ingest cdrApp 2017-06-30T20:37:20.947Z aac86417-22f1-4cf6-b34c-2c21f31ce694 modifyDatastreamByValue RELS-EXT fedoraAdmin 2017-06-30T23:18:58.472Z Setting exclusive relation modifyDatastreamByValue RELS-EXT fedoraAdmin 2017-06-30T23:19:09.309Z Setting exclusive relation addDatastream MD_TECHNICAL fedoraAdmin 2017-06-30T23:19:18.693Z Adding technical metadata derived by FITS modifyDatastreamByValue RELS-EXT fedoraAdmin 2017-06-30T23:19:37.269Z Setting exclusive relation addDatastream MD_FULL_TEXT fedoraAdmin 2017-06-30T23:19:49.909Z Adding full text metadata extracted by Apache Tika modifyDatastreamByValue RELS-EXT fedoraAdmin 2017-06-30T23:20:09.900Z Setting exclusive relation modifyDatastreamByValue RELS-EXT cdrApp 2017-07-05T17:48:04.242Z Setting exclusive relation modifyDatastreamByValue MD_DESCRIPTIVE cdrApp 2018-01-25T07:11:02.290Z modifyDatastreamByValue MD_DESCRIPTIVE cdrApp 2018-01-27T07:42:54.846Z modifyDatastreamByValue MD_DESCRIPTIVE cdrApp 2018-03-14T04:01:32.624Z modifyDatastreamByValue MD_DESCRIPTIVE cdrApp 2018-05-17T15:42:43.767Z modifyDatastreamByValue MD_DESCRIPTIVE cdrApp 2018-07-11T02:30:27.100Z modifyDatastreamByValue MD_DESCRIPTIVE cdrApp 2018-07-17T22:51:32.906Z modifyDatastreamByValue MD_DESCRIPTIVE cdrApp 2018-08-15T19:00:46.508Z modifyDatastreamByValue MD_DESCRIPTIVE cdrApp 2018-09-21T19:22:20.471Z modifyDatastreamByValue MD_DESCRIPTIVE cdrApp 2018-09-26T22:41:30.334Z modifyDatastreamByValue MD_DESCRIPTIVE cdrApp 2018-10-11T23:13:50.846Z modifyDatastreamByValue MD_DESCRIPTIVE cdrApp 2019-03-20T17:01:34.799Z Elizabeth Teel Author Curriculum in Human Movement Science School of Medicine The Effect of ACTIVE Training on Clinical and Physiological Outcomes in Healthy and Concussed College-Aged Participants Concussions are a pathophysiological injury resulting in symptom, clinical, and physiological deficits. Current guidelines dictate complete physical rest until asymptomatic but a shift towards more active recovery is being advised. Exercise as rehabilitation has been successful in patients with chronic concussion dysfunction, but has not been thoroughly studied acutely following injury. The expected changes of brief aerobic training on clinical and physiological outcomes remain unknown. The acute concussion therapy intervention (ACTIVE) training is an aerobic exercise program designed to expedite clinical and physiological healing following concussion, but first must be vetted in healthy populations. The primary purpose of this study was to evaluate the feasibility and effectiveness of ACTIVE training in healthy college-aged participants. Participants were randomly assigned to ACTIVE training or control groups. All participants received clinical and physiological assessments at two test sessions approximately 14 days apart. ACTIVE training participants completed six training bouts between test sessions. ACTIVE training was feasible, with no adverse events reported and high adherence to the progressively increasing training protocol. Heart rate (P=0.01), percentage of predicted maximal heart rate (P=0.01), and test duration (P=0.03) significantly increased in the intervention group between test sessions. The intervention group had significantly increased central alpha power between sessions and higher central theta compared to the control group (p=0.02) during eyes closed (p=0.006) conditions. Clinical outcomes were stable in response to ACTIVE training, with no mean differences exceeding reliable change scores. These cardiopulmonary improvements provide an important proof of concept in translating ACTIVE training to concussed patients, suggesting that aerobic training may target the physiological domains affected following concussion and help athletes maintain fitness during recovery. EEG outcomes may represent the neural underpinning of psychological and cognitive domains, which may have additional relevance to concussed populations and should be studied further in the future. The stability of clinical variables following ACTIVE training highlights their utility as diagnostic and management tools, as any changes seen in these assessments following injury represents subsequent healing and are not a byproduct of exercise alone. Spring 2017 2017 Kinesiology clinical, concussion, exercise, feasbility, physiology, rehabiliation eng Doctor of Philosophy Dissertation University of North Carolina at Chapel Hill Graduate School Degree granting institution Human Movement Science Jason Mihalik Thesis advisor Gregory Appelbaum Thesis advisor Claudio Battaglini Thesis advisor Kevin Guskiewicz Thesis advisor Stephen Marshall Thesis advisor Johna Register-Mihalik Thesis advisor text Elizabeth Teel Creator Curriculum in Human Movement Science School of Medicine The Effect of ACTIVE Training on Clinical and Physiological Outcomes in Healthy and Concussed College-Aged Participants Concussions are a pathophysiological injury resulting in symptom, clinical, and physiological deficits. Current guidelines dictate complete physical rest until asymptomatic but a shift towards more active recovery is being advised. Exercise as rehabilitation has been successful in patients with chronic concussion dysfunction, but has not been thoroughly studied acutely following injury. The expected changes of brief aerobic training on clinical and physiological outcomes remain unknown. The acute concussion therapy intervention (ACTIVE) training is an aerobic exercise program designed to expedite clinical and physiological healing following concussion, but first must be vetted in healthy populations. The primary purpose of this study was to evaluate the feasibility and effectiveness of ACTIVE training in healthy college-aged participants. Participants were randomly assigned to ACTIVE training or control groups. All participants received clinical and physiological assessments at two test sessions approximately 14 days apart. ACTIVE training participants completed six training bouts between test sessions. ACTIVE training was feasible, with no adverse events reported and high adherence to the progressively increasing training protocol. Heart rate (P=0.01), percentage of predicted maximal heart rate (P=0.01), and test duration (P=0.03) significantly increased in the intervention group between test sessions. The intervention group had significantly increased central alpha power between sessions and higher central theta compared to the control group (p=0.02) during eyes closed (p=0.006) conditions. Clinical outcomes were stable in response to ACTIVE training, with no mean differences exceeding reliable change scores. These cardiopulmonary improvements provide an important proof of concept in translating ACTIVE training to concussed patients, suggesting that aerobic training may target the physiological domains affected following concussion and help athletes maintain fitness during recovery. EEG outcomes may represent the neural underpinning of psychological and cognitive domains, which may have additional relevance to concussed populations and should be studied further in the future. The stability of clinical variables following ACTIVE training highlights their utility as diagnostic and management tools, as any changes seen in these assessments following injury represents subsequent healing and are not a byproduct of exercise alone. Spring 2017 2017 Kinesiology clinical, concussion, exercise, feasbility, physiology, rehabiliation eng Doctor of Philosophy Dissertation University of North Carolina at Chapel Hill Graduate School Degree granting institution Human Movement Science Jason Mihalik Thesis advisor Gregory Appelbaum Thesis advisor Claudio Battaglini Thesis advisor Kevin Guskiewicz Thesis advisor Stephen Marshall Thesis advisor Johna Register-Mihalik Thesis advisor text Elizabeth Teel Creator Curriculum in Human Movement Science School of Medicine The Effect of ACTIVE Training on Clinical and Physiological Outcomes in Healthy and Concussed College-Aged Participants Concussions are a pathophysiological injury resulting in symptom, clinical, and physiological deficits. Current guidelines dictate complete physical rest until asymptomatic but a shift towards more active recovery is being advised. Exercise as rehabilitation has been successful in patients with chronic concussion dysfunction, but has not been thoroughly studied acutely following injury. The expected changes of brief aerobic training on clinical and physiological outcomes remain unknown. The acute concussion therapy intervention (ACTIVE) training is an aerobic exercise program designed to expedite clinical and physiological healing following concussion, but first must be vetted in healthy populations. The primary purpose of this study was to evaluate the feasibility and effectiveness of ACTIVE training in healthy college-aged participants. Participants were randomly assigned to ACTIVE training or control groups. All participants received clinical and physiological assessments at two test sessions approximately 14 days apart. ACTIVE training participants completed six training bouts between test sessions. ACTIVE training was feasible, with no adverse events reported and high adherence to the progressively increasing training protocol. Heart rate (P=0.01), percentage of predicted maximal heart rate (P=0.01), and test duration (P=0.03) significantly increased in the intervention group between test sessions. The intervention group had significantly increased central alpha power between sessions and higher central theta compared to the control group (p=0.02) during eyes closed (p=0.006) conditions. Clinical outcomes were stable in response to ACTIVE training, with no mean differences exceeding reliable change scores. These cardiopulmonary improvements provide an important proof of concept in translating ACTIVE training to concussed patients, suggesting that aerobic training may target the physiological domains affected following concussion and help athletes maintain fitness during recovery. EEG outcomes may represent the neural underpinning of psychological and cognitive domains, which may have additional relevance to concussed populations and should be studied further in the future. The stability of clinical variables following ACTIVE training highlights their utility as diagnostic and management tools, as any changes seen in these assessments following injury represents subsequent healing and are not a byproduct of exercise alone. Spring 2017 2017 Kinesiology clinical, concussion, exercise, feasbility, physiology, rehabiliation eng Doctor of Philosophy Dissertation University of North Carolina at Chapel Hill Graduate School Degree granting institution Human Movement Science Jason Mihalik Thesis advisor Gregory Appelbaum Thesis advisor Claudio Battaglini Thesis advisor Kevin Guskiewicz Thesis advisor Stephen Marshall Thesis advisor Johna Register-Mihalik Thesis advisor text Elizabeth Teel Creator Curriculum in Human Movement Science School of Medicine The Effect of ACTIVE Training on Clinical and Physiological Outcomes in Healthy and Concussed College-Aged Participants Concussions are a pathophysiological injury resulting in symptom, clinical, and physiological deficits. Current guidelines dictate complete physical rest until asymptomatic but a shift towards more active recovery is being advised. Exercise as rehabilitation has been successful in patients with chronic concussion dysfunction, but has not been thoroughly studied acutely following injury. The expected changes of brief aerobic training on clinical and physiological outcomes remain unknown. The acute concussion therapy intervention (ACTIVE) training is an aerobic exercise program designed to expedite clinical and physiological healing following concussion, but first must be vetted in healthy populations. The primary purpose of this study was to evaluate the feasibility and effectiveness of ACTIVE training in healthy college-aged participants. Participants were randomly assigned to ACTIVE training or control groups. All participants received clinical and physiological assessments at two test sessions approximately 14 days apart. ACTIVE training participants completed six training bouts between test sessions. ACTIVE training was feasible, with no adverse events reported and high adherence to the progressively increasing training protocol. Heart rate (P=0.01), percentage of predicted maximal heart rate (P=0.01), and test duration (P=0.03) significantly increased in the intervention group between test sessions. The intervention group had significantly increased central alpha power between sessions and higher central theta compared to the control group (p=0.02) during eyes closed (p=0.006) conditions. Clinical outcomes were stable in response to ACTIVE training, with no mean differences exceeding reliable change scores. These cardiopulmonary improvements provide an important proof of concept in translating ACTIVE training to concussed patients, suggesting that aerobic training may target the physiological domains affected following concussion and help athletes maintain fitness during recovery. EEG outcomes may represent the neural underpinning of psychological and cognitive domains, which may have additional relevance to concussed populations and should be studied further in the future. The stability of clinical variables following ACTIVE training highlights their utility as diagnostic and management tools, as any changes seen in these assessments following injury represents subsequent healing and are not a byproduct of exercise alone. 2017-05 2017 Kinesiology clinical, concussion, exercise, feasbility, physiology, rehabiliation eng Doctor of Philosophy Dissertation University of North Carolina at Chapel Hill Graduate School Degree granting institution Human Movement Science Jason Mihalik Thesis advisor Gregory Appelbaum Thesis advisor Claudio Battaglini Thesis advisor Kevin Guskiewicz Thesis advisor Stephen Marshall Thesis advisor Johna Register-Mihalik Thesis advisor text Elizabeth Teel Creator Curriculum in Human Movement Science School of Medicine The Effect of ACTIVE Training on Clinical and Physiological Outcomes in Healthy and Concussed College-Aged Participants Concussions are a pathophysiological injury resulting in symptom, clinical, and physiological deficits. Current guidelines dictate complete physical rest until asymptomatic but a shift towards more active recovery is being advised. Exercise as rehabilitation has been successful in patients with chronic concussion dysfunction, but has not been thoroughly studied acutely following injury. The expected changes of brief aerobic training on clinical and physiological outcomes remain unknown. The acute concussion therapy intervention (ACTIVE) training is an aerobic exercise program designed to expedite clinical and physiological healing following concussion, but first must be vetted in healthy populations. The primary purpose of this study was to evaluate the feasibility and effectiveness of ACTIVE training in healthy college-aged participants. Participants were randomly assigned to ACTIVE training or control groups. All participants received clinical and physiological assessments at two test sessions approximately 14 days apart. ACTIVE training participants completed six training bouts between test sessions. ACTIVE training was feasible, with no adverse events reported and high adherence to the progressively increasing training protocol. Heart rate (P=0.01), percentage of predicted maximal heart rate (P=0.01), and test duration (P=0.03) significantly increased in the intervention group between test sessions. The intervention group had significantly increased central alpha power between sessions and higher central theta compared to the control group (p=0.02) during eyes closed (p=0.006) conditions. Clinical outcomes were stable in response to ACTIVE training, with no mean differences exceeding reliable change scores. These cardiopulmonary improvements provide an important proof of concept in translating ACTIVE training to concussed patients, suggesting that aerobic training may target the physiological domains affected following concussion and help athletes maintain fitness during recovery. EEG outcomes may represent the neural underpinning of psychological and cognitive domains, which may have additional relevance to concussed populations and should be studied further in the future. The stability of clinical variables following ACTIVE training highlights their utility as diagnostic and management tools, as any changes seen in these assessments following injury represents subsequent healing and are not a byproduct of exercise alone. 2017 Kinesiology clinical, concussion, exercise, feasbility, physiology, rehabiliation eng Doctor of Philosophy Dissertation University of North Carolina at Chapel Hill Graduate School Degree granting institution Human Movement Science Jason Mihalik Thesis advisor Gregory Appelbaum Thesis advisor Claudio Battaglini Thesis advisor Kevin Guskiewicz Thesis advisor Stephen Marshall Thesis advisor Johna Register-Mihalik Thesis advisor text 2017-05 Elizabeth Teel Creator Curriculum in Human Movement Science School of Medicine The Effect of ACTIVE Training on Clinical and Physiological Outcomes in Healthy and Concussed College-Aged Participants Concussions are a pathophysiological injury resulting in symptom, clinical, and physiological deficits. Current guidelines dictate complete physical rest until asymptomatic but a shift towards more active recovery is being advised. Exercise as rehabilitation has been successful in patients with chronic concussion dysfunction, but has not been thoroughly studied acutely following injury. The expected changes of brief aerobic training on clinical and physiological outcomes remain unknown. The acute concussion therapy intervention (ACTIVE) training is an aerobic exercise program designed to expedite clinical and physiological healing following concussion, but first must be vetted in healthy populations. The primary purpose of this study was to evaluate the feasibility and effectiveness of ACTIVE training in healthy college-aged participants. Participants were randomly assigned to ACTIVE training or control groups. All participants received clinical and physiological assessments at two test sessions approximately 14 days apart. ACTIVE training participants completed six training bouts between test sessions. ACTIVE training was feasible, with no adverse events reported and high adherence to the progressively increasing training protocol. Heart rate (P=0.01), percentage of predicted maximal heart rate (P=0.01), and test duration (P=0.03) significantly increased in the intervention group between test sessions. The intervention group had significantly increased central alpha power between sessions and higher central theta compared to the control group (p=0.02) during eyes closed (p=0.006) conditions. Clinical outcomes were stable in response to ACTIVE training, with no mean differences exceeding reliable change scores. These cardiopulmonary improvements provide an important proof of concept in translating ACTIVE training to concussed patients, suggesting that aerobic training may target the physiological domains affected following concussion and help athletes maintain fitness during recovery. EEG outcomes may represent the neural underpinning of psychological and cognitive domains, which may have additional relevance to concussed populations and should be studied further in the future. The stability of clinical variables following ACTIVE training highlights their utility as diagnostic and management tools, as any changes seen in these assessments following injury represents subsequent healing and are not a byproduct of exercise alone. 2017 Kinesiology clinical, concussion, exercise, feasbility, physiology, rehabiliation eng Doctor of Philosophy Dissertation University of North Carolina at Chapel Hill Graduate School Degree granting institution Human Movement Science Jason Mihalik Thesis advisor Gregory Appelbaum Thesis advisor Claudio Battaglini Thesis advisor Kevin Guskiewicz Thesis advisor Stephen Marshall Thesis advisor Johna Register-Mihalik Thesis advisor text 2017-05 Elizabeth Teel Creator Curriculum in Human Movement Science School of Medicine The Effect of ACTIVE Training on Clinical and Physiological Outcomes in Healthy and Concussed College-Aged Participants Concussions are a pathophysiological injury resulting in symptom, clinical, and physiological deficits. Current guidelines dictate complete physical rest until asymptomatic but a shift towards more active recovery is being advised. Exercise as rehabilitation has been successful in patients with chronic concussion dysfunction, but has not been thoroughly studied acutely following injury. The expected changes of brief aerobic training on clinical and physiological outcomes remain unknown. The acute concussion therapy intervention (ACTIVE) training is an aerobic exercise program designed to expedite clinical and physiological healing following concussion, but first must be vetted in healthy populations. The primary purpose of this study was to evaluate the feasibility and effectiveness of ACTIVE training in healthy college-aged participants. Participants were randomly assigned to ACTIVE training or control groups. All participants received clinical and physiological assessments at two test sessions approximately 14 days apart. ACTIVE training participants completed six training bouts between test sessions. ACTIVE training was feasible, with no adverse events reported and high adherence to the progressively increasing training protocol. Heart rate (P=0.01), percentage of predicted maximal heart rate (P=0.01), and test duration (P=0.03) significantly increased in the intervention group between test sessions. The intervention group had significantly increased central alpha power between sessions and higher central theta compared to the control group (p=0.02) during eyes closed (p=0.006) conditions. Clinical outcomes were stable in response to ACTIVE training, with no mean differences exceeding reliable change scores. These cardiopulmonary improvements provide an important proof of concept in translating ACTIVE training to concussed patients, suggesting that aerobic training may target the physiological domains affected following concussion and help athletes maintain fitness during recovery. EEG outcomes may represent the neural underpinning of psychological and cognitive domains, which may have additional relevance to concussed populations and should be studied further in the future. The stability of clinical variables following ACTIVE training highlights their utility as diagnostic and management tools, as any changes seen in these assessments following injury represents subsequent healing and are not a byproduct of exercise alone. 2017 Kinesiology clinical, concussion, exercise, feasbility, physiology, rehabiliation eng Doctor of Philosophy Dissertation University of North Carolina at Chapel Hill Graduate School Degree granting institution Human Movement Science Jason Mihalik Thesis advisor Gregory Appelbaum Thesis advisor Claudio Battaglini Thesis advisor Kevin Guskiewicz Thesis advisor Stephen Marshall Thesis advisor Johna Register-Mihalik Thesis advisor text 2017-05 Elizabeth Teel Creator Curriculum in Human Movement Science School of Medicine The Effect of ACTIVE Training on Clinical and Physiological Outcomes in Healthy and Concussed College-Aged Participants Concussions are a pathophysiological injury resulting in symptom, clinical, and physiological deficits. Current guidelines dictate complete physical rest until asymptomatic but a shift towards more active recovery is being advised. Exercise as rehabilitation has been successful in patients with chronic concussion dysfunction, but has not been thoroughly studied acutely following injury. The expected changes of brief aerobic training on clinical and physiological outcomes remain unknown. The acute concussion therapy intervention (ACTIVE) training is an aerobic exercise program designed to expedite clinical and physiological healing following concussion, but first must be vetted in healthy populations. The primary purpose of this study was to evaluate the feasibility and effectiveness of ACTIVE training in healthy college-aged participants. Participants were randomly assigned to ACTIVE training or control groups. All participants received clinical and physiological assessments at two test sessions approximately 14 days apart. ACTIVE training participants completed six training bouts between test sessions. ACTIVE training was feasible, with no adverse events reported and high adherence to the progressively increasing training protocol. Heart rate (P=0.01), percentage of predicted maximal heart rate (P=0.01), and test duration (P=0.03) significantly increased in the intervention group between test sessions. The intervention group had significantly increased central alpha power between sessions and higher central theta compared to the control group (p=0.02) during eyes closed (p=0.006) conditions. Clinical outcomes were stable in response to ACTIVE training, with no mean differences exceeding reliable change scores. These cardiopulmonary improvements provide an important proof of concept in translating ACTIVE training to concussed patients, suggesting that aerobic training may target the physiological domains affected following concussion and help athletes maintain fitness during recovery. EEG outcomes may represent the neural underpinning of psychological and cognitive domains, which may have additional relevance to concussed populations and should be studied further in the future. The stability of clinical variables following ACTIVE training highlights their utility as diagnostic and management tools, as any changes seen in these assessments following injury represents subsequent healing and are not a byproduct of exercise alone. 2017 Kinesiology clinical, concussion, exercise, feasbility, physiology, rehabiliation eng Doctor of Philosophy Dissertation Human Movement Science Jason Mihalik Thesis advisor Gregory Appelbaum Thesis advisor Claudio L. Battaglini Thesis advisor Kevin M. Guskiewicz Thesis advisor Stephen Marshall Thesis advisor Johna Register-Mihalik Thesis advisor text 2017-05 University of North Carolina at Chapel Hill Degree granting institution Elizabeth Teel Creator Curriculum in Human Movement Science School of Medicine The Effect of ACTIVE Training on Clinical and Physiological Outcomes in Healthy and Concussed College-Aged Participants Concussions are a pathophysiological injury resulting in symptom, clinical, and physiological deficits. Current guidelines dictate complete physical rest until asymptomatic but a shift towards more active recovery is being advised. Exercise as rehabilitation has been successful in patients with chronic concussion dysfunction, but has not been thoroughly studied acutely following injury. The expected changes of brief aerobic training on clinical and physiological outcomes remain unknown. The acute concussion therapy intervention (ACTIVE) training is an aerobic exercise program designed to expedite clinical and physiological healing following concussion, but first must be vetted in healthy populations. The primary purpose of this study was to evaluate the feasibility and effectiveness of ACTIVE training in healthy college-aged participants. Participants were randomly assigned to ACTIVE training or control groups. All participants received clinical and physiological assessments at two test sessions approximately 14 days apart. ACTIVE training participants completed six training bouts between test sessions. ACTIVE training was feasible, with no adverse events reported and high adherence to the progressively increasing training protocol. Heart rate (P=0.01), percentage of predicted maximal heart rate (P=0.01), and test duration (P=0.03) significantly increased in the intervention group between test sessions. The intervention group had significantly increased central alpha power between sessions and higher central theta compared to the control group (p=0.02) during eyes closed (p=0.006) conditions. Clinical outcomes were stable in response to ACTIVE training, with no mean differences exceeding reliable change scores. These cardiopulmonary improvements provide an important proof of concept in translating ACTIVE training to concussed patients, suggesting that aerobic training may target the physiological domains affected following concussion and help athletes maintain fitness during recovery. EEG outcomes may represent the neural underpinning of psychological and cognitive domains, which may have additional relevance to concussed populations and should be studied further in the future. The stability of clinical variables following ACTIVE training highlights their utility as diagnostic and management tools, as any changes seen in these assessments following injury represents subsequent healing and are not a byproduct of exercise alone. 2017 Kinesiology clinical, concussion, exercise, feasbility, physiology, rehabiliation eng Doctor of Philosophy Dissertation University of North Carolina at Chapel Hill Graduate School Degree granting institution Human Movement Science Jason Mihalik Thesis advisor Gregory Appelbaum Thesis advisor Claudio Battaglini Thesis advisor Kevin Guskiewicz Thesis advisor Stephen Marshall Thesis advisor Johna Register-Mihalik Thesis advisor text 2017-05 Elizabeth Teel Creator Curriculum in Human Movement Science School of Medicine The Effect of ACTIVE Training on Clinical and Physiological Outcomes in Healthy and Concussed College-Aged Participants Concussions are a pathophysiological injury resulting in symptom, clinical, and physiological deficits. Current guidelines dictate complete physical rest until asymptomatic but a shift towards more active recovery is being advised. Exercise as rehabilitation has been successful in patients with chronic concussion dysfunction, but has not been thoroughly studied acutely following injury. The expected changes of brief aerobic training on clinical and physiological outcomes remain unknown. The acute concussion therapy intervention (ACTIVE) training is an aerobic exercise program designed to expedite clinical and physiological healing following concussion, but first must be vetted in healthy populations. The primary purpose of this study was to evaluate the feasibility and effectiveness of ACTIVE training in healthy college-aged participants. Participants were randomly assigned to ACTIVE training or control groups. All participants received clinical and physiological assessments at two test sessions approximately 14 days apart. ACTIVE training participants completed six training bouts between test sessions. ACTIVE training was feasible, with no adverse events reported and high adherence to the progressively increasing training protocol. Heart rate (P=0.01), percentage of predicted maximal heart rate (P=0.01), and test duration (P=0.03) significantly increased in the intervention group between test sessions. The intervention group had significantly increased central alpha power between sessions and higher central theta compared to the control group (p=0.02) during eyes closed (p=0.006) conditions. Clinical outcomes were stable in response to ACTIVE training, with no mean differences exceeding reliable change scores. These cardiopulmonary improvements provide an important proof of concept in translating ACTIVE training to concussed patients, suggesting that aerobic training may target the physiological domains affected following concussion and help athletes maintain fitness during recovery. EEG outcomes may represent the neural underpinning of psychological and cognitive domains, which may have additional relevance to concussed populations and should be studied further in the future. The stability of clinical variables following ACTIVE training highlights their utility as diagnostic and management tools, as any changes seen in these assessments following injury represents subsequent healing and are not a byproduct of exercise alone. 2017 Kinesiology clinical; concussion; exercise; feasbility; physiology; rehabiliation eng Doctor of Philosophy Dissertation Human Movement Science Jason Mihalik Thesis advisor Gregory Appelbaum Thesis advisor Claudio L. Battaglini Thesis advisor Kevin M. Guskiewicz Thesis advisor Stephen Marshall Thesis advisor Johna Register-Mihalik Thesis advisor text 2017-05 University of North Carolina at Chapel Hill Degree granting institution Elizabeth Teel Creator Curriculum in Human Movement Science School of Medicine The Effect of ACTIVE Training on Clinical and Physiological Outcomes in Healthy and Concussed College-Aged Participants Concussions are a pathophysiological injury resulting in symptom, clinical, and physiological deficits. Current guidelines dictate complete physical rest until asymptomatic but a shift towards more active recovery is being advised. Exercise as rehabilitation has been successful in patients with chronic concussion dysfunction, but has not been thoroughly studied acutely following injury. The expected changes of brief aerobic training on clinical and physiological outcomes remain unknown. The acute concussion therapy intervention (ACTIVE) training is an aerobic exercise program designed to expedite clinical and physiological healing following concussion, but first must be vetted in healthy populations. The primary purpose of this study was to evaluate the feasibility and effectiveness of ACTIVE training in healthy college-aged participants. Participants were randomly assigned to ACTIVE training or control groups. All participants received clinical and physiological assessments at two test sessions approximately 14 days apart. ACTIVE training participants completed six training bouts between test sessions. ACTIVE training was feasible, with no adverse events reported and high adherence to the progressively increasing training protocol. Heart rate (P=0.01), percentage of predicted maximal heart rate (P=0.01), and test duration (P=0.03) significantly increased in the intervention group between test sessions. The intervention group had significantly increased central alpha power between sessions and higher central theta compared to the control group (p=0.02) during eyes closed (p=0.006) conditions. Clinical outcomes were stable in response to ACTIVE training, with no mean differences exceeding reliable change scores. These cardiopulmonary improvements provide an important proof of concept in translating ACTIVE training to concussed patients, suggesting that aerobic training may target the physiological domains affected following concussion and help athletes maintain fitness during recovery. EEG outcomes may represent the neural underpinning of psychological and cognitive domains, which may have additional relevance to concussed populations and should be studied further in the future. The stability of clinical variables following ACTIVE training highlights their utility as diagnostic and management tools, as any changes seen in these assessments following injury represents subsequent healing and are not a byproduct of exercise alone. 2017 Kinesiology clinical, concussion, exercise, feasbility, physiology, rehabiliation eng Doctor of Philosophy Dissertation University of North Carolina at Chapel Hill Graduate School Degree granting institution Human Movement Science Jason Mihalik Thesis advisor Gregory Appelbaum Thesis advisor Claudio L. Battaglini Thesis advisor Kevin M. Guskiewicz Thesis advisor Stephen Marshall Thesis advisor Johna Register-Mihalik Thesis advisor text 2017-05 Elizabeth Teel Creator Curriculum in Human Movement Science School of Medicine Concussions are a pathophysiological injury resulting in symptom, clinical, and physiological deficits. Current guidelines dictate complete physical rest until asymptomatic but a shift towards more active recovery is being advised. Exercise as rehabilitation has been successful in patients with chronic concussion dysfunction, but has not been thoroughly studied acutely following injury. The expected changes of brief aerobic training on clinical and physiological outcomes remain unknown. The acute concussion therapy intervention (ACTIVE) training is an aerobic exercise program designed to expedite clinical and physiological healing following concussion, but first must be vetted in healthy populations. The primary purpose of this study was to evaluate the feasibility and effectiveness of ACTIVE training in healthy college-aged participants. Participants were randomly assigned to ACTIVE training or control groups. All participants received clinical and physiological assessments at two test sessions approximately 14 days apart. ACTIVE training participants completed six training bouts between test sessions. ACTIVE training was feasible, with no adverse events reported and high adherence to the progressively increasing training protocol. Heart rate (P=0.01), percentage of predicted maximal heart rate (P=0.01), and test duration (P=0.03) significantly increased in the intervention group between test sessions. The intervention group had significantly increased central alpha power between sessions and higher central theta compared to the control group (p=0.02) during eyes closed (p=0.006) conditions. Clinical outcomes were stable in response to ACTIVE training, with no mean differences exceeding reliable change scores. These cardiopulmonary improvements provide an important proof of concept in translating ACTIVE training to concussed patients, suggesting that aerobic training may target the physiological domains affected following concussion and help athletes maintain fitness during recovery. EEG outcomes may represent the neural underpinning of psychological and cognitive domains, which may have additional relevance to concussed populations and should be studied further in the future. The stability of clinical variables following ACTIVE training highlights their utility as diagnostic and management tools, as any changes seen in these assessments following injury represents subsequent healing and are not a byproduct of exercise alone. 2017 Kinesiology clinical; concussion; exercise; feasbility; physiology; rehabiliation eng Doctor of Philosophy Dissertation University of North Carolina at Chapel Hill Graduate School Degree granting institution Jason Mihalik Thesis advisor Gregory Appelbaum Thesis advisor Claudio L. Battaglini Thesis advisor Kevin M. Guskiewicz Thesis advisor Stephen Marshall Thesis advisor Johna Register-Mihalik Thesis advisor text 2017-05 Teel_unc_0153D_16738.pdf uuid:8b03313d-b316-44fb-b04c-1d6d48ea1883 proquest 2017-04-17T17:13:14Z 2019-06-30T00:00:00 application/pdf 3993564 yes