage with these processes has been the layer wise assembly method, which yields mechanically weak parts. Additionally, many methods impart an unintentional porosity on the resulting structure that deviates from CAD and aids in the mechanical failure mechanisms. This work sought to investigate and apply a novel AM platform, continuous liquid interface production (CLIP), to the fabrication of porous architected structures. The platform utilizes photopolymerization to reconstruct the CAD in a continuous manner. The platform was investigated for porous structure compatibility through assessment of the fabrication mechanism. It was found that CLIP structures fabricated continuously were layerless, addressing one of the key disadvantages with other platforms. The resolution of CLIP was preliminaryily explored and several contributing factors were identified. The resolution of the CLIP platform was investigated for the fabrication of porous architected structures. Void volumes in the hundreds of microns regime was explored through the fabrication of microlattices. Structures were systematically varied by unit cell type, size, orientation, resin formulation, and CLIP fabrication parameters. The resulting mechanical and physical property space was investigated. The lessons of the importance of low viscosity resin and exposure were carried forward. The tens of micron size range was explored through the fabrication of chromatography columns containg ordered internal architectures with CLIP. Functional resins to enable different separation mechanisms were developed and optimized for CLIP. The pore size of the internal architecture of the column was systematically reduced. The computational limit for CAD generation of complex structures was found and an angular hexagonally packed unit cell designed to facilitate computation as well as mimic monolithic column flow profiles was developed. Columns assembled with CLIP fabricated external housings were assessed for stability. Methods to circumvent computational constraints were developed to allow direct exposure of the light source which enabled the fabrication of smaller pore sizes approaching the theoretical limit of resolution. Spring 2018 2018 Analytical chemistry Materials Science Polymer chemistry 3D printing, Chromatography, Medical Devices, Scaffolds, Stereolithography, Tissue Engineering eng Doctor of Philosophy Dissertation University of North Carolina at Chapel Hill Graduate School Degree granting institution Chemistry Joseph DeSimone Thesis advisor James Jorgenson Thesis advisor Leslie Hicks Thesis advisor Matthew Lockett Thesis advisor Sergei Sheiko Thesis advisor text Rima Janusziewicz Author Department of Chemistry College of Arts and Sciences Continuous Liquid Interface Production (CLIP) for the Fabrication of Porous Architected Structures Porous structures have long been investigated for advanced material properties however conventional fabrication methods do not have the necessary specificity to dictate void volume size, shape and distribution. Additive manufacturing (AM), or more commonly 3D printing, is a rapidly growing field in which material is selectively deposited in a layer wise manner as instructed by a computer-aided design (CAD). Therefore, AM has been seen as an attractive route for fabrication of porous structures. While many AM platforms have been investigated, the overall disadvantage with these processes has been the layer wise assembly method, which yields mechanically weak parts. Additionally, many methods impart an unintentional porosity on the resulting structure that deviates from CAD and aids in the mechanical failure mechanisms. This work sought to investigate and apply a novel AM platform, continuous liquid interface production (CLIP), to the fabrication of porous architected structures. The platform utilizes photopolymerization to reconstruct the CAD in a continuous manner. The platform was investigated for porous structure compatibility through assessment of the fabrication mechanism. It was found that CLIP structures fabricated continuously were layerless, addressing one of the key disadvantages with other platforms. The resolution of CLIP was preliminaryily explored and several contributing factors were identified. The resolution of the CLIP platform was investigated for the fabrication of porous architected structures. Void volumes in the hundreds of microns regime was explored through the fabrication of microlattices. Structures were systematically varied by unit cell type, size, orientation, resin formulation, and CLIP fabrication parameters. The resulting mechanical and physical property space was investigated. The lessons of the importance of low viscosity resin and exposure were carried forward. The tens of micron size range was explored through the fabrication of chromatography columns containg ordered internal architectures with CLIP. Functional resins to enable different separation mechanisms were developed and optimized for CLIP. The pore size of the internal architecture of the column was systematically reduced. The computational limit for CAD generation of complex structures was found and an angular hexagonally packed unit cell designed to facilitate computation as well as mimic monolithic column flow profiles was developed. Columns assembled with CLIP fabricated external housings were assessed for stability. Methods to circumvent computational constraints were developed to allow direct exposure of the light source which enabled the fabrication of smaller pore sizes approaching the theoretical limit of resolution. Spring 2018 2018 Analytical chemistry Materials Science Polymer chemistry 3D printing, Chromatography, Medical Devices, Scaffolds, Stereolithography, Tissue Engineering eng Doctor of Philosophy Dissertation University of North Carolina at Chapel Hill Graduate School Degree granting institution Chemistry Joseph DeSimone Thesis advisor James Jorgenson Thesis advisor Leslie Hicks Thesis advisor Matthew Lockett Thesis advisor Sergei Sheiko Thesis advisor text Rima Janusziewicz Author Department of Chemistry College of Arts and Sciences Continuous Liquid Interface Production (CLIP) for the Fabrication of Porous Architected Structures Porous structures have long been investigated for advanced material properties however conventional fabrication methods do not have the necessary specificity to dictate void volume size, shape and distribution. Additive manufacturing (AM), or more commonly 3D printing, is a rapidly growing field in which material is selectively deposited in a layer wise manner as instructed by a computer-aided design (CAD). Therefore, AM has been seen as an attractive route for fabrication of porous structures. While many AM platforms have been investigated, the overall disadvantage with these processes has been the layer wise assembly method, which yields mechanically weak parts. Additionally, many methods impart an unintentional porosity on the resulting structure that deviates from CAD and aids in the mechanical failure mechanisms. This work sought to investigate and apply a novel AM platform, continuous liquid interface production (CLIP), to the fabrication of porous architected structures. The platform utilizes photopolymerization to reconstruct the CAD in a continuous manner. The platform was investigated for porous structure compatibility through assessment of the fabrication mechanism. It was found that CLIP structures fabricated continuously were layerless, addressing one of the key disadvantages with other platforms. The resolution of CLIP was preliminaryily explored and several contributing factors were identified. The resolution of the CLIP platform was investigated for the fabrication of porous architected structures. Void volumes in the hundreds of microns regime was explored through the fabrication of microlattices. Structures were systematically varied by unit cell type, size, orientation, resin formulation, and CLIP fabrication parameters. The resulting mechanical and physical property space was investigated. The lessons of the importance of low viscosity resin and exposure were carried forward. The tens of micron size range was explored through the fabrication of chromatography columns containg ordered internal architectures with CLIP. Functional resins to enable different separation mechanisms were developed and optimized for CLIP. The pore size of the internal architecture of the column was systematically reduced. The computational limit for CAD generation of complex structures was found and an angular hexagonally packed unit cell designed to facilitate computation as well as mimic monolithic column flow profiles was developed. Columns assembled with CLIP fabricated external housings were assessed for stability. Methods to circumvent computational constraints were developed to allow direct exposure of the light source which enabled the fabrication of smaller pore sizes approaching the theoretical limit of resolution. Spring 2018 2018 Analytical chemistry Materials Science Polymer chemistry 3D printing, Chromatography, Medical Devices, Scaffolds, Stereolithography, Tissue Engineering eng Doctor of Philosophy Dissertation University of North Carolina at Chapel Hill Graduate School Degree granting institution Chemistry Joseph DeSimone Thesis advisor James Jorgenson Thesis advisor Leslie Hicks Thesis advisor Matthew Lockett Thesis advisor Sergei Sheiko Thesis advisor text Rima Janusziewicz Author Department of Chemistry College of Arts and Sciences Continuous Liquid Interface Production (CLIP) for the Fabrication of Porous Architected Structures Porous structures have long been investigated for advanced material properties however conventional fabrication methods do not have the necessary specificity to dictate void volume size, shape and distribution. Additive manufacturing (AM), or more commonly 3D printing, is a rapidly growing field in which material is selectively deposited in a layer wise manner as instructed by a computer-aided design (CAD). Therefore, AM has been seen as an attractive route for fabrication of porous structures. While many AM platforms have been investigated, the overall disadvantage with these processes has been the layer wise assembly method, which yields mechanically weak parts. Additionally, many methods impart an unintentional porosity on the resulting structure that deviates from CAD and aids in the mechanical failure mechanisms. This work sought to investigate and apply a novel AM platform, continuous liquid interface production (CLIP), to the fabrication of porous architected structures. The platform utilizes photopolymerization to reconstruct the CAD in a continuous manner. The platform was investigated for porous structure compatibility through assessment of the fabrication mechanism. It was found that CLIP structures fabricated continuously were layerless, addressing one of the key disadvantages with other platforms. The resolution of CLIP was preliminaryily explored and several contributing factors were identified. The resolution of the CLIP platform was investigated for the fabrication of porous architected structures. Void volumes in the hundreds of microns regime was explored through the fabrication of microlattices. Structures were systematically varied by unit cell type, size, orientation, resin formulation, and CLIP fabrication parameters. The resulting mechanical and physical property space was investigated. The lessons of the importance of low viscosity resin and exposure were carried forward. The tens of micron size range was explored through the fabrication of chromatography columns containg ordered internal architectures with CLIP. Functional resins to enable different separation mechanisms were developed and optimized for CLIP. The pore size of the internal architecture of the column was systematically reduced. The computational limit for CAD generation of complex structures was found and an angular hexagonally packed unit cell designed to facilitate computation as well as mimic monolithic column flow profiles was developed. Columns assembled with CLIP fabricated external housings were assessed for stability. Methods to circumvent computational constraints were developed to allow direct exposure of the light source which enabled the fabrication of smaller pore sizes approaching the theoretical limit of resolution. Spring 2018 2018 Analytical chemistry Materials Science Polymer chemistry 3D printing, Chromatography, Medical Devices, Scaffolds, Stereolithography, Tissue Engineering eng Doctor of Philosophy Dissertation Chemistry Joseph M. DeSimone Thesis advisor James Jorgenson Thesis advisor Leslie Hicks Thesis advisor Matthew Lockett Thesis advisor Sergei Sheiko Thesis advisor text University of North Carolina at Chapel Hill Degree granting institution Rima Janusziewicz Creator Department of Chemistry College of Arts and Sciences Continuous Liquid Interface Production (CLIP) for the Fabrication of Porous Architected Structures Porous structures have long been investigated for advanced material properties however conventional fabrication methods do not have the necessary specificity to dictate void volume size, shape and distribution. Additive manufacturing (AM), or more commonly 3D printing, is a rapidly growing field in which material is selectively deposited in a layer wise manner as instructed by a computer-aided design (CAD). Therefore, AM has been seen as an attractive route for fabrication of porous structures. While many AM platforms have been investigated, the overall disadvantage with these processes has been the layer wise assembly method, which yields mechanically weak parts. Additionally, many methods impart an unintentional porosity on the resulting structure that deviates from CAD and aids in the mechanical failure mechanisms. This work sought to investigate and apply a novel AM platform, continuous liquid interface production (CLIP), to the fabrication of porous architected structures. The platform utilizes photopolymerization to reconstruct the CAD in a continuous manner. The platform was investigated for porous structure compatibility through assessment of the fabrication mechanism. It was found that CLIP structures fabricated continuously were layerless, addressing one of the key disadvantages with other platforms. The resolution of CLIP was preliminaryily explored and several contributing factors were identified. The resolution of the CLIP platform was investigated for the fabrication of porous architected structures. Void volumes in the hundreds of microns regime was explored through the fabrication of microlattices. Structures were systematically varied by unit cell type, size, orientation, resin formulation, and CLIP fabrication parameters. The resulting mechanical and physical property space was investigated. The lessons of the importance of low viscosity resin and exposure were carried forward. The tens of micron size range was explored through the fabrication of chromatography columns containg ordered internal architectures with CLIP. Functional resins to enable different separation mechanisms were developed and optimized for CLIP. The pore size of the internal architecture of the column was systematically reduced. The computational limit for CAD generation of complex structures was found and an angular hexagonally packed unit cell designed to facilitate computation as well as mimic monolithic column flow profiles was developed. Columns assembled with CLIP fabricated external housings were assessed for stability. Methods to circumvent computational constraints were developed to allow direct exposure of the light source which enabled the fabrication of smaller pore sizes approaching the theoretical limit of resolution. Analytical chemistry Materials Science Polymer chemistry 3D printing; Chromatography; Medical Devices; Scaffolds; Stereolithography; Tissue Engineering eng Doctor of Philosophy Dissertation Chemistry Joseph M. DeSimone Thesis advisor James Jorgenson Thesis advisor Leslie Hicks Thesis advisor Matthew Lockett Thesis advisor Sergei Sheiko Thesis advisor text University of North Carolina at Chapel Hill Degree granting institution 2018 2018-05 Rima Janusziewicz Author Department of Chemistry College of Arts and Sciences Continuous Liquid Interface Production (CLIP) for the Fabrication of Porous Architected Structures Porous structures have long been investigated for advanced material properties however conventional fabrication methods do not have the necessary specificity to dictate void volume size, shape and distribution. Additive manufacturing (AM), or more commonly 3D printing, is a rapidly growing field in which material is selectively deposited in a layer wise manner as instructed by a computer-aided design (CAD). Therefore, AM has been seen as an attractive route for fabrication of porous structures. While many AM platforms have been investigated, the overall disadvantage with these processes has been the layer wise assembly method, which yields mechanically weak parts. Additionally, many methods impart an unintentional porosity on the resulting structure that deviates from CAD and aids in the mechanical failure mechanisms. This work sought to investigate and apply a novel AM platform, continuous liquid interface production (CLIP), to the fabrication of porous architected structures. The platform utilizes photopolymerization to reconstruct the CAD in a continuous manner. The platform was investigated for porous structure compatibility through assessment of the fabrication mechanism. It was found that CLIP structures fabricated continuously were layerless, addressing one of the key disadvantages with other platforms. The resolution of CLIP was preliminaryily explored and several contributing factors were identified. The resolution of the CLIP platform was investigated for the fabrication of porous architected structures. Void volumes in the hundreds of microns regime was explored through the fabrication of microlattices. Structures were systematically varied by unit cell type, size, orientation, resin formulation, and CLIP fabrication parameters. The resulting mechanical and physical property space was investigated. The lessons of the importance of low viscosity resin and exposure were carried forward. The tens of micron size range was explored through the fabrication of chromatography columns containg ordered internal architectures with CLIP. Functional resins to enable different separation mechanisms were developed and optimized for CLIP. The pore size of the internal architecture of the column was systematically reduced. The computational limit for CAD generation of complex structures was found and an angular hexagonally packed unit cell designed to facilitate computation as well as mimic monolithic column flow profiles was developed. Columns assembled with CLIP fabricated external housings were assessed for stability. Methods to circumvent computational constraints were developed to allow direct exposure of the light source which enabled the fabrication of smaller pore sizes approaching the theoretical limit of resolution. Spring 2018 2018 Analytical chemistry Materials Science Polymer chemistry 3D printing, Chromatography, Medical Devices, Scaffolds, Stereolithography, Tissue Engineering eng Doctor of Philosophy Dissertation University of North Carolina at Chapel Hill Graduate School Degree granting institution Chemistry Joseph M. DeSimone Thesis advisor James Jorgenson Thesis advisor Leslie Hicks Thesis advisor Matthew Lockett Thesis advisor Sergei Sheiko Thesis advisor text Rima Janusziewicz Creator Department of Chemistry College of Arts and Sciences Porous structures have long been investigated for advanced material properties however conventional fabrication methods do not have the necessary specificity to dictate void volume size, shape and distribution. Additive manufacturing (AM), or more commonly 3D printing, is a rapidly growing field in which material is selectively deposited in a layer wise manner as instructed by a computer-aided design (CAD). Therefore, AM has been seen as an attractive route for fabrication of porous structures. While many AM platforms have been investigated, the overall disadvantage with these processes has been the layer wise assembly method, which yields mechanically weak parts. Additionally, many methods impart an unintentional porosity on the resulting structure that deviates from CAD and aids in the mechanical failure mechanisms. This work sought to investigate and apply a novel AM platform, continuous liquid interface production (CLIP), to the fabrication of porous architected structures. The platform utilizes photopolymerization to reconstruct the CAD in a continuous manner. The platform was investigated for porous structure compatibility through assessment of the fabrication mechanism. It was found that CLIP structures fabricated continuously were layerless, addressing one of the key disadvantages with other platforms. The resolution of CLIP was preliminaryily explored and several contributing factors were identified. The resolution of the CLIP platform was investigated for the fabrication of porous architected structures. Void volumes in the hundreds of microns regime was explored through the fabrication of microlattices. Structures were systematically varied by unit cell type, size, orientation, resin formulation, and CLIP fabrication parameters. The resulting mechanical and physical property space was investigated. The lessons of the importance of low viscosity resin and exposure were carried forward. The tens of micron size range was explored through the fabrication of chromatography columns containg ordered internal architectures with CLIP. Functional resins to enable different separation mechanisms were developed and optimized for CLIP. The pore size of the internal architecture of the column was systematically reduced. The computational limit for CAD generation of complex structures was found and an angular hexagonally packed unit cell designed to facilitate computation as well as mimic monolithic column flow profiles was developed. Columns assembled with CLIP fabricated external housings were assessed for stability. Methods to circumvent computational constraints were developed to allow direct exposure of the light source which enabled the fabrication of smaller pore sizes approaching the theoretical limit of resolution. 2018-05 2018 Analytical chemistry Materials Science Polymer chemistry 3D printing; Chromatography; Medical Devices; Scaffolds; Stereolithography; Tissue Engineering eng Doctor of Philosophy Dissertation University of North Carolina at Chapel Hill Graduate School Degree granting institution Joseph M. DeSimone Thesis advisor James Jorgenson Thesis advisor Leslie Hicks Thesis advisor Matthew Lockett Thesis advisor Sergei Sheiko Thesis advisor text Janusziewicz_unc_0153D_17486.pdf uuid:9d650568-38b5-4697-b38f-4747d72707e8 2020-06-13T00:00:00 2018-03-20T14:32:30Z proquest application/pdf 16198360