ingest cdrApp 2017-07-05T20:13:42.459Z b743dd6f-fb31-445f-b2b9-a0aa4f8b7562 modifyDatastreamByValue RELS-EXT fedoraAdmin 2017-07-05T20:30:20.861Z Setting exclusive relation modifyDatastreamByValue RELS-EXT fedoraAdmin 2017-07-05T20:30:21.755Z Setting exclusive relation addDatastream MD_TECHNICAL fedoraAdmin 2017-07-05T20:30:22.222Z Adding technical metadata derived by FITS modifyDatastreamByValue RELS-EXT fedoraAdmin 2017-07-05T20:30:22.866Z Setting exclusive relation addDatastream MD_FULL_TEXT fedoraAdmin 2017-07-05T20:30:31.402Z Adding full text metadata extracted by Apache Tika modifyDatastreamByValue RELS-EXT fedoraAdmin 2017-07-05T20:30:47.585Z Setting exclusive relation modifyDatastreamByValue RELS-EXT cdrApp 2017-07-06T11:39:24.481Z Setting exclusive relation modifyDatastreamByValue MD_DESCRIPTIVE cdrApp 2018-01-05T12:55:04.940Z modifyDatastreamByValue MD_DESCRIPTIVE cdrApp 2018-01-25T09:48:56.653Z modifyDatastreamByValue MD_DESCRIPTIVE cdrApp 2018-01-27T10:02:25.507Z modifyDatastreamByValue MD_DESCRIPTIVE cdrApp 2018-03-14T06:44:41.651Z modifyDatastreamByValue MD_DESCRIPTIVE cdrApp 2018-05-17T18:20:53.240Z modifyDatastreamByValue MD_DESCRIPTIVE cdrApp 2018-07-11T05:13:02.233Z modifyDatastreamByValue MD_DESCRIPTIVE cdrApp 2018-07-18T01:27:46.182Z modifyDatastreamByValue MD_DESCRIPTIVE cdrApp 2018-08-16T14:38:46.733Z modifyDatastreamByValue MD_DESCRIPTIVE cdrApp 2018-09-27T01:10:10.754Z modifyDatastreamByValue MD_DESCRIPTIVE cdrApp 2018-10-12T01:43:19.952Z modifyDatastreamByValue MD_DESCRIPTIVE cdrApp 2019-03-20T19:58:51.407Z Krystal Reyes Viruet Author Department of Periodontology School of Dentistry EXPLORING THE RELATIONSHIPS AMONG THE PLACENTAL AND UMBILICAL MICROBIOMES, THE ORAL MICROBIOTA, AND ADVERSE PREGNANCY OUTCOMES ABSTRACT KRYSTAL REYES VIRUET: Exploring the Relationships among the Placental and Umbilical Microbiomes, the Oral Microbiota, and Adverse Pregnancy Outcomes (Under the direction of Flavia Teles, DDS, MS, DMSc, Steven Offenbacher, DDS, PhD, MS, and Andrea Azcarate-Peril, PhD) Aims: To compare the microbiomes of placenta and umbilicus samples from 44 women presenting periodontal diseases who experienced full term (FTB, n=22) and preterm births (PTB; <35 weeks, n=22), as well as, the level of maternal subgingival periodontal species in each group pre and post-partum. Materials and methods: Clinical and demographic data, subgingival plaque samples, as well as, placenta and umbilical cord tissues samples were obtained. The microbial content of the tissue samples were analyzed using 16rRNA sequencing, while subgingival biofilm samples were analyzed using checkerboard DNA-DNA hybridization method. Results: Most abundant phylum in both placenta and umbilicus samples was Firmicutes. Most abundant genera in both placenta and umbilicus samples was Veillonella. Some of the most common species detected were Neisseria elongata, Pyramidobacter piscolens, and Gemella morbillorum. Conclusion: PTB and FTB exhibit distinct umbilical microbiomes. PTB samples are more heavily colonized by oral pathogenic taxa, whereas FTB specimens had higher levels of commensal organisms. Spring 2017 2017 Microbiology Obstetrics Microbiome, Oral, Placenta, Pregnancy, Preterm, Umbilicus eng Master of Science Thesis University of North Carolina at Chapel Hill Graduate School Degree granting institution Dentistry (Periodontology) Flavia Teles Thesis advisor Steven Offenbacher Thesis advisor Andrea Azcarate-Peril Thesis advisor Flavia Teles Thesis advisor text Krystal Reyes Viruet Author Department of Periodontology School of Dentistry Exploring the Relationships among the Placental and Umbilical Microbiomes, the Oral Microbiota, and Adverse Pregnancy Outcomes ABSTRACT KRYSTAL REYES VIRUET: Exploring the Relationships among the Placental and Umbilical Microbiomes, the Oral Microbiota, and Adverse Pregnancy Outcomes (Under the direction of Flavia Teles, DDS, MS, DMSc, Steven Offenbacher, DDS, PhD, MS, and Andrea Azcarate-Peril, PhD) Aims: To compare the microbiomes of placenta and umbilicus samples from 44 women presenting periodontal diseases who experienced full term (FTB, n=22) and preterm births (PTB; <35 weeks, n=22), as well as, the level of maternal subgingival periodontal species in each group pre and post-partum. Materials and methods: Clinical and demographic data, subgingival plaque samples, as well as, placenta and umbilical cord tissues samples were obtained. The microbial content of the tissue samples were analyzed using 16rRNA sequencing, while subgingival biofilm samples were analyzed using checkerboard DNA-DNA hybridization method. Results: Most abundant phylum in both placenta and umbilicus samples was Firmicutes. Most abundant genera in both placenta and umbilicus samples was Veillonella. Some of the most common species detected were Neisseria elongata, Pyramidobacter piscolens, and Gemella morbillorum. Conclusion: PTB and FTB exhibit distinct umbilical microbiomes. PTB samples are more heavily colonized by oral pathogenic taxa, whereas FTB specimens had higher levels of commensal organisms. Spring 2017 2017 Microbiology Obstetrics Microbiome, Oral, Placenta, Pregnancy, Preterm, Umbilicus eng Master of Science Thesis University of North Carolina at Chapel Hill Graduate School Degree granting institution Dentistry (Periodontology) Flavia Teles Thesis advisor Steven Offenbacher Thesis advisor Andrea Azcarate-Peril Thesis advisor Flavia Teles Thesis advisor text Krystal Reyes Viruet Creator Department of Periodontology School of Dentistry Exploring the Relationships among the Placental and Umbilical Microbiomes, the Oral Microbiota, and Adverse Pregnancy Outcomes Aims: To compare the microbiomes of placenta and umbilicus samples from 44 women presenting periodontal diseases who experienced full term (FTB, n=22) and preterm births (PTB; <35 weeks, n=22), as well as, the level of maternal subgingival periodontal species in each group pre and post-partum. Materials and methods: Clinical and demographic data, subgingival plaque samples, as well as, placenta and umbilical cord tissues samples were obtained. The microbial content of the tissue samples were analyzed using 16rRNA sequencing, while subgingival biofilm samples were analyzed using checkerboard DNA-DNA hybridization method. Results: Most abundant phylum in both placenta and umbilicus samples was Firmicutes. Most abundant genera in both placenta and umbilicus samples was Veillonella. Some of the most common species detected were Neisseria elongata, Pyramidobacter piscolens, and Gemella morbillorum. Conclusion: PTB and FTB exhibit distinct umbilical microbiomes. PTB samples are more heavily colonized by oral pathogenic taxa, whereas FTB specimens had higher levels of commensal organisms. Spring 2017 2017 Microbiology Obstetrics Microbiome, Oral, Placenta, Pregnancy, Preterm, Umbilicus eng Master of Science Thesis University of North Carolina at Chapel Hill Graduate School Degree granting institution Dentistry (Periodontology) Flavia Teles Thesis advisor Steven Offenbacher Thesis advisor Andrea Azcarate-Peril Thesis advisor Flavia Teles Thesis advisor text Krystal Reyes Viruet Creator Department of Periodontology School of Dentistry Exploring the Relationships among the Placental and Umbilical Microbiomes, the Oral Microbiota, and Adverse Pregnancy Outcomes Aims: To compare the microbiomes of placenta and umbilicus samples from 44 women presenting periodontal diseases who experienced full term (FTB, n=22) and preterm births (PTB; <35 weeks, n=22), as well as, the level of maternal subgingival periodontal species in each group pre and post-partum. Materials and methods: Clinical and demographic data, subgingival plaque samples, as well as, placenta and umbilical cord tissues samples were obtained. The microbial content of the tissue samples were analyzed using 16rRNA sequencing, while subgingival biofilm samples were analyzed using checkerboard DNA-DNA hybridization method. Results: Most abundant phylum in both placenta and umbilicus samples was Firmicutes. Most abundant genera in both placenta and umbilicus samples was Veillonella. Some of the most common species detected were Neisseria elongata, Pyramidobacter piscolens, and Gemella morbillorum. Conclusion: PTB and FTB exhibit distinct umbilical microbiomes. PTB samples are more heavily colonized by oral pathogenic taxa, whereas FTB specimens had higher levels of commensal organisms. Spring 2017 2017 Microbiology Obstetrics Microbiome, Oral, Placenta, Pregnancy, Preterm, Umbilicus eng Master of Science Thesis University of North Carolina at Chapel Hill Graduate School Degree granting institution Dentistry (Periodontology) Flavia Teles Thesis advisor Steven Offenbacher Thesis advisor Andrea Azcarate-Peril Thesis advisor Flavia Teles Thesis advisor text Krystal Reyes Viruet Creator Department of Periodontology School of Dentistry Exploring the Relationships among the Placental and Umbilical Microbiomes, the Oral Microbiota, and Adverse Pregnancy Outcomes Aims: To compare the microbiomes of placenta and umbilicus samples from 44 women presenting periodontal diseases who experienced full term (FTB, n=22) and preterm births (PTB; <35 weeks, n=22), as well as, the level of maternal subgingival periodontal species in each group pre and post-partum. Materials and methods: Clinical and demographic data, subgingival plaque samples, as well as, placenta and umbilical cord tissues samples were obtained. The microbial content of the tissue samples were analyzed using 16rRNA sequencing, while subgingival biofilm samples were analyzed using checkerboard DNA-DNA hybridization method. Results: Most abundant phylum in both placenta and umbilicus samples was Firmicutes. Most abundant genera in both placenta and umbilicus samples was Veillonella. Some of the most common species detected were Neisseria elongata, Pyramidobacter piscolens, and Gemella morbillorum. Conclusion: PTB and FTB exhibit distinct umbilical microbiomes. PTB samples are more heavily colonized by oral pathogenic taxa, whereas FTB specimens had higher levels of commensal organisms. 2017-05 2017 Microbiology Obstetrics Microbiome, Oral, Placenta, Pregnancy, Preterm, Umbilicus eng Master of Science Masters Thesis University of North Carolina at Chapel Hill Graduate School Degree granting institution Dentistry (Periodontology) Flavia Teles Thesis advisor Steven Offenbacher Thesis advisor Andrea Azcarate-Peril Thesis advisor Flavia Teles Thesis advisor text Krystal Reyes Viruet Creator Department of Periodontology School of Dentistry Exploring the Relationships among the Placental and Umbilical Microbiomes, the Oral Microbiota, and Adverse Pregnancy Outcomes Aims: To compare the microbiomes of placenta and umbilicus samples from 44 women presenting periodontal diseases who experienced full term (FTB, n=22) and preterm births (PTB; <35 weeks, n=22), as well as, the level of maternal subgingival periodontal species in each group pre and post-partum. Materials and methods: Clinical and demographic data, subgingival plaque samples, as well as, placenta and umbilical cord tissues samples were obtained. The microbial content of the tissue samples were analyzed using 16rRNA sequencing, while subgingival biofilm samples were analyzed using checkerboard DNA-DNA hybridization method. Results: Most abundant phylum in both placenta and umbilicus samples was Firmicutes. Most abundant genera in both placenta and umbilicus samples was Veillonella. Some of the most common species detected were Neisseria elongata, Pyramidobacter piscolens, and Gemella morbillorum. Conclusion: PTB and FTB exhibit distinct umbilical microbiomes. PTB samples are more heavily colonized by oral pathogenic taxa, whereas FTB specimens had higher levels of commensal organisms. 2017 Microbiology Obstetrics Microbiome, Oral, Placenta, Pregnancy, Preterm, Umbilicus eng Master of Science Masters Thesis University of North Carolina at Chapel Hill Graduate School Degree granting institution Dentistry (Periodontology) Flavia Teles Thesis advisor Steven Offenbacher Thesis advisor Andrea Azcarate-Peril Thesis advisor Flavia Teles Thesis advisor text 2017-05 Krystal Reyes Viruet Creator Department of Periodontology School of Dentistry Exploring the Relationships among the Placental and Umbilical Microbiomes, the Oral Microbiota, and Adverse Pregnancy Outcomes Aims: To compare the microbiomes of placenta and umbilicus samples from 44 women presenting periodontal diseases who experienced full term (FTB, n=22) and preterm births (PTB; <35 weeks, n=22), as well as, the level of maternal subgingival periodontal species in each group pre and post-partum. Materials and methods: Clinical and demographic data, subgingival plaque samples, as well as, placenta and umbilical cord tissues samples were obtained. The microbial content of the tissue samples were analyzed using 16rRNA sequencing, while subgingival biofilm samples were analyzed using checkerboard DNA-DNA hybridization method. Results: Most abundant phylum in both placenta and umbilicus samples was Firmicutes. Most abundant genera in both placenta and umbilicus samples was Veillonella. Some of the most common species detected were Neisseria elongata, Pyramidobacter piscolens, and Gemella morbillorum. Conclusion: PTB and FTB exhibit distinct umbilical microbiomes. PTB samples are more heavily colonized by oral pathogenic taxa, whereas FTB specimens had higher levels of commensal organisms. 2017 Microbiology Obstetrics Microbiome, Oral, Placenta, Pregnancy, Preterm, Umbilicus eng Master of Science Masters Thesis University of North Carolina at Chapel Hill Graduate School Degree granting institution Dentistry (Periodontology) Flavia Teles Thesis advisor Steven Offenbacher Thesis advisor Andrea Azcarate-Peril Thesis advisor Flavia Teles Thesis advisor text 2017-05 Krystal Reyes Viruet Creator Department of Periodontology School of Dentistry Exploring the Relationships among the Placental and Umbilical Microbiomes, the Oral Microbiota, and Adverse Pregnancy Outcomes Aims: To compare the microbiomes of placenta and umbilicus samples from 44 women presenting periodontal diseases who experienced full term (FTB, n=22) and preterm births (PTB; <35 weeks, n=22), as well as, the level of maternal subgingival periodontal species in each group pre and post-partum. Materials and methods: Clinical and demographic data, subgingival plaque samples, as well as, placenta and umbilical cord tissues samples were obtained. The microbial content of the tissue samples were analyzed using 16rRNA sequencing, while subgingival biofilm samples were analyzed using checkerboard DNA-DNA hybridization method. Results: Most abundant phylum in both placenta and umbilicus samples was Firmicutes. Most abundant genera in both placenta and umbilicus samples was Veillonella. Some of the most common species detected were Neisseria elongata, Pyramidobacter piscolens, and Gemella morbillorum. Conclusion: PTB and FTB exhibit distinct umbilical microbiomes. PTB samples are more heavily colonized by oral pathogenic taxa, whereas FTB specimens had higher levels of commensal organisms. 2017 Microbiology Obstetrics Microbiome, Oral, Placenta, Pregnancy, Preterm, Umbilicus eng Master of Science Masters Thesis University of North Carolina at Chapel Hill Graduate School Degree granting institution Dentistry (Periodontology) Flavia Teles Thesis advisor Steven Offenbacher Thesis advisor Andrea Azcarate-Peril Thesis advisor Flavia Teles Thesis advisor text 2017-05 Krystal Reyes Viruet Creator Department of Periodontology School of Dentistry Exploring the Relationships among the Placental and Umbilical Microbiomes, the Oral Microbiota, and Adverse Pregnancy Outcomes Aims: To compare the microbiomes of placenta and umbilicus samples from 44 women presenting periodontal diseases who experienced full term (FTB, n=22) and preterm births (PTB; <35 weeks, n=22), as well as, the level of maternal subgingival periodontal species in each group pre and post-partum. Materials and methods: Clinical and demographic data, subgingival plaque samples, as well as, placenta and umbilical cord tissues samples were obtained. The microbial content of the tissue samples were analyzed using 16rRNA sequencing, while subgingival biofilm samples were analyzed using checkerboard DNA-DNA hybridization method. Results: Most abundant phylum in both placenta and umbilicus samples was Firmicutes. Most abundant genera in both placenta and umbilicus samples was Veillonella. Some of the most common species detected were Neisseria elongata, Pyramidobacter piscolens, and Gemella morbillorum. Conclusion: PTB and FTB exhibit distinct umbilical microbiomes. PTB samples are more heavily colonized by oral pathogenic taxa, whereas FTB specimens had higher levels of commensal organisms. 2017 Microbiology Obstetrics Microbiome, Oral, Placenta, Pregnancy, Preterm, Umbilicus eng Master of Science Masters Thesis Dentistry (Periodontology) Flavia Teles Thesis advisor Steven Offenbacher Thesis advisor Andrea Azcarate-Peril Thesis advisor Flavia Teles Thesis advisor text 2017-05 University of North Carolina at Chapel Hill Degree granting institution Krystal Reyes Viruet Creator Department of Periodontology School of Dentistry Exploring the Relationships among the Placental and Umbilical Microbiomes, the Oral Microbiota, and Adverse Pregnancy Outcomes Aims: To compare the microbiomes of placenta and umbilicus samples from 44 women presenting periodontal diseases who experienced full term (FTB, n=22) and preterm births (PTB; <35 weeks, n=22), as well as, the level of maternal subgingival periodontal species in each group pre and post-partum. Materials and methods: Clinical and demographic data, subgingival plaque samples, as well as, placenta and umbilical cord tissues samples were obtained. The microbial content of the tissue samples were analyzed using 16rRNA sequencing, while subgingival biofilm samples were analyzed using checkerboard DNA-DNA hybridization method. Results: Most abundant phylum in both placenta and umbilicus samples was Firmicutes. Most abundant genera in both placenta and umbilicus samples was Veillonella. Some of the most common species detected were Neisseria elongata, Pyramidobacter piscolens, and Gemella morbillorum. Conclusion: PTB and FTB exhibit distinct umbilical microbiomes. PTB samples are more heavily colonized by oral pathogenic taxa, whereas FTB specimens had higher levels of commensal organisms. 2017 Microbiology Obstetrics Microbiome; Oral; Placenta; Pregnancy; Preterm; Umbilicus eng Master of Science Masters Thesis Dentistry (Periodontology) Flavia Teles Thesis advisor Steven Offenbacher Thesis advisor Andrea Azcarate-Peril Thesis advisor Flavia Teles Thesis advisor text 2017-05 University of North Carolina at Chapel Hill Degree granting institution Krystal Reyes Viruet Creator Department of Periodontology School of Dentistry Exploring the Relationships among the Placental and Umbilical Microbiomes, the Oral Microbiota, and Adverse Pregnancy Outcomes Aims: To compare the microbiomes of placenta and umbilicus samples from 44 women presenting periodontal diseases who experienced full term (FTB, n=22) and preterm births (PTB; <35 weeks, n=22), as well as, the level of maternal subgingival periodontal species in each group pre and post-partum. Materials and methods: Clinical and demographic data, subgingival plaque samples, as well as, placenta and umbilical cord tissues samples were obtained. The microbial content of the tissue samples were analyzed using 16rRNA sequencing, while subgingival biofilm samples were analyzed using checkerboard DNA-DNA hybridization method. Results: Most abundant phylum in both placenta and umbilicus samples was Firmicutes. Most abundant genera in both placenta and umbilicus samples was Veillonella. Some of the most common species detected were Neisseria elongata, Pyramidobacter piscolens, and Gemella morbillorum. Conclusion: PTB and FTB exhibit distinct umbilical microbiomes. PTB samples are more heavily colonized by oral pathogenic taxa, whereas FTB specimens had higher levels of commensal organisms. 2017 Microbiology Obstetrics Microbiome, Oral, Placenta, Pregnancy, Preterm, Umbilicus eng Master of Science Masters Thesis University of North Carolina at Chapel Hill Graduate School Degree granting institution Dentistry (Periodontology) Flavia Teles Thesis advisor Steven Offenbacher Thesis advisor Andrea Azcarate-Peril Thesis advisor Flavia Teles Thesis advisor text 2017-05 Krystal Reyes Viruet Creator Department of Periodontology School of Dentistry Aims: To compare the microbiomes of placenta and umbilicus samples from 44 women presenting periodontal diseases who experienced full term (FTB, n=22) and preterm births (PTB; <35 weeks, n=22), as well as, the level of maternal subgingival periodontal species in each group pre and post-partum. Materials and methods: Clinical and demographic data, subgingival plaque samples, as well as, placenta and umbilical cord tissues samples were obtained. The microbial content of the tissue samples were analyzed using 16rRNA sequencing, while subgingival biofilm samples were analyzed using checkerboard DNA-DNA hybridization method. Results: Most abundant phylum in both placenta and umbilicus samples was Firmicutes. Most abundant genera in both placenta and umbilicus samples was Veillonella. Some of the most common species detected were Neisseria elongata, Pyramidobacter piscolens, and Gemella morbillorum. Conclusion: PTB and FTB exhibit distinct umbilical microbiomes. PTB samples are more heavily colonized by oral pathogenic taxa, whereas FTB specimens had higher levels of commensal organisms. 2017 Microbiology Obstetrics Microbiome; Oral; Placenta; Pregnancy; Preterm; Umbilicus eng Master of Science Masters Thesis University of North Carolina at Chapel Hill Graduate School Degree granting institution Flavia Teles Thesis advisor Steven Offenbacher Thesis advisor Andrea Azcarate-Peril Thesis advisor Flavia Teles Thesis advisor text 2017-05 ReyesViruet_unc_0153M_16994.pdf uuid:b8754e82-24fe-4eff-b78e-9479d3a51386 proquest 2019-07-05T00:00:00 2017-04-22T03:25:12Z application/pdf 1713321 yes