TY - JOUR AB - Novel coronavirus disease 2019 (COVID-19) is a growing public health crisis. Despite initial focus on the elderly population with comorbidities, it seems that large studies from the worst affected countries follow a sex-disaggregation pattern. Analysis of available data showed marked variations in reported cases between males and females among different countries with higher mortality in males.  At this early stage of the pandemic, medical datasets at the individual level are not available; therefore, it is challenging to conclude how different factors have impacted COVID-19 susceptibility. Thus, in the absence of patients' level data, we attempted to provide a theoretical description of how other determinants have affected COVID-19 susceptibility in males compared to females.  In this article, we have identified and discussed possible biological and behavioral factors that could be responsible for the increased male susceptibility. Biological factors include - an absence of X-chromosomes (a powerhouse for immune-related genes), a high level of testosterone that inhibits antibody production, and the presence of Angiotensin-converting enzyme 2 (ACE2) receptors that facilitate viral replication. Similarly, behavioral factors constitute - higher smoking and alcohol consumptions, low level of handwashing practices, and high-risk behavior like non-adherence to health services and reluctance to follow public health measures in males. Keywords: COVID-19; gender; males; sex disaggregation; susceptibility. AD - Western Vascular Institute, Galway University Hospital, National University of Ireland, Galway, Ireland Nepal Health Research Council, Kathmandu, Nepal Nobel Medical College Teaching Hospital, Biratnagar, Nepal Tribhuvan University Teaching Hospital, Kathmandu, Nepal Cecil G Sheps Center for Health Service Research, University of North Carolina, Chapel Hill, United States AU - Acharya, Y. AU - Pant, S. AU - Gyanwali, P. AU - Dangal, G. AU - Karki, P. AU - Bista, N. R. AU - Tandan, M. C2 - 33210622 DB - Scopus DO - 10.33314/jnhrc.v18i3.3108 IS - 3 J2 - J Nepal Health Res Counc KW - testosterone biosynthesis comorbidity epidemiology health behavior human metabolism Nepal pandemic sex factor social environment X chromosome Angiotensin-Converting Enzyme 2 Chromosomes, Human, X COVID-19 Humans Pandemics SARS-CoV-2 Sex Factors LA - English M3 - Review N1 - Cited By :4 Export Date: 4 May 2021 Chemicals/CAS: testosterone, 58-22-0; Angiotensin-Converting Enzyme 2; Testosterone PY - 2020 SN - 19996217 (ISSN) SP - 345-350 ST - Gender Disaggregation in COVID-19 and Increased Male Susceptibility T2 - Journal of Nepal Health Research Council TI - Gender Disaggregation in COVID-19 and Increased Male Susceptibility UR - https://www.scopus.com/inward/record.uri?eid=2-s2.0-85096408117&doi=10.33314%2fjnhrc.v18i3.3108&partnerID=40&md5=2624bedf0a43858908344c81c3ffce40 VL - 18 ID - 289 ER - TY - JOUR AB - Background: The coronavirus disease (COVID-19) has been identified as the cause of an outbreak of respiratory illness in Wuhan, Hubei Province, China beginning in December 2019. As of 31 January 2020, this epidemic had spread to 19 countries with 11 791 confirmed cases, including 213 deaths. The World Health Organization has declared it a Public Health Emergency of International Concern. Methods: A scoping review was conducted following the methodological framework suggested by Arksey and O'Malley. In this scoping review, 65 research articles published before 31 January 2020 were analyzed and discussed to better understand the epidemiology, causes, clinical diagnosis, prevention and control of this virus. The research domains, dates of publication, journal language, authors' affiliations, and methodological characteristics were included in the analysis. All the findings and statements in this review regarding the outbreak are based on published information as listed in the references. Results: Most of the publications were written using the English language (89.2%). The largest proportion of published articles were related to causes (38.5%) and a majority (67.7%) were published by Chinese scholars. Research articles initially focused on causes, but over time there was an increase of the articles related to prevention and control. Studies thus far have shown that the virus' origination is in connection to a seafood market in Wuhan, but specific animal associations have not been confirmed. Reported symptoms include fever, cough, fatigue, pneumonia, headache, diarrhea, hemoptysis, and dyspnea. Preventive measures such as masks, hand hygiene practices, avoidance of public contact, case detection, contact tracing, and quarantines have been discussed as ways to reduce transmission. To date, no specific antiviral treatment has proven effective; hence, infected people primarily rely on symptomatic treatment and supportive care. Conclusions: There has been a rapid surge in research in response to the outbreak of COVID-19. During this early period, published research primarily explored the epidemiology, causes, clinical manifestation and diagnosis, as well as prevention and control of the novel coronavirus. Although these studies are relevant to control the current public emergency, more high-quality research is needed to provide valid and reliable ways to manage this kind of public health emergency in both the short- and long-term. © 2020 The Author(s). AD - West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, China Department of Communication Studies, California State University, Long Beach, CA 90802, United States Health Policy and Management, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States Freeman Spogli Institute for International Studies, Stanford University, Stanford, CA, United States Department of Public Health, Erasmus MC - University Medical Center Rotterdam, Rotterdam, CA 3000, Netherlands AU - Adhikari, S. P. AU - Meng, S. AU - Wu, Y. J. AU - Mao, Y. P. AU - Ye, R. X. AU - Wang, Q. Z. AU - Sun, C. AU - Sylvia, S. AU - Rozelle, S. AU - Raat, H. AU - Zhou, H. C2 - 32183901 C7 - 29 DB - Scopus DO - 10.1186/s40249-020-00646-x IS - 1 J2 - Infect. Dis. Pover. KW - Causes COVID-19 Epidemiology Prevention and control Review 2019 novel coronavirus coronavirus disease 2019 coughing diarrhea disease severity disease surveillance disease transmission dyspnea fatigue fever headache health care hemoptysis high throughput sequencing human incubation time meta analysis mortality rate pathogenesis pneumonia priority journal public health public health service quality control real time polymerase chain reaction respiratory tract infection rhinorrhea severe acute respiratory syndrome Severe acute respiratory syndrome coronavirus 2 systematic review virology Betacoronavirus China Coronavirus infection epidemic infection control virus pneumonia Coronavirus Infections Cough Disease Outbreaks Humans Pneumonia, Viral LA - English M3 - Review N1 - Cited By :590 Export Date: 4 May 2021 Correspondence Address: Zhou, H.; West China School of Public Health and West China Fourth Hospital, China; email: zhouhuan@scu.edu.cn Chemicals/CAS: COVID-19; severe acute respiratory syndrome coronavirus 2 References: (2020) Wuhan Municipal Health and Health Commission's Briefing on the Current Pneumonia Epidemic Situation in Our City, , http://wjw.wuhan.gov.cn/front/web/showDetail/2019123108989, WMHC, Accessed 1 Feb 2020; Li, Q., Guan, X., Wu, P., Wang, X., Zhou, L., Tong, Y., Early transmission dynamics in Wuhan, China, of novel coronavirus-infected pneumonia (2020) N Engl J Med., , https://doi.org/10.1056/NEJMoa2001316; (2019) Novel Coronavirus, , https://www.cdc.gov/coronavirus/2019-nCoV/summary.html, CDC, Wuhan, China, Accessed 1 Feb 2020; (2020), https://www.who.int/csr/don/12-january-2020-novel-coronavirus-china/en/, WHO. 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Accessed 3 Feb 2020; (2020) Guidelines for Public Protection against Novel Coronavirus Infection, , http://www.nhc.gov.cn/jkj/s7915/202001/bc661e49b5bc487dba182f5c49ac445b.shtml, National Health Commission of People's Republic of China, Accessed 31 Jan 2020 PY - 2020 SN - 20955162 (ISSN) ST - Epidemiology, causes, clinical manifestation and diagnosis, prevention and control of coronavirus disease (COVID-19) during the early outbreak period: A scoping review T2 - Infectious Diseases of Poverty TI - Epidemiology, causes, clinical manifestation and diagnosis, prevention and control of coronavirus disease (COVID-19) during the early outbreak period: A scoping review UR - https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082020443&doi=10.1186%2fs40249-020-00646-x&partnerID=40&md5=be6536042dfd0cfa5e465cfff6b364aa VL - 9 ID - 523 ER - TY - JOUR AD - Projahnmo Research Foundation, Dhaka, Bangladesh NIHR Global Health Unit on Respiratory Health (RESPIRE), London, United Kingdom University of North Carolina Project Malawi, Lilongwe, Malawi Department of Pediatrics, University of North Carolina-Chapel Hill, Chapel Hill, NC, United States KEMRI-Wellcome Trust Research Programme, Nairobi, Kenya Malaria Consortium, London, United Kingdom Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, United States Center for Global Health, Usher Institute, University of Edinburgh Medical School, Edinburgh, United Kingdom Division of Pulmonary and Critical Care, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, United States Dhaka Hospital, Nutrition and Clinical Services Division, International Centre for Diarrhoeal Disease and Research, Bangladesh (Icddr, B), Dhaka, Bangladesh Global Health Institute, University College London, London, United Kingdom Centre for Inflammation Research, University of Edinburgh, Edinburgh, United Kingdom Paediatric Intensive Care Unit, Royal Children's Hospital, Melbourne, VIC, Australia Department of Paediatrics, University of Melbourne, Melbourne, VIC, Australia School of Medicine and Health Sciences, University of Papua New Guinea, Goroka, Papua New Guinea Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxfordshire, United Kingdom Division of Paediatric Pulmonology, Department of Paediatrics, College of Medicine, University College Hospital, Ibadan, Nigeria Global and Tropical Health Division, Menzies School of Health Research, Charles Darwin University, Darwin, NT, Australia Clinical Trial Center, University of Washington, Seattle, United States Centre for International Child Health, MCRI, University of Melbourne, Melbourne, VIC, Australia Department of Paediatrics, University College Hospital Ibadan, Ibadan, Nigeria Division Paediatric Pulmonology, Department of Paediatrics, University of Cape Town, Cape Town, South Africa Department of Community Medicine and School of Public Health, Postgraduate Institute of Medical Education and Research, Chandigarh, India Desmond Tutu TB Centre, Department of Paediatrics and Child Health, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa Department of Pediatrics, Section of Pediatric Emergency Medicine, Baylor College of Medicine, Houston, United States Pulmonology and Infectious Disease Unit, Department of Paediatrics and Child Health, University of Ilorin, University of Ilorin Teaching Hospital, Ilorin, Nigeria Department of Global Public Health, Karolinska Institutet, Stockholm, Sweden Gangarosa Department of Environmental Health, Rollins School of Public Health, Emory University, Atlanta, GA, United States Department of Global Health and Population, Harvard T.H. Chan School of Public Health, Boston, United States Instituto de Investigación Nutricional, Lima, Peru Department of Pediatrics, School of Medicine, Vanderbilt University, Nashville, TN, United States Community Health Sciences Unit, Malawi Ministry of Health, Lilongwe, Malawi MRC Unit, Gambia at LSHTM, Fajara, Gambia Faculty of Infectious and Tropical Diseases, LSHTM, London, United Kingdom Murdoch Children's Research Institute, Melbourne, VIC, Australia Center for Health Studies, Universidad Del Valle de Guatemala, Guatemala City, Guatemala Divisions of Pulmonary Medicine and Global Health, Department of Pediatrics, Massachusetts General Hospital, Boston, MA, United States Department of Child Health, University of Benin Teaching Hospital, Benin City, Nigeria Papua New Guinea Institute of Medical Research, Goroka, Papua New Guinea Department of Infectious Diseases, Imperial College London, London, United Kingdom Baylor College of Medicine Children's Foundation-Lesotho, Maseru, Lesotho Department of Pediatrics, Baylor College of Medicine, Houston, TX, United States International Pediatric AIDS Initiative (BIPAI), Texas Children's Hospital, Baylor College of Medicine, Houston, TX, United States Department of Paediatrics and Child Health, Stellenbosch University, Cape Town, South Africa Division of Paediatric Pulmonology, Department of Paediatrics, Chris Hani Baragwanath Academic Hospital, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa Respiratory and Meningeal Pathogens Research Unit, Medical Research Council, University of the Witwatersrand, Johannesburg, South Africa Department of Pediatric Infectious Diseases, Institute of Tropical Medicine, Nagasaki University, Nagasaki, Japan Department of Paediatrics and Child Health, Red Cross War Memorial Children's Hospital, University of Cape Town, Cape Town, South Africa SA-MRC Unit on Child and Adolescent Health, University of Cape Town, Cape Town, South Africa Department of Paediatrics: Child and Youth Health, University of Auckland, Auckland, New Zealand Johns Hopkins Global Program in Pediatric Respiratory Sciences, Eudowood Division of Pediatric Respiratory Sciences, Department of Pediatrics, Johns Hopkins School of Medicine, Baltimore, MD, United States AU - Ahmed, S. AU - Mvalo, T. AU - Akech, S. AU - Agweyu, A. AU - Baker, K. AU - Bar-Zeev, N. AU - Campbell, H. AU - Checkley, W. AU - Chisti, M. J. AU - Colbourn, T. AU - Cunningham, S. AU - Duke, T. AU - English, M. AU - Falade, A. G. AU - Fancourt, N. S. S. AU - Ginsburg, A. S. AU - Graham, H. R. AU - Gray, D. M. AU - Gupta, M. AU - Hammitt, L. AU - Hesseling, A. C. AU - Hooli, S. AU - Johnson, A. W. B. R. AU - King, C. AU - Kirby, M. A. AU - Lanata, C. F. AU - Lufesi, N. AU - MacKenzie, G. A. AU - McCracken, J. P. AU - Moschovis, P. P. AU - Nair, H. AU - Oviawe, O. AU - Pomat, W. S. AU - Santosham, M. AU - Seddon, J. A. AU - Thahane, L. K. AU - Wahl, B. AU - Van Der Zalm, M. AU - Verwey, C. AU - Yoshida, L. M. AU - Zar, H. J. AU - Howie, S. R. C. AU - McCollum, E. D. C7 - e002844 DB - Scopus DO - 10.1136/bmjgh-2020-002844 IS - 5 J2 - BMJ Glob. Health KW - child health paediatrics pneumonia respiratory infections LA - English M3 - Review N1 - Cited By :7 Export Date: 4 May 2021 Correspondence Address: Mccollum, E.D.; Department of International Health, United States; email: emccoll3@jhmi.edu References: Dong, Y., Mo, X., Hu, Y., Epidemiology of COVID-19 among children in China (2020) Pediatrics, p. e20200702; Lu, X., Zhang, L., Du, H., SARS-CoV-2 infection in children (2020) N Engl J Med, 382, pp. 1663-1665; Coronavirus disease 2019 in children-united states, February 12-April 2, 2020 (2020) MMWR Morb Mortal Wkly Rep, 69, pp. 422-426. , CDC COVID-19 Response Team; Tagarro, A., Epalza, C., Santos, M., Screening and severity of coronavirus disease 2019 (COVID-19) in children in Madrid, Spain (2020) JAMA Pediatr, , [Epub ahead of print: 08 Apr 2020]; Quantifying risks and interventions that have affected the burden of lower respiratory infections among children younger than 5 years: An analysis for the global burden of disease study 2017 (2020) Lancet Infect Dis, 20, pp. 60-79. , GBD 2017 Lower Respiratory Infections Collaborators; Sonego, M., Pellegrin, M.C., Becker, G., Risk factors for mortality from acute lower respiratory infections (ALRI) in children under fve years of age in low and middle-income countries: A systematic review and meta-analysis of observational studies (2015) PLoS One, 10, pp. e0116380; Lazzerini, M., Sonego, M., Pellegrin, M.C., Hypoxaemia as a mortality risk factor in acute lower respiratory infections in children in low and middle-income countries: Systematic review and meta-analysis (2015) PLoS One, 10, pp. e0136166 PY - 2020 SN - 20597908 (ISSN) ST - Protecting children in low-income and middle-income countries from COVID-19 T2 - BMJ Global Health TI - Protecting children in low-income and middle-income countries from COVID-19 UR - https://www.scopus.com/inward/record.uri?eid=2-s2.0-85085699936&doi=10.1136%2fbmjgh-2020-002844&partnerID=40&md5=e3a66912a93e130d50c52aeb3a778a96 VL - 5 ID - 496 ER - TY - CONF A4 - Acm, Sigchi AB - Tracking the type and frequency of cough events is critical for monitoring respiratory diseases. Coughs are one of the most common symptoms of respiratory and infectious diseases like COVID-19, and a cough monitoring system could have been vital in remote monitoring during a pandemic like COVID-19. While the existing solutions for cough monitoring use unimodal (e.g., audio) approaches for detecting coughs, a fusion of multimodal sensors (e.g., audio and accelerometer) from multiple devices (e.g., phone and watch) are likely to discover additional insights and can help to track the exacerbation of the respiratory conditions. However, such multimodal and multidevice fusion requires accurate time synchronization, which could be challenging for coughs as coughs are usually concise events (0.3-0.7 seconds). In this paper, we first demonstrate the time synchronization challenges of cough synchronization based on the cough data collected from two studies. Then we highlight the performance of a cross-correlation based time synchronization algorithm on the alignment of cough events. Our algorithm can synchronize 98.9% of cough events with an average synchronization error of 0.046s from two devices. © 2020 ACM. AD - Digital Health Lab, Samsung Research America, Mountain View, CA, United States Computer Science, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States AU - Ahmed, T. AU - Ahmed, M. Y. AU - Rahman, M. M. AU - Nemati, E. AU - Islam, B. AU - Vatanparvar, K. AU - Nathan, V. AU - McCaffrey, D. AU - Kuang, J. AU - Gao, J. A. C3 - ICMI 2020 - Proceedings of the 2020 International Conference on Multimodal Interaction DB - Scopus DO - 10.1145/3382507.3418855 KW - cough data collection mobile health time synchronization Interactive computer systems Cross correlations Infectious disease Monitoring system Multimodal sensor Remote monitoring Synchronization error Time synchronization algorithms Synchronization LA - English N1 - Conference code: 164395 Cited By :1 Export Date: 4 May 2021 References: Abaza, A.A., Day, J.B., Reynolds, J.S., Mahmoud, A.M., Travis Goldsmith, W., McKinney, W.G., Lee Petsonk, E., Frazer, D.G., Classification of voluntary cough sound and airflow patterns for detecting abnormal pulmonary function (2009) Cough (London, England), 5, pp. 8-8. , https://doi.org/10.1186/1745-9974-5-8, Nov. 2009; Barry, S.J., Dane, A.D., Morice, A.H., DWalmsley, A., The automatic recognition and counting of cough (2006) Cough, 2 (1), p. 8. , 2006; Benndorf, M., Haenselmann, T., Time synchronization on android devices for mobile construction assessment (2016) the Tenth International Conference on Sensor Technologies and Applications. 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M. K. DB - Scopus DO - 10.1007/s40670-020-01037-5 IS - 4 J2 - Med. Sci. Educ. LA - English M3 - Note N1 - Cited By :2 Export Date: 4 May 2021 Correspondence Address: Alexander, S.M.K.; School of Medicine, CB 3280, United States; email: seth_alexander@med.unc.edu References: Paules, C.I., Marston, H.D., Fauci, A.S., Coronavirus infections—more than just the common cold (2020) JAMA., 323 (8), p. 707; Ranney, M.L., Griffeth, V., Jha, A.K., Critical supply shortages — the need for ventilators and personal protective equipment during the Covid-19 pandemic (2020) N Engl J Med, 382 (18); Important Guidance for Medical Students on Clinical Rotations during the Coronavirus (COVID-19) Outbreak, , https://www.aamc.org/news-insights/press-releases/important-guidance-medical-students-clinical-rotations-during-coronavirus-covid-19-outbreak, AAMC, Published 2020. Accessed May 22, 2020; Rose, S., Medical student education in the time of COVID-19 (2020) JAMA, 323, p. 2131; https://www.wma.net/policies-post/wma-declaration-of-geneva/, Published 2017. Accessed May 22, 2020UR - https://www.scopus.com/inward/record.uri?eid=2-s2.0-85088659465&doi=10.1007%2fs40670-020-01037-5&partnerID=40&md5=43c53c848b8c7fc21603f5eeae7f13f8 PY - 2020 SN - 21568650 (ISSN) SP - 1639-1640 ST - Learning Amidst a Crisis—a Student Perspective on COVID-19 T2 - Medical Science Educator TI - Learning Amidst a Crisis—a Student Perspective on COVID-19 VL - 30 ID - 280 ER - TY - JOUR AB - The current COVID-19 pandemic, caused by SARS-CoV-2, has impacted many facets of hematopoietic cell transplantation (HCT) in both developed and developing countries. Realizing the challenges as a result of this pandemic affecting the daily practice of the HCT centers and the recognition of the variability in practice worldwide, the Worldwide Network for Blood and Marrow Transplantation (WBMT) and the Center for International Blood and Marrow Transplant Research's (CIBMTR) Health Services and International Studies Committee have jointly produced an expert opinion statement as a general guide to deal with certain aspects of HCT, including diagnostics for SARS-CoV-2 in HCT recipient, pre- and post-HCT management, donor issues, medical tourism, and facilities management. During these crucial times, which may last for months or years, the HCT community must reorganize to proceed with transplantation activity in those patients who urgently require it, albeit with extreme caution. This shared knowledge may be of value to the HCT community in the absence of high-quality evidence-based medicine. © 2020 American Society for Transplantation and Cellular Therapy. Published by Elsevier Inc. © 2020 American Society for Transplantation and Cellular Therapy AD - Department of Medicine, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia Department of Adult Hematology and Stem Cell Transplant, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia Department of Haematology, St George's Hospital and Medical School, London, United Kingdom Cell Therapy Facility, Blood Services Group, Health Sciences Authority, Singapore Division of Hematology/Oncology, Medical College of Wisconsin, Milwaukee, WI, United States Department of Cellular Therapy and Allogeneic Stem Cell Transplantation, Karolinska University Hospital Huddinge, Stockholm, Sweden Division of Hematology, Department of Medicine Huddinge, Karolinska Institutet, Stockholm, Sweden Division of Hematology, Oncology and Transplantation, University of Minnesota, Minnesota Center for Hematopoietic Stem Cell Transplantation, Aichi Medical University Hospital, Nagakute, Japan Clinical Haematology at Peter MacCallum Cancer Centre and The Royal Melbourne Hospital, Melbourne, Victoria, Australia Cord Blood Bank, King Abdullah International Medical Research Center, College of Science and Health Professions, King Saud bin Abdulaziz University for Health Sciences, Ministry of National Guard Health Affairs, Riyadh, Saudi Arabia Division of Hematology, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States Division of Biostatistics, Medical College of Wisconsin, Milwaukee, WI, United States Department of Pediatric Hematology-Oncology, Dana-Farber Cancer Institute, Boston, MA, United States Department of Medicine, Universidade Federal de Sao Paulo Escola Paulista de Medicina, Sao Paulo, Brazil Hematology and Oncology Department, Hebei Yanda Ludaopei Hospital, Langfang, China Adult Bone Marrow Transplantation Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New YorkNew York, United States Weill Cornell Medical College, New YorkNew York, United States Department of Blood Group Serology and Transfusion Medicine, Medical University of Vienna, Vienna, Austria Division of Hematology, Department of Medicine, Keio University School of Medicine, Tokyo, Japan Department of Haematology, Christian Medical College, Vellore, Tamil Nadu, India Department of Infectious Diseases, Infection Control, and Employee Health, The University of Texas MD Anderson Cancer Center, Houston, TX, United States Hematology Department, Henri Mondor Hospital, and University Paris-Est Créteil, France Bone Marrow Transplantation and Immune Deficiency, Cincinnati Children's Hospital Medical Center, Department of Pediatrics, University of Cincinnati, Cincinnati, OH, United States Division of Hematology and Oncology, Department of Medicine, University of Florida, Gainesville, FL, United States Division of Hematology-Oncology, Mayo Clinic, Jacksonville, FL, United States Blood and Marrow Transplant Program, Cleveland Clinic, Cleveland, OH, United States Division of Pediatric Infectious Diseases, Department of Pediatrics, University of Washington and Vaccine and Infectious Diseases Division, Fred Hutchinson Cancer Research Center, Seattle, WA, United States Duke Cancer Institute, Duke University Medical Center, Durham, NC, United States Department of Stem Cell Transplantation, University Hospital Hamburg-Eppendorf, Hamburg, Germany Service d'Hématologie Clinique et Thérapie Cellulaire, Hôpital Saint-Antoine, Sorbonne Université, INSERM UMRS 938, Paris, France Division of Hematology and Medical Oncology, University of Leipzig, Leipzig, Germany Division of Hematology, Medical University of Graz, Graz, Austria Department of Internal Medicine, Mayo Clinic, Minnesota, Rochester AU - Algwaiz, G. AU - Aljurf, M. AU - Koh, M. AU - Horowitz, M. M. AU - Ljungman, P. AU - Weisdorf, D. AU - Saber, W. AU - Kodera, Y. AU - Szer, J. AU - Jawdat, D. AU - Wood, W. A. AU - Brazauskas, R. AU - Lehmann, L. AU - Pasquini, M. C. AU - Seber, A. AU - Lu, P. H. AU - Atsuta, Y. AU - Riches, M. AU - Perales, M. A. AU - Worel, N. AU - Okamoto, S. AU - Srivastava, A. AU - Chemaly, R. F. AU - Cordonnier, C. AU - Dandoy, C. E. AU - Wingard, J. R. AU - Kharfan-Dabaja, M. A. AU - Hamadani, M. AU - Majhail, N. S. AU - Waghmare, A. A. AU - Chao, N. AU - Kröger, N. AU - Shaw, B. AU - Mohty, M. AU - Niederwieser, D. AU - Greinix, H. AU - Hashmi, S. K. 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Blood Marrow Transplant. KW - COVID-19 Pandemic Stem cells Transplantation azithromycin chloroquine corticosteroid dipeptidyl carboxypeptidase inhibitor eculizumab favipiravir hydroxychloroquine ibrutinib immunosuppressive agent lopinavir plus ritonavir Nigella sativa extract posaconazole remdesivir ruxolitinib SARS-CoV-2 convalescent plasma siltuximab tocilizumab umifenovir voriconazole Article coronavirus disease 2019 donor evidence based medicine hematopoietic stem cell transplantation hospitalization human mesenchymal stroma cell nonhuman recipient Severe acute respiratory syndrome coronavirus 2 treatment planning bone marrow transplantation diagnosis epidemiology practice guideline therapy Humans SARS-CoV-2 LA - English M3 - Article N1 - Cited By :10 Export Date: 4 May 2021 CODEN: BBMTF Correspondence Address: Aljurf, M.; Department of Adult Hematology and Stem Cell Transplantation, Riyadh, SA, Zahrawi St, Al Maathe, Al Maazer; email: maljurf@kfshrc.edu.sa Chemicals/CAS: azithromycin, 83905-01-5, 117772-70-0, 121470-24-4; chloroquine, 132-73-0, 3545-67-3, 50-63-5, 54-05-7; eculizumab, 219685-50-4; favipiravir, 259793-96-9; hydroxychloroquine, 118-42-3, 525-31-5; ibrutinib, 936563-96-1; posaconazole, 171228-49-2; remdesivir, 1809249-37-3; ruxolitinib, 1092939-17-7, 941678-49-5; siltuximab, 541502-14-1; tocilizumab, 375823-41-9; umifenovir, 131707-23-8, 131707-25-0; voriconazole, 137234-62-9 Funding details: Pfizer Funding details: Merck Funding details: Novartis Funding details: Sanofi Funding details: Gilead Sciences Funding details: Janssen Biotech Funding details: Alexion Pharmaceuticals Funding details: Spectrum Pharmaceuticals Funding details: AbbVie Funding details: Takeda Pharmaceutical Company Funding details: Janssen Pharmaceuticals Funding details: Takeda Canada Funding details: Daiichi Sankyo Company Funding details: Astellas Pharma Funding text 1: Conflict of interest statement: M.K. has received honoraria from Gilead and Alexion. M.K.D. has served as a consultant for Pharmacyclics and Daiichi Sankyo. M.H. has received research support/funding from Takeda Pharmaceutical, Spectrum Pharmaceuticals, and Astellas Pharma; served as a consultant for Janssen R&D and Incyte; and served on the speaker's bureau for Sanofi Genzyme and AstraZeneca. D.W. reports research support from Incyte and consulting fees from FATE. S.H. reports honoraria and travel funding from Pfizer, Novartis, Gilead, Merck, Sanofi, Mallinckrodt, and Janssen. M.-A.P. has received honoraria from Abbvie, Bellicum, Celgene, Bristol-Myers Squibb, Incyte, Kite/Gilead, Merck, Novartis, Nektar Therapeutics, Omeros, and Takeda; has served on data safety and monitoring boards for Cidara Therapeutics, Servier, and Medigene and scientific advisory boards for MolMed and NexImmune; has received research support for clinical trials from Incyte, Kite/Gilead; and Miltenyi Biotec; and serves in a volunteer capacity as a member of the Board of Directors of Be The Match (National Marrow Donor Program), as well as on the CIBMTR Cellular Immunotherapy Data Resource Executive Committee. C.C. reports honoraria/travel funding from Astellas Pharma, Gilead, Merck, and Pfizer. A.W. has received research support from Ansun, WB Tech, Amazon and Allovir, and is a consultant for Kyorin. Funding text 2: Financial disclosure:, Conflict of interest statement: M.K. has received honoraria from Gilead and Alexion. M.K.D. has served as a consultant for Pharmacyclics and Daiichi Sankyo. M.H. has received research support/funding from Takeda Pharmaceutical, Spectrum Pharmaceuticals, and Astellas Pharma; served as a consultant for Janssen R&D and Incyte; and served on the speaker's bureau for Sanofi Genzyme and AstraZeneca. D.W. reports research support from Incyte and consulting fees from FATE. S.H. reports honoraria and travel funding from Pfizer, Novartis, Gilead, Merck, Sanofi, Mallinckrodt, and Janssen. M.-A.P. has received honoraria from Abbvie, Bellicum, Celgene, Bristol-Myers Squibb, Incyte, Kite/Gilead, Merck, Novartis, Nektar Therapeutics, Omeros, and Takeda; has served on data safety and monitoring boards for Cidara Therapeutics, Servier, and Medigene and scientific advisory boards for MolMed and NexImmune; has received research support for clinical trials from Incyte, Kite/Gilead; and Miltenyi Biotec; and serves in a volunteer capacity as a member of the Board of Directors of Be The Match (National Marrow Donor Program), as well as on the CIBMTR Cellular Immunotherapy Data Resource Executive Committee. C.C. reports honoraria/travel funding from Astellas Pharma, Gilead, Merck, and Pfizer. A.W. has received research support from Ansun, WB Tech, Amazon and Allovir, and is a consultant for Kyorin. Financial disclosure: See Acknowledgments on page 2188. PY - 2020 SN - 10838791 (ISSN) SP - 2181-2189 ST - Real-World Issues and Potential Solutions in Hematopoietic Cell Transplantation during the COVID-19 Pandemic: Perspectives from the Worldwide Network for Blood and Marrow Transplantation and Center for International Blood and Marrow Transplant Research Health Services and International Studies Committee T2 - Biology of Blood and Marrow Transplantation TI - Real-World Issues and Potential Solutions in Hematopoietic Cell Transplantation during the COVID-19 Pandemic: Perspectives from the Worldwide Network for Blood and Marrow Transplantation and Center for International Blood and Marrow Transplant Research Health Services and International Studies Committee UR - https://www.scopus.com/inward/record.uri?eid=2-s2.0-85089451061&doi=10.1016%2fj.bbmt.2020.07.021&partnerID=40&md5=d25e07215c8e085e43e6ba389a0dd2b5 VL - 26 ID - 278 ER - TY - JOUR AB - BACKGROUND Testing of vaccine candidates to prevent infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in an older population is important, since increased incidences of illness and death from coronavirus disease 2019 (Covid-19) have been associated with an older age. METHODS We conducted a phase 1, dose-escalation, open-label trial of a messenger RNA vaccine, mRNA-1273, which encodes the stabilized prefusion SARS-CoV-2 spike protein (S-2P) in healthy adults. The trial was expanded to include 40 older adults, who were stratified according to age (56 to 70 years or ≥71 years). All the participants were assigned sequentially to receive two doses of either 25 μg or 100 μg of vaccine administered 28 days apart. RESULTS Solicited adverse events were predominantly mild or moderate in severity and most frequently included fatigue, chills, headache, myalgia, and pain at the injection site. Such adverse events were dose-dependent and were more common after the second immunization. Binding-antibody responses increased rapidly after the first immunization. By day 57, among the participants who received the 25-μg dose, the anti-S-2P geometric mean titer (GMT) was 323,945 among those between the ages of 56 and 70 years and 1,128,391 among those who were 71 years of age or older; among the participants who received the 100-μg dose, the GMT in the two age subgroups was 1,183,066 and 3,638,522, respectively. After the second immunization, serum neutralizing activity was detected in all the participants by multiple methods. Binding- and neutralizing-antibody responses appeared to be similar to those previously reported among vaccine recipients between the ages of 18 and 55 years and were above the median of a panel of controls who had donated convalescent serum. The vaccine elicited a strong CD4 cytokine response involving type 1 helper T cells. CONCLUSIONS In this small study involving older adults, adverse events associated with the mRNA-1273 vaccine were mainly mild or moderate. The 100-μg dose induced higher binding- and neutralizing-antibody titers than the 25-μg dose, which supports the use of the 100-μg dose in a phase 3 vaccine trial. © 2020 Massachusetts Medical Society. AD - Center for Childhood Infections and Vaccines of Children's Healthcare of Atlanta, Department of Pediatrics, Emory University School of Medicine, Georgia, MD, United States Emory Vaccine Center, Yerkes National Primate Research Center, Emory University, Georgia, MD, United States Hope Clinic, Department of Medicine, Emory University School of Medicine, Decatur, GA, United States Vaccine Research CenterMD, United States Division of Microbiology and Infectious DiseasesMD, United States National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, University of Maryland School of Medicine, Baltimore, MD, United States Emmes Company, Rockville, MD, United States Kaiser Permanente Washington Health Research Institute, Seattle, United States Department of Pediatrics, Nashville, United States Vanderbilt Institute for Infection, Immunology, Nashville, United States Departments of Pathology, Microbiology, and Immunology, Nashville, United States Vanderbilt University Medical Center, Nashville, United States Moderna, Cambridge, MA, United States Departments of Epidemiology and Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, United States AU - Anderson, E. J. AU - Rouphael, N. G. AU - Widge, A. T. AU - Jackson, L. A. AU - Roberts, P. C. AU - Makhene, M. AU - Chappell, J. D. AU - Denison, M. R. AU - Stevens, L. J. AU - Pruijssers, A. J. AU - McDermott, A. B. AU - Flach, B. AU - Lin, B. C. AU - Doria-Rose, N. A. AU - O'Dell, S. AU - Schmidt, S. D. AU - Corbett, K. S. AU - Swanson, P. A., II AU - Padilla, M. AU - Neuzil, K. M. AU - Bennett, H. AU - Leav, B. AU - Makowski, M. AU - Albert, J. AU - Cross, K. AU - Edara, V. V. AU - Floyd, K. AU - Suthar, M. S. AU - Martinez, D. R. AU - Baric, R. AU - Buchanan, W. AU - Luke, C. J. AU - Phadke, V. K. AU - Rostad, C. A. AU - Ledgerwood, J. E. AU - Graham, B. S. AU - Beigel, J. H. AU - the m, R. N. A. Study Group C2 - 32991794 DB - Scopus DO - 10.1056/NEJMoa2028436 IS - 25 J2 - New Engl. J. Med. KW - mRNA 1273 neutralizing antibody RNA vaccine SARS-CoV-2 vaccine unclassified drug virus spike protein coronavirus spike glycoprotein mRNA-1273 vaccine spike protein, SARS-CoV-2 virus antibody adult age aged antibody blood level antibody detection antibody response antibody titer antigen binding Article CD4+ T lymphocyte cellular immunity chill clinical article coronavirus disease 2019 cytokine response disease severity drug safety fatigue female headache human immunogenicity injection site pain male myalgia phase 1 clinical trial priority journal Severe acute respiratory syndrome coronavirus 2 Th1 cell time to treatment administration and dosage adverse event blood clinical trial dose response immunology middle aged physiology prevention and control serodiagnosis T lymphocyte Antibodies, Neutralizing Antibodies, Viral COVID-19 COVID-19 Vaccines Dose-Response Relationship, Drug Humans Neutralization Tests SARS-CoV-2 Spike Glycoprotein, Coronavirus T-Lymphocytes LA - English M3 - Article N1 - Cited By :147 Export Date: 4 May 2021 CODEN: NEJMA Correspondence Address: Anderson, E.J.; Departments of Pediatrics and Medicine, 2015 Uppergate Dr., United States; email: evanderson@emory.edu Chemicals/CAS: Antibodies, Neutralizing; Antibodies, Viral; COVID-19 Vaccines; mRNA-1273 vaccine; Spike Glycoprotein, Coronavirus; spike protein, SARS-CoV-2 Funding details: National Institutes of Health, NIH, UL1 TR002243 Funding details: National Institute of Allergy and Infectious Diseases, NIAID Funding details: National Center for Advancing Translational Sciences, NCATS Funding details: School of Medicine, University of North Carolina at Chapel Hill Funding details: Vanderbilt University Medical Center, VUMC, HHSN272201500002C Funding details: Coalition for Epidemic Preparedness Innovations, CEPI Funding text 1: Supported by grants (UM1AI148373, to Kaiser Washington; UM1AI148576, UM1AI148684, and NIH P51 OD011132, to Emory University; NIH AID AI149644, to the University of North Carolina; UM1Al148684-01S1, to Vanderbilt University Medical Center; and HHSN272201500002C, to Emmes) from the National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH); by a grant (UL1 TR002243, to Vanderbilt University Medical Center) from the National Center for Advancing Translational Sciences, NIH; and by the Dolly Parton Covid-19 Research Fund (to Vanderbilt University Medical Center). Laboratory efforts were in part supported by the Emory Executive Vice President for Health Affairs Synergy Fund award, the Center for Childhood Infections and Vaccines, Children’s Healthcare of Atlanta, Covid-Catalyst-I3 Funds from the Woodruff Health Sciences Center and Emory School of Medicine, and North Carolina Policy Collaboratory at the University of North Carolina at Chapel Hill, with funding from the North Carolina Coronavirus Relief Fund established and appropriated by the North Carolina General Assembly. Funding for the manufacture of mRNA-1273 phase 1 material was provided by the Coalition for Epidemic Preparedness Innovation. 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AU - Apisarnthanarak, P. AU - Siripraparat, C. AU - Saengaram, P. AU - Leeprechanon, N. AU - Weber, D. J. C2 - 32507115 DB - Scopus DO - 10.1017/ice.2020.280 IS - 9 J2 - Infect. Control Hosp. Epidemiol. KW - adult anxiety disorder Article coronavirus disease 2019 epidemic fear female generalized anxiety disorder hand washing health care personnel health care policy health survey hospital policy human infection control infection prevention infection risk major clinical study male nurse nursing assistant patient safety physician private hospital social distancing Thailand university hospital virus transmission anxiety Betacoronavirus clinical practice Coronavirus infection disease transmission health care survey health personnel attitude middle aged nursing practice pandemic prevention and control procedures psychology statistical model virus pneumonia Attitude of Health Personnel Coronavirus Infections Health Care Surveys Health Personnel Humans Infectious Disease Transmission, Patient-to-Professional Logistic Models Pandemics Pneumonia, Viral Practice Patterns, Nurses' Practice Patterns, Physicians' LA - English M3 - Article N1 - Cited By :17 Export Date: 4 May 2021 CODEN: ICEPE Correspondence Address: Apisarnthanarak, A.; Division of Infectious Diseases, Thailand; email: anapisarn@yahoo.com Funding text 1: No financial support was provided relevant to this article. References: Hoehl, S., Rabenau, H., Berger, A., Evidence of SARS-CoV-2 infection in returning travelers from Wuhan, China (2020) N Eng J Med, 382, pp. 1278-1280; Chirico, F., Nucera, G., Magnavita, N., COVID-19: Protecting healthcare workers is a priority (2020) Infect Control Hosp Epidemiol, , Apr 17 [Epub ahead of print]; Gandhi, M., Yokoe, D.S., Havlir, D.V., Asymptomatic transmission, the Achilles' heel of current strategies to control COVID-19 (2020) N Eng J Med, 382, pp. 2158-2160; (2020) COVID-19 Infection Situation Report, , https://covid19.ddc.moph.go.th/en, Department of Disease Control website., Published, Accessed April 26, 2020; Lu, W., Wang, H., Lin, Y., Li, L., Psychological status of medical workforce during the COVID-19 pandemic: A cross-sectional study (2020) Physchiatry Res, 288, p. 112936; Lima, C.K.T., Carvalho, P.M.M., Lima, I.A.A.S., The emotional impact of coronavirus 2019-nCoV (new coronavirus disease) (2020) Physchiatry Res, 287, p. 1112915; Spitzer, R.L., Kroenke, K., Williams, J.B., Lowe, B., A brief measure for accessing generalized anxiety disorder: The GAD-7 (2006) Arch Intern Med, 166, pp. 1092-1097 PY - 2020 SN - 0899823X (ISSN) SP - 1093-1094 ST - Impact of anxiety and fear for COVID-19 toward infection control practices among Thai healthcare workers T2 - Infection Control and Hospital Epidemiology TI - Impact of anxiety and fear for COVID-19 toward infection control practices among Thai healthcare workers UR - https://www.scopus.com/inward/record.uri?eid=2-s2.0-85086249425&doi=10.1017%2fice.2020.280&partnerID=40&md5=bad8ea0a7975fb263bd77a0079a44ae9 VL - 41 ID - 402 ER - TY - JOUR AD - Division of Infectious Diseases, Faculty of Medicine, Thammasat University, Prathum Thani, Thailand Manorom Hospital, Bangkok, Thailand Division of Diagnostic Radiology, Department of Radiology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand Research and Consulting Service, Michael Ullmann Consulting, United States Bumrungrad Hospital, Bangkok, Thailand Department of Ophthalmology, Rutnin Hospital, Bangkok, Thailand Division of Infectious Diseases, University of North Carolina, Chapel Hill, United States AU - Apisarnthanarak, A. AU - Siripraparat, C. AU - Apisarnthanarak, P. AU - Ullmann, M. AU - Saengaram, P. AU - Leeprechanon, N. AU - Weber, D. J. DB - Scopus DO - 10.1017/ice.2020.1240 J2 - Infect. Control Hosp. Epidemiol. KW - Anxiety Confidence COVID-19 Fear Infection control practices Patients LA - English M3 - Letter N1 - Cited By :1 Export Date: 4 May 2021 CODEN: ICEPE Correspondence Address: Apisarnthanarak, A.; Division of Infectious Diseases, Thailand; email: anapisarn@yahoo.com References: Lima, C.K.T., Carvalho, P.M.M., Lima, I.A.A.S., The emotional impact of coronavirus 2019-nCOV (new coronavirus disease) (2020) Phychiatry Res, , in press; Li, W., Yang, Y., Liu, Z.H., Progression of mental health service during COVID-19 outbreak in China (2020) Int J Biol Sci, 16, pp. 1732-1738; Lu, W., Wang, H., Lin, Y., Li, L., Psychological status of medical workforce during the COVID-19 pandemic: A cross-sectional study (2020) Physchiatry Res, 288, p. 112936; Spitzer, R.L., Kroenke, K., Williams, J.B., Lowe, B., A brief measure for accessing generalized anxiety disorder: The GAD-7 (2006) Arch Intern Med, 166, pp. 1092-1097; Bruns, D.P., Kraguljac, N.V., Bruns, T.R., CoviD-19: Facts, cultural consideration and risk of stigmatization (2020) J Transcult Nurs, 31, pp. 326-332 PY - 2020 SN - 0899823X (ISSN) ST - Patients’ anxiety, fear and panic for covid-19 and confidence in hospital infection control policy in outpatient departments: A survey from four Thai hospitals T2 - Infection Control and Hospital Epidemiology TI - Patients’ anxiety, fear and panic for covid-19 and confidence in hospital infection control policy in outpatient departments: A survey from four Thai hospitals UR - https://www.scopus.com/inward/record.uri?eid=2-s2.0-85092572811&doi=10.1017%2fice.2020.1240&partnerID=40&md5=8e296e1c0e22e660a90435542e5c9e37 ID - 548 ER - TY - JOUR AB - Chemical reactions on indoor surfaces play an important role in air quality in indoor environments, where humans spend 90% of their time. We focus on the challenges of understanding the complex chemistry that takes place on indoor surfaces and identify crucial steps necessary to gain a molecular-level understanding of environmental indoor surface chemistry: (1) elucidate key surface reaction mechanisms and kinetics important to indoor air chemistry, (2) define a range of relevant and representative surfaces to probe, and (3) define the drivers of surface reactivity, particularly with respect to the surface composition, light, and temperature. Within the drivers of surface composition are the roles of adsorbed/absorbed water associated with indoor surfaces and the prevalence, inhomogeneity, and properties of secondary organic films that can impact surface reactivity. By combining laboratory studies, field measurements, and modeling we can gain insights into the molecular processes necessary to further our understanding of the indoor environment. © 2020 Elsevier Inc. Humans spend ∼90% of their time indoors. However, understanding the chemistry that occurs on indoor surfaces and its impact on air quality is still in its nascent stages due to the complexity of indoor surfaces. High surface-to-volume ratios indoors increase gas-surface collisions, but molecular mechanisms for surface reactions are often poorly understood, despite their importance becoming increasingly clear. Equilibrium thermodynamics poorly explain indoor surface chemistry, with key kinetic effects observed. Drivers of surface reactivity include relative humidity, temperature, light, and surface pH. Highlighted findings are the ubiquitous presence of aqueous and secondary organic films, their ability to act as reservoirs of contaminants, and impacts on gas and particle lifetimes. Indoor surface chemistry impacts multiple U.N. Sustainable Global Goals that point to the importance of further integration of laboratory, modeling, and real-world measurements to understand the air we breathe indoors. © 2020 Elsevier Inc. AD - Department of Chemistry, University of Michigan, Ann Arbor, MI 48109, United States Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA 92093, United States Scripps Institution of Oceanography, University of California, San Diego, La Jolla, CA 92037, United States Department of Nanoengineering, University of California, San Diego, La Jolla, CA 92093, United States Department of Environment and Geography, University of York, York, North Yorkshire YO10 5NG, United Kingdom Department of Chemistry, University of Toronto, Toronto, ON M5S 3H6, Canada Department of Chemistry, Bucknell University, Lewisburg, PA 17837, United States Indoor Environment Group, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, United States Department of Physical and Environmental Sciences, University of Toronto, Toronto, ON M1C 1A4, Canada Department of Chemistry, Colorado State University, Fort Collins, CO 80523, United States Department of Chemistry and Cooperative Institute for Research in Environmental Sciences (CIRES), University of Colorado Boulder, Boulder, CO 80309, United States Department of Chemical Engineering, Columbia University, New York, NY 10027, United States Department of Environmental Sciences and Engineering, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, United States Department of Chemistry, College of William and Mary, Williamsburg, VA 23185, United States Department of Chemistry, University of California Irvine, Irvine, CA 92697, United States Department of Mechanical Engineering, University of Colorado Boulder, Boulder, CO 80309, United States National Institute for Occupational Safety and Health, Morgantown, WV 26505, United States Materials Science and Engineering Program, University of California, San Diego, La Jolla, CA 92093, United States AU - Ault, A. P. AU - Grassian, V. H. AU - Carslaw, N. AU - Collins, D. B. AU - Destaillats, H. AU - Donaldson, D. J. AU - Farmer, D. K. AU - Jimenez, J. L. AU - McNeill, V. F. AU - Morrison, G. C. AU - O'Brien, R. E. AU - Shiraiwa, M. AU - Vance, M. E. AU - Wells, J. R. AU - Xiong, W. DB - Scopus DO - 10.1016/j.chempr.2020.08.023 IS - 12 J2 - Chem KW - acid-base chemistry adsorption indoor air quality indoor chemistry indoor surfaces partitioning photochemistry SDG11: Sustainable cities and communities SDG3: Good health and well-being SDG9: Industry, innovation, and infrastructure surface chemistry volatile and semi-volatile organic compounds LA - English M3 - Review N1 - Cited By :8 Export Date: 4 May 2021 CODEN: CHEMV Correspondence Address: Ault, A.P.; Department of Chemistry, United States; email: aulta@umich.edu Correspondence Address: Grassian, V.H.; Department of Chemistry and Biochemistry, United States; email: vhgrassian@ucsd.edu Funding details: Centers for Disease Control and Prevention, CDC Funding details: Alfred P. Sloan Foundation, G-2018-10122 Funding text 1: Dr. Paula Olsiewski is acknowledged for her leadership of the Chemistry of Indoor Environments program, which enabled this review. This work was supported by the Sloan Foundation’s Chemistry of Indoor Environments (CIE) program, specifically grant G-2018-10122 (Ault), which funded the “Molecular Insights into Chemical Reactions on Indoor Surfaces” workshop at the University of Michigan, May 7–8, 2018, organized by Professors Ault and Grassian, which inspired many of the ideas behind this work. The Sloan Surface Consortium for Chemistry of Indoor Environments (SURF-CIE) grew out of this workshop and has driven further efforts (Sloan grant: G-2019-12365 ). The MOdelling Consortium for Chemistry of Indoor Environments ( MOCCIE) modeling effort (Sloan grant: G-2019-12306 ) has helped drive the exploration of the role of the surface in indoor air chemistry. Professor Doug Tobias is acknowledged for the molecular model representation of an indoor surface depicted through the magnifying glass in Figure 1 . Nicole Olson is acknowledged for the electron microscopy images in Figure 1 . Lightbulb and thermometer in Figure 2 are from FlatIcon. The findings and conclusions in this report are those of the authors and do not necessarily represent the official position of the Centers for Disease Control and Prevention/the Agency for Toxic Substances and Disease Registry. Mention of any commercial product or trade name does not constitute endorsement by the Centers for Disease Control and Prevention/National Institute for Occupational Safety and Health. Funding text 2: Dr. Paula Olsiewski is acknowledged for her leadership of the Chemistry of Indoor Environments program, which enabled this review. This work was supported by the Sloan Foundation's Chemistry of Indoor Environments (CIE) program, specifically grant G-2018-10122 (Ault), which funded the ?Molecular Insights into Chemical Reactions on Indoor Surfaces? workshop at the University of Michigan, May 7?8, 2018, organized by Professors Ault and Grassian, which inspired many of the ideas behind this work. The Sloan Surface Consortium for Chemistry of Indoor Environments (SURF-CIE) grew out of this workshop and has driven further efforts (Sloan grant: G-2019-12365). The MOdelling Consortium for Chemistry of Indoor Environments (MOCCIE) modeling effort (Sloan grant: G-2019-12306) has helped drive the exploration of the role of the surface in indoor air chemistry. Professor Doug Tobias is acknowledged for the molecular model representation of an indoor surface depicted through the magnifying glass in Figure 1. Nicole Olson is acknowledged for the electron microscopy images in Figure 1. Lightbulb and thermometer in Figure 2 are from FlatIcon. The findings and conclusions in this report are those of the authors and do not necessarily represent the official position of the Centers for Disease Control and Prevention/the Agency for Toxic Substances and Disease Registry. 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Sci.: Processes Impacts, 21, pp. 1240-1254; Farmer, D.K., Vance, M.E., Abbatt, J.P.D., Abeleira, A., Alves, M.R., Arata, C., Boedicker, E., Corsi, R., Overview of HOMEChem: house observations of microbial and environmental chemistry (2019) Environ. Sci.: Processes Impacts, 21, pp. 1280-1300 PY - 2020 SN - 24519308 (ISSN) SP - 3203-3218 ST - Indoor Surface Chemistry: Developing a Molecular Picture of Reactions on Indoor Interfaces T2 - Chem TI - Indoor Surface Chemistry: Developing a Molecular Picture of Reactions on Indoor Interfaces UR - https://www.scopus.com/inward/record.uri?eid=2-s2.0-85091218274&doi=10.1016%2fj.chempr.2020.08.023&partnerID=40&md5=f950bcd77c36e3f48734f0309462a3c7 VL - 6 ID - 248 ER - TY - JOUR AD - Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale Fetal Care Center, Yale University School of Medicine, New Haven, CT, United States Department of Obstetrics and Gynecology, Johns Hopkins Center for Fetal Therapy, Baltimore, MD, United States Department of Obstetrics and Gynaecology, University Hospitals Leuven, Leuven, Belgium Department of Obstetrics and Gynaecology, University College London Hospital, London, United Kingdom Department of Obstetrics, Gynecology, and Reproductive Sciences, University of Pittsburgh, Pittsburgh, PA, United States Department of Obstetrics and Gynecology, University of North Carolina School of Medicine, 3010 Old Clinic Building, CB No. 7516, Chapel Hill, NC 27599, United States Division of Maternal Fetal Medicine, University of Texas Health Science, Center at Houston, Houston, TX, United States Department of Obstetrics and Gynecology, Zucker School of Medicine at Hofstra/Northwell, Hempstead, NY, United States Center for Fetal Diagnosis and Treatment, Children's Hospital of Philadelphia, Philadelphia, PA, United States Fetal Medicine Unit, Ontario Fetal Centre, Department of Obstetrics and Gynaecology, Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada Department of Pediatric Surgery, University of Texas Health Science Center at Houston, Houston, TX, United States Fetal Concerns Center, Department of Pediatric Surgery, Children's Hospital of Wisconsin, Milwaukee, WI, United States Maternal-Fetal Care Unit, Department of Obstetrics and Gynecology, Colorado Fetal Care Center, Denver, CO, United States AU - Bahtiyar, M. O. AU - Baschat, A. AU - Deprest, J. AU - Emery, S. AU - Goodnight, W. H. AU - Johnson, A. AU - McCullough, L. AU - Moldenhauer, J. S. AU - Ryan, G. AU - Tsao, K. AU - Van Mieghem, T. AU - Wagner, A. AU - Zaretsky, M. C2 - 32348742 DB - Scopus DO - 10.1016/j.ajog.2020.04.025 IS - 2 J2 - Am. J. Obstet. Gynecol. KW - coronavirus disease 2019 health care health care personnel human infection risk intrauterine blood transfusion Letter morbidity North American pandemic pregnant woman priority journal risk benefit analysis Severe acute respiratory syndrome coronavirus 2 vertical transmission Coronavirus infection female fetal therapy pregnancy prenatal care risk assessment United States virus pneumonia Coronavirus Infections Fetal Therapies Humans Pandemics Pneumonia, Viral LA - English M3 - Letter N1 - Cited By :3 Export Date: 4 May 2021 CODEN: AJOGA Funding details: Eunice Kennedy Shriver National Institute of Child Health and Human Development, NICHD, 5R131HD059293-05 Funding text 1: The authors report no conflict of interest. The North American Fetal Therapy Network is supported through funding by the Eunice Kennedy Shriver National Institute of Child Health and Human Development ( 5R131HD059293-05 ). References: Deprest, J., VanRanst, M., Lannoo, L., SAR-CoV2 (COVID-19) infection: is fetal surgery in times of national disasters reasonable? (2020) Prenat Diagn, , [Epub ahead of print]; Boelig, R.C., Saccone, G., Bellussi, F., Berghella, V., MFM guidance for COVID-19 (2020) Am J Obstet Gynecol MFM, , [Epub ahead of print]; Hollander, J.E., Carr, B.G., Virtually perfect? 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Quaternary ammonium compounds such as ammonium chloride, cetylpyridinium and miramistin represent widely accessible antiseptic molecules with well-known broad-spectrum antiviral activities and represent a repurposing opportunity as therapeutics against SARS-CoV-2. © 2020, Springer Science+Business Media, LLC, part of Springer Nature. AD - Leidos, Research Triangle Park, Durham, NC, United States Center for Computational Toxicology and Exposure, Office of Research and Development, U.S. Environmental Protection Agency (U.S. EPA), Research Triangle Park, Durham, NC, United States Laboratory for Molecular Modeling, UNC Eshelman School of Pharmacy, UNC Chapel Hill, Chapel Hill, NC 27599, United States Collaborations Pharmaceuticals, Inc., 840 Main Campus Drive, Lab 3510, Raleigh, NC 27606, United States UNC Catalyst for Rare Diseases, Eshelman School of Pharmacy, UNC Chapel Hill, Chapel Hill, NC 27599, United States AU - Baker, N. AU - Williams, A. J. AU - Tropsha, A. AU - Ekins, S. C2 - 32451736 C7 - 104 DB - Scopus DO - 10.1007/s11095-020-02842-8 IS - 6 J2 - Pharm. Res. KW - ammonium chloride antiseptic cetylpyridinium chloride SARS-CoV-2 cetylpyridinium salt miramistin quaternary ammonium derivative unclassified drug mouthwash nose spray topical antiinfective agent Article bibliometrics coronavirus disease 2019 drug repositioning human nonhuman priority journal Severe acute respiratory syndrome coronavirus 2 Betacoronavirus Coronavirus infection drug effect pandemic procedures virus pneumonia Anti-Infective Agents, Local Coronavirus Infections Humans Mouthwashes Nasal Sprays Pandemics Pneumonia, Viral Quaternary Ammonium Compounds LA - English M3 - Article N1 - Cited By :15 Export Date: 4 May 2021 CODEN: PHREE Correspondence Address: Ekins, S.; UNC Catalyst for Rare Diseases, United States; email: sean@collaborationspharma.com Chemicals/CAS: ammonium chloride, 12125-02-9; cetylpyridinium salt, 123-03-5, 140-72-7, 2349-55-5, 7773-52-6; Anti-Infective Agents, Local; Mouthwashes; Nasal Sprays; Quaternary Ammonium Compounds Funding text 1: This work has been reviewed at the US EPA and has been approved for publication. The views expressed in this publication are those of the authors and do not necessarily represent the views or policies of the United States Environment Protection Agency. Reference to commercial products or services does not constitute endorsement. References: Gates, B., Responding to Covid-19 - a once-in-a-century pandemic? 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[study of the anti-HIV activity of miramistin] (1994) Vopr Virusol, 39 (6), pp. 267-269. , COI: 1:STN:280:DyaK2M3jt12gtQ%3D%3D, PID: 7716921; Agafonov, A.P., Skarnovich, M.O., Petrishchenko, V.A., Shishkina, L.N., Sergeev, A.N., Svistov, V.V., Smirnov, I.V., Krivoshein, I.S., In vitro study of antiviral activity of Myramistin against subtypes H3N2 and H5N1 of influenza virus (2005) Antibiot Khimioter, 50 (12), pp. 9-11. , COI: 1:CAS:528:DC%2BD2sXhsVKlsb7O, PID: 19140480 PY - 2020 SN - 07248741 (ISSN) ST - Repurposing Quaternary Ammonium Compounds as Potential Treatments for COVID-19 T2 - Pharmaceutical Research TI - Repurposing Quaternary Ammonium Compounds as Potential Treatments for COVID-19 UR - https://www.scopus.com/inward/record.uri?eid=2-s2.0-85085305168&doi=10.1007%2fs11095-020-02842-8&partnerID=40&md5=ed4c2383142f79d95308e642cafdb723 VL - 37 ID - 490 ER - TY - JOUR AB - Objective. To characterize hydroxychloroquine (HCQ) exposure in patients with rheumatic disease receiving longterm HCQ compared to target concentrations with reported antiviral activity against the coronavirus disease 2019 caused by SARS-CoV-2 (COVID-19). Method. We evaluated total HCQ concentrations in serum and plasma from published literature values, frozen serum samples from a pediatric systemic lupus erythematosus trial, and simulated concentrations using a published pharmacokinetic model during pregnancy. For each source, we compared observed or predicted HCQ concentrations to target concentrations with reported antiviral activity against SARS-CoV-2. Results. The average total serum/plasma HCQ concentrations were below the lowest SARS-CoV-2 target of 0.48 mg/l in all studies. Assuming the highest antiviral target exposure (total plasma concentration of 4.1 mg/l), all studies had about one-tenth the necessary concentration for in vitro viral inhibition. Pharmacokinetic model simulations confirmed that pregnant adults receiving common dosing for rheumatic diseases did not achieve target exposures; however, the models predict that a dosage of 600 mg once a day during pregnancy would obtain the lowest median target exposure for most patients after the first dose. Conclusion. We found that the average patient receiving treatment with HCQ for rheumatic diseases, including children and non-pregnant/pregnant adults, are unlikely to achieve total serum or plasma concentrations shown to inhibit SARS-CoV-2 in vitro. Nevertheless, patients receiving HCQ long term may have tissue concentrations far exceeding that of serum/plasma. Because the therapeutic window for HCQ in the setting of SARS-CoV-2 is unknown, well-designed clinical trials that include patients with rheumatic disease are urgently needed to characterize the efficacy, safety, and target exposures for HCQ. © 2020. All rights reserved. AD - Department of Rheumatology and Immunology, Duke University School of Medicine, Durham, NC, United States Duke Clinical Research Institute, Durham, NC, United States Department of Pediatrics, Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Duke University School of Medicine, Durham, NC, United States Department of Pediatrics, Northwestern University, Feinberg School of Medicine, Evanston, IL, United States Division of Pharmacotherapy and Experimental Therapeutics, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States AU - Balevic, S. J. AU - Hornik, C. P. AU - Green, T. P. AU - Clowse, M. E. B. AU - Gonzalez, D. AU - Maharaj, A. R. AU - Schanberg, L. E. AU - Eudy, A. M. AU - Swamy, G. K. AU - Hughes, B. L. AU - Cohen-Wolkowiez, M. C2 - 32393664 DB - Scopus DO - 10.3899/jrheum.200493 IS - 9 J2 - J. Rheumatol. KW - COVID-19 HYDROXYCHLOROQUINE PREGNANCY RHEUMATIC DISEASE SYSTEMIC LUPUS ERYTHEMATOSUS antiviral activity Article blood sampling clinical observation coronavirus disease 2019 cryopreservation drug blood level drug efficacy drug exposure drug safety drug targeting high performance liquid chromatography human in vitro study mass spectrometry medical research prediction priority journal Severe acute respiratory syndrome coronavirus 2 simulation therapeutic index treatment duration virus inhibition LA - English M3 - Article N1 - Cited By :8 Export Date: 4 May 2021 CODEN: JRHUA Correspondence Address: Balevic, S.J.; Department of Rheumatology and Immunology, 2301 Erwin Road, CHC, T-Level, United States; email: stephen.balevic@duke.edu Chemicals/CAS: hydroxychloroquine, 118-42-3, 525-31-5 Funding details: 2T32GM086330-06 Funding details: National Institutes of Health, NIH, 1R01HD083003-01, HHSN272201300017I Funding details: Centers for Disease Control and Prevention, CDC, 200-2012-53663 Funding details: U.S. Food and Drug Administration, FDA, 1R01-FD006099, 5U18-FD006298, 5U18FD006298-03 Funding details: National Institute of Allergy and Infectious Diseases, NIAID Funding details: National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIAMS, N01-AR-2-2265 Funding details: National Institute of Child Health and Human Development, NICHD, 1K23HD090239, R13HD102136 Funding details: Pfizer Funding details: Thrasher Research Fund, TRF Funding details: Patient-Centered Outcomes Research Institute, PCORI Funding details: National Center for Advancing Translational Sciences, NCATS, 1UL1TR002553-01, R21AI132677, UG1 HD068258-06 Funding details: Rheumatology Research Foundation, RRF Funding details: Eunice Kennedy Shriver National Institute of Child Health and Human Development, NICHD, 5R01-HD076676-04, 5R01HD096435, 8177, HHSN275201800003I, U19AR069522 Funding details: National Heart and Lung Institute, NHLI, R61/R33HL147833 Funding details: Apple University Development Fund, Apple University Consortium, AUDF Funding text 1: From the Department of Rheumatology and Immunology, Duke University School of Medicine, Durham, North Carolina, USA; Duke Clinical Research Institute, Durham, North Carolina, USA; Department of Pediatrics, and the Division of Maternal-Fetal Medicine, Department of Obstetrics & Gynecology, Duke University School of Medicine, Durham, North Carolina, USA; Department of Pediatrics, Northwestern University, Feinberg School of Medicine, Evanston, Illinois, USA; Division of Pharmacotherapy and Experimental Therapeutics, UNC Eshelman School of Pharmacy, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA. This study was supported by the Rheumatology Research Foundation’s Scientist Development Award, the Thrasher Research Fund, the Childhood Arthritis and Rheumatology Research Alliance/Arthritis Foundation, the Derfner Foundation, NIGMS/NICHD (2T32GM086330-06), NICHD (5R01-HD076676-04, HHSN275201000003I), and a Duke Health/Private Diagnostic Clinic ENABLE grant. The Atherosclerosis Prevention in Pediatric Lupus Erythematosus [APPLE (ClinicalTrials. gov: NCT00065806)] trial is supported by the US National Institutes of Health (NIH) National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) contract N01-AR-2-2265, the Edna and Fred L. Mandel Jr. Center for Hypertension and Atherosclerosis, and Pfizer, which provided atorvastatin and matching placebo. Funding text 2: S.J.B. receives support from the NIH (5R01-HD076676-04, 1R01HD083003-01, HHSN275201000003I, HHSN275201800003I, HHSN272201500006I 5U24-TR001608-03), the US Food and Drug Administration (5U18FD006298-03), the Patient-Centered Outcomes Research Institute (PCORI), the Rheumatology Research Foundation’s Scientist Development Award, the Thrasher Research Fund, and the Childhood Arthritis and Rheumatology Research Alliance/Arthritis Foundation. C.P.H. receives salary support for research from the National Institute for Child Health and Human Development (NICHD; 1K23HD090239; R13HD102136), National Heart Lung and Blood Institute (R61/R33HL147833), FDA (1R01-FD006099, PI: Laughon; and 5U18-FD006298, PI: Benjamin), the US government for his work in pediatric clinical pharmacology (Government Contract HHSN275201800003I, PI: Benjamin under the Best Pharmaceuticals for Children Act), the nonprofit Burrhoughs Wellcome Fund, and other sponsors for drug development in adults and children (dcri.org/about-us/ conflict-of-interest). D.G. receives support for research from the Eunice Kennedy Shriver NICHD (5R01HD096435). A.M. receives research support from the Thrasher Research Fund (www.thrasherresearch.org). L.E.S. receives support for research from the NIH (U19AR069522), PCORI (8177), and the Childhood Arthritis and Rheumatology Research Alliance. She is on the Data Safety Monitoring Board for investigational Funding text 3: product trials for UCB (Cimzia) and Sanofi (sarilumab). Sanofi is a maker of hydroxychloroquine. Samples used in this publication were collected as part of NIH/NIAMS (N01-AR-2-2265). A.M.E. receives support from the NIH National Center for Advancing Translational Sciences. G.K.S. receives support for research from the NIH (UG1 HD068258-06, HHSN272201300017I, 1UL1TR002553-01, R21AI132677) and the Centers for Disease Control and Prevention (200-2012-53663). She chairs an Independent Data Monitoring Committee for GlaxoSmithKline (RSV vaccine trials). M.C.W. receives support for research from the NIH (1R01-HD076676-01A1 and 1K24-AI143971), National Institute of Allergy and Infectious Diseases (HHSN272201500006I and HHSN272201300017I), NICHD (HHSN275201000003I), FDA (5U18-FD006298), and the industry for drug development in adults and children. S.J. Balevic, MD, MHS, Department of Rheumatology and Immunology, and Department of Pediatrics, Duke University School of Medicine, and Duke Clinical Research Institute; C.P. Hornik, MD, PhD, Duke Clinical Research Institute, and Department of Pediatrics, Duke University School of Medicine; T.P. Green, MD, MS, Department of Pediatrics, Northwestern University, Feinberg School of Medicine; M.E. Clowse, MD, MPH, Department of Rheumatology and Immunology, Duke University School of Medicine; D. Gonzalez, PharmD, PhD, Division of Pharmacotherapy and Experimental Therapeutics, UNC Eshelman School of Pharmacy, The University of North Carolina at Chapel Hill; A.R. Maharaj, PhD, Duke Clinical Research Institute; L.E. Schanberg, MD, Duke Clinical Research Institute, and Department of Pediatrics, Duke University School of Medicine; A.M. Eudy, PhD, Department of Rheumatology and Immunology, Duke University School of Medicine; G.K. Swamy, MD, Division of Maternal-Fetal Medicine, Department of Obstetrics & Gynecology, Duke University School of Medicine; B.L. Hughes, MD, MSc, Division of Maternal-Fetal Medicine, Department of Obstetrics & Gynecology, Duke University School of Medicine; M. Cohen-Wolkowiez, MD, PhD, Duke Clinical Research Institute, and Department of Pediatrics, Duke University School of Medicine. Address correspondence to Dr. S.J. Balevic, Department of Rheumatology and Immunology, Duke University School of Medicine, 2301 Erwin Road, CHC, T-Level, Durham, North Carolina 27710, USA. E-mail: stephen.balevic@duke.edu Full Release Article. For details see Reprints and Permissions at jrheum. org Accepted for publication May 14, 2019. Funding text 4: This study was supported by the Rheumatology Research Foundation's Scientist Development Award, the Thrasher Research Fund, the Childhood Arthritis and Rheumatology Research Alliance/Arthritis Foundation, the Derfner Foundation, NIGMS/NICHD (2T32GM086330-06), NICHD (5R01-HD076676-04, HHSN275201000003I), and a Duke Health/Private Diagnostic Clinic ENABLE grant. The Atherosclerosis Prevention in Pediatric Lupus Erythematosus [APPLE (ClinicalTrials. gov: NCT00065806)] trial is supported by the US National Institutes of Health (NIH) National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) contract N01-AR-2-2265, the Edna and Fred L. Mandel Jr. Center for Hypertension and Atherosclerosis, and Pfizer, which provided atorvastatin and matching placebo. S.J.B. receives support from the NIH (5R01-HD076676-04, 1R01HD083003-01, HHSN275201000003I, HHSN275201800003I, HHSN272201500006I 5U24-TR001608-03), the US Food and Drug Administration (5U18FD006298-03), the Patient-Centered Outcomes Research Institute (PCORI), the Rheumatology Research Foundation's Scientist Development Award, the Thrasher Research Fund, and the Childhood Arthritis and Rheumatology Research Alliance/Arthritis Foundation. C.P.H. receives salary support for research from the National Institute for Child Health and Human Development (NICHD; 1K23HD090239; R13HD102136), National Heart Lung and Blood Institute (R61/R33HL147833), FDA (1R01-FD006099, PI: Laughon; and 5U18-FD006298, PI: Benjamin), the US government for his work in pediatric clinical pharmacology (Government Contract HHSN275201800003I, PI: Benjamin under the Best Pharmaceuticals for Children Act), the nonprofit Burrhoughs Wellcome Fund, and other sponsors for drug development in adults and children (dcri.org/about-us/ conflict-of-interest). D.G. receives support for research from the Eunice Kennedy Shriver NICHD (5R01HD096435). A.M. receives research support from the Thrasher Research Fund (www.thrasherresearch.org). L.E.S. receives support for research from the NIH (U19AR069522), PCORI (8177), and the Childhood Arthritis and Rheumatology Research Alliance. She is on the Data Safety Monitoring Board for investigational product trials for UCB (Cimzia) and Sanofi (sarilumab). Sanofi is a maker of hydroxychloroquine. Samples used in this publication were collected as part of NIH/NIAMS (N01-AR-2-2265). A.M.E. receives support from the NIH National Center for Advancing Translational Sciences. G.K.S. receives support for research from the NIH (UG1 HD068258-06, HHSN272201300017I, 1UL1TR002553-01, R21AI132677) and the Centers for Disease Control and Prevention (200-2012-53663). She chairs an Independent Data Monitoring Committee for GlaxoSmithKline (RSV vaccine trials). M.C.W. receives support for research from the NIH (1R01-HD076676-01A1 and 1K24-AI143971), National Institute of Allergy and Infectious Diseases (HHSN272201500006I and HHSN272201300017I), NICHD (HHSN275201000003I), FDA (5U18-FD006298), and the industry for drug development in adults and children. 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Accessed May 19, 2020]; A randomized study of the effect of withdrawing hydroxychloroquine sulfate in systemic lupus erythematosus (1991) N Engl J Med, 324, pp. 150-154. , Canadian Hydroxychloroquine Study Group PY - 2020 SN - 0315162X (ISSN) SP - 1424-1430 ST - Hydroxychloroquine in patients with rheumatic disease complicated by COVID-19: Clarifying target exposures and the need for clinical trials T2 - Journal of Rheumatology TI - Hydroxychloroquine in patients with rheumatic disease complicated by COVID-19: Clarifying target exposures and the need for clinical trials UR - https://www.scopus.com/inward/record.uri?eid=2-s2.0-85087371715&doi=10.3899%2fjrheum.200493&partnerID=40&md5=8d941fca80d6a15b3ad84636133eee63 VL - 47 ID - 399 ER - TY - JOUR AB - This article draws on findings of an international study of social workers’ ethical challenges during COVID-19, based on 607 responses to a qualitative survey. Ethical challenges included the following: maintaining trust, privacy, dignity and service user autonomy in remote relationships; allocating limited resources; balancing rights and needs of different parties; deciding whether to break or bend policies in the interests of service users; and handling emotions and ensuring care of self and colleagues. The article considers regional contrasts, the ‘ethical logistics’ of complex decision-making, the impact of societal inequities, and lessons for social workers and professional practice around the globe. © The Author(s) 2020. AD - Durham University, United Kingdom University of Applied Sciences, Netherlands British Association of Social Workers IFSW Ethics Commission, United Kingdom Hong Kong Baptist University, Hong Kong University of Ljubljana, Slovenia University of North Carolina, Chapel Hill, United States IFSW Secretary-General, Switzerland Public University of Navarre, Spain Dalhousie University, Canada AU - Banks, S. AU - Cai, T. AU - de Jonge, E. AU - Shears, J. AU - Shum, M. AU - Sobočan, A. M. AU - Strom, K. AU - Truell, R. AU - Úriz, M. J. AU - Weinberg, M. DB - Scopus DO - 10.1177/0020872820949614 IS - 5 J2 - Int. Soc. Work. KW - COVID-19 ethical logistics ethics inequities pandemic social work LA - English M3 - Article N1 - Cited By :2 Export Date: 4 May 2021 Correspondence Address: Banks, S.; Durham UniversityUnited Kingdom; email: s.j.banks@durham.ac.uk Funding details: Economic and Social Research Council, ESRC, ES/T501888/1 Funding details: Durham University Funding text 1: The author(s) disclosed receipt of the following financial support for the research, authorship and/or publication of this article: A small grant for research assistance was received from Durham University (UK) from the Economic and Social Research Council Impact Acceleration Account, reference ES/T501888/1. Funding text 2: Thanks to all the social workers, students and academics who took time away from their busy lives to share their insights and experiences; national and provincial associations of social workers for distributing the survey; members of the IFSW Ethics Commission and IFSW staff for their support; Didier Dubasque, Audrey Gonin, Brenda Harvey, Annalisa Pasini, Maria Sanfelia, Sirpa Saario and Viktor Virag for additional translation and interviews; Mariko Kimura and Viktor Virag for work on the Japanese survey; Teresa Bertotti for ongoing support and encouragement; and Durham University for financial assistance. The author(s) disclosed receipt of the following financial support for the research, authorship and/or publication of this article: A small grant for research assistance was received from Durham University (UK) from the Economic and Social Research Council Impact Acceleration Account, reference ES/T501888/1. 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Subramanian, R., (2018) Disaster Management, , New Delhi, Vikas Publishing; Truell, R., (2020) Covid-19: The Struggle, Success and Expansion of Social Work, , www.ifsw.org/covid-19-the-struggle-success-and-expansion-of-social-work, Rheinfelden, International Federation of Social Workers, accessed 13 July 2020, :, Available online at; Van Dorn, A., Cooney, R., Sabin, M., ‘COVID-19 Exacerbating Inequalities in the US’ (2020) The Lancet, 395. , 1243–4; Walter-McCabe, H., ‘Coronavirus Pandemic Calls for an Immediate Social Work Response’ (2020) Social Work in Public Health, 35 (3), pp. 69-72; (2020) ‘Food Security and COVID-19’, , https://www.worldbank.org/en/topic/agriculture/brief/food-security-and-covid-19, accessed 13 July 2020, Available online at PY - 2020 SN - 00208728 (ISSN) SP - 569-583 ST - Practising ethically during COVID-19: Social work challenges and responses T2 - International Social Work TI - Practising ethically during COVID-19: Social work challenges and responses UR - https://www.scopus.com/inward/record.uri?eid=2-s2.0-85089580441&doi=10.1177%2f0020872820949614&partnerID=40&md5=9633330942053ce7f4ce08366f8b967f VL - 63 ID - 388 ER - TY - JOUR AB - This study analyzes the possibility that COVID-19 will increase the risk of a military conflict between the United States and People’s Republic of China. The mechanism is that COVID-19 weakens American economic output, which undermines the U.S. capability to project force. This enables China’s efforts to revise the status quo. Although a rapid collapse of American power due to COVID-19 would theoretically increase the likelihood of an armed conflict, this scenario is unlikely due to the centrality of the U.S. dollar in the global financial system. I therefore argue that COVID-19 increases the short term risk of military crises, particularly in the South China Sea and Persian Gulf, but does not significantly increase the likelihood of a power transition and full scale war. However, the long term depends on the ability of the U.S. to respond adequately to the COVID-19 crisis. © 2020 De Gruyter. All rights reserved. AD - University of North Carolina, Chapel Hill, United States AU - Bapat, N. C7 - 20200047 DB - Scopus DO - 10.1515/peps-2020-0047 IS - 3 J2 - Peace Econ. Peace Sci. 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Understanding the case of the U.S. And China T2 - Peace Economics, Peace Science and Public Policy TI - Will covid-19 cause a war? Understanding the case of the U.S. And China UR - https://www.scopus.com/inward/record.uri?eid=2-s2.0-85093526291&doi=10.1515%2fpeps-2020-0047&partnerID=40&md5=b6fc618512772748fc16a98333d4f10d VL - 26 ID - 369 ER - TY - JOUR AD - Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, United States AU - Baric, R. S. C2 - 33326716 DB - Scopus DO - 10.1056/NEJMcibr2032888 IS - 27 J2 - New Engl. J. Med. KW - angiotensin converting enzyme 2 SARS-CoV-2 vaccine Article cause of death China coronavirus disease 2019 disease severity epidemic genotype herd immunity human infection prevention nonhuman pandemic prevalence priority journal Severe acute respiratory syndrome coronavirus 2 Severe acute respiratory syndrome coronavirus 2 D614 Severe acute respiratory syndrome coronavirus 2 G614 upper respiratory tract virus cell interaction virus load virus mutation virus neutralization virus pathogenesis virus recombinant virus replication virus strain virus transmission virus virulence mutation virus genome COVID-19 Genome, Viral Humans SARS-CoV-2 LA - English M3 - Article N1 - Cited By :15 Export Date: 4 May 2021 CODEN: NEJMA Correspondence Address: Baric, R.S.; Department of Epidemiology, United States References: Lam, T.T.-Y., Zhu, H., Guan, Y., Holmes, E.C., Genomic analysis of the emergence, evolution, and spread of human respiratory RNA viruses (2016) Annu Rev Genomics Hum Genet, 17, pp. 193-218; Shang, J., Ye, G., Shi, K., Structural basis of receptor recognition by SARS-CoV-2 (2020) Nature, 581, pp. 221-224; Molecular evolution of the SARS coronavirus during the course of the SARS epidemic in China (2004) Science, 303, pp. 1666-1669; Korber, B., Fischer, W.M., Gnanakaran, S., Tracking changes in SARS-CoV-2 spike: Evidence that D614G increases infectivity of the COVID-19 Virus (2020) Cell, 182 (4), pp. 812e19-827e19; Plante, J.A., Liu, Y., Liu, J., Spike mutation D614G alters SARS-CoV-2 fitness (2020) Nature, , October 26 (Epub ahead of print) PY - 2020 SN - 00284793 (ISSN) SP - 2684-2686 ST - Emergence of a highly fit SARS-CoV-2 variant T2 - New England Journal of Medicine TI - Emergence of a highly fit SARS-CoV-2 variant UR - https://www.scopus.com/inward/record.uri?eid=2-s2.0-85098662432&doi=10.1056%2fNEJMcibr2032888&partnerID=40&md5=f3decd6ca734ec6f4ac2548417f2bc74 VL - 383 ID - 234 ER - TY - JOUR AB - Characterizing the asymptomatic spread of SARS-CoV-2 is important for understanding the COVID-19 pandemic. This study was aimed at determining asymptomatic spread of SARS-CoV-2 in a suburban, Southern U.S. population during a period of state restrictions and physical distancing mandates. This is one of the first published seroprevalence studies from North Carolina and included multicenter, primary care, and emergency care facilities serving a low-density, suburban and rural population since description of the North Carolina state index case introducing the SARS-CoV-2 respiratory pathogen to this population. To estimate point seroprevalence of SARS-CoV-2 among asymptomatic individuals over time, two cohort studies were examined. The first cohort study, named ScreenNC, was comprised of outpatient clinics, and the second cohort study, named ScreenNC2, was comprised of inpatients unrelated to COVID-19. Asymptomatic infection by SARS-CoV-2 (with no clinical symptoms) was examined using an Emergency Use Authorization (EUA)-approved antibody test (Abbott) for the presence of SARS-CoV-2 IgG. This assay as performed under CLIA had a reported specificity/sensitivity of 100%/99.6%. ScreenNC identified 24 out of 2,973 (0.8%) positive individuals among asymptomatic participants accessing health care during 28 April to 19 June 2020, which was increasing over time. A separate cohort, ScreenNC2, sampled from 3 March to 4 June 2020, identified 10 out of 1,449 (0.7%) positive participants. IMPORTANCE This study suggests limited but accelerating asymptomatic spread of SARS-CoV-2. Asymptomatic infections, like symptomatic infections, disproportionately affected vulnerable communities in this population, and seroprevalence was higher in African American participants than in White participants. The low, overall prevalence may reflect the success of shelter-in-place mandates at the time this study was performed and of maintaining effective physical distancing practices among suburban populations. Under these public health measures and aggressive case finding, outbreak clusters did not spread into the general population. © 2020 Barzin et al. AD - The University of North Carolina at Chapel Hill School of Medicine, Department of Family Medicine, Chapel Hill, NC, United States The University of North Carolina at Chapel Hill School of Medicine, Department of Pathology and Laboratory Medicine and UNC Hospitals McLendon Clinical Laboratories, Chapel Hill, NC, United States The University of North Carolina at Chapel Hill Gillings School of Global Public Health, Department of Biostatistics, Chapel Hill, NC, United States UNC Physicians Network, Chapel Hill, NC, United States The University of North Carolina at Chapel Hill School of Medicine, Center for Environmental Medicine, Asthma and Lung Biology, Chapel Hill, NC, United States The University of North Carolina at Chapel Hill Gillings School of Global Public Health, Department of Epidemiology, Chapel Hill, NC, United States UNC Health Information Services Division, Chapel Hill, NC, United States The University of North Carolina at Chapel Hill School of Medicine, Department of Emergency Medicine, Chapel Hill, NC, United States The University of North Carolina at Chapel Hill, North Carolina Translational and Clinical Sciences Institute, Chapel Hill, NC, United States UNC REX Healthcare, Raleigh, NC, United States UNC Health Nash General Hospital, Rocky Mount, NC, United States The University of North Carolina at Chapel Hill School of Medicine, Department of Microbiology and Immunology, Chapel Hill, NC, United States The University of North Carolina at Chapel Hill School of Medicine, Lineberger Comprehensive Cancer Center, Chapel Hill, NC, United States The University of North Carolina at Chapel Hill School of Medicine, Department of Pediatrics, Chapel Hill, NC, United States AU - Barzin, A. AU - Schmitz, J. L. AU - Rosin, S. AU - Sirpal, R. AU - Almond, M. AU - Robinette, C. AU - Wells, S. AU - Hudgens, M. AU - Olshan, A. AU - Deen, S. AU - Krejci, P. AU - Quackenbush, E. AU - Chronowski, K. AU - Cornaby, C. AU - Goins, J. AU - Butler, L. AU - Aucoin, J. AU - Boyer, K. AU - Faulk, J. AU - Alston-Johnson, D. AU - Page, C. AU - Zhou, Y. AU - Fiscus, L. AU - Damania, B. AU - Dittmer, D. P. AU - Peden, D. B. C2 - 32994333 C7 - e02426-20 DB - Scopus DO - 10.1128/mBio.02426-20 IS - 5 J2 - mBio KW - Antibody Coronavirus COVID-19 SARS-CoV-2 Seroprevalence immunoglobulin G virus antibody adult African American aged antibody detection Article asymptomatic disease Caucasian chemiluminescence immunoassay cohort analysis controlled study coronavirus disease 2019 emergency care epidemic female health care access health care facility human immunoassay major clinical study male middle aged nonhuman outpatient patient participation population research primary medical care priority journal rural population sensitivity and specificity Severe acute respiratory syndrome coronavirus 2 social distancing suburban area United States very elderly virus transmission Betacoronavirus blood clinical trial Coronavirus infection immunology isolation and purification mandatory program multicenter study North Carolina pandemic seroepidemiology virus pneumonia Antibodies, Viral Asymptomatic Diseases Cohort Studies Coronavirus Infections Humans Mandatory Programs Pandemics Pneumonia, Viral Seroepidemiologic Studies LA - English M3 - Article N1 - Export Date: 4 May 2021 Correspondence Address: Damania, B.; The University of North Carolina at Chapel Hill School of Medicine, United States; email: damania@med.unc.edu Correspondence Address: Dittmer, D.P.; The University of North Carolina at Chapel Hill School of Medicine, United States; email: ddittmer@med.unc.edu Correspondence Address: Peden, D.B.; The University of North Carolina at Chapel Hill School of Medicine, United States; email: david_peden@med.unc.edu Correspondence Address: Peden, D.B.; The University of North Carolina at Chapel Hill, United States; email: david_peden@med.unc.edu Chemicals/CAS: immunoglobulin G, 97794-27-9; Antibodies, Viral Funding details: National Science Foundation, NSF, GRFP DGE-1650116 Funding details: National Institutes of Health, NIH Funding details: U.S. Environmental Protection Agency, EPA, CR 83578501, UL1TR002489 Funding details: National Center for Advancing Translational Sciences, NCATS Funding details: University of North Carolina, UNC, P30 CA016086 Funding details: U.S. Public Health Service, USPHS, CA016086, CA239583, DE02821, ES025124 Funding details: Center for AIDS Research, University of North Carolina at Chapel Hill, UNC CFAR, P30 AI050410 Funding details: School of Medicine, University of North Carolina at Chapel Hill Funding text 1: This project was funded by the UNC School of Medicine, UNC Health, and the University Cancer Research Fund (UCRF). This work was also supported by Public Health Service grants CA239583, CA016086, DE02821, and ES025124; the UNC Center for AIDS Research (P30 AI050410); the UNC Lineberger Cancer Center (P30 CA016086); US EPA (CR 83578501); and UL1TR002489 from the National Center for Advancing Translational Sciences (NCATS) and from the National Science Foundation (GRFP DGE-1650116). Funding text 2: We thank all the team members for their efforts and the participants of this study for their willingness to participate. We also thank the nurses and physicians who helped study enrollment. This project was funded by the UNC School of Medicine, UNC Health, and the University Cancer Research Fund (UCRF). This work was also supported by Public Health Service grants CA239583, CA016086, DE02821, and ES025124; the UNC Center for AIDS Research (P30 AI050410); the UNC Lineberger Cancer Center (P30 CA016086); US EPA (CR 83578501); and UL1TR002489 from the National Center for Advancing Translational Sciences (NCATS) and from the National Science Foundation (GRFP DGE-1650116). The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. UNC Health data and further analysis were provided by Marshall Clark, James Champion, Kellie Walters, and Anna Jojic at the North Carolina Translational and Clinical Sciences Institute. 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AU - Wohl, D. A. AU - Daaleman, T. P. C2 - 32928767 DB - Scopus DO - 10.1370/afm.2558 IS - 5 J2 - Ann Fam Med KW - COVID-19 rapid testing respiratory diagnostic center Betacoronavirus Coronavirus infection environmental planning health care delivery human laboratory technique mass screening North Carolina organization and management pandemic pathophysiology patient care procedures protective equipment university hospital virus pneumonia Academic Medical Centers Clinical Laboratory Techniques Coronavirus Infections Delivery of Health Care Environment Design Humans Pandemics Patient-Centered Care Personal Protective Equipment Pneumonia, Viral LA - English M3 - Article N1 - Export Date: 4 May 2021 PY - 2020 SN - 15441717 (ISSN) SP - 464 ST - Development and Implementation of a COVID-19 Respiratory Diagnostic Center T2 - Annals of family medicine TI - Development and Implementation of a COVID-19 Respiratory Diagnostic Center UR - https://www.scopus.com/inward/record.uri?eid=2-s2.0-85091052135&doi=10.1370%2fafm.2558&partnerID=40&md5=b546993bf8bba56072b42c4bdc6fda6b VL - 18 ID - 373 ER - TY - JOUR AB - Topical intra-nasal sprays are amongst the most commonly prescribed therapeutic options for sinonasal diseases in humans. However, inconsistency and ambiguity in instructions show a lack of definitive knowledge on best spray use techniques. In this study, we have identified a new usage strategy for nasal sprays available over-the-counter, that registers an average 8-fold improvement in topical delivery of drugs at diseased sites, when compared to prevalent spray techniques. The protocol involves re-orienting the spray axis to harness inertial motion of particulates and has been developed using computational fluid dynamics simulations of respiratory airflow and droplet transport in medical imaging-based digital models. Simulated dose in representative models is validated through in vitro spray measurements in 3D-printed anatomic replicas using the gamma scintigraphy technique. This work breaks new ground in proposing an alternative user-friendly strategy that can significantly enhance topical delivery inside human nose. While these findings can eventually translate into personalized spray usage instructions and hence merit a change in nasal standard-of-care, this study also demonstrates how relatively simple engineering analysis tools can revolutionize everyday healthcare. Finally, with respiratory mucosa as the initial coronavirus infection site, our findings are relevant to intra-nasal vaccines that are in-development, to mitigate the COVID-19 pandemic. © 2020, The Author(s). AD - Department of Mechanical Engineering, South Dakota State University, Brookings, SD 57007, United States Center for Environmental Medicine, Asthma and Lung Biology, University of North Carolina, Chapel Hill, NC 27599, United States Department of Otolaryngology/Head and Neck Surgery, School of Medicine – University of North Carolina, Chapel Hill, NC 27599, United States Department of Biostatistics, University of North Carolina, Chapel Hill, NC 27599, United States Department of Head and Neck Surgery & Communication Sciences, Duke University Medical Center, Durham, NC 27708, United States Joint Department of Biomedical Engineering, Medical College of Wisconsin and Marquette University, Milwaukee, WI 53226, United States AU - Basu, S. AU - Holbrook, L. T. AU - Kudlaty, K. AU - Fasanmade, O. AU - Wu, J. AU - Burke, A. AU - Langworthy, B. W. AU - Farzal, Z. AU - Mamdani, M. AU - Bennett, W. D. AU - Fine, J. P. AU - Senior, B. A. AU - Zanation, A. M. AU - Ebert, C. S., Jr. AU - Kimple, A. J. AU - Thorp, B. D. AU - Frank-Ito, D. O. AU - Garcia, G. J. M. AU - Kimbell, J. S. C2 - 32601278 C7 - 10568 DB - Scopus DO - 10.1038/s41598-020-66716-0 IS - 1 J2 - Sci. Rep. KW - nose spray virus vaccine anatomy and histology Betacoronavirus computer simulation Coronavirus infection drug delivery system drug effect human hydrodynamics inhalational drug administration intranasal drug administration nebulizer nose cavity nose mucosa pandemic paranasal sinus procedures virology virus pneumonia Administration, Inhalation Administration, Intranasal Coronavirus Infections Drug Delivery Systems Humans Nasal Cavity Nasal Mucosa Nasal Sprays Nebulizers and Vaporizers Pandemics Paranasal Sinuses Pneumonia, Viral Viral Vaccines LA - English M3 - Article N1 - Cited By :2 Export Date: 4 May 2021 Correspondence Address: Basu, S.; Department of Mechanical Engineering, United States; email: Saikat.Basu@sdstate.edu Chemicals/CAS: Nasal Sprays; Viral Vaccines Funding details: National Institutes of Health, NIH, R01HL122154 Funding details: National Heart, Lung, and Blood Institute, NHLBI Funding details: National Institute on Deafness and Other Communication Disorders, NIDCD, T32DC005360 Funding details: National Center for Advancing Translational Sciences, NCATS, KL2TR002490 Funding details: South Dakota State University, SDSU Funding text 1: The authors sincerely thank Dr. John S Rhee, MD, MPH (at the Department of Otolaryngology, Medical College of Wisconsin) for numerous fruitful discussions. Thanks are also due to Dr. Julie Suman (Next Breath, LLC) for the experimental measurement of nasal spray parameters. The authors additionally acknowledge: (a) Christopher Jadelis (at UNC Chapel Hill) for his assistance on the experimental setup; (b) several past/present UNC rhinology residents and fellows (Drs. Andrew Coniglio, Satyan Sreenath, Kibwei McKinney, Gita Madan, Parth Shah, and Stan McClurg) for their inputs; and (c) Dr. Ola Harrysson’s group at NC State University (at the Edward P Fitts Department of Industrial and Systems Engineering), Matthew White (at NCSU), and Dr. Tim Horn (Director of Research, Center for Additive Manufacturing and Logistics at NCSU) for help on 3D printing. Finally, thanks are also due to Alison Turner and Carolyn Hamby (both at UNC School of Medicine) for their assistance in patient recruitment scheduling. The project was supported by: (a) the National Heart, Lung, and Blood Institute (NHLBI) of the National Institutes of Health (NIH), under award number R01HL122154 (PI: JSK); (b) the National Center for Advancing Translational Sciences (NCATS) at NIH, through award number KL2TR002490 (PI: AJK); (c) the National Institute on Deafness and Other Communication Disorders (NIDCD) at NIH, under award number T32DC005360 (ZF); and (d) SB’s faculty start-up funds at the Department of Mechanical Engineering at South Dakota State University. Content of this study is solely the responsibility of the authors and does not necessarily represent the official views of the NIH. References: Doorly, D.J., Taylor, D.J., Gambaruto, A.M., Schroter, R.C., Tolley, N., Nasal architecture: form and flow. 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Air Pollution: Respiratory and Novel Health Effects, pp. A1742-A1742. , American Thoracic Society PY - 2020 SN - 20452322 (ISSN) ST - Numerical evaluation of spray position for improved nasal drug delivery T2 - Scientific Reports TI - Numerical evaluation of spray position for improved nasal drug delivery UR - https://www.scopus.com/inward/record.uri?eid=2-s2.0-85087009445&doi=10.1038%2fs41598-020-66716-0&partnerID=40&md5=995630e418b1ecee5d39482208341f62 VL - 10 ID - 281 ER - TY - JOUR AD - Department of Pediatrics, The Ohio State University College of Medicine, Columbus, OH, United States Department of Pediatrics, University of Washington School of Medicine, Seattle, Wash, United States Department of Pediatrics, Baylor College of Medicine, Houston, Tex, United States Department of Pediatrics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pa, United States Department of Pediatrics, University of Texas Health Science Center at San Antonio, San Antonio, Tex, United States Department of Pediatrics, University of North Carolina School of Medicine, Chapel Hill, NC, United States AU - Beer, L. AU - Gray, M. AU - Carbajal, M. M. AU - French, H. AU - Vasquez, M. AU - Bauserman, M. AU - Bonachea, E. M. C2 - 32502533 DB - Scopus DO - 10.1016/j.acap.2020.05.027 IS - 6 J2 - Acad. Pediatr. KW - coronavirus disease 2019 e-learning education program human medical education Note pandemic professional knowledge resident LA - English M3 - Note N1 - Cited By :3 Export Date: 4 May 2021 Correspondence Address: Beer, L.; Department of Pediatrics, 700 Children's Dr, United States; email: Lindsey.Beer@nationwidechildrens.org References: (2020), https://acgme.org/COVID-19/Stage-2-Increased-Clinical-Demands-Guidance, Accreditation Council for Graduate Medical Education. Stage 2: increased clinical demands guidance. ACGME main page. Available at: Accessed April 14; French, H., Gray, M., Gillam-Krakauer, M., Flipping the classroom: a national pilot curriculum for physiology in neonatal–perinatal medicine (2018) J Perinatol, 38, pp. 1420-1427 PY - 2020 SN - 18762859 (ISSN) SP - 758-759 ST - “Megaflip,” a Novel Approach to National Collaboration for Flipped Classroom Education T2 - Academic Pediatrics TI - “Megaflip,” a Novel Approach to National Collaboration for Flipped Classroom Education UR - https://www.scopus.com/inward/record.uri?eid=2-s2.0-85087204605&doi=10.1016%2fj.acap.2020.05.027&partnerID=40&md5=fe95fb419b1422dbdf4ef1fd54a6a6fd VL - 20 ID - 429 ER - TY - JOUR AB - Background: The SARS-CoV-2 pandemic has led to drastic changes in how psychiatric consultation-liaison (C-L) services conduct business and required rapid transition to telepsychiatry. We describe the practice changes implemented to rapid transition to virtual care in a large, academic psychiatry C-L service in response to the pandemic. Objective: To describe clinical service structural changes, timelines and impacts on consultation volume as well as present quantitative and qualitative data regarding the experience of this transition from the standpoints of both psychiatric trainees and attending physicians. Methods: We present the narrative descriptions of transition details based on focused interviews with inpatient C-L leadership. Inpatient consult volume and charge data were gathered using analysis of health system data. Attending and trainee experience of the transition to virtual care were assessed using anonymous, online surveys. Results: During the pandemic, the average weekly consultation volume and average weekly charges were significantly lower compared with prepandemic. Both volume and charges were affected by addition of video consultation capability. Both attendings and trainees had moderate or high comfort and moderate satisfaction with telephone and video consultations. Overall, the trainee satisfaction with supervision, learning, and their consult psychiatry experience did not seem to be affected by the pandemic. Conclusions: Our results support the feasibility of the rapid implementation of virtual care in a psychiatric academic C-L service without negatively impacting the learner's consult psychiatry experience. This should provide comfort to academic C-L services that required rapid implementation of virtual care. © 2020 Academy of Consultation-Liaison Psychiatry AD - Department of Psychiatry, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC, United States AU - Beran, C. AU - Sowa, N. A. DB - Scopus DO - 10.1016/j.psym.2020.11.002 J2 - Psychosomatics KW - academic consultation-liaison COVID-19 implementation SARS-CoV-2 telepsychiatry LA - English M3 - Article N1 - Export Date: 4 May 2021 CODEN: PSYCB Correspondence Address: Sowa, N.A.; Department of Psychiatry, 101 Manning Drive, CB 7160, United States; email: nate_sowa@med.unc.edu References: Bojdani, E., Rajagopalan, A., Chen, A., COVID-19 pandemic: impact on psychiatric care in the United States (2020) Psychiatry Res, 289, p. 113069; Funk, M.C., Beach, S.R., Shah, S.B., Boland, R., Consultation-liaison psychiatry in the age of COVID-19: reaffirming ourselves and our worth (2020) Psychosomatics, 61, pp. 571-572; Shah, S.B., Report from Brigham and Women's Hospital consultation-liaison service [internet] (2020), p. 2. , https://www.clpsychiatry.org/wp-content/uploads/Submission-Report-from-Brigham-and-Women-Hospital-032420.pdf, Brigham and Women's Hospital and Harvard Medical School Boston, MA Available from:; Desan, P., Report from Yale New Haven Hospital [internet] (2020), p. 2. , https://www.clpsychiatry.org/wp-content/uploads/Submission-Report-from-Yale-New-Haven-Hospital-032420.pdf, Yale School of Medicine New Haven, CT Available from:; Soeprono, T., Dubovsky, A., COVID-19 inpatient CL workforce preservation plan [internet] (2020), p. 4. , https://www.clpsychiatry.org/wp-content/uploads/U-of-W-COVID-CL-preservation-plan-032920.pdf, University of Washington Seattle, WA Available from:; Kimmel, R.J., Toor, R., Telepsychiatry by a public, academic medical center for inpatient consults at an unaffiliated, community hospital (2019) Psychosomatics, 60, pp. 468-473; DeVido, J., Glezer, A., Branagan, L., Lau, A., Bourgeois, J.A., Telepsychiatry for inpatient consultations at a separate campus of an academic medical center (2016) Telemed J E Health, 22, pp. 572-576; Graziane, J.A., Gopalan, P., Cahalane, J., Telepsychiatry consultation for medical and surgical inpatient units (2018) Psychosomatics, 59, pp. 62-66; Cabrera, M.A., Karamsetty, L., Simpson, S.A., Coronavirus and its implications for psychiatry: a rapid review of the early literature (2020) Psychosomatics, 61, pp. 607-615 PY - 2020 SN - 00333182 (ISSN) ST - Adaptation of an Academic Inpatient Consultation-Liaison Psychiatry Service During the SARS-CoV-2 Pandemic: Effects on Clinical Practice and Trainee Supervision T2 - Psychosomatics TI - Adaptation of an Academic Inpatient Consultation-Liaison Psychiatry Service During the SARS-CoV-2 Pandemic: Effects on Clinical Practice and Trainee Supervision UR - https://www.scopus.com/inward/record.uri?eid=2-s2.0-85097235202&doi=10.1016%2fj.psym.2020.11.002&partnerID=40&md5=279d441e9caeae3584e07eb39aa21c19 ID - 537 ER - TY - JOUR AD - Division of General Medicine and Clinical Epidemiology, Department of Medicine, Cecil G. Sheps Center for Health Services Research, University of North Carolina at Chapel Hill School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, United States Division of General Internal Medicine, Boston Health Care for Homeless Program, Department of Medicine, Boston University School of Medicine and Boston Medical Center, Boston, United States AU - Berkowitz, S. A. AU - Cenã, C. W. AU - Chatterjee, A. C2 - 32706955 C7 - e76 DB - Scopus DO - 10.1056/NEJMp2021209 IS - 12 J2 - New Engl. J. Med. KW - Black person Caucasian clinical practice community care coronavirus disease 2019 financial management food insecurity health care delivery health care policy health care system health disparity health equity health program Hispanic human indigenous people investment mortality nutritional support pandemic priority journal public health service racism Short Survey social determinants of health social distancing social status unemployment unemployment insurance United States Betacoronavirus catering service Coronavirus infection economics insurance legislation and jurisprudence virus pneumonia Coronavirus Infections Food Supply Health Policy Humans Pandemics Pneumonia, Viral LA - English M3 - Short Survey N1 - Cited By :10 Export Date: 4 May 2021 CODEN: NEJMA References: Price-Haywood, E.G., Burton, J., Fort, D., Seoane, L., Hospitalization and mortality among black patients and white patients with Covid-19 (2020) N Engl J Med, 382, pp. 2534-2543; Hooper, M.W., Nápoles, A.M., Pérez-Stable, E.J., COVID-19 and racial/ethnic disparities (2020) Jama Network, , https://jamanetwork.com/journals/jama/fullarticle/2766098, May 11; Bibbins-Domingo, K., This time must be different: Disparities during the COVID-19 pandemic (2020) Annals of Internal Medicine, , https://www.acpjournals.org/doi/10.7326/M20-2247, April 28; Fitzpatrick, K.M., Harris, C., Drawve, G., (2020) Assessing U.S. Food Insecurity in the United States during COVID-19 Pandemic, , https://fulbright.uark.edu/departments/sociology/research-centers/community-family-institute/_resources/community-and-family-institute/revised-assessing-food-insecurity-brief.pdf, Fayetteville: University of Arkansas; Konczal, M., Unemployment insurance is a vital part of economic freedom (2020) The Nation, , https://www.thenation.com/article/economy/cares-act-unemployment/, May 29 PY - 2020 SN - 00284793 (ISSN) ST - Covid-19 and Health Equity-Time to Think Big T2 - New England Journal of Medicine TI - Covid-19 and Health Equity-Time to Think Big UR - https://www.scopus.com/inward/record.uri?eid=2-s2.0-85091191549&doi=10.1056%2fNEJMp2021209&partnerID=40&md5=391b3f5e74671ae9cec82cd95b033aa0 VL - 383 ID - 363 ER - TY - JOUR AB - Background Although chloroquine, hydroxychloroquine, and quinine are used for a range of medical conditions, recent research suggested a potential role in treating COVID-19. The resultant increase in prescribing was accompanied by an increase in adverse events, including severe toxicity and death. The Extracorporeal Treatments in Poisoning (EXTRIP) workgroup sought to determine the effect of and indications for extracorporeal treatments in cases of poisoning with these drugs. Methods We conducted systematic reviews of the literature, screened studies, extracted data, and summarized findings following published EXTRIP methods. Results A total of 44 studies (three in vitro studies, two animal studies, 28 patient reports or patient series, and 11 pharmacokinetic studies) met inclusion criteria regarding the effect of extracorporeal treatments. Toxicokinetic or pharmacokinetic analysis was available for 61 patients (13 chloroquine, three hydroxychloroquine, and 45 quinine). Clinical data were available for analysis from 38 patients, including 12 with chloroquine toxicity, one with hydroxychloroquine toxicity, and 25 with quinine toxicity. All three drugs were classified as non-dialyzable (not amenable to clinically significant removal by extracorporeal treatments). The available data do not support using extracorporeal treatments in addition to standard care for patients severely poisoned with either chloroquine or quinine (strong recommendation, very low quality of evidence). Although hydroxychloroquine was assessed as being non-dialyzable, the clinical evidence was not sufficient to support a formal recommendation regarding the use of extracorporeal treatments for this drug. Conclusions On the basis of our systematic review and analysis, the EXTRIP workgroup recommends against using extracorporeal methods to enhance elimination of these drugs in patients with severe chloroquine or quinine poisoning. Copyright © 2020 by the American Society of Nephrology AD - Department of Emergency Medicine, Calvary Mater Newcastle, Waratah, NSW, Australia Department of Clinical Toxicology and Pharmacology, Calvary Mater Newcastle, Waratah, NSW, Australia School of Medicine and Public Health, University of Newcastle, Newcastle, NSW, Australia Department of Medicine, School of Medicine, School of Pharmacy, University of Maryland, Baltimore, MD, United States Maryland Poison Center, Baltimore, MD, United States Division of Practice Advancement and Clinical Education, University of North Carolina, Eshelman School of Pharmacy, Chapel Hill, NC, United States Division of Medical Toxicology, Ronald O. Perelman Department of Emergency Medicine, New York University, Grossman School of Medicine, New York City, NY, United States Poison Control Section, Department of Environmental and Occupational Health, Ministry of Health, Muscat, Oman Research Center, Centre Intégré Universitaire de Santé et de Services Sociaux du Nord-de-l'île-de-Montréal, Hôpital du Sacré-Coeur de Montréal, Montreal, QC, Canada Department of Renal Medicine and Transplantation, St. Vincent's Hospital, Sydney, NSW, Australia Department of Clinical Pharmacology and Toxicology, St. Vincent's Hospital, Sydney, NSW, Australia St. Vincent's Clinical School, University of New South Wales, Sydney, NSW, Australia Centre Intégré de Santé, Services Sociaux Montérégie-Centre Emergency Department, Hôpital Charles-Lemoyne, Greenfield Park, QC, Canada Department of Emergency Medicine, McGill University, Montreal, QC, Canada Centre Antipoison du Québec, Quebec City, QC, Canada Research Center, Centre Intégré Universitaire de Santé et de Services Sociaux du Nord-de-l'île-de-Montréal, Hôpital du Sacré-Coeur de Montréal, University of Montreal, Montreal, QC, Canada Department of Pharmacy and Therapeutics, University of Pittsburgh, School of Pharmacy, Pittsburgh, PA, United States Department of Medicine, Renal-Electrolyte Division, University of Pittsburgh, School of Medicine, Pittsburgh, PA, United States AU - Berling, I. AU - King, J. D. AU - Shepherd, G. AU - Hoffman, R. S. AU - Alhatali, B. AU - Lavergne, V. AU - Roberts, D. M. AU - Gosselin, S. AU - Wilson, G. AU - Nolin, T. D. AU - Ghannoum, M. AU - Anseeuw, K. AU - Bird, S. AU - Bunchman, T. AU - Bouchard, J. AU - Calello, D. AU - Chin, P. AU - Doi, K. AU - Galvao, T. AU - Goldfarb, D. AU - Hassanian, H. AU - Hoegberg, L. AU - Kallab, S. AU - Kebede, S. AU - Kielstein, J. AU - Lewington, A. AU - Li, Y. AU - Macedo, E. AU - MacLaren, R. AU - Megarbane, B. AU - Mowry, J. AU - Osterman, M. AU - Peng, A. AU - Roy, J. P. AU - Vijayan, A. AU - Walsh, S. AU - Wong, A. AU - Wood, D. AU - Yates, C. AU - workgroup, Extrip C2 - 32963091 DB - Scopus DO - 10.1681/ASN.2020050564 IS - 10 J2 - J. Am. Soc. Nephrol. KW - chloroquine hydroxychloroquine quinine Article drug blood level drug intoxication exchange blood transfusion extracorporeal therapy hemodialysis human nonhuman peritoneal dialysis priority journal systematic review toxicokinetics complication Coronavirus infection female male pandemic practice guideline procedures risk assessment therapy United States virus pneumonia Coronavirus Infections Humans Outcome Assessment, Health Care Pandemics Pneumonia, Viral Poisoning Practice Guidelines as Topic Renal Dialysis LA - English M3 - Article N1 - Cited By :2 Export Date: 4 May 2021 CODEN: JASNE Correspondence Address: Ghannoum, M.; Verdun Hospital, 4000 Lasalle Boulevard, Canada; email: marcghannoum@gmail.com Chemicals/CAS: chloroquine, 132-73-0, 3545-67-3, 50-63-5, 54-05-7; hydroxychloroquine, 118-42-3, 525-31-5; quinine, 130-89-2, 130-95-0, 14358-44-2, 549-48-4, 549-49-5, 60-93-5, 7549-43-1; Chloroquine; Hydroxychloroquine; Quinine Funding text 1: Thomas D. Nolin reports personal fees from MediBeacon, personal fees from CytoSorbents, and other from McGraw-Hill Education outside the submitted work. Marc Ghannoum is a scholar of the Fonds de Recherche du Québec - Santé. Darren Roberts acknowledges support of St. Vincent’s Centre for Applied Medical Research Clinician “Buy-Out” Program. All remaining authors have nothing to disclose. 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AU - Fabbri, C. AU - Cerna-Turoff, I. AU - Tanton, C. AU - Knight, L. AU - Turner, E. AU - Lokot, M. AU - Lees, S. AU - Cislaghi, B. AU - Peterman, A. AU - Guedes, A. AU - Devries, K. C2 - 33012855 DB - Scopus DO - 10.2471/BLT.20.263467 IS - 9 J2 - Bull. WHO KW - caregiver child child abuse child care child nutrition child protection cholera coronavirus disease 2019 Ebola hemorrhagic fever Editorial emotional abuse gender based violence harassment health care access human interview parental stress physical violence prevalence quarantine refugee sexual exploitation sexual violence social distance tension violence vulnerable population adolescent Betacoronavirus Coronavirus infection female infant male pandemic preschool child prevention and control virus pneumonia Child, Preschool Coronavirus Infections Humans Pandemics Pneumonia, Viral LA - English M3 - Editorial N1 - Cited By :2 Export Date: 4 May 2021 CODEN: BWHOA Correspondence Address: Bhatia, A.; Department of Global Health and Development, 15-17 Tavistock Place, Saint Pancras, United Kingdom; email: amiya.bhatia@​lshtm​.ac​.uk References: Hillis, S, Mercy, J, Amobi, A, Kress, H., Global prevalence of past-year violence against children: a systematic review and minimum estimates (2016) Pediatrics, 137 (3), p. e20154079. , http://​dx​.doi​.org/​10​.1542/​peds​.2015​-4079, Mar; PMID: 26810785; Peterman, A, O’Donnell, M, Palermo, T., (2020) COVID-19 and violence against women and children. what have we learned so far?, , https://​www​.cgdev​.org/​sites/​default/​files/​covid​-and​-violence​-against​-women​-and​-children​-what​-we​-have​-learned​.pdf, Washington (DC): Center for Global Development; [cited 2020 Jul 24]; https://​www​.savethechildren​.net/​news/​spike​-violence​-against​-venezuelan​-children​-covid​-19​-deepens​-crisis, Spike in violence against Venezuelan children as COVID-19 deepens crisis. 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[cited 2020 Jul 23] PY - 2020 SN - 00429686 (ISSN) SP - 583-583A ST - COVID-19 response measures and violence against children T2 - Bulletin of the World Health Organization TI - COVID-19 response measures and violence against children UR - https://www.scopus.com/inward/record.uri?eid=2-s2.0-85090520017&doi=10.2471%2fBLT.20.263467&partnerID=40&md5=b3f68dbc61348730c5c8d2c116e4665c VL - 98 ID - 374 ER - TY - JOUR AB - The reaction of the scientific community to COVID-19 is the most rapid outbreak response in recent history. Developing treatments for COVID-19 and preparing for future epidemics requires long-term investment in antiviral research. © 2020 Elsevier Ltd Here, we explore the dynamics of the response of the scientific community to several epidemics, including Coronavirus Disease 2019 (COVID-19), as assessed by the numbers of clinical trials, publications, and level of research funding over time. All six prior epidemics studied [bird flu, severe acute respiratory syndrome (SARS), swine flu, Middle East Respiratory Syndrome (MERS), Ebola, and Zika] were characterized by an initial spike of research response that flattened shortly thereafter. Unfortunately, no antiviral medications have been discovered to date as treatments for any of these diseases. By contrast, the HIV/AIDS pandemic has garnered consistent research investment since it began and resulted in drugs being developed within 7 years of its start date, with many more to follow. We argue that, to develop effective treatments for COVID-19 and be prepared for future epidemics, long-term, consistent investment in antiviral research is needed. © 2020 Elsevier Ltd AD - Laboratory for Molecular Modeling, Division of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC 27599, United States Department of Computer Science, University of North Carolina, Chapel Hill, NC 27599, United States Office of Data Science, National Toxicology Program, NIEHS, Morrisville, NC 27560, United States Department of Biochemistry and Biophysics, University of North Carolina, Chapel Hill, NC 27599, United States Toxicoinformatics Group, National Toxicology Program, NIEHS, Morrisville, NC 27560, United States Department of Microbiology and Immunology, University of North Carolina, Chapel Hill, NC 27599, United States Department of Pharmaceutical Sciences, Federal University of Paraiba, Joao Pessoa, PB, Brazil AU - Bobrowski, T. AU - Melo-Filho, C. C. AU - Korn, D. AU - Alves, V. M. AU - Popov, K. I. AU - Auerbach, S. AU - Schmitt, C. AU - Moorman, N. J. AU - Muratov, E. N. AU - Tropsha, A. C2 - 32679173 DB - Scopus DO - 10.1016/j.drudis.2020.07.008 IS - 9 J2 - Drug Discov. Today KW - antivirus agent antiretroviral therapy avian influenza comparative study coronavirus disease 2019 drug research Ebola hemorrhagic fever high throughput screening human Human immunodeficiency virus learning curve long term care prevention and control quantitative structure activity relation Review social distancing swine influenza Zika fever Betacoronavirus Coronavirus infection drug development epidemic history organization and management pandemic procedures research virus pneumonia Antiviral Agents Coronavirus Infections Epidemics History, 20th Century History, 21st Century Humans Pandemics Pneumonia, Viral LA - English M3 - Review N1 - Cited By :6 Export Date: 4 May 2021 CODEN: DDTOF Correspondence Address: Muratov, E.N.; Laboratory for Molecular Modeling, United States; email: murik@email.unc.edu Chemicals/CAS: Antiviral Agents Funding details: National Science Foundation, NSF Funding details: National Institutes of Health, NIH, 1U01CA207160 Funding details: U.S. Department of Defense, DOD Funding details: U.S. Environmental Protection Agency, EPA Funding details: National Center for Advancing Translational Sciences, NCATS, OT2R002514, OT3TR002020 Funding text 1: Alexander Tropsha is a K.H. Lee distinguished professor and associate dean for data science at the UNC Eshelman School of Pharmacy, UNC-Chapel Hill. Professor Tropsha was awarded a PhD in chemical enzymology in 1986 from Moscow State University. His research interests are in the areas of computer-assisted drug design, computational toxicology, cheminformatics, (nano)materials informatics, and structural bioinformatics. His has authored ∼250 peer-reviewed scientific papers, book chapters, and co-edited two monographs. His research has been supported by multiple grants from the NIH, NSF, EPA, DOD, foundations, and private companies. Funding text 2: The authors wish to thank D. Adalsteinsson and P. Schultz for multiple discussions of the capabilities of DataGraph software used to create the figures, and Kennie Merz for the suggestion to add the analysis of the HIV/AIDS pandemic. 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(2020) N. Engl. J. Med., 382, pp. 1677-1679; Thanh, L.T., The COVID-19 vaccine development landscape (2020) Nat. Rev. Drug Discov., 19, pp. 305-306 PY - 2020 SN - 13596446 (ISSN) SP - 1604-1613 ST - Learning from history: do not flatten the curve of antiviral research! T2 - Drug Discovery Today TI - Learning from history: do not flatten the curve of antiviral research! UR - https://www.scopus.com/inward/record.uri?eid=2-s2.0-85088397961&doi=10.1016%2fj.drudis.2020.07.008&partnerID=40&md5=e846c1ad9444f5f272f4cafc1e0efb00 VL - 25 ID - 395 ER - TY - JOUR AB - This document addresses the current coronavirus disease 2019 (COVID-19) pandemic for providers and patients in labor and delivery (L&D). The goals are to provide guidance regarding methods to appropriately screen and test pregnant patients for COVID-19 prior to, and at admission to L&D reduce risk of maternal and neonatal COVID-19 disease through minimizing hospital contact and appropriate isolation; and provide specific guidance for management of L&D of the COVID-19-positive woman, as well as the critically ill COVID-19-positive woman. The first 5 sections deal with L&D issues in general, for all women, during the COVID-19 pandemic. These include Section 1: Appropriate screening, testing, and preparation of pregnant women for COVID-19 before visit and/or admission to L&D Section 2: Screening of patients coming to L&D triage; Section 3: General changes to routine L&D work flow; Section 4: Intrapartum care; Section 5: Postpartum care; Section 6 deals with special care for the COVID-19-positive or suspected pregnant woman in L&D and Section 7 deals with the COVID-19-positive/suspected woman who is critically ill. These are suggestions, which can be adapted to local needs and capabilities. © 2020 Elsevier Inc. All rights reserved. AD - Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Thomas Jefferson University, Philadelphia, United States Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, University of North Carolina-Chapel Hill and UNC Health ,Chapel Hill Department of Maternal and Child Health and Urological Sciences, Sapienza University of Rome, Rome, Italy Department of Neuroscience, Reproductive Sciences and Dentistry, School of Medicine, University of Naples Federico II, Naples, Italy AU - Boelig, R. C. AU - Manuck, T. AU - Oliver, E. A. AU - Di Mascio, D. AU - Saccone, G. AU - Bellussi, F. AU - Berghella, V. C2 - 32518901 DB - Scopus DO - 10.1016/j.ajogmf.2020.100110 IS - 2 J2 - Am J Obstet Gynecol MFM KW - coronavirus COVID-19 obstetric protocol pandemic critical illness emergency health service epidural anesthesia female hospital discharge human labor labor induction length of stay mass screening obstetric anesthesia obstetric delivery patient isolation postnatal care practice guideline pregnancy pregnancy complication prevention and control procedures protective equipment workflow Anesthesia, Epidural Anesthesia, Obstetrical Delivery, Obstetric Humans Labor, Induced Labor, Obstetric Patient Discharge Personal Protective Equipment Practice Guidelines as Topic Pregnancy Complications, Infectious SARS-CoV-2 Triage LA - English M3 - Review N1 - Cited By :45 Export Date: 4 May 2021 PY - 2020 SN - 25899333 (ISSN) SP - 100110 ST - Labor and delivery guidance for COVID-19 T2 - American journal of obstetrics & gynecology MFM TI - Labor and delivery guidance for COVID-19 UR - https://www.scopus.com/inward/record.uri?eid=2-s2.0-85099998624&doi=10.1016%2fj.ajogmf.2020.100110&partnerID=40&md5=cdce7b1277b32092402d3336696fe0c0 VL - 2 ID - 504 ER - TY - JOUR AB - Objective: Coronavirus disease 2019 (COVID-19) is associated with derangement in biomarkers of coagulation and endothelial function and has been likened to the coagulopathy of sepsis. However clinical laboratory metrics suggest key differences in these pathologies. We sought to determine whether plasma coagulation and fibrinolytic potential in patients with COVID-19 differ compared with healthy donors and critically ill patients with sepsis. Approach and Results: We performed comparative studies on plasmas from a single-center, cross-sectional observational study of 99 hospitalized patients (46 with COVID-19 and 53 with sepsis) and 18 healthy donors. We measured biomarkers of endogenous coagulation and fibrinolytic activity by immunoassays, thrombin, and plasmin generation potential by fluorescence and fibrin formation and lysis by turbidity. Compared with healthy donors, patients with COVID-19 or sepsis both had elevated fibrinogen, d-dimer, soluble TM (thrombomodulin), and plasmin-antiplasmin complexes. Patients with COVID-19 had increased thrombin generation potential despite prophylactic anticoagulation, whereas patients with sepsis did not. Plasma from patients with COVID-19 also had increased endogenous plasmin potential, whereas patients with sepsis showed delayed plasmin generation. The collective perturbations in plasma thrombin and plasmin generation permitted enhanced fibrin formation in both COVID-19 and sepsis. Unexpectedly, the lag times to thrombin, plasmin, and fibrin formation were prolonged with increased disease severity in COVID-19, suggesting a loss of coagulation-initiating mechanisms accompanies severe COVID-19. Conclusions: Both COVID-19 and sepsis are associated with endogenous activation of coagulation and fibrinolysis, but these diseases differently impact plasma procoagulant and fibrinolytic potential. Dysregulation of procoagulant and fibrinolytic pathways may uniquely contribute to the pathophysiology of COVID-19 and sepsis. © 2020 Lippincott Williams and Wilkins. All rights reserved. AD - Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, 8018A Mary Ellen Jones Bldg, Chapel Hill, NC 27599, United States University of Utah Molecular Medicine Program, Salt Lake City, UT, United States Department of Internal Medicine, University of Utah, Salt Lake City, United States Department of Pediatrics, University of Utah, Salt Lake City, United States Synapse Research Institute, Maastricht, Netherlands PEEL Therapeutics, Inc, Salt Lake City, UT, United States George E. Wahlen VAMC Department of Internal Medicine and GRECC, Salt Lake City, UT, United States AU - Bouck, E. G. AU - Denorme, F. AU - Holle, L. A. AU - Middelton, E. A. AU - Blair, A. M. AU - De Laat, B. AU - Schiffman, J. D. AU - Yost, C. C. AU - Rondina, M. T. AU - Wolberg, A. S. AU - Campbell, R. A. C2 - 33196292 DB - Scopus DO - 10.1161/ATVBAHA.120.315338 J2 - Arterioscler. Thromb. Vasc. Biol. KW - fibrin fibrinogen fibrinolysis sepsis thrombin biological marker plasmin blood blood clotting blood clotting disorder complication cross-sectional study epidemiology female human male metabolism middle aged pandemic physiology Biomarkers Blood Coagulation Blood Coagulation Disorders COVID-19 Cross-Sectional Studies Fibrinolysin Humans Pandemics SARS-CoV-2 LA - English M3 - Article N1 - Cited By :4 Export Date: 4 May 2021 CODEN: ATVBF Correspondence Address: Wolberg, A.S.; Department of Pathology and Laboratory Medicine, 8018A Mary Ellen Jones Bldg, United States; email: alisa_wolberg@med.unc.edu Chemicals/CAS: plasmin, 9001-90-5, 9004-09-5; Biomarkers; Fibrinolysin References: Https://coronavirus.jhu.edu/ Johns Hopkins Coronavirus Resource Center; Bikdeli, B., Madhavan, M.V., Jimenez, D., Chuich, T., Dreyfus, I., Driggin, E., Nigoghossian, C., Guo, Y., COVID-19 and thrombotic or thromboembolic disease: Implications for prevention, antithrombotic therapy, and follow-up: JACC state-of-the-art review (2020) J Am Coll Cardiol., 75, pp. 2950-2973. , Global COVID-19 Thrombosis Collaborative Group, Endorsed by the ISTH, NATF, ESVM, and the IUA, Supported by the ESC Working Group on Pulmonary Circulation and Right Ventricular Function; 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To do this, we formed an international consortium (4CE) of 96 hospitals across five countries (www.covidclinical.net). Contributors utilized the Informatics for Integrating Biology and the Bedside (i2b2) or Observational Medical Outcomes Partnership (OMOP) platforms to map to a common data model. The group focused on temporal changes in key laboratory test values. Harmonized data were analyzed locally and converted to a shared aggregate form for rapid analysis and visualization of regional differences and global commonalities. Data covered 27,584 COVID-19 cases with 187,802 laboratory tests. Case counts and laboratory trajectories were concordant with existing literature. Laboratory tests at the time of diagnosis showed hospital-level differences equivalent to country-level variation across the consortium partners. Despite the limitations of decentralized data generation, we established a framework to capture the trajectory of COVID-19 disease in patients and their response to interventions. © 2020, The Author(s). AD - Department of Biomedical Informatics, Harvard Medical School, Boston, MA, United States IRCCS ICS Maugeri, Pavia, Italy Department of Internal Medicine and Medical Therapy, University of Pavia, Pavia, Italy UAB Informatics Institute, Birmingham, AL, United States Department of Internal Medicine, Division of Medical Informatics, University of Kansas Medical Center, Kansas City, KS, United States Department of Computational Medicine & Bioinformatics, University of Michigan, Ann Arbor, MI, United States Institute for Biomedical Informatics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, United States Department of Biostatistics, Epidemiology, and Informatics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, United States Department of Neurology, Massachusetts General Hospital, Boston, MA, United States Department of Electrical Computer and Biomedical Engineering, University of Pavia, Pavia, Italy Department of Pediatrics, University of Michigan Medical School, Ann Arbor, MI, United States Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA, United States Computational Health Informatics Program, Boston Children’s Hospital, Boston, MA, United States Department of Medicine, Massachusetts General Hospital, Boston, MA, United States Scientific Direction, IRCCS Ca’ Granda Ospedale Maggiore Policlinico di Milano, Milano, Italy BIOMERIS (BIOMedical Research Informatics Solutions), Pavia, Italy Biomedical Informatics Center, Medical University of South Carolina, Charleston, SC, United States Bordeaux University Hospital, Bordeaux, France UOC Ricerca, Innovazione e Brand Reputation, ASST Papa Giovanni XXIII, Bergamo, Italy Department of Medical Informatics, University of Erlangen-Nürnberg, Erlangen, Germany Center for Medical Information and Communication Technology, University Hospital Erlangen, Erlangen, Germany National University Health Systems, Singapore, Singapore Department of Oncology, ASST Papa Giovanni XXIII, Bergamo, Italy Penn Medicine, Data Analytics Center, Philadelphia, PA, United States Department of Biomedical and Health Informatics, Children’s Hospital of Philadelphia, Philadelphia, PA, United States North Carolina Translational and Clinical Sciences (NC TraCS) Institute, UNC Chapel Hill, Chapel Hill, NC, United States WIND Department APHP Greater Paris University Hospital, Paris, France Department of Biomedical Informatics, HEGP, APHP Greater Paris University Hospital, Paris, France Clinical Research Unit, Saint Antoine Hospital, APHP Greater Paris University Hospital, Paris, France Strategy and Transformation Department, APHP Greater Paris University Hospital, Paris, France Heinrich-Lanz-Center for Digital Health, University Medicine Mannheim, Heidelberg University, Mannheim, Germany INRIA Sophia-Antipolis—ZENITH Team, LIRMM, Montpellier, France Institute of Medical Biometry and Statistics, Medical Center, University of Freiburg, Freiburg im Breisgau, Germany Clinical Research Unit, Paris Saclay, APHP Greater Paris University Hospital, Paris, France SED/SIERRA, Inria Centre de Paris, Paris, France Université Paris-Saclay, Inria, CEA, Paris, France Clevy.io, Paris, France SequeL, Inria Lille, Paris, France ENS, PSL University, Paris, France Institute of Digitalization in Medicine, Faculty of Medicine and Medical Center, University of Freiburg, Freiburg im Breisgau, Germany IRCCS Ca’ Granda Ospedale Maggiore Policlinico di Milano, Milano, Italy Brenner Children’s Hospital, Wake Forest School of Medicine, Winston-Salem, NC, United States AU - Brat, G. 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Inform., 27, pp. 129-139; I2b2: Informatics for Integrating Biology & the Bedside, , https://www.i2b2.org/, orld Health Organization, 2020); Consortium, C.T.S.A.A.C.T., ; Bodenreider, O., The Unified Medical Language System (UMLS): integrating biomedical terminology (2004) Nucleic Acids Res., 32, pp. D267-D270. , COI: 1:CAS:528:DC%2BD3sXhtVSrurvM PY - 2020 SN - 23986352 (ISSN) ST - International electronic health record-derived COVID-19 clinical course profiles: the 4CE consortium T2 - npj Digital Medicine TI - International electronic health record-derived COVID-19 clinical course profiles: the 4CE consortium UR - https://www.scopus.com/inward/record.uri?eid=2-s2.0-85089557407&doi=10.1038%2fs41746-020-00308-0&partnerID=40&md5=cdf7c1a791e588caf4d267271077d407 VL - 3 ID - 277 ER - TY - JOUR AD - Department of Pediatric Gastroenterology, University of North Carolina Children's Hospital, Chapel Hill, NC 27514, United States The Henry D Janowitz Division of Gastroenterology, Icahn School of Medicine at Mount Sinai, New York, NY, United States AU - Brenner, E. J. AU - Ungaro, R. C. AU - Colombel, J. F. AU - Kappelman, M. D. C2 - 32941833 DB - Scopus DO - 10.1016/S2468-1253(20)30269-7 IS - 10 J2 - Lancet Gastroenterol. Hepatol. KW - biological product corticosteroid tumor necrosis factor inhibitor awareness clinical decision making clinical outcome clinician coronavirus disease 2019 data analysis electronic medical record gastroenterology human immunosuppressive treatment inflammatory bowel disease international cooperation intersectoral collaboration Letter pandemic priority journal register social media Betacoronavirus comorbidity Coronavirus infection disease management procedures virus pneumonia Coronavirus Infections Humans Immunosuppression Inflammatory Bowel Diseases Pandemics Pneumonia, Viral LA - English M3 - Letter N1 - Cited By :3 Export Date: 4 May 2021 Funding details: Leona M. and Harry B. Helmsley Charitable Trust Funding text 1: EJB and RCU contributed equally to this Correspondence. SECURE-IBD was funded by the Helmsley Charitable Trust (2003-04445), CTSA grant number UL1TR002489, T32DK007634 (EJB), and K23KD111995-01A1 (RCU). Additional funding was provided by Pfizer, Takeda, Janssen, AbbVie, Lilly, Genentech, Boehringer Ingelheim, Bristol Myers Squibb, Celltrion, and Arena Pharmaceuticals. RCU is supported by an NIH K23 Career Development Award (K23KD111995-01A1); has served as an advisory board member or consultant for Eli Lilly, Janssen, Pfizer, and Takeda; and has received research support from AbbVie, Boehringer Ingelheim, and Pfizer. J-FC reports receiving research grants from AbbVie, Janssen Pharmaceuticals, and Takeda; payment for lectures from AbbVie, Amgen, Allergan, Ferring Pharmaceuticals, Shire, and Takeda; consulting fees from AbbVie, Amgen, Arena Pharmaceuticals, Boehringer Ingelheim, Celgene Corporation, Celltrion, Eli Lilly, Enterome, Ferring Pharmaceuticals, Genentech, Janssen Pharmaceuticals, Landos, Ipsen, Medimmune, Merck, Novartis, Pfizer, Shire, Takeda, TiGenix, and Viela Bio; and holds stock options in Intestinal Biotech Development and Genfit. MDK has consulted for AbbVie, Janssen, and Takeda; is a shareholder in Johnson & Johnson; and has received research support from AbbVie and Janssen. EJB declares no competing interests. References: Our partners covidibd.org/our-partners, (Accessed 17 August 2020); SECURE-EoE/EGID registry (2020), https://eureos.online/newsreader-2102/secure-eoe-egid-registry.html, (Accessed 17 August 2020); Gianfrancesco, M., Hyrich, K.L., Al-Adely, S., Characteristics associated with hospitalisation for COVID-19 in people with rheumatic disease: data from the COVID-19 Global Rheumatology Alliance physician-reported registry (2020) Ann Rheum Dis, 79, p. 859; Brenner, E.J., Ungaro, R.C., Gearry, R.B., Corticosteroids, but not TNF antagonists, are associated with adverse COVID-19 outcomes in patients with inflammatory bowel diseases: results from an international registry (2020) Gastroenterology, 159, pp. 481-491 PY - 2020 SN - 24681253 (ISSN) SP - 887-888 ST - IBD in the COVID-19 era: the value of international collaboration T2 - The Lancet Gastroenterology and Hepatology TI - IBD in the COVID-19 era: the value of international collaboration UR - https://www.scopus.com/inward/record.uri?eid=2-s2.0-85090577846&doi=10.1016%2fS2468-1253%2820%2930269-7&partnerID=40&md5=32ef60be7d483af47455521c508d7c81 VL - 5 ID - 346 ER - TY - JOUR AB - Background and Aims: The impact of Coronavirus disease 2019 (COVID-19) on patients with inflammatory bowel disease (IBD) is unknown. We sought to characterize the clinical course of COVID-19 among patients with IBD and evaluate the association among demographics, clinical characteristics, and immunosuppressant treatments on COVID-19 outcomes. Methods: Surveillance Epidemiology of Coronavirus Under Research Exclusion for Inflammatory Bowel Disease (SECURE-IBD) is a large, international registry created to monitor outcomes of patients with IBD with confirmed COVID-19. We calculated age-standardized mortality ratios and used multivariable logistic regression to identify factors associated with severe COVID-19, defined as intensive care unit admission, ventilator use, and/or death. Results: 525 cases from 33 countries were reported (median age 43 years, 53% men). Thirty-seven patients (7%) had severe COVID-19, 161 (31%) were hospitalized, and 16 patients died (3% case fatality rate). Standardized mortality ratios for patients with IBD were 1.8 (95% confidence interval [CI], 0.9–2.6), 1.5 (95% CI, 0.7–2.2), and 1.7 (95% CI, 0.9–2.5) relative to data from China, Italy, and the United States, respectively. Risk factors for severe COVID-19 among patients with IBD included increasing age (adjusted odds ratio [aOR], 1.04; 95% CI, 1.01–1.02), ≥2 comorbidities (aOR, 2.9; 95% CI, 1.1–7.8), systemic corticosteroids (aOR, 6.9; 95% CI, 2.3–20.5), and sulfasalazine or 5-aminosalicylate use (aOR, 3.1; 95% CI, 1.3–7.7). Tumor necrosis factor antagonist treatment was not associated with severe COVID-19 (aOR, 0.9; 95% CI, 0.4–2.2). Conclusions: Increasing age, comorbidities, and corticosteroids are associated with severe COVID-19 among patients with IBD, although a causal relationship cannot be definitively established. Notably, tumor necrosis factor antagonists do not appear to be associated with severe COVID-19. © 2020 AGA Institute AD - University of North Carolina Department of Pediatric Gastroenterology, Children's Hospital, Chapel Hill, NC, United States The Henry D. Janowitz Division of Gastroenterology, Icahn School of Medicine at Mount Sinai, New York, NY, United States University of Otago Department of Medicine, Christchurch, New Zealand University of Calgary, Departments of Medicine and Community Health Sciences, Calgary, AB, Canada Mount Sinai Medical Center, New York, NY, United States The University of Pennsylvania, Philadelphia, PA, United States Department of Medicine and Therapeutics, Institute of Digestive Disease, State Key Laboratory of Digestive Disease, Li Ka Shing Institute of Health Science, The Chinese University of Hong Kong, Shatin, NT, Hong Kong SAR, China Department of Gastroenterology, Université catholique de Louvain, CHU UCL Namur 5530 Yvoir, Belgium Medical University of Vienna, Department Internal Medicine III, Division Gastroenterology & HepatologyVienna, Austria Université de Paris, France Assistance-Publique- Hôpitaux de Paris, Hôpital Necker Enfants Malades, Service de Gastroentérologie pédiatrique, Paris, France Hospital Israelita Albert Einstein, São Paulo, Brazil University of North Carolina, Department of Gastroenterology, Chapel Hill, NC, United States AU - Brenner, E. J. AU - Ungaro, R. C. AU - Gearry, R. B. AU - Kaplan, G. G. AU - Kissous-Hunt, M. AU - Lewis, J. D. AU - Ng, S. C. AU - Rahier, J. F. AU - Reinisch, W. AU - Ruemmele, F. M. AU - Steinwurz, F. AU - Underwood, F. E. AU - Zhang, X. AU - Colombel, J. F. AU - Kappelman, M. D. C2 - 32425234 DB - Scopus DO - 10.1053/j.gastro.2020.05.032 IS - 2 J2 - Gastroenterology KW - COVID-19 Crohn's Disease Inflammatory Bowel Disease Ulcerative Colitis azathioprine budesonide chloroquine corticosteroid hydroxychloroquine immunologic agent integrin inhibitor interleukin 12 inhibitor interleukin 23 inhibitor Janus kinase inhibitor lopinavir plus ritonavir mercaptopurine mesalazine methotrexate oseltamivir protein inhibitor remdesivir salazosulfapyridine steroid tocilizumab tumor necrosis factor inhibitor unclassified drug immunosuppressive agent adolescent adult adverse outcome age aged Article artificial ventilation child China cohort analysis combination drug therapy comorbidity coronavirus disease 2019 Crohn disease disease registry disease severity female fetus hospital admission human infant infection risk intensive care unit Italy major clinical study male monotherapy newborn priority journal standardized mortality ratio treatment outcome United States very elderly Betacoronavirus Coronavirus infection health survey hospitalization intensive care middle aged mortality odds ratio pandemic register risk factor virology virus pneumonia Adrenal Cortex Hormones Coronavirus Infections Critical Care Humans Immunosuppressive Agents Inflammatory Bowel Diseases Pandemics Pneumonia, Viral Population Surveillance Registries Respiration, Artificial Risk Factors Sulfasalazine Tumor Necrosis Factor Inhibitors LA - English M3 - Article N1 - Cited By :156 Export Date: 4 May 2021 CODEN: GASTA Correspondence Address: Brenner, E.J.; University of North Carolina Department of Pediatric Gastroenterology, 333 S. Columbia Street, 247 MacNider Hall, CB# 7229, United States; email: Erica.Brenner@unchealth.unc.edu Correspondence Address: Ungaro, R.C.; The Henry D. Janowitz Division of Gastroenterology, 17 E 102nd St 5th Floor, United States; email: Ryan.ungaro@mssm.edu Chemicals/CAS: azathioprine, 446-86-6; budesonide, 51333-22-3, 51372-29-3; chloroquine, 132-73-0, 3545-67-3, 50-63-5, 54-05-7; hydroxychloroquine, 118-42-3, 525-31-5; mercaptopurine, 31441-78-8, 50-44-2, 6112-76-1; mesalazine, 89-57-6; methotrexate, 15475-56-6, 59-05-2, 7413-34-5; oseltamivir, 196618-13-0, 204255-09-4, 204255-11-8; remdesivir, 1809249-37-3; salazosulfapyridine, 599-79-1; tocilizumab, 375823-41-9; Adrenal Cortex Hormones; Immunosuppressive Agents; Sulfasalazine; Tumor Necrosis Factor Inhibitors Funding details: National Institutes of Health, NIH, K23KD111995–01A1 Funding details: Boehringer Ingelheim, BI Funding details: Amgen Funding details: Pfizer Funding details: Gilead Sciences Funding details: Celgene Funding details: AbbVie Funding details: Meso Scale Diagnostics, MSD Funding details: Takeda Pharmaceuticals U.S.A., TPUSA Funding details: Janssen Pharmaceuticals Funding details: Nestlé Health Science Funding details: Nestlé Nutrition Institute, NNI Funding text 1: Conflict of Interest These authors disclose the following: Ryan C. Ungaro: Supported by an NIH K23 Career Development Award (K23KD111995–01A1); has served as an advisory board member or consultant for Eli Lilly, Janssen, Pfizer, and Takeda; research support from AbbVie, Boehringer-Ingelheim, and Pfizer. Richard B. Gearry: Speaker fees and Scientific Advisory Boards for AbbVie and Janssen. Gilaad G. Kaplan: Received honoraria for speaking or consultancy from AbbVie, Janssen, Pfizer, and Takeda. He has received research support from Ferring, Janssen, Abbvie, GlaxoSmith Kline, Merck, and Shire. He shares ownership of a patent: TREATMENT OF INFLAMMATORY DISORDERS, AUTOIMMUNE DISEASE, AND PBC. UTI Limited Partnership, assignee. Patent WO2019046959A1. PCT/CA2018/051098. 7 Sept. 2018. Michele Kissous-Hunt: Speaker/consultant for AbbVie, Janssesn, Takeda. James Lewis: Personal fees from Johnson & Johnson Consumer Inc, grants, personal fees and other from Takeda Pharmaceuticals, personal fees and nonfinancial support from AbbVie, grants and personal fees from Janssen Pharmaceuticals, personal fees from Eli Lilly and Company, personal fees from Samsung Bioepis, personal fees from UCB, personal fees from Bristol-Myers Squibb, grants and personal fees from Nestle Health Science, personal fees from Bridge Biotherapeutics, personal fees from Celgene, personal fees from Merck, personal fees and other from Pfizer, personal fees from Gilead, personal fees from Arena Parmaceuticals, personal fees from Protagonist Therapeutics, outside the submitted work. Siew C. Ng: Received honoraria for speaking or consultancy from AbbVie, Janssen, Ferring, Tillotts and Takeda. She has received research support from Ferring and AbbVie. Jean-Francois Rahier: Received lecture fees from AbbVie, MSD, Takeda, Pfizer, Ferring, and Falk, consulting fees from AbbVie, Takeda, Hospira, Mundipharma, MSD, Pfizer, GlaxoSK, and Amgen, and research support from Takeda and AbbVie. Walter Reinisch: Served as a speaker for Abbott Laboratories, AbbVie, Aesca, Aptalis, Astellas, Centocor, Celltrion, Danone Austria, Elan, Falk Pharma GmbH, Ferring, Immundiagnostik, Mitsubishi Tanabe Pharma Corporation, MSD, Otsuka, PDL, Pharmacosmos, PLS Education, Schering-Plough, Shire, Takeda, Therakos, Vifor, Yakult. He has been a consultant for Abbott Laboratories, Abbvie, Aesca, Algernon, Amgen, AM Pharma, AMT, AOP Orphan, Arena Pharmaceuticals, Astellas, Astra Zeneca, Avaxia, Roland Berger GmbH, Bioclinica, Biogen IDEC, Boehringer-Ingelheim, Bristol-Myers Squibb, Cellerix, Chemocentryx, Celgene, Centocor, Celltrion, Covance, Danone Austria, DSM, Elan, Eli Lilly, Ernest & Young, Falk Pharma GmbH, Ferring, Galapagos, Genentech, Gilead, Grünenthal, ICON, Index Pharma, Inova, Intrinsic Imaging, Janssen, Johnson & Johnson, Kyowa Hakko Kirin Pharma, Lipid Therapeutics, LivaNova, Mallinckrodt, Medahead, MedImmune, Millenium, Mitsubishi Tanabe Pharma Corporation, MSD, Nash Pharmaceuticals, Nestle, Nippon Kayaku, Novartis, Ocera, OMass, Otsuka, Parexel, PDL, Periconsulting, Pharmacosmos, Philip Morris Institute, Pfizer, Procter & Gamble, Prometheus, Protagonist, Provention, Robarts Clinical Trial, Sandoz, Schering-Plough, Second Genome, Seres Therapeutics, Setpointmedical, Sigmoid, Sublimity, Takeda, Therakos, Theravance, Tigenix, UCB, Vifor, Zealand, Zyngenia, and 4SC. He has been an advisory board member for Abbott Laboratories, AbbVie, Aesca, Amgen, AM Pharma, Astellas, Astra Zeneca, Avaxia, Biogen IDEC, Boehringer-Ingelheim, Bristol-Myers Squibb, Cellerix, Chemocentryx, Celgene, Centocor, Celltrion, Danone Austria, DSM, Elan, Ferring, Galapagos, Genentech, Grünenthal, Inova, Janssen, Johnson & Johnson, Kyowa Hakko Kirin Pharma, Lipid Therapeutics, MedImmune, Millenium, Mitsubishi Tanabe Pharma Corporation, MSD, Nestle, Novartis, Ocera, Otsuka, PDL, Pharmacosmos, Pfizer, Procter & Gamble, Prometheus, Sandoz, Schering-Plough, Second Genome, Setpointmedical, Takeda, Therakos, Tigenix, UCB, Zealand, Zyngenia, and 4SC. He has received research funding from Abbott La oratories, Abbvie, Aesca, Centocor, Falk Pharma GmbH, Immundiagnsotik, and MSD. Frank Ruemmele: Received consultation fee, research grant, or honorarium from Janssen, Pfizer, AbbVie, Takeda, Celgene, Nestlé Health Science, Nestlé Nutrition Institute. Flavio Steinwurz: Speaker and consultant for AbbVie, Eurofarma, Ferring, Janssen, Pfizer, Sanofi, Takeda, and UCB. Jean-Frederic Colombel: Research grants from AbbVie, Janssen Pharmaceuticals and Takeda; receiving payment for lectures from AbbVie, Amgen, Allergan, Inc. Ferring Pharmaceuticals, Shire, and Takeda; receiving consulting fees from AbbVie, Amgen, Arena Pharmaceuticals, Boehringer-Ingelheim, Celgene Corporation, Celltrion, Eli Lilly, Enterome, Ferring Pharmaceuticals, Genentech, Janssen Pharmaceuticals, Landos, Ipsen, Medimmune, Merck, Novartis, Pfizer, Shire, Takeda, Tigenix, Viela bio; and hold stock options in Intestinal Biotech Development, and Genfit. Michael D. Kappelman: Consulted for AbbVie, Janssen, and Takeda, is a shareholder in Johnson & Johnson, and has received research support from AbbVie and Janssen. The remaining authors disclose no conflicts. Funding text 2: Funding This work was funded by CTSA grant number UL1TR002489 and K23KD111995–01A1 (to Ryan C. Ungaro). The study sponsor ( National Institutes of Health ) had no role in the collection, analysis, and interpretation of data. References: Morens, D.M., Daszak, P., Taubenberger, J.K., Escaping Pandora's box - another novel coronavirus (2020) N Engl J Med, 382, pp. 1293-1295; Onder, G., Rezza, G., Brusaferro, S., Case-fatality rate and characteristics of patients dying in relation to COVID-19 in Italy [published online ahead of print March 23, 2020]. JAMA ; Wu, Z., McGoogan, J.M., Characteristics of and important lessons from the Coronavirus Disease 2019 (COVID-19) outbreak in China: summary of a report of 72314 cases from the Chinese Center for Disease Control and Prevention [published online ahead of print February 24, 2020]. JAMA ; Preliminary estimates of the prevalence of selected underlying health conditions among patients with Coronavirus Disease 2019 - United States, February 12-March 28, 2020 (2020) MMWR Morb Mortal Wkly Rep, 69, pp. 382-386; Ng, S.C., Shi, H.Y., Hamidi, N., Worldwide incidence and prevalence of inflammatory bowel disease in the 21st century: a systematic review of population-based studies (2018) Lancet, 390, pp. 2769-2778; Torres, J., Mehandru, S., Colombel, J.F., Crohn's disease (2017) Lancet, 389, pp. 1741-1755; Ungaro, R., Mehandru, S., Allen, P.B., Ulcerative colitis (2017) Lancet, 389, pp. 1756-1770; Lichtenstein, G.R., Loftus, E.V., Isaacs, K.L., ACG clinical guideline: management of Crohn's disease in adults (2018) Am J Gastroenterol, 113, pp. 481-517; Matsuoka, K., Kobayashi, T., Ueno, F., Evidence-based clinical practice guidelines for inflammatory bowel disease (2018) J Gastroenterol, 53, pp. 305-353; Rahier, J.F., Magro, F., Abreu, C., Second European evidence-based consensus on the prevention, diagnosis and management of opportunistic infections in inflammatory bowel disease (2014) J Crohns Colitis, 8, pp. 443-468; Ananthakrishnan, A.N., McGinley, E.L., Infection-related hospitalizations are associated with increased mortality in patients with inflammatory bowel diseases (2013) J Crohns Colitis, 7, pp. 107-112; Kirchgesner, J., Lemaitre, M., Carrat, F., Risk of serious and opportunistic infections associated with treatment of inflammatory bowel diseases (2018) Gastroenterology, 155, pp. 337-346.e10; Long, M.D., Martin, C., Sandler, R.S., Increased risk of pneumonia among patients with inflammatory bowel disease (2013) Am J Gastroenterol, 108, pp. 240-248; Ma, C., Lee, J.K., Mitra, A.R., Systematic review with meta-analysis: efficacy and safety of oral Janus kinase inhibitors for inflammatory bowel disease (2019) Aliment Pharmacol Ther, 50, pp. 5-23; Tinsley, A., Williams, E., Liu, G., The incidence of influenza and influenza-related complications in inflammatory bowel disease patients across the United States: 1833 (2013) Am J Gastroenterol, p. 108; Michot, J.M., Albies, L., Chaput, N., Tocilizumab, an anti-IL6 receptor antibody, to treat Covid-19-related respiratory failure: a case report (2020) Ann Oncol, 31, pp. 961-964; Zhang, X., Song, K., Tong, F., First case of COVID-19 in a patient with multiple myeloma successfully treated with tocilizumab (2020) Blood Advances, 4, pp. 1307-1310; Guan, W.J., Ni, Z.Y., Hu, Y., Clinical characteristics of Coronavirus disease 2019 in China (2020) N Engl J Med, 382, pp. 1708-1720; Liang, W., Guan, W., Chen, R., Wang, W., Cancer patients in SARS-CoV-2 infection: a nationwide analysis in China (2020) Lancet Oncol, 21, pp. 335-337; Mazza, S., Sorce, A., Peyvandi, F., A fatal case of COVID-19 pneumonia occurring in a patient with severe acute ulcerative colitis (2020) Gut, 69, pp. 1148-1149; Jenks, G., The data model concept in statistical mapping (1967) Int Yearb Carto, 7, pp. 186-190; Turner, D., Huang, Y., Martín-de-Carpi, J., COVID-19 and paediatric inflammatory bowel diseases: global experience and provisional guidance (March 2020) from the Paediatric IBD Porto group of ESPGHAN (2020) J Pediatr Gastroenterol Nutr, 70, pp. 727-733; [The epidemiological characteristics of an outbreak of 2019 novel coronavirus diseases (COVID-19) in China] (2020) Zhonghua Liu Xing Bing Xue Za Zhi, 41, pp. 145-151; Coronavirus Disease 2019 Cases in U.S https://www.cdc.gov/coronavirus/2019-ncov/cases-updates/cases-in-us.html, Available at: Published April 16, 2020. Accessed April 17, 2020; Provisional Death Counts for Coronavirus Disease (COVID-19) https://www.cdc.gov/nchs/nvss/vsrr/COVID19/, Available at: Published April 17, 2020. Accessed April 17, 2020; Russell, C.D., Millar, J.E., Baillie, J.K., Clinical evidence does not support corticosteroid treatment for 2019-nCoV lung injury (2020) Lancet, 395, pp. 473-475; Feldmann, M., Maini, R.N., Woody, J.N., Trials of anti-tumour necrosis factor therapy for COVID-19 are urgently needed (2020) Lancet, 395, pp. 1407-1409 PY - 2020 SN - 00165085 (ISSN) SP - 481-491.e3 ST - Corticosteroids, But Not TNF Antagonists, Are Associated With Adverse COVID-19 Outcomes in Patients With Inflammatory Bowel Diseases: Results From an International Registry T2 - Gastroenterology TI - Corticosteroids, But Not TNF Antagonists, Are Associated With Adverse COVID-19 Outcomes in Patients With Inflammatory Bowel Diseases: Results From an International Registry UR - https://www.scopus.com/inward/record.uri?eid=2-s2.0-85086564179&doi=10.1053%2fj.gastro.2020.05.032&partnerID=40&md5=8d5101272903bc64c8dc1fe51f757e18 VL - 159 ID - 431 ER - TY - JOUR AB - Populations disproportionately affected by coronavirus disease 2019 (COVID-19) are also at higher risk for oral diseases and experience oral health and oral health care disparities at higher rates. COVID-19 has led to closure and reduced hours of dental practices except for emergency and urgent services, limiting routine care and prevention. Dental care includes aerosol-generating procedures that can increase viral transmission. The pandemic offers an opportunity for the dental profession to shift more toward nonaerosolizing, prevention-centric approaches to care and away from surgical interventions. Regulatory barrier changes to oral health care access during the pandemic could have a favorable impact if sustained into the future. © Centers for Disease Control and Prevention (CDC). AD - North Carolina Oral Health Collaborative, Foundation for Health Leadership and Innovation, Cary, NC, United States University of North Carolina at Chapel Hill Adams School of Dentistry and Gillings School of Global Public Health, Chapel Hill, NC, United States AU - Brian, Z. AU - Weintraub, J. A. C2 - 32790606 C7 - 266 DB - Scopus DO - 10.5888/PCD17.200266 J2 - Prev. Chronic Dis. KW - Betacoronavirus Coronavirus infection global health health human hygiene pandemic virus pneumonia Coronavirus Infections Humans Oral Health Pandemics Pneumonia, Viral LA - English M3 - Article N1 - Cited By :5 Export Date: 4 May 2021 Correspondence Address: Brian, Z.; North Carolina Oral Health Collaborative, 2401 Weston Parkway, Suite 203, United States; email: zachary.brian@foundationhli.org Funding details: Centers for Disease Control and Prevention, CDC Funding text 1: The authors received no financial support for this work. The findings and conclusions in this report are those of the authors and do not necessarily represent the official position of the Centers for Disease Control and Prevention. No borrowed material, copyrighted surveys, instruments, or tools were used for this article. 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Accessed July 16, 2020 PY - 2020 SN - 15451151 (ISSN) ST - Oral Health and COVID-19: Increasing the need for prevention and access T2 - Preventing Chronic Disease TI - Oral Health and COVID-19: Increasing the need for prevention and access UR - https://www.scopus.com/inward/record.uri?eid=2-s2.0-85089508395&doi=10.5888%2fPCD17.200266&partnerID=40&md5=a26c261ee1ec43c87024e3a8d76d1e36 VL - 17 ID - 423 ER - TY - JOUR AB - We propose a generative model and an inference scheme for epidemic processes on dynamic, adaptive contact networks. Network evolution is formulated as a link-Markovian process, which is then coupled to an individual-level stochastic susceptible-infectious-recovered model, to describe the interplay between the dynamics of the disease spread and the contact network underlying the epidemic. A Markov chain Monte Carlo framework is developed for likelihood-based inference from partial epidemic observations, with a novel data augmentation algorithm specifically designed to deal with missing individual recovery times under the dynamic network setting. Through a series of simulation experiments, we demonstrate the validity and flexibility of the model as well as the efficacy and efficiency of the data augmentation inference scheme. The model is also applied to a recent real-world dataset on influenza-like-illness transmission with high-resolution social contact tracking records. Supplementary materials for this article are available online. © 2020 American Statistical Association. AD - Department of Statistical Science, Duke University, Durham, NC, United States Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States AU - Bu, F. AU - Aiello, A. E. AU - Xu, J. AU - Volfovsky, A. DB - Scopus DO - 10.1080/01621459.2020.1790376 J2 - J. Am. Stat. Assoc. KW - Bayesian data augmentation Conditional simulation Contact networks Continuous-time Markov chains Mobile healthcare Stochastic susceptible-infectious-removed model LA - English M3 - Article N1 - Export Date: 4 May 2021 Correspondence Address: Xu, J.; Department of Statistical Science, United States; email: jason.q.xu@duke.edu Funding details: 2030355, DMS 1606177, U01 CK000185, W911NF1810233 Funding details: National Institutes of Health, NIH, R01 EB025021 Funding text 1: This work was partially supported by NIH funding: R01 EB025021, NSF DMS 2030355 and DMS 1606177, and W911NF1810233. The eX-FLU data were supported by U01 CK000185. 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Co, (,), p; Yang, C.H., Jung, H., “Topological Dynamics of the 2015 South Korea MERS-CoV Spread-on-Contact Networks (2020) Scientific Reports, 10, p. 4327 PY - 2020 SN - 01621459 (ISSN) ST - Likelihood-Based Inference for Partially Observed Epidemics on Dynamic Networks T2 - Journal of the American Statistical Association TI - Likelihood-Based Inference for Partially Observed Epidemics on Dynamic Networks UR - https://www.scopus.com/inward/record.uri?eid=2-s2.0-85089582187&doi=10.1080%2f01621459.2020.1790376&partnerID=40&md5=21f6d8db608dd27c30251a2b91bd7e84 ID - 560 ER - TY - JOUR AB - Background: Adults with chronic conditions are disproportionately burdened by COVID-19 morbidity and mortality. Although COVID-19 mobile health (mHealth) apps have emerged, research on attitudes toward using COVID-19 mHealth tools among those with chronic conditions is scarce. Objective: This study aimed to examine attitudes toward COVID-19, identify determinants of COVID-19 mHealth tool use across demographic and health-related characteristics, and evaluate associations between chronic health conditions and attitudes toward using COVID-19 mHealth tools (eg, mHealth or web-based methods for tracking COVID-19 exposures, symptoms, and recommendations). Methods: We used nationally representative data from the COVID-19 Impact Survey collected from April to June 2020 (n=10,760). Primary exposure was a history of chronic conditions, which were defined as self-reported diagnoses of cardiometabolic, respiratory, immune-related, and mental health conditions and overweight/obesity. Primary outcomes were attitudes toward COVID-19 mHealth tools, including the likelihood of using (1) a mobile phone app to track COVID-19 symptoms and receive recommendations; (2) a website to track COVID-19 symptoms, track location, and receive recommendations; and (3) an app using location data to track potential COVID-19 exposure. Outcome response options for COVID-19 mHealth tool use were extremely/very likely, moderately likely, or not too likely/not likely at all. Multinomial logistic regression was used to compare the likelihood of COVID-19 mHealth tool use between people with different chronic health conditions, with not too likely/not likely at all responses used as the reference category for each outcome. We evaluated the determinants of each COVID-19 mHealth intervention using Poisson regression. Results: Of the 10,760 respondents, 21.8% of respondents were extremely/very likely to use a mobile phone app or a website to track their COVID-19 symptoms and receive recommendations. Additionally, 24.1% of respondents were extremely/very likely to use a mobile phone app to track their location and receive push notifications about whether they have been exposed to COVID-19. After adjusting for age, race/ethnicity, sex, socioeconomic status, and residence, adults with mental health conditions were the most likely to report being extremely/very or moderately likely to use each mHealth intervention compared to those without such conditions. Adults with respiratory-related chronic diseases were extremely/very (conditional odds ratio 1.16, 95% CI 1.00-1.35) and moderately likely (conditional odds ratio 1.23, 95% CI 1.04-1.45) to use a mobile phone app to track their location and receive push notifications about whether they have been exposed to COVID-19. Conclusions: Our study demonstrates that attitudes toward using COVID-19 mHealth tools vary widely across modalities (eg, web-based method vs app) and chronic health conditions. These findings may inform the adoption of long-term engagement with COVID-19 apps, which is crucial for determining their potential in reducing disparities in COVID-19 morbidity and mortality among individuals with chronic health conditions. © 2020 Marlene Camacho-Rivera, Jessica Yasmine Islam, Argelis Rivera, Denise Christina Vidot. AD - Department of Community Health Sciences, State University of New York Downstate Health Sciences University, Brooklyn, NY, United States University of North Carolina, Lineberger Comprehensive Cancer Center, Chapel Hill, NC, United States Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, United States University of Miami School of Nursing and Health Studies, Coral Gables, FL, United States AU - Camacho-Rivera, M. AU - Islam, J. Y. AU - Rivera, A. AU - Vidot, D. C. C2 - 33301415 C7 - e24693 DB - Scopus DO - 10.2196/24693 IS - 12 J2 - JMIR mHealth uHealth KW - Attitude Chronic disease Chronic health conditions Contact tracing COVID-19 Data analysis Disparity Health disparities MHealth Mobile app Perception Smartphone adolescent adult attitude to health female health care survey human male middle aged mobile application prevention and control procedures psychology telemedicine young adult Health Care Surveys Health Knowledge, Attitudes, Practice Humans Mobile Applications LA - English M3 - Article N1 - Export Date: 4 May 2021 Correspondence Address: Camacho-Rivera, M.; Department of Community Health Sciences, 450 Clarkson Avenue, MSC 43, United States; email: marlene.camacho-rivera@downstate.edu Funding details: 5S21MD012474-02 Funding details: 2T32CA116339-11 Funding text 1: MCR is supported by the Association of American Medical Colleges Herbert W. Nickens Faculty Fellowship and Translational Program of Health Disparities Research Training (5S21MD012474-02). JYI is supported by the University of North Carolina's Cancer Care Quality Training Program (2T32CA116339-11). Funding text 2: MCR is supported by the Association of American Medical Colleges Herbert W. Nickens Faculty Fellowship and Translational Program of Health Disparities Research Training (5S21MD012474-02). JYI is supported by the University of North Carolina’s Cancer Care Quality Training Program (2T32CA116339-11). References: Centers for Disease Control and Prevention, , https://www.cdc.gov/coronavirus/2019-ncov/cases-updates/cases-in-us.html, CDC COVID Data Tracker. [accessed 2020-12-09]; Centers for Disease Control and Prevention, , https://www.cdc.gov/coronavirus/2019-ncov/prevent-getting-sick/prevention.html, How to Protect Yourself & Others. 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While COVID-19 related disparities among those with chronic conditions have been observed, research regarding the uptake of COVID-related preventive behaviors is scarce. Methods: We utilized data from a sample of 2190 U.S. adults from the COVID-19 Impact Survey to examine associations between the presence of underlying chronic health conditions and COVID-19-related preventive behaviors (e.g., use of face masks, hand washing, social distancing, etc.). We used multivariable logistic regression models to model associations between COVID-19 preventive behaviors across demographic and health characteristics. Results: Adults with cardiometabolic disease were more likely to report staying home because they felt unwell, compared with individuals without cardiometabolic disease. Individuals with underlying respiratory conditions were more likely to work from home, compared with individuals without a respiratory condition. Adults with immune conditions were twice more likely to report wearing a face mask when compared with individuals without immune conditions. Conclusion: This study provides U.S. national prevalence estimates and differences in adherence to COVID-19 preventive behaviors among those with and without the presence of underlying chronic health conditions. The prevalence of key preventive measures was high in the overall sample. Yet, engagement in COVID-19-related preventive behaviors varied significantly across chronic disease conditions. Messages around continued maintenance of the behaviors should be reinforced. Study implications suggest a need for more targeted messaging and resources available for individuals with certain underlying chronic conditions. © Marlene Camacho-Rivera et al., 2020; Published by Mary Ann Liebert, Inc. 2020. AD - Department of Community Health Sciences, School of Public Health, SUNY Downstate Health Sciences University, Brooklyn, NY, United States University of North Carolina Lineberger Cancer Center, Chapel Hill, NC, United States University of Miami School of Nursing and Health Studies, Coral Gables, FL, United States AU - Camacho-Rivera, M. AU - Islam, J. Y. AU - Vidot, D. C. DB - Scopus DO - 10.1089/heq.2020.0031 IS - 1 J2 - Health Equity KW - chronic disease COVID-19 health disparities LA - English M3 - Article N1 - Cited By :5 Export Date: 4 May 2021 Correspondence Address: Camacho-Rivera, M.; Department of Community Health Sciences, 450 Clarkson Avenue, MSC 43, United States; email: marlene.camacho-rivera@downstate.edu Funding details: 2T32CA116339-11 Funding details: FP7 Transport, 5S21MD012474-02 Funding text 1: Dr. Camacho-Rivera is supported by TRANSPORT— The Translational Program of Health Disparities Research Training (5S21MD012474-02). Dr. Islam is supported by UNCs Cancer Care Quality Training 2T32CA116339-11. References: (2020) Coronavirus (COVID-19) Events As They Happen, , https://www.who.int/emergencies/diseases/novel-coronavirus-2019/events-asthey-happen, Accessed May 8, 2020; (2020) Cases in the U. S. J CDC, , https://www.cdc.gov/coronavirus/2019-ncov/cases-updates/cases-in-us.html, Accessed June 12, 2020; (2020) Advice for Public, , https://www.who.int/emergencies/diseases/novel-coronavirus-2019/advice-for-public, Accessed May 8, 2020; (2020) How to Protect Yourself & Others J CDC, , https://www.cdc.gov/coronavirus/2019-ncov/prevent-getting-sick/prevention.html, Accessed May 8, 2020; Rosenfeld, D.L., Rothgerber, H., Wilson, T., Politicizing the COVID-19 pandemic: Ideological differences in adherence to social distancing (2020) PysArXiv, , 22 Apr 2020 web. 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It's not that simple (2016) Ann Thorac Surg., 101, pp. 1644-1645; (2020) No Adjustments Are Needed for Multiple Comparisons: Epidemiology, , https://journals.lww.com/epidem/Abstract/1990/01000/No_Adjustments_Are_Needed_for_Multiple_Comparisons.10.aspx, Accessed May 14, 2020; COVID-19: Underlying metabolic health in the spotlight (2020) Lancet Diabetes Endocrinol., 8, p. 457. , The Lancet Diabetes & Endocrinology; Grasselli, G., Zangrillo, A., Zanella, A., Baseline characteristics and outcomes of 1591 patients infected with SARS-CoV-2 admitted to ICUs of the Lombardy region (2020) JAMA., 323, pp. 1574-1581. , Italy; Lighter, J., Phillips, M., Hochman, S., Obesity in patients younger than 60 years is a risk factor for Covid-19 hospital admission (2020) Clin Infect Dis, , [Epub ahead of print]; Dietz, W., Santos-Burgoa, C., Obesity and its implications for COVID-19 mortality (2020) Obesity (Silver Spring)., 28, p. 1005; Richardson, S., Hirsch, J.S., Narasimhan, M., Presenting characteristics, comorbidities, and outcomes among 5700 patients hospitalized with COVID-19 in the New York City area (2020) JAMA., 323, pp. 2052-2059; Webb Hooper, M., Nápoles, A.M., Pérez-Stable, E.J., COVID-19 and racial/ ethnic disparities (2020) JAMA, , Epub ahead of print; Yancy, C.W., COVID-19 and African Americans (2020) JAMA, , Epub ahead of print; Ross, J., Diaz, C.M., Starrels, J.L., The disproportionate burden of COVID-19 for immigrants in the Bronx, New York (2020) JAMA Intern Med, , Epub ahead of print; Ahmed, F., Ahmed, N., Pissarides, C., Why inequality could spread COVID-19 (2020) Lancet Public Health., 5, p. e240; NúñEz, A., Madison, M., Schiavo, R., Responding to healthcare disparities and challenges with access to care during COVID-19 (2020) Health Equity., 4, pp. 117-128; Madjid, M., Safavi-Naeini, P., Solomon, S.D., Potential effects of coronaviruses on the cardiovascular system: A review (2020) JAMA Cardiol, , Epub ahead of print PY - 2020 SN - 24731242 (ISSN) SP - 336-344 ST - Associations between chronic health conditions and COVID-19 preventive behaviors among a nationally representative sample of U.S. Adults: An analysis of the COVID impact survey T2 - Health Equity TI - Associations between chronic health conditions and COVID-19 preventive behaviors among a nationally representative sample of U.S. Adults: An analysis of the COVID impact survey UR - https://www.scopus.com/inward/record.uri?eid=2-s2.0-85090035318&doi=10.1089%2fheq.2020.0031&partnerID=40&md5=60afa265402f90ebd15a16398d375754 VL - 4 ID - 421 ER - TY - JOUR AB - Background: Few studies have documented rural community pharmacy disaster preparedness. Objectives: To: (1) describe rural community pharmacies’ preparedness for and responses to COVID-19 and (2) examine whether responses vary by level of pharmacy rurality. Methods: A convenience sample of rural community pharmacists completed an online survey (62% response rate) that assessed: (a) demographic characteristics; (b) COVID-19 information source use; (c) interest in COVID-19 testing; (d) infection control procedures; (e) disaster preparedness training, and (f) medication supply impacts. Descriptive statistics were calculated and differences by pharmacy rurality were explored. Results: Pharmacists used the CDC (87%), state health departments (77%), and state pharmacy associations (71%) for COVID-19 information, with half receiving conflicting information. Most pharmacists (78%) were interested in offering COVID-19 testing but needed personal protective equipment and training to do so. Only 10% had received disaster preparedness training in the past five years. Although 73% had disaster preparedness plans, 27% were deemed inadequate for the pandemic. Nearly 70% experienced negative impacts in medication supply. There were few differences by rurality level. Conclusion: Rural pharmacies may be better positioned to respond to pandemics if they had disaster preparedness training, updated disaster preparedness plans, and received regular policy guidance from professional bodies. © 2020 Elsevier Inc. AD - Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States College of Pharmacy, University of South Carolina, Columbia, SC, United States Harrison School of Pharmacy, Auburn University, Auburn, AL, United States School of Pharmacy, University of Mississippi, Oxford, MS, United States Departments of Pharmacy Practice and Psychiatry, University of Arkansas for Medical SciencesAR, United States AU - Carpenter, D. M. AU - Hastings, T. AU - Westrick, S. AU - Rosenthal, M. AU - Mashburn, P. AU - Kiser, S. AU - Shepherd, J. G. AU - Curran, G. DB - Scopus DO - 10.1016/j.sapharm.2020.10.008 J2 - Res. Soc. Adm. Pharm. KW - Community pharmacies COVID-19 Disaster preparedness Rural health LA - English M3 - Article N1 - Export Date: 4 May 2021 Correspondence Address: Carpenter, D.M.; Eshelman School of Pharmacy, Chapel Hill, United States; email: dmcarpenter@unc.edu Funding details: National Institutes of Health, NIH, UL1TR002489 Funding details: National Center for Advancing Translational Sciences, NCATS Funding details: Eshelman Institute for Innovation, University of North Carolina at Chapel Hill Funding details: Translational Research Institute, University of Arkansas for Medical Sciences, TRI, UAMS, UL1 TR003107 Funding text 1: The project described was supported by the National Center for Advancing Translational Sciences (NCATS), National Institutes of Health, through Grant Award Number UL1TR002489 and the Eshelman Institute for Innovation. The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH. Dr. Curran was supported by the Translational Research Institute (TRI), UL1 TR003107, through the National Center for Advancing Translational Sciences of the National Institutes of Health (NIH). Funding text 2: The project described was supported by the National Center for Advancing Translational Sciences (NCATS) , National Institutes of Health , through Grant Award Number UL1TR002489 and the Eshelman Institute for Innovation . The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH. Dr. Curran was supported by the Translational Research Institute (TRI) , UL1 TR003107 , through the National Center for Advancing Translational Sciences of the National Institutes of Health (NIH ). 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University of California, San Francisco, Mexico AU - Centor, R. M. AU - Kumfer, A. M. AU - Shekarchian, S. C2 - 32574072 DB - Scopus DO - 10.7326/A19-0033 IS - 1 J2 - Ann. Intern. Med. 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A key unanswered question is whether infection with SARS-CoV-2 results in protective immunity against reexposure. We developed a rhesus macaque model of SARS-CoV-2 infection and observed that macaques had high viral loads in the upper and lower respiratory tract, humoral and cellular immune responses, and pathologic evidence of viral pneumonia. After the initial viral clearance, animals were rechallenged with SARS-CoV-2 and showed 5 log10 reductions in median viral loads in bronchoalveolar lavage and nasal mucosa compared with after the primary infection. Anamnestic immune responses after rechallenge suggested that protection was mediated by immunologic control. These data show that SARS-CoV-2 infection induced protective immunity against reexposure in nonhuman primates. © 2020 American Association for the Advancement of Science. All rights reserved. AD - Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, United States Tufts University Cummings School of Veterinary Medicine, North Grafton, MA 01536, United States Harvard Medical School, Boston, MA 02115, United States Oregon Health & Sciences University, Beaverton, OR 97006, United States University of North Carolina, Chapel Hill, NC 27599, United States Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA 02139, United States Bioqual, Rockville, MD 20852, United States Janssen Vaccines & Prevention BV, Leiden, Netherlands Massachusetts Consortium on Pathogen Readiness, Boston, MA 02215, United States Cornell University College of Veterinary Medicine, Ithaca, NY 14853, United States AU - Chandrashekar, A. AU - Liu, J. AU - Martino, A. J. AU - McMahan, K. AU - Mercad, N. B. AU - Peter, L. AU - Tostanosk, L. H. AU - Yu, J. AU - Maliga, Z. AU - Nekorchuk, M. AU - Busman-Sahay, K. AU - Terry, M. AU - Wriji, L. M. AU - Ducat, S. AU - Martine, D. R. AU - Atyeo, C. AU - Fischinger, S. AU - Burk, J. S. AU - Slei, M. D. AU - Pessaint, L. AU - Van Ry, A. AU - Greenhouse, J. AU - Taylor, T. AU - Blade, K. AU - Cook, A. AU - Finneyfrock, B. AU - Brown, R. AU - Teow, E. AU - Velasco, J. AU - Zahn, R. AU - Wegmann, F. AU - Abbink, P. AU - Bondzi, E. A. AU - Dagotto, G. AU - Gebr, M. S. AU - He, X. AU - Jacob-Dolan, C. AU - Kordana, N. AU - Li, Z. AU - Lifto, M. A. AU - Mahrokhia, S. H. AU - Maxfiel, L. F. AU - Nityanandam, R. AU - Nkolol, J. P. AU - Schmid, A. G. AU - Mille, A. D. AU - Bari, R. S. AU - Alter, G. AU - Sorge, P. K. AU - Este, J. D. AU - Andersen, H. AU - Lewi, M. G. AU - Barou, D. H. C2 - 32434946 DB - Scopus DO - 10.1126/science.abc4776 IS - 6505 J2 - Sci. KW - virus antibody virus RNA coronavirus spike glycoprotein neutralizing antibody spike protein, SARS-CoV-2 drug development immune response immunity infectivity medicine primate public health respiratory disease viral disease virus antibody response Article CD4+ T lymphocyte CD8+ T lymphocyte cellular immunity coronavirus disease 2019 disease course human humoral immunity immunohistochemistry immunology immunophenotyping inflammatory cell interstitial pneumonia lower respiratory tract lung infiltrate lung lavage neutrophil chemotaxis nonhuman nose mucosa priority journal rhesus monkey Severe acute respiratory syndrome coronavirus 2 upper respiratory tract viral clearance virion virology virus cell interaction virus load virus neutralization virus pneumonia virus replication animal Betacoronavirus blood bronchoalveolar lavage fluid Coronavirus infection disease model female immunological memory interstitial lung disease lung male pandemic pathology physiology recurrent disease Animalia Coronavirus Macaca Macaca mulatta Primates SARS coronavirus Animals Antibodies, Neutralizing Antibodies, Viral Coronavirus Infections Disease Models, Animal Immunity, Cellular Immunity, Humoral Immunologic Memory Lung Diseases, Interstitial Nasal Mucosa Pandemics Pneumonia, Viral Recurrence Spike Glycoprotein, Coronavirus Viral Load LA - English M3 - Article N1 - Cited By :228 Export Date: 4 May 2021 CODEN: SCIEA Correspondence Address: Barou, D.H.; Center for Virology and Vaccine Research, United States; email: dbarouch@bidmc.harvard.edu Chemicals/CAS: Antibodies, Neutralizing; Antibodies, Viral; Spike Glycoprotein, Coronavirus; spike protein, SARS-CoV-2 References: Wu, F., (2020) Nature, 579, pp. 265-269; Zhou, P., (2020) Nature, 579, pp. 270-273; Holshue, M. L., (2020) N. Engl. J. Med, 382, pp. 929-936; Li, Q., (2020) N. Engl. J. Med, 382, pp. 1199-1207; Zhu, N., (2020) N. Engl. J. Med, 382, pp. 727-733; Chen, N., (2020) Lancet, 395, pp. 507-513; Huang, C., (2020) Lancet, 395, pp. 497-506; Chan, J. F., (2020) Lancet, 395, pp. 514-523; Wölfel, R., (2020) Nature, 581, pp. 465-469; Yang, Z. Y., (2004) Nature, 428, pp. 561-564; Scobey, T., (2013) Proc. Natl. Acad. Sci. U.S.A, 110, pp. 16157-16162; Yount, B., (2003) Proc. Natl. Acad. Sci. U.S.A, 100, pp. 12995-13000; Chung, A. W., (2015) Cell, 163, pp. 988-998; Deleage, C., (2016) JCI Insight, 1, p. e87065; Deleage, C., (2016) Pathog. Immun, 1, pp. 68-106; Lin, J. R., (2018) eLife, 7, p. e31657; Altfeld, M., (2002) Nature, 420, pp. 434-439; Callow, K. A., Parry, H. F., Sergeant, M., Tyrrell, D. A., (1990) Epidemiol. Infect, 105, pp. 435-446; Immunity passports' in the context of COVID-19 Scientific Brief, , https://www.who.int/news-room/commentaries/detail/immunity-passports-inthe-context-of-covid-19, World Health Organization, 24 April 2020; Rockx, B., (2020) Science, 368, pp. 1012-1015 PY - 2020 SN - 00368075 (ISSN) SP - 812-817 ST - SARS-CoV-2 infection protects against rechallenge in rhesus macaques T2 - Science TI - SARS-CoV-2 infection protects against rechallenge in rhesus macaques UR - https://www.scopus.com/inward/record.uri?eid=2-s2.0-85086120411&doi=10.1126%2fscience.abc4776&partnerID=40&md5=97e1edae3fbd8d500233ae5b7f68c667 VL - 369 ID - 410 ER - TY - JOUR AB - Background: Many studies have modeled and predicted the spread of COVID-19 (coronavirus disease 2019) in the U.S. using data that begins with the first reported cases. However, the shortage of testing services to detect infected persons makes this approach subject to error due to its underdetection of early cases in the U.S. Our new approach overcomes this limitation and provides data supporting the public policy decisions intended to combat the spread of COVID-19 epidemic. Methods: We used Centers for Disease Control and Prevention data documenting the daily new and cumulative cases of confirmed COVID-19 in the U.S. from January 22 to April 6, 2020, and reconstructed the epidemic using a 5-parameter logistic growth model. We fitted our model to data from a 2-week window (i.e., from March 21 to April 4, approximately one incubation period) during which large-scale testing was being conducted. With parameters obtained from this modeling, we reconstructed and predicted the growth of the epidemic and evaluated the extent and potential effects of underdetection. Results: The data fit the model satisfactorily. The estimated daily growth rate was 16.8% overall with 95% CI: [15.95, 17.76%], suggesting a doubling period of 4 days. Based on the modeling result, the tipping point at which new cases will begin to decline will be on April 7th, 2020, with a peak of 32,860 new cases on that day. By the end of the epidemic, at least 792,548 (95% CI: [789,162, 795,934]) will be infected in the U.S. Based on our model, a total of 12,029 cases were not detected between January 22 (when the first case was detected in the U.S.) and April 4. Conclusions: Our findings demonstrate the utility of a 5-parameter logistic growth model with reliable data that comes from a specified period during which governmental interventions were appropriately implemented. Beyond informing public health decision-making, our model adds a tool for more faithfully capturing the spread of the COVID-19 epidemic. © 2020, The Author(s). AD - School of Social Work, University of North Carolina, Tate-Turner Kuralt Building 548-C, CB #3550, Chapel Hill, NC 27599, United States Department of Statistics, University of Pretoria, Pretoria, South Africa Department of Epidemiology, University of Florida, Gainesville, United States Department of Statistics and Data Science, Cornell University, Ithaca, United States AU - Chen, D. G. AU - Chen, X. AU - Chen, J. K. C7 - 25 DB - Scopus DO - 10.1186/s41256-020-00152-5 IS - 1 J2 - Glob. Health. Res. Policy KW - COVID-19 Disease dynamics Epidemics Logistic growth model Population-based model Prediction Reconstruction Tipping point Under-detection USA LA - English M3 - Article N1 - Cited By :2 Export Date: 4 May 2021 Correspondence Address: Chen, D.-G.; Department of Statistics, South Africa; email: dinchen@email.unc.edu References: Chen, X., Li, H., Lucero-Prisno, D., Abdullah, A., Huang, J., Laurence, C., What is global health? Key concepts and clarification of misperceptions: report of the 2019 GHRP editorial meeting (2020) Glob Health Res Policy, 5. , (,)., https://doi.org/10.1186/s41256-020-00142-7; Huang, Y., Yang, L., Dai, H., Tian, F., Chen, K., Epidemic situation and forecasting of COVID-19 in and outside China (2020) Bull World Health Organ, , https://doi.org/10.2471/BLT.20.255158, [Epub ahead of print]; Richards, F.J., A flexible growth function for empirical use (1959) J Exp Bot, 10 (2), pp. 290-301; McIntosh, R.P., (1985) The background of ecology, , Cambridge University Press, New York; Renshaw, E., (1991) Modeling biological populations in space and time, , Cambridge University Press, New York; Kingsland, S.E., (1995) Modeling nature: episodes in the history of population ecology, , University of Chicago Press, Chicago; Vandermeer, J., How populations grow: the exponential and logistic equations (2010) Nature Education Knowledge, 3 (10), p. 15. , https://www.nature.com/scitable/knowledge/library/how-populations-grow-the-exponential-and-logistic-13240157/, [cited 2020 Apr 23]. Available from: https://www.nature.com/scitable/knowledge/library/how-populations-grow-the-exponential-and-logistic-13240157/; Gottschalk, P.G., Dunn, J.R., The five-parameter logistic: a characterization and comparison with the four-parameter logistic (2005) Anal Biochem, 343 (1), pp. 54-65; Motulsky, H.J., Brown, R.E., Assessing the (a) symmetry of concentration-effect curves: empirical versus mechanistic models (2006) BMC Bioinformatics, 7, p. 123; Chen, X., Yu, B., First two months of the 2019 coronavirus disease (COVID-19) epidemic in China: real-time surveillance and evaluation with a second derivative model (2020) Glob Health Res Policy, 5. , (,)., https://doi.org/10.1186/s41256-020-00137-4; (2020) Cases of coronavirus disease (COVID-19) in the U.S, , https://www.cdc.gov/coronavirus/2019-ncov/cases-updates/cases-in-us.html, [cited 2020, Apr 7]. Available from: https://www.cdc.gov/coronavirus/2019-ncov/cases-updates/cases-in-us.html; (2020) New cases of COVID-19 in world countries, , https://coronavirus.jhu.edu/data/new-cases, [cited 2020, Apr 22]. Available from: https://coronavirus.jhu.edu/data/new-cases; Ferguson, N.L., Laydon, D., Nedjati-Gilani, G., Imai, N., Ainslie, K., Baguelin, M., (2020) Impact of Non-Pharmaceutical Interventions (Npis) to Reduce COVID-19 Mortality and Healthcare Demand: WHO Collaborating Centre for Infectious Disease Modelling, MRC Centre for Global Infectious Disease Analysis, Abdul Latif Jameel Institute for Disease and Emergency Analytics, , https://www.imperial.ac.uk/media/imperial-college/medicine/sph/ide/gida-fellowships/Imperial-College-COVID19-NPI-modelling-16-03-2020.pdf, Imperial College London;, Accessed 12 Apr 2020; Danner, C., (2020) CDC’s Worst-Case Coronavirus Model: 214 Million Infected, 1.7 Million Dead, , https://nymag.com/intelligencer/2020/03/cdcs-worst-case-coronavirus-model-210m-infected-1-7m-dead.html, New York Intelligencer, [cited 2020, Apr 12]; Available from PY - 2020 SN - 23970642 (ISSN) ST - Reconstructing and forecasting the COVID-19 epidemic in the United States using a 5-parameter logistic growth model T2 - Global Health Research and Policy TI - Reconstructing and forecasting the COVID-19 epidemic in the United States using a 5-parameter logistic growth model UR - https://www.scopus.com/inward/record.uri?eid=2-s2.0-85103350686&doi=10.1186%2fs41256-020-00152-5&partnerID=40&md5=ba432e268e5cd3f26b72fb713e80811b VL - 5 ID - 250 ER - TY - JOUR AD - University of North Carolina, School of Medicine, Chapel Hill, NC, United States Timber Ridge Treatment Center, Gold Hill, NC, United States AU - Chepke, C. DB - Scopus IS - 5 J2 - Curr. Psychiatry KW - esketamine long acting drug neuroleptic agent administrative personnel coronavirus disease 2019 depression emergency ward human medication therapy management Note pandemic psychiatrist risk evaluation and mitigation strategy telepsychiatry terrorism virus transmission LA - English M3 - Note N1 - Cited By :1 Export Date: 4 May 2021 Correspondence Address: Chepke, C.; University of North Carolina, United States Chemicals/CAS: esketamine, 33643-46-8, 33643-47-9 PY - 2020 SN - 15378276 (ISSN) SP - 29-30 ST - Drive-up pharmacotherapy during the COVID-19 pandemic T2 - Current Psychiatry TI - Drive-up pharmacotherapy during the COVID-19 pandemic UR - https://www.scopus.com/inward/record.uri?eid=2-s2.0-85090992270&partnerID=40&md5=31b5f98eaae19764dc381065f146841a VL - 19 ID - 505 ER - TY - JOUR AD - Department of Radiation Oncology, University of North Carolina, School of Medicine, Chapel Hill, NC, United States Department of Radiation Medicine, Northwell Health Cancer Institute, Lake Success NY and Zucker School of Medicine, Hempstead, NY, United States AU - Chera, B. S. AU - Potters, L. AU - Marks, L. B. C2 - 32888525 DB - Scopus DO - 10.1016/j.prro.2020.07.001 IS - 5 J2 - Pract. Radiat. Oncol. KW - clinical effectiveness coronavirus disease 2019 Editorial health care quality human medical decision making medical record medical society medical staff methodology multidisciplinary team palliative therapy patient safety peer review prescription priority journal quality control radiation oncology radiotherapy responsibility simulation teaching round three-dimensional imaging treatment planning United States videoconferencing x-ray computed tomography LA - English M3 - Editorial N1 - Cited By :1 Export Date: 4 May 2021 Correspondence Address: Chera, B.S.; Department of Radiation Oncology, United States; email: bchera@med.unc.edu References: Marks, L.B., Adams, R.D., Pawlicki, T., Enhancing the role of case-oriented peer review to improve quality and safety in radiation oncology: Executive summary (2013) Pract Radiat Oncol, 3, pp. 149-156; Talcott, W.J., Lincoln, H., Kelly, J.R., A blinded, prospective study of error detection during physician chart rounds in radiation oncology (2020) Pract Radiat Oncol, 10, pp. 312-320; Brunskill, K., Nguyen, T.K., Boldt, R.G., Does peer review of radiation plans affect clinical care? A systematic review of the literature (2017) Int J Radiat Oncol Biol Phys, 97, pp. 27-34; Ballo, M.T., Chronowski, G.M., Schlembach, P.J., Bloom, E.S., Arzu, I.Y., Kuban, D.A., Prospective peer review quality assurance for outpatient radiation therapy (2014) Pract Radiat Oncol, 4, pp. 279-284; Boxer, M., Forstner, D., Kneebone, A., Impact of a real-time peer review audit on patient management in a radiation oncology department (2009) J Med Imaging Radiat Oncol, 53, pp. 405-411; Brundage, M.D., Dixon, P.F., Mackillop, W.J., A real-time audit of radiation therapy in a regional cancer center (1999) Int J Radiat Oncol Biol Phys, 43, pp. 115-124; Lefresne, S., Olivotto, I.A., Joe, H., Blood, P.A., Olson, R.A., Impact of quality assurance rounds in a Canadian radiation therapy department (2013) Int J Radiat Oncol Biol Phys, 85, pp. e117-e121; Lo, A.C., Liu, M., Chan, E., The impact of peer review of volume delineation in stereotactic body radiation therapy planning for primary lung cancer: A multicenter quality assurance study (2014) J Thorac Oncol, 9, pp. 527-533; Matuszak, M.M., Hadley, S.W., Feng, M., Enhancing safety and quality through preplanning peer review for patients undergoing stereotactic body radiation therapy (2016) Pract Radiat Oncol, 6, pp. e39-e46; Rouette, J., Gutierrez, E., O'Donnell, J., Directly improving the quality of radiation treatment through peer review: A cross-sectional analysis of cancer centers across a provincial cancer program (2017) Int J Radiat Oncol Biol Phys, 98, pp. 521-529; Thaker, N.G., Sturdevant, L., Jhingran, A., Assessing the quality of a radiation oncology case-based, peer-review program in an integrated academic and community cancer center network (2016) J Oncol Pract, 12, pp. e476-e486; Walker, G.V., Shirvani, S.M., Borghero, Y., Palliation or prolongation? The impact of a peer-review intervention on shortening radiotherapy schedules for bone metastases (2018) J Oncol Pract, 14, pp. e513-e516; Walburn, T., Wang, K., Sud, S., A prospective analysis of radiation oncologist compliance with early peer review recommendations (2019) Int J Radiat Oncol Biol Phys, 104, pp. 494-500; Bogadanich, W., Radiation offers new cures and ways to do harm (2010), Section A, 1 New York Times; Chera, B.S., Mazur, L., Jackson, M., Quantification of the impact of multifaceted initiatives intended to improve operational efficiency and the safety culture: A case study from an academic medical center radiation oncology department (2014) Pract Radiat Oncol, 4, pp. e101-e108; Cox, B.W., Kapur, A., Sharma, A., Prospective contouring rounds: A novel, high-impact tool for optimizing quality assurance (2015) Pract Radiat Oncol, 5, pp. e431-e436; Cox, B.W., Teckie, S., Kapur, A., Chou, H., Potters, L., Prospective peer review in radiation therapy treatment planning: Long-term results from a longitudinal study (2020) Pract Radiat Oncol, 10, pp. e199-e206; Riegel, A.C., Vaccarelli, M., Cox, B.W., Chou, H., Cao, Y., Potters, L., Impact of multi-institutional prospective peer review on target and organ-at-risk delineation in radiation therapy (2019) Pract Radiat Oncol, 9, pp. e228-e235 PY - 2020 SN - 18798500 (ISSN) SP - 321-323 ST - Restructuring Our Approach to Peer Review: A Critical Need to Improve the Quality and Safety of Radiation Therapy T2 - Practical Radiation Oncology TI - Restructuring Our Approach to Peer Review: A Critical Need to Improve the Quality and Safety of Radiation Therapy UR - https://www.scopus.com/inward/record.uri?eid=2-s2.0-85089805612&doi=10.1016%2fj.prro.2020.07.001&partnerID=40&md5=02d21e4e111c1a23ee0dcb71dde3854c VL - 10 ID - 384 ER - TY - JOUR AB - Starting with the power law for the total number of detected infections, we propose differential equations describing the effect of momentum epidemic management. Our 2-phase formula matches very well the curves of the total numbers of the Covid-19 infection in many countries; the first phase is described by Bessel functions. It provides projections for the saturation, assuming that the management is steady. We discuss Austria, Brazil, Germany, Japan, India, Israel, Italy, the Netherlands, Sweden, Switzerland, UK, and the USA, including some analysis of the second waves. © 2020 AD - Department of Mathematics, UNC Chapel Hill, North Carolina, 27599, United States AU - Cherednik, I. C7 - 110234 DB - Scopus DO - 10.1016/j.chaos.2020.110234 J2 - Chaos Solitons Fractals KW - Bessel functions Epidemic psychology Epidemic spread Binary alloys Differential equations Potassium alloys Austria Management IS Netherlands Power-law Switzerland Uranium alloys LA - English M3 - Article N1 - Export Date: 4 May 2021 CODEN: CSFOE Funding details: National Science Foundation, NSF, 1901796, DMS–1901796 Funding details: Simons Foundation, SF Funding text 1: Partially supported by NSF grant DMS?1901796 and the Simons Foundation. Funding text 2: Partially supported by NSF grant DMS–1901796 and the Simons Foundation . References: Carrasco-Hernandez, R., Jácome, R., Vidal, Y.L., de León, S.P., Are RNA viruses candidate agents for the next global pandemic? A review (2017) ILAR J, 58 (3), pp. 343-358; Castro, M., López-Garcia, M., Lythe, G., First passage events in biological systems with non-exponential inter-event times (2018) Sci Rep, 8 (15054); Cherednik I. Artificial intelligence approach to momentum risk-taking. 2019. (q-fin). arXiv:; Cherednik I. A surprising formula for the spread of covid-19 under aggressive management. 2020., Preprint: medRxiv; Cheridito, P., Mixed fractional Brownian motion (2001) Bernoulli, 7, pp. 913-934; Cobey, S., Modeling infectious disease dynamics (2020) Science, (24 Apr.); Hethcote, H., The mathematics of infectious diseases (2000) SIAM Rev, 42 (4), pp. 599-653; Hethcote, H., Levin, S., Periodicity in epidemiological models (1989) Applied mathematical ecology. Biomathematics, 18, pp. 193-211. , Levin S. Hallam T. Gross L. Springer Berlin, Heidelberg; Katori M. Bessel process, Schramm-Loewner evolution, and Dyson model. 2011. arXiv:; Meyer, S., Held, L., Power-law models for infectious disease spread (2014) Ann Appl Stat, 8 (3), pp. 1612-1639; Strong, P., Epidemic psychology: a model (1990) Sociol Health Illness, 12 (3), pp. 249-259; Watson, G.N., A treatise on the theory of bessel functions (1944), 2nd ed. Cambridge University Press CambridgeUR - https://www.scopus.com/inward/record.uri?eid=2-s2.0-85092078789&doi=10.1016%2fj.chaos.2020.110234&partnerID=40&md5=b199941f816f678676c72c6c63e6e9c1 PY - 2020 SN - 09600779 (ISSN) ST - Momentum managing epidemic spread and Bessel functions T2 - Chaos, Solitons and Fractals TI - Momentum managing epidemic spread and Bessel functions VL - 139 ID - 340 ER - TY - JOUR AB - This statement was released in June 2020 by the Alliance for Academic Internal Medicine to provide guidance for the 2020-2021 residency application cycle in light of the COVID-19 pandemic. While many of the recommendations are specific to this cycle, others, such as the Department Summary Letter of Evaluation, are meant to be an enduring change to the internal medicine residency application process. AAIM realizes that some schools may not yet have the tools or resources to implement the template fully this cycle and look toward collaboration within the internal medicine education community to facilitate adoption in the cycles to come. © 2020 Elsevier Inc. AD - Department of Medicine, George Washington University School of Medicine and Health Sciences, Washington, DC, United States Department of Medicine, Creighton University School of Medicine, Omaha, NE, United States Department of Medicine, UT Southwestern Medical Center, Dallas, TX, United States Department of Internal Medicine, University of California Davis School of Medicine, Sacramento, CA, United States Department of Internal Medicine, Atlantic Health System, Morristown, NJ, United States Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI, United States Department of Medicine, Weill Cornell Medical College, New York, NY, United States Department of Medicine, University of Massachusetts Medical School, Worcester, MA Department of Medicine, Baylor College of Medicine, Houston, TX, United States Department of Medicine, Renaissance School of Medicine at Stony BrookNY, United States Department of Medicine and Pediatrics, Alpert Medical School of Brown University, Providence, RI, United States Department of Medicine, University of Minnesota Medical School, Minneapolis, United States Department of Medicine, University of North Carolina College of Medicine, Chapel Hill, NC, United States Department of Medicine, Cleveland Clinic Lerner College of Medicine, Cleveland, OH, United States Department of Medicine, Ohio State University College of Medicine, Columbus, OH, United States Department of Medicine, University of Alabama at Birmingham School of MedicineAL, United States AU - Chretien, K. C. AU - Raj, J. M. AU - Abraham, R. A. AU - Aronowitz, P. AU - Astiz, D. J. AU - Chheda, S. G. AU - Esquivel, E. L. AU - Garcia, M. M. AU - Ismail, N. AU - Lane, S. AU - McLaughlin, S. E. AU - Pereira, A. AU - Shaheen, A. W. AU - Spencer, A. L. AU - Tartaglia, K. M. AU - Willett, L. L. C2 - 32659220 DB - Scopus DO - 10.1016/j.amjmed.2020.06.002 IS - 10 J2 - Am. J. Med. KW - COVID-19 pandemic Graduate medical education Residency application cycle Student advising Undergraduate medical education coronavirus disease 2019 educational status human internal medicine interview medical school medical society medical student Note pandemic priority journal residency education virtual learning environment Coronavirus infection job finding medical education organization and management virus pneumonia writing Coronavirus Infections Correspondence as Topic Humans Internship and Residency Job Application Pandemics Pneumonia, Viral LA - English M3 - Note N1 - Cited By :3 Export Date: 4 May 2021 CODEN: AJMEA Correspondence Address: Chretien, K.C.2300 Eye Street, NW, Ross Hall 708E, United States; email: kchretie@gwu.edu References: Lang, V.J., Aboff, B.M., Bordley, D.R., Call, S., DeZee, K.J., Fazio, S.B., Fitz, M., Wayne, D.B., Guidelines for writing department of medicine summary letters (2013) Am J Med, 126 (5), pp. 458-463 PY - 2020 SN - 00029343 (ISSN) SP - 1223-1226.e6 ST - AAIM Recommendations for the 2020-2021 Internal Medicine Residency Application Cycle in Response to the COVID-19 Pandemic T2 - American Journal of Medicine TI - AAIM Recommendations for the 2020-2021 Internal Medicine Residency Application Cycle in Response to the COVID-19 Pandemic UR - https://www.scopus.com/inward/record.uri?eid=2-s2.0-85089148461&doi=10.1016%2fj.amjmed.2020.06.002&partnerID=40&md5=18ec3ca7c849683542037700e702ed97 VL - 133 ID - 353 ER - TY - JOUR AB - Because of the Coronavirus (COVID-19) pandemic, “Circuit-breaker” safety distancing was implemented in Singapore from April to May 2020. Schools and workplaces were closed and parents had to balance telecommuting with parenting responsibilities. Coupled with the high degree of economic uncertainty and reduced social support, these circumstances are hypothesized to increase parenting stress. Based on the Parental Stress Model, this study aims to understand how parents’ perceived impact of COVID-19 increased harsh parenting and reduced parent-child relationship closeness through the mediating effects of parenting stress. We collected data from 258 parents living in Singapore using online surveys disseminated through Facebook and community organizations. Our predictor was the perceived impact of COVID-19. Parental stress (mediator) was measured with the Parental Stress Scale. Two outcomes were used: parent-child relationship closeness and harsh parenting (spanking, yelling). Using mediation analysis in the SEM framework, we tested the indirect effects using bias-corrected bootstrap confidence intervals. Our results indicated that parenting stress was a significant mediator in the relationship between the perceived impact of COVID-19 and (a) parent-child closeness (indirect effect = −.30, Bootstrap 99% CI[−.59, −.11]) and (b) harsh parenting (indirect effect =.58, Bootstrap 99% CI[.25,.94]). The impact of COVID-19 and stay-home orders can increase parenting stress. This, in turn, has a negative impact on parenting by affecting parents’ relationship with their children and increasing the use of harsh parenting. Given that these are risk factors for potential child abuse, supporting parents and mitigating the impact of COVID-19 are important. © 2020, Springer Science+Business Media, LLC, part of Springer Nature. AD - School of Social Work, University of North Carolina at Chapel Hill, Tate-Turner-Kuralt Building, 325 Pittsboro Street CB# 3550, Chapel Hill, NC 27599-3550, United States Department of Social Work, National University of Singapore, BLK AS3 Level 4, 3 Arts Link Singapore, Singapore, 117570, Singapore AU - Chung, G. AU - Lanier, P. AU - Wong, P. Y. J. DB - Scopus DO - 10.1007/s10896-020-00200-1 J2 - J. Fam. Violence KW - Coronavirus (COVID-19) Harsh parenting Parental stress Relationship Singapore LA - English M3 - Article N1 - Cited By :16 Export Date: 4 May 2021 Correspondence Address: Chung, G.; School of Social Work, Tate-Turner-Kuralt Building, 325 Pittsboro Street CB# 3550, United States; email: gcsk1982@live.unc.edu References: Abidin, R.R., The determinants of parenting behavior (1992) Journal of Clinical Child Psychology, 21 (4), pp. 407-412; Agrawal, N., The Coronavirus Could Cause a Child Abuse Epidemic (2020) The New York Times, , https://www.nytimes.com/2020/04/07/opinion/coronavirus-child-abuse.html; Azhari, A., Leck, W.Q., Gabrieli, G., Bizzego, A., Rigo, P., Setoh, P., Bornstein, M.H., Esposito, G., Parenting stress undermines mother-child brain-to-brain synchrony: A Hyperscanning study (2019) Scientific Reports, 9 (1), pp. 1-9; User’s guide for the fragile families and child wellbeing study public data (2018) Bendheim-Thoman Center for Research, , https://fragilefamilies.princeton.edu/sites/fragilefamilies/files/year_3_guide.pdf; Berkovits, M.D., O’Brien, K.A., Carter, C.G., Eyberg, S.M., Early identification and intervention for behavior problems in primary care: A comparison of two abbreviated versions of parent-child interaction therapy (2010) Behavior Therapy, 41 (3), pp. 375-387; Berry, J.O., Jones, W.H., The parental stress scale: Initial psychometric evidence (1995) Journal of Social and Personal Relationships, 12 (3), pp. 463-472; Bornstein, M.H., Putnick, D.L., Suwalsky, J.T.D., Parenting cognitions → parenting practices → child adjustment? 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People with disabilities experience numerous barriers to using transportation to access essential goods, like fresh food, and services, like medical care, that are necessary for maintaining health. The pandemic and the pandemic response threaten to exacerbate persistent health disparities and add to transportation barriers that disadvantage people with disabilities. To better understand difficulties that individuals with disabilities are facing using transportation and meeting their needs during the pandemic, I conducted in-depth interviews with 21 San Francisco Bay Area residents with disabilities between March 20 and April 6, 2020, immediately following adoption of the first shelter-in-place orders in the region. Analyzing these interviews, I find that the pandemic is aggravating many difficulties accessing transportation and other essentials that people with disabilities regularly encounter. These include challenges accessing reliable and safe transportation as well as up-to-date communications about transportation and public health, and difficulties getting needed assistance using transportation and completing activities of daily living ranging from personal care to getting groceries. I recommend that those involved in the pandemic response make a concerted and intentional effort to address barriers to accessing needed transportation, communications, and assistance that people with disabilities are facing during the pandemic, paving the way for a more inclusive pandemic response. © 2020 AD - Department of City and Regional Planning, University of North Carolina at Chapel Hill, New East Building, CB #3140, Chapel Hill, NC 27599, United States AU - Cochran, A. L. C7 - 100263 DB - Scopus DO - 10.1016/j.trip.2020.100263 J2 - Transp. Res. Interdiscip. Perspect. KW - COVID-19 Disability Health Interviews Pandemic response Travel behavior LA - English M3 - Article N1 - Cited By :4 Export Date: 4 May 2021 Funding details: University of California Berkeley, UCB Funding text 1: I am grateful to all study respondents for sharing their time and valuable insights. I thank LightHouse for the Blind and Visually Impaired and the Center for Independent Living for their help with recruiting participants. The University of California, Berkeley, Undergraduate Research Apprentice Program (URAP) funded two students who assisted with this research: Jordan Collins and Rachel Schten. I thank them for their help. This research was presented in an early stage at the Pandemic Urbanism Symposium, hosted by the University of Washington in May 2020. I thank all event attendees for their feedback. 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Evaluating the accessibility of Web-based emergency alert sign-ups in the northeastern United States (2014) Government Information Quarterly, 31, pp. 488-497; Wolfe, M.K., McDonald, N.C., Holmes, G.M., Transportation Barriers to Health Care in the United States: Findings From the National Health Interview Survey, 1997–2017 (2020) Am. J. Public Health, 110, pp. 815-822 PY - 2020 SN - 25901982 (ISSN) ST - Impacts of COVID-19 on access to transportation for people with disabilities T2 - Transportation Research Interdisciplinary Perspectives TI - Impacts of COVID-19 on access to transportation for people with disabilities UR - https://www.scopus.com/inward/record.uri?eid=2-s2.0-85097167635&doi=10.1016%2fj.trip.2020.100263&partnerID=40&md5=2b7caf303b269fa87c060cc4dfba33b5 VL - 8 ID - 297 ER - TY - JOUR AD - From the Institute for Global Heath and Infectious Diseases, University of North Carolina at Chapel Hill, Chapel Hill AU - Cohen, M. S. C2 - 32492298 DB - Scopus DO - 10.1056/NEJMe2020388 IS - 6 J2 - N. Engl. J. Med. KW - hydroxychloroquine Betacoronavirus Coronavirus infection human pandemic virus pneumonia Coronavirus Infections Humans Pandemics Pneumonia, Viral LA - English M3 - Editorial N1 - Cited By :36 Export Date: 4 May 2021 Chemicals/CAS: hydroxychloroquine, 118-42-3, 525-31-5; Hydroxychloroquine PY - 2020 SN - 15334406 (ISSN) SP - 585-586 ST - Hydroxychloroquine for the Prevention of Covid-19 - Searching for Evidence T2 - The New England journal of medicine TI - Hydroxychloroquine for the Prevention of Covid-19 - Searching for Evidence UR - https://www.scopus.com/inward/record.uri?eid=2-s2.0-85087564064&doi=10.1056%2fNEJMe2020388&partnerID=40&md5=62b3ada3b6bea5ce003d0a9f17229e9f VL - 383 ID - 415 ER - TY - JOUR AD - Department of Medicine, Division of Infectious Diseases, Institute for Global Health and Infectious Diseases, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA, United States Laboratory Medicine and Medicine, University of Washington, Seattle, WA, United States AU - Cohen, M. S. AU - Corey, L. C2 - 32381692 DB - Scopus DO - 10.1126/science.abc5798 IS - 6491 J2 - Sci. KW - remdesivir severe acute respiratory syndrome vaccine zidovudine antivirus agent COVID-19 vaccine monoclonal antibody virus vaccine acquired immune deficiency syndrome airborne virus behavior change condom use contact examination coronavirus disease 2019 disease severity disease transmission drug effect Editorial epidemic hand washing health promotion hospitalization human Human immunodeficiency virus infection infection prevention infection risk nonhuman patient isolation priority journal quarantine randomized controlled trial (topic) risk reduction sexual behavior treatment duration virus load virus replication behavior Betacoronavirus clinical trial (topic) communicable disease control Coronavirus infection immunology laboratory technique pandemic virus pneumonia Antibodies, Monoclonal Antiviral Agents Clinical Laboratory Techniques Clinical Trials as Topic Coronavirus Infections HIV Infections Humans Pandemics Pneumonia, Viral Viral Vaccines LA - English M3 - Editorial N1 - Cited By :9 Export Date: 4 May 2021 CODEN: SCIEA Chemicals/CAS: remdesivir, 1809249-37-3; zidovudine, 30516-87-1; Antibodies, Monoclonal; Antiviral Agents; COVID-19 vaccine; Viral Vaccines PY - 2020 SN - 00368075 (ISSN) SP - 551 ST - Combination prevention for COVID-19 T2 - Science TI - Combination prevention for COVID-19 UR - https://www.scopus.com/inward/record.uri?eid=2-s2.0-85084567113&doi=10.1126%2fscience.abc5798&partnerID=40&md5=e0adff9d029840be7bd48d0fa8f7cf70 VL - 368 ID - 501 ER - TY - JOUR AB - Context: The role of robot-assisted surgery continues to expand at a time when trainers and proctors have travel restrictions during the coronavirus disease 2019 (COVID-19) pandemic. Objective: To provide guidance on setting up and running an optimised telementoring service that can be integrated into current validated curricula. We define a standardised approach to training candidates in skill acquisition via telepresence technologies. We aim to describe an approach based on the current evidence and available technologies, and define the key elements within optimised telepresence services, by seeking consensus from an expert committee comprising key opinion leaders in training. Evidence acquisition: This project was carried out in phases: a systematic review of the current literature, a teleconference meeting, and then an initial survey were conducted based on the current evidence and expert opinion, and sent to the committee. Twenty-four experts in training, including clinicians, academics, and industry, contributed to the Delphi process. An accelerated Delphi process underwent three rounds and was completed within 72 h. Additions to the second- and third-round surveys were formulated based on the answers and comments from the previous rounds. Consensus opinion was defined as ≥80% agreement. Evidence synthesis: There was 100% consensus regarding an urgent need for international agreement on guidance for optimised telepresence. Consensus was reached in multiple areas, including (1) infrastructure and functionality; (2) definitions and terminology; (3) protocols for training, communication, and safety issues; and (4) accountability including ethical and legal issues. The resulting formulated guidance showed good internal consistency among experts, with a Cronbach alpha of 0.90. Conclusions: Using the Delphi methodology, we achieved international consensus among experts for development and content validation of optimised telepresence services for robotic surgery training. This guidance lays the foundation for launching telepresence services in robotic surgery. This guidance will require further validation. Patient summary: Owing to travel restrictions during the coronavirus disease 2019 (COVID-19) pandemic, development of remote training and support via telemedicine is becoming increasingly important. We report a key opinion leader consensus view on a standardised approach to telepresence. There is currently a lack of high-level evidence on utilising telepresence technologies to train in robot-assisted surgery. We report Delphi process consensus views, formulated by US and European training and industry experts, on safe launching of telepresence for robotic surgery. © 2020 AD - Division of Surgery and Interventional Science, Research Department of Targeted Intervention, University College London, London, United Kingdom Department of Uro-Oncology, University College London Hospital, London, United Kingdom Wellcome/ESPRC Centre for Interventional and Surgical Sciences (WEISS), University College London, London, United Kingdom University of Rochester Medical Center, Rochester, NY, United States Keck School of Medicine of USC, Los Angeles, CA, United States Plymouth Hospitals NHS Trust, Plymouth, United Kingdom Hampshire Hospitals NHS Foundation Trust, Hampshire, United Kingdom Department of Psychology, Florida State University, Tallahassee, FL, United States Department of Surgery, St. Joseph's Healthcare, McMaster University, Hamilton, ON, Canada InTouch Health, Santa Barbara, CA, United States Division of Cardiology and Critical Care, Sacré-Coeur Hospital, University of Montreal, Montreal, QC, Canada Department of Plastic Surgery, Royal Free London NHS Foundation Trust, London, United Kingdom IRCAD, Research Institute Against Digestive Cancer, Strasbourg, France Institute for Surgical Excellence, Philadelphia, PA, United States MRC Centre for Transplantation, Kings College London, London, United Kingdom Indiana University School of Medicine, Indianapolis, IN, United States University of Southern Florida, Tampa, FL, United States Division of C Surgery, University of North Carolina, Chapel Hill, NC, United States Global Robotics Institute, Celebration, FL, United States Department of Obstetrics and Gynaecology, Addenbrooke's Hospital, Cambridge, United Kingdom University of Washington Medical Center, Seattle, WA, United States AU - Collins, J. W. AU - Ghazi, A. AU - Stoyanov, D. AU - Hung, A. AU - Coleman, M. AU - Cecil, T. AU - Ericsson, A. AU - Anvari, M. AU - Wang, Y. AU - Beaulieu, Y. AU - Haram, N. AU - Sridhar, A. AU - Marescaux, J. AU - Diana, M. AU - Marcus, H. J. AU - Levy, J. AU - Dasgupta, P. AU - Stefanidis, D. AU - Martino, M. AU - Feins, R. AU - Patel, V. AU - Slack, M. AU - Satava, R. M. AU - Kelly, J. D. DB - Scopus DO - 10.1016/j.euros.2020.09.005 J2 - Eu. Uro. Op. Sci KW - Communication Curriculum development Deliberate practice Patient safety Robotic-assisted surgery Surgical education Telementoring Telepresence Telesurgery Training protocol clinical protocol clinician consensus Delphi study human Internet medical expert medical technology priority journal Review robot assisted surgery skill surgical training telecommunication teleconference LA - English M3 - Review N1 - Cited By :1 Export Date: 4 May 2021 Correspondence Address: Collins, J.W.; University College LondonUnited Kingdom; email: justin.collins@ucl.ac.uk Funding text 1: Funding/Support and role of the sponsor: This work was supported by CMR Surgical. 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F. AU - Mathews, A. AU - Choko, A. T. AU - Nelson, L. E. C7 - 599521 DB - Scopus DO - 10.3389/fmed.2020.599521 J2 - Front. Med. KW - COVID-19 COVID-19 testing HIV - human immunodeficiency virus implementation science framework SARS-CoV-2 self-testing SARS-CoV-2 antibody Article coronavirus disease 2019 diagnostic accuracy home diagnostic test human immunoassay nonhuman point of care testing self evaluation Severe acute respiratory syndrome coronavirus 2 LA - English M3 - Article N1 - Cited By :1 Export Date: 4 May 2021 Correspondence Address: Conserve, D.F.; Department of Prevention and Community Health, United States; email: dconservejr@gwu.edu Correspondence Address: Conserve, D.F.; Department of Health Behavior, Chapel Hill, United States; email: dconservejr@gwu.edu Manufacturers: guangzhou wondfo biotech; orient gene biotech Funding details: 00MH110343, 25HL105444, 25MH080665 Funding text 1: DFC was supported by a training grant from the National Institute of Health (#R00MH110343 PI: DFC), the HIV Dissemination Science Training Program for Underrepresented Investigators grant award #R25MH080665, and the BSM PRIDE program #R25HL105444. 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N. AU - Sahin, M. AU - Piven, J. AU - Rodgers, R. AU - Tschida, J. C2 - 32854530 DB - Scopus DO - 10.1176/appi.ajp.2020.20060780 IS - 11 J2 - Am. J. Psychiatry KW - coronavirus disease 2019 developmental disorder disease burden health care access health care personnel health care policy human intellectual impairment Letter patient right practice guideline priority journal social distancing social welfare virtual reality Coronavirus infection health care disparity health care planning pandemic United States virus pneumonia vulnerable population Coronavirus Infections Developmental Disabilities Health Priorities Healthcare Disparities Humans Intellectual Disability Pandemics Pneumonia, Viral Vulnerable Populations LA - English M3 - Letter N1 - Cited By :7 Export Date: 4 May 2021 CODEN: AJPSA Correspondence Address: Constantino, J.N.; Department of Psychiatry, United States; email: constantino@wustl.edu Funding details: Astellas Pharma US Funding details: Roche Funding details: Biogen Funding details: Takeda Pharmaceuticals U.S.A., TPUSA Funding details: Ipsen Biopharmaceuticals Funding text 1: Dr. Sahin has received grant support from Astellas, Biogen, the Boston Children?s Hospital Intellectual and Developmental Disabilities Research Center, Bridgebio, the Developmental Synaptopathies Consortium, Ipsen, LAM Therapeutics, Novartis, Pfizer, Quadrant Biosciences, and Roche, and he has served on scientific advisory boards for Aeovian, Celgene, Regenxbio, Roche, Sage, and Takeda. The other authors report no financial relationships with commercial interests. References: Mills, WR, Sender, S, Lichtefeld, J, Supporting individuals with intellectual and developmental disability during the first 100 days of the COVID-19 outbreak in the USA (2020) J Intellect Disabil Res, 64, pp. 489-496; Rubin, MA, Bonnie, RJ, Epstein, L, AAN position statement: the COVID-19 pandemic and the ethical duties of the neurologist (2020) Neurology, 95, pp. 167-172; Mello, MM, Persad, G, White, DB, Respecting disability rights: toward improved crisis standards of care (2020) N Engl J Med, 383, p. e26; Turk, MA, Landes, SD, Formica, MK, Intellectual and developmental disability and COVID-19 case-fatality trends: TriNetX analysis (2020) Disabil Health J, 13, p. 100942; den Houting, J, Stepping out of isolation: autistic people and COVID-19 (2020) Autism Adulthood, 2, pp. 1-3 PY - 2020 SN - 0002953X (ISSN) SP - 1091-1093 ST - The Impact of COVID-19 on Individuals with Intellectual and Developmental Disabilities: Clinical and Scientific Priorities T2 - American Journal of Psychiatry TI - The Impact of COVID-19 on Individuals with Intellectual and Developmental Disabilities: Clinical and Scientific Priorities UR - https://www.scopus.com/inward/record.uri?eid=2-s2.0-85092449384&doi=10.1176%2fappi.ajp.2020.20060780&partnerID=40&md5=6beda102a5a8ca16d97447feec39dd8e VL - 177 ID - 302 ER - TY - JOUR AB - A vaccine for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is needed to control the coronavirus disease 2019 (COVID-19) global pandemic. Structural studies have led to the development of mutations that stabilize Betacoronavirus spike proteins in the prefusion state, improving their expression and increasing immunogenicity1. This principle has been applied to design mRNA-1273, an mRNA vaccine that encodes a SARS-CoV-2 spike protein that is stabilized in the prefusion conformation. Here we show that mRNA-1273 induces potent neutralizing antibody responses to both wild-type (D614) and D614G mutant2 SARS-CoV-2 as well as CD8+ T cell responses, and protects against SARS-CoV-2 infection in the lungs and noses of mice without evidence of immunopathology. mRNA-1273 is currently in a phase III trial to evaluate its efficacy. © 2020, This is a U.S. government work and not under copyright protection in the U.S.; foreign copyright protection may apply. AD - Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, United States Moderna Inc, Cambridge, MA, United States Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States Department of Microbiology and Immunology, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, United States Institute for Biomedical Sciences, George Washington University, Washington, DC, United States Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN, United States Department of Molecular Biosciences, University of Texas at Austin, Austin, TX, United States Biostatistics Research Branch, Division of Clinical Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, United States AU - Corbett, K. S. AU - Edwards, D. K. AU - Leist, S. R. AU - Abiona, O. M. AU - Boyoglu-Barnum, S. AU - Gillespie, R. A. AU - Himansu, S. AU - Schäfer, A. AU - Ziwawo, C. T. AU - DiPiazza, A. T. AU - Dinnon, K. H. AU - Elbashir, S. M. AU - Shaw, C. A. AU - Woods, A. AU - Fritch, E. J. AU - Martinez, D. R. AU - Bock, K. W. AU - Minai, M. AU - Nagata, B. M. AU - Hutchinson, G. B. AU - Wu, K. AU - Henry, C. AU - Bahl, K. AU - Garcia-Dominguez, D. AU - Ma, L. Z. AU - Renzi, I. AU - Kong, W. P. AU - Schmidt, S. D. AU - Wang, L. AU - Zhang, Y. AU - Phung, E. AU - Chang, L. A. AU - Loomis, R. J. AU - Altaras, N. E. AU - Narayanan, E. AU - Metkar, M. AU - Presnyak, V. AU - Liu, C. AU - Louder, M. K. AU - Shi, W. AU - Leung, K. AU - Yang, E. S. AU - West, A. AU - Gully, K. L. AU - Stevens, L. J. AU - Wang, N. AU - Wrapp, D. AU - Doria-Rose, N. A. AU - Stewart-Jones, G. AU - Bennett, H. AU - Alvarado, G. S. AU - Nason, M. C. AU - Ruckwardt, T. J. AU - McLellan, J. S. AU - Denison, M. R. AU - Chappell, J. D. AU - Moore, I. N. AU - Morabito, K. M. AU - Mascola, J. R. AU - Baric, R. S. AU - Carfi, A. AU - Graham, B. S. C2 - 32756549 DB - Scopus DO - 10.1038/s41586-020-2622-0 IS - 7830 J2 - Nature KW - nanoparticle neutralizing antibody SARS-CoV-2 vaccine COVID-19 vaccine messenger RNA Tlr4 protein, mouse toll like receptor 4 virus RNA virus vaccine design method disease control immune response immunity mutation virus animal experiment animal model animal tissue antibody response Article CD8+ T lymphocyte controlled study coronavirus disease 2019 drug design female human human cell immunopathology male mouse nonhuman priority journal Th1 cell Th2 cell animal Betacoronavirus chemistry Coronavirus infection genetics immunology lung nose pandemic phase 3 clinical trial (topic) virology virus pneumonia Coronavirus Mus SARS coronavirus Animals Antibodies, Neutralizing CD8-Positive T-Lymphocytes Clinical Trials, Phase III as Topic Coronavirus Infections Mice Pandemics Pneumonia, Viral RNA, Messenger RNA, Viral Th1 Cells Toll-Like Receptor 4 Viral Vaccines LA - English M3 - Article N1 - Cited By :108 Export Date: 4 May 2021 CODEN: NATUA Correspondence Address: Graham, B.S.; Vaccine Research Center, United States; email: bgraham@nih.gov Correspondence Address: Carfi, A.; Moderna IncUnited States; email: andrea.carfi@modernatx.com Chemicals/CAS: toll like receptor 4, 203811-83-0; Antibodies, Neutralizing; COVID-19 vaccine; RNA, Messenger; RNA, Viral; Tlr4 protein, mouse; Toll-Like Receptor 4; Viral Vaccines Funding details: 5494549, 75N93019F00132, HHSN272201700036I, T32-AI007151 Funding details: AI100625, AI149644, R01-AI127521 Funding details: National Institutes of Health, NIH Funding details: U.S. Department of Health and Human Services, HHS Funding details: National Institute of Allergy and Infectious Diseases, NIAID Funding details: Burroughs Wellcome Fund, BWF Funding details: Office of the Assistant Secretary for Health, OASH Funding details: Biomedical Advanced Research and Development Authority, BARDA, 17x198, 75A50120C00034 Funding text 1: Acknowledgements We thank K. Bok, K. Carlton, M. Kanekiyo, R. Seder and other members of all included laboratories for critical discussions, advice and review of the manuscript; J. Stein for technology transfer; M. Young for administrative support; members of the NIH NIAID VRC Translational Research Program for technical assistance with mouse experiments; B. Hartman for assistance with graphics; H. Mu and M. Farzan for the ACE2-overexpressing 293 cells; and M. Whitt for support on VSV-based pseudovirus production. This work was supported by the Intramural Research Program of the VRC and the Division of Intramural Research, NIAID, NIH (B.S.G.), NIH NIAID grant R01-AI127521 (J.S.M.), and NIH grants AI149644 and AI100625 (R.S.B.). mRNA-1273 has been funded in part with Federal funds from the Department of Health and Human Services, Office of the Assistant Secretary for Preparedness and Response, Biomedical Advanced Research and Development Authority, under contract 75A50120C00034. 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Virol, 80, pp. 9896-9898; Whitt, M.A., Generation of VSV pseudotypes using recombinant ΔG-VSV for studies on virus entry, identification of entry inhibitors, and immune responses to vaccines (2010) J. Virol. Methods, 169, pp. 365-374. , COI: 1:CAS:528:DC%2BC3cXht1WisrjM PY - 2020 SN - 00280836 (ISSN) SP - 567-571 ST - SARS-CoV-2 mRNA vaccine design enabled by prototype pathogen preparedness T2 - Nature TI - SARS-CoV-2 mRNA vaccine design enabled by prototype pathogen preparedness UR - https://www.scopus.com/inward/record.uri?eid=2-s2.0-85088965235&doi=10.1038%2fs41586-020-2622-0&partnerID=40&md5=fb76420160f36a64ab05edcb68f3451f VL - 586 ID - 320 ER - TY - JOUR AB - BACKGROUND Vaccines to prevent coronavirus disease 2019 (Covid-19) are urgently needed. The effect of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines on viral replication in both upper and lower airways is important to evaluate in nonhuman primates. METHODS Nonhuman primates received 10 or 100 μg of mRNA-1273, a vaccine encoding the prefusion-stabilized spike protein of SARS-CoV-2, or no vaccine. Antibody and T-cell responses were assessed before upper- and lower-airway challenge with SARS-CoV-2. Active viral replication and viral genomes in bronchoalveolar-lavage (BAL) fluid and nasal swab specimens were assessed by polymerase chain reaction, and histopathological analysis and viral quantification were performed on lung-tissue specimens. RESULTS The mRNA-1273 vaccine candidate induced antibody levels exceeding those in human convalescent-phase serum, with live-virus reciprocal 50% inhibitory dilution (ID50) geometric mean titers of 501 in the 10-μg dose group and 3481 in the 100-μg dose group. Vaccination induced type 1 helper T-cell (Th1)–biased CD4 T-cell responses and low or undetectable Th2 or CD8 T-cell responses. Viral replication was not detectable in BAL fluid by day 2 after challenge in seven of eight animals in both vaccinated groups. No viral replication was detectable in the nose of any of the eight animals in the 100-μg dose group by day 2 after challenge, and limited inflammation or detectable viral genome or antigen was noted in lungs of animals in either vaccine group. CONCLUSIONS Vaccination of nonhuman primates with mRNA-1273 induced robust SARS-CoV-2 neutralizing activity, rapid protection in the upper and lower airways, and no pathologic changes in the lung. Copyright © 2020 Massachusetts Medical Society. AD - Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, United States Infectious Disease Pathogenesis Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, United States Biostatistics Research Branch, Division of Clinical Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, United States Bioqual, Rockville, MD, United States Public Health Service Commissioned Corps, Rockville, MD, United States Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, MA, United States Moderna, Cambridge, MA, United States Institute for Biomedical Sciences, George Washington University, Washington, DC, United States AU - Corbett, K. S. AU - Flynn, B. AU - Foulds, K. E. AU - Francica, J. R. AU - Boyoglu-Barnum, S. AU - Werner, A. P. AU - Flach, B. AU - O'Connell, S. AU - Bock, K. W. AU - Minai, M. AU - Nagata, B. M. AU - Andersen, H. AU - Martinez, D. R. AU - Noe, A. T. AU - Douek, N. AU - Donaldson, M. M. AU - Nji, N. N. AU - Alvarado, G. S. AU - Edwards, D. K. AU - Flebbe, D. R. AU - Lamb, E. AU - Doria-Rose, N. A. AU - Lin, B. C. AU - Louder, M. K. AU - O'Dell, S. AU - Schmidt, S. D. AU - Phung, E. AU - Chang, L. A. AU - Yap, C. AU - Todd, J. P. M. AU - Pessaint, L. AU - Van Ry, A. AU - Browne, S. AU - Greenhouse, J. AU - Putman-Taylor, T. AU - Strasbaugh, A. AU - Campbell, T. A. AU - Cook, A. AU - Dodson, A. AU - Steingrebe, K. AU - Shi, W. AU - Zhang, Y. AU - Abiona, O. M. AU - Wang, L. AU - Pegu, A. AU - Yang, E. S. AU - Leung, K. AU - Zhou, T. AU - Teng, I. T. AU - Widge, A. AU - Gordon, I. AU - Novik, L. AU - Gillespie, R. A. AU - Loomis, R. J. AU - Moliva, J. I. AU - Stewart-Jones, G. AU - Himansu, S. AU - Kong, W. P. AU - Nason, M. C. AU - Morabito, K. M. AU - Ruckwardt, T. J. AU - Ledgerwood, J. E. AU - Gaudinski, M. R. AU - Kwong, P. D. AU - Mascola, J. R. AU - Carfi, A. AU - Lewis, M. G. AU - Baric, R. S. AU - McDermott, A. AU - Moore, I. N. AU - Sullivan, N. J. AU - Roederer, M. AU - Seder, R. A. AU - Graham, B. S. C2 - 32722908 DB - Scopus DO - 10.1056/NEJMoa2024671 IS - 16 J2 - New Engl. J. Med. KW - mRNA 1273 RNA vaccine SARS-CoV-2 antibody SARS-CoV-2 vaccine unclassified drug CD4 antigen coronavirus spike glycoprotein COVID-19 vaccine neutralizing antibody spike protein, SARS-CoV-2 virus antibody virus vaccine animal experiment animal model animal tissue antibody response Article bronchoalveolar lavage fluid CD4+ T lymphocyte CD8+ T lymphocyte controlled study coronavirus disease 2019 drug screening female histopathology male nonhuman nose smear polymerase chain reaction primate priority journal Th1 cell Th2 cell vaccination virus genome virus replication animal Betacoronavirus blood Coronavirus infection disease model dose response immunology lung pandemic passive immunization pathology physiology rhesus monkey T lymphocyte virology virus load virus pneumonia Animals Antibodies, Neutralizing Antibodies, Viral CD4 Antigens Coronavirus Infections Disease Models, Animal Dose-Response Relationship, Immunologic Immunization, Passive Macaca mulatta Pandemics Pneumonia, Viral Spike Glycoprotein, Coronavirus T-Lymphocytes Viral Load Viral Vaccines LA - English M3 - Article N1 - Cited By :165 Export Date: 4 May 2021 CODEN: NEJMA Chemicals/CAS: Antibodies, Neutralizing; Antibodies, Viral; CD4 Antigens; COVID-19 vaccine; Spike Glycoprotein, Coronavirus; spike protein, SARS-CoV-2; Viral Vaccines Funding details: National Institutes of Health, NIH Funding details: U.S. Department of Health and Human Services, HHS, 75A50120C00034, F32 AI152296, T32-AI007151 Funding details: National Institute of Allergy and Infectious Diseases, NIAID Funding details: Burroughs Wellcome Fund, BWF Funding details: Office of the Assistant Secretary for Health, OASH Funding details: Biomedical Advanced Research and Development Authority, BARDA Funding details: Vaccine Research Center, VRC Funding text 1: Supported by the Intramural Research Program of the Vaccine Research Center (VRC), National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH); and the Office of the Assistant Secretary for Preparedness and Response, Biomedical Advanced Research and Development Authority, Department of Health and Human Services (contract 75A50120C00034). Dr. Corbett is the recipient of a research fellowship that was partially funded by the Undergraduate Scholarship Program, Office of Intramural Training and Education, Office of the Director, NIH. Dr. Martinez was funded by grants from the NIAID (T32-AI007151 and F32 AI152296) and a Burroughs Wellcome Fund Postdoctoral Enrichment Program Award. 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J. Bioeth, 16, pp. 3-11 PY - 2020 SN - 16617827 (ISSN) ST - Risk perception and covid-19 T2 - International Journal of Environmental Research and Public Health TI - Risk perception and covid-19 UR - https://www.scopus.com/inward/record.uri?eid=2-s2.0-85084276281&doi=10.3390%2fijerph17093114&partnerID=40&md5=4df1e65de4780e137fb01cd7680d25fa VL - 17 ID - 510 ER - TY - JOUR AD - Department of Microbiology Immunology, University of North Carolina—Chapel Hill, Chapel Hill, NC, United States AU - Cotter, P. A. C2 - 32703893 DB - Scopus DO - 10.1128/JCM.01228-20 IS - 8 J2 - J. Clin. Microbiol. KW - COVID-19 COVID-19 testing Molecular diagnostics SARS-CoV-2 asymptomatic infection case report chest tightness chill clinical article common cold symptom contact examination coronavirus disease 2019 cycling disease course false negative result false positive result fatigue female fever human influenza intensive care unit isolation laboratory test medical record North Carolina Note personal experience priority journal quarantine Severe acute respiratory syndrome coronavirus 2 social interaction telehealth throat culture virus detection virus transmission Betacoronavirus Coronavirus infection isolation and purification laboratory technique organization and management pandemic preventive health service procedures university hospital virology virus pneumonia Academic Medical Centers Clinical Laboratory Techniques Coronavirus Infections Diagnostic Services Hospitals, University Humans Pandemics Pneumonia, Viral LA - English M3 - Note N1 - Export Date: 4 May 2021 CODEN: JCMID Correspondence Address: Cotter, P.A.; Department of Microbiology Immunology, United States; email: pcotter@med.unc.edu PY - 2020 SN - 00951137 (ISSN) ST - My experience with SARS-CoV-2, with a focus on testing T2 - Journal of Clinical Microbiology TI - My experience with SARS-CoV-2, with a focus on testing UR - https://www.scopus.com/inward/record.uri?eid=2-s2.0-85088497274&doi=10.1128%2fJCM.01228-20&partnerID=40&md5=b96f238bab7045e00b068795db25c40f VL - 58 ID - 425 ER - TY - JOUR AB - Objectives To determine how self-reported level of exposure to patients with novel coronavirus 2019 (COVID-19) affected the perceived safety, training and well-being of residents and fellows. Methods We administered an anonymous, voluntary, web-based survey to a convenience sample of trainees worldwide. The survey was distributed by email and social media posts from April 20th to May 11th, 2020. Respondents were asked to estimate the number of patients with COVID-19 they cared for in March and April 2020 (0, 1-30, 31-60, >60). Survey questions addressed (1) safety and access to personal protective equipment (PPE), (2) training and professional development and (3) well-being and burnout. Results Surveys were completed by 1420 trainees (73% residents, 27% fellows), most commonly from the USA (n=670), China (n=150), Saudi Arabia (n=76) and Taiwan (n=75). Trainees who cared for a greater number of patients with COVID-19 were more likely to report limited access to PPE and COVID-19 testing and more likely to test positive for COVID-19. Compared with trainees who did not take care of patients with COVID-19, those who took care of 1-30 patients (adjusted OR [AOR] 1.80, 95% CI 1.29 to 2.51), 31-60 patients (AOR 3.30, 95% CI 1.86 to 5.88) and >60 patients (AOR 4.03, 95% CI 2.12 to 7.63) were increasingly more likely to report burnout. Trainees were very concerned about the negative effects on training opportunities and professional development irrespective of the number of patients with COVID-19 they cared for. Conclusion Exposure to patients with COVID-19 is significantly associated with higher burnout rates in physician trainees. © Author(s) (or their employer(s)) 2020. No commercial re-use. See rights and permissions. Published by BMJ. AD - Division of Gastroenterology, Department of Medicine, Veterans Affairs Puget Sound Healthcare System, University of Washington, Seattle, WA, United States Department of Gastroenterology and Hepatology, Washington DC Veterans Affair Medical Center, Washington, DC, United States Department of Medicine, University of Maryland, Baltimore, MD, United States Department of Medicine, Rutgers Robert Wood Johnson Medical School, New Brunswick, United States Division of Gastroenterology, Department of Medicine, Duke University Hospital, Durham, NC, United States Division of Gastroenterology and Hepatology, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States CHESS Center, Institute of Portal Hypertension, First Hospital of Lanzhou University, Lanzhou, China VA New York Harbor Health Care System and NYU Langone Health, New York, NY, United States Division of Gastroenterology, Hepatology, and Nutrition, University of Minnesota, Minneapolis, MN, United States Department of Gastroenterology, NorthShore University Health System, Evanston, IL, United States University of Texas, Southwestern Medical Center, Dallas, TX, United States Division of Gastroenterology, David Geffen School of Medicine at UCLA, Division of Digestive Diseases, VA Greater Los Angeles Healthcare System, Los Angeles, CA, United States Division of Gastroenterology and Hepatology, Mayo Clinic, Jacksonville, FL, United States Division of Gastroenterology and Hepatology, University of Toledo Medical Center, Toledo, OH, United States Division of Gastroenterology and Transplant Hepatology, University of Jeddah, Jeddah, Saudi Arabia Department of Medicine, Phoenix Veterans Affairs Medical Center, University of Arizona, College of Medicine, Phoenix, AZ, United States AU - Cravero, A. L. AU - Kim, N. J. AU - Feld, L. D. AU - Berry, K. AU - Rabiee, A. AU - Bazarbashi, N. AU - Bassin, S. AU - Lee, T. H. AU - Moon, A. M. AU - Qi, X. AU - Liang, P. S. AU - Aby, E. S. AU - Khan, M. Q. AU - Young, K. J. AU - Patel, A. AU - Wijarnpreecha, K. AU - Kobeissy, A. AU - Hashim, A. AU - Houser, A. AU - Ioannou, G. N. C2 - 33087533 C7 - 138789 DB - Scopus DO - 10.1136/postgradmedj-2020-138789 J2 - Postgrad. Med. J. LA - English M3 - Review N1 - Cited By :1 Export Date: 4 May 2021 CODEN: PGMJA Correspondence Address: Ioannou, G.N.; Veterans Affairs Puget Sound Healthcare System, 1660 S. Columbian Way, United States; email: georgei@medicine.washington.edu References: Li, Q., Guan, X., Wu, P., Early transmission dynamics in Wuhan, China, of novel coronavirus-infected pneumonia (2020) N Engl J Med, 382, pp. 1199-1207; (2020) WHO Director-General's Opening Remarks at the Media Briefing on COVID-19: 11 March 2020, , WHO. 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Participants Members of the SBSM COVID-19 Task Force. Results/Conclusions Herein is a summary of the resources developed by the SBSM COVID-19 Task force, which includes links to online materials developed for use by providers and patients, as well as brief descriptions of key recommendations by the Task Force for specific sleep conditions (e.g., acute insomnia, nightmares) and vulnerable populations (e.g., parents, essential/healthcare workers, older adults). © 2020, © 2020 Taylor & Francis Group, LLC. AD - Behavioral Health Program, Mental Health Care Line, Michael E. DeBakey VA Medical Center, Houston, TX, United States Division of Public Health, Department of Family and Preventive Medicine, University of Utah, Salt Lake, UT, United States Department of Psychiatry, University of Arizona College of Medicine, Tucson, AZ, United States Division of Developmental/Behavioral Pediatrics & Psychology, Rainbow Babies & Children’s Hospital, University Hospitals Cleveland Medical Center, Cleveland, OH, United States Department of Psychiatry, University of Missouri, Columbia, MO, United States Department of Psychology, Mississippi State UniversityMS, United States Department of Medicine - Health Services Research, Baylor College of Medicine, Houston, TX, United States Division of Pain Medicine, Department of Anesthesiology, UNC School of Medicine, Chapel Hill, NC, United States , Society of Behavioral Sleep Medicine, Lexington, KY, United States AU - Crew, E. C. AU - Baron, K. G. AU - Grandner, M. A. AU - Ievers-Landis, C. E. AU - McCrae, C. S. AU - Nadorff, M. R. AU - Nowakowski, S. AU - Ochsner Margolies, S. AU - Hansen, K. DB - Scopus DO - 10.1080/15402002.2020.1776288 IS - 4 J2 - Behav. Sleep Med. LA - English M3 - Article N1 - Cited By :4 Export Date: 4 May 2021 Correspondence Address: Crew, E.C.; Behavioral Health Program, United States; email: earl.crew2@va.gov References: Ellis, J.G., Cushing, T., Germain, A., Treating acute insomnia: A randomized controlled trial of a “single-shot” of cognitive behavioral therapy for insomnia (2015) Sleep, 38 (6), pp. 971-978. , https://doi.org/10.5665/sleep.4752; Ong, J.C., Arand, D., Schmitz, M., Baron, K., Blackburn, R., Grandner, M.A., Lichstein, K.L., Hansen, K., A concept map of behavioral sleep medicine: Defining the scope of the field and strategic priorities (2018) Behavioral Sleep Medicine, 16 (6), pp. 523-526. , https://doi.org/10.1080/15402002.2018.1507672 PY - 2020 SN - 15402002 (ISSN) SP - 570-572 ST - The Society of Behavioral Sleep Medicine (SBSM) COVID-19 Task Force: Objectives and Summary Recommendations for Managing Sleep during a Pandemic T2 - Behavioral Sleep Medicine TI - The Society of Behavioral Sleep Medicine (SBSM) COVID-19 Task Force: Objectives and Summary Recommendations for Managing Sleep during a Pandemic UR - https://www.scopus.com/inward/record.uri?eid=2-s2.0-85087413201&doi=10.1080%2f15402002.2020.1776288&partnerID=40&md5=eab7e2ac03900407a3df1c8d4ab13d32 VL - 18 ID - 450 ER - TY - JOUR AB - Antimicrobial surface coatings function as a contact biocide and are extensively used to prevent the growth and transmission of pathogens on environmental surfaces. Currently, scientists and researchers are intensively working to develop antimicrobial, antiviral coating solutions that would efficiently impede/stop the contagion of COVID-19 via surface contamination. Herein we present a flavonoid-based antimicrobial surface coating fabricated by laser processing that has the potential to eradicate COVID-19 contact transmission. Quercetin-containing coatings showed better resistance to microbial colonization than antibiotic-containing ones. Copyright © The Author(s), 2020, published on behalf of Materials Research Society by Cambridge University Press. AD - National Institute for Lasers, Plasma and Radiation Physics, Lasers Department, Bucharest-Magurele, Romania Biomedical Engineering, University of North Carolina, Chapel Hill, NC, United States Department of Physics and Engineering Physics, Tulane University, New Orleans, LA, United States AU - Cristescu, R. AU - Narayan, R. J. AU - Chrisey, D. B. DB - Scopus DO - 10.1557/adv.2020.418 J2 - MRS Advances KW - Coatings Microorganisms Antimicrobial surface Antimicrobial surface coatings Coating solution Environmental surfaces Flavonoid Laser process Microbial colonization Surface contaminations Transmissions LA - English M3 - Article N1 - Export Date: 4 May 2021 Correspondence Address: Narayan, R.J.; Biomedical Engineering, United States; email: roger_narayan@unc.edu References: Xu, S., Li, Y., (2020) The Lancet, 395, pp. 1321-1322; https://www.worldometers.info/coronavirus, World Coronavirus Statistics 2020 accessed 17 September 2020; Pushpakom, S., Iorio, F., Eyers, P.A., Escott, K.J., Hopper, S., Wells, A., Doig, A., Norris, A., (2019) Nat. Rev. Drug Discov, 18, p. 41; Abian, O., Ortega-Alarcon, D., Jimenez-Alesanco, A., Ceballos-Laita, L., Vega, S., Reyburn, H.T., Rizzuti, B., Velazquez-Campoy, A., (2020) Int. J. Biol. Macromol, 164, p. 1693; Rawson, T.M., Ming, D., Ahmad, R., More, L.S.P., Holmes, A.H., (2020) Nat. Rev. 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Wellesley: BCC Research PY - 2020 SN - 20598521 (ISSN) ST - Novel antimicrobial surfaces to defeat COVID-19 transmission T2 - MRS Advances TI - Novel antimicrobial surfaces to defeat COVID-19 transmission UR - https://www.scopus.com/inward/record.uri?eid=2-s2.0-85097297720&doi=10.1557%2fadv.2020.418&partnerID=40&md5=687157643dc8251fa089141880a2c449 ID - 536 ER - TY - JOUR AB - Urgent responses to the COVID-19 pandemic depend on increased collaboration and sharing of data, models, and resources among scientists and researchers. In many scientific fields and disciplines, institutional norms treat data, models, and resources as proprietary, emphasizing competition among scientists and researchers locally and internationally. Concurrently, long-standing norms of open data and collaboration exist in some scientific fields and have accelerated within the last two decades. In both cases—where the institutional arrangements are ready to accelerate for the needed collaboration in a pandemic and where they run counter to what is needed—the rules of the game are “on the table” for institutional-level renegotiation. These challenges to the negotiated order in science are important, difficult to study, and highly consequential. The COVID-19 pandemic offers something of a natural experiment to study these dynamics. Preliminary findings highlight: the chilling effect of politics where open sharing could be expected to accelerate; the surprisingly conservative nature of contests and prizes; open questions around whether collaboration will persist following an inflection point in the pandemic; and the strong potential for launching and sustaining pre-competitive initiatives. © 2020 President and Fellows of Harvard College AD - Heller School for Social Policy and Management, Brandeis University, United States School of Information Sciences, University of Illinois at Urbana Champaign, United States University of Notre Dame, United States Fletcher, School of Law and Diplomacy, Tufts University, United States CEO of WayMark Analytics, Inc, United States Department of Genetics and Biochemistry at Clemson University, United States Department of Management, Faculty of Management and Economics at, Universidad de Santiago de Chile, United States University of Virginia, United States School of Information, University of Michigan, United States San Diego Supercomputer Center, University of California, San Diego, United States Environmental Data Science and Systems, RENCI (Renaissance Computer Institute), University of North Carolina at Chapel Hill, United States Brandeis University, United States School of Labor and Employment Relations, Penn State University, United States WayMark Analytics, United States Philosophy of Justice, Rights, and Social Change at the Heller School for Social Policy and Management, Brandeis University, United States Seidenberg School of Computer Science and Information Systems, Pace University, United States American Geophysical Union, United States College of Information Studies, University of Maryland, United States Alaska Center for Energy and Power, University of Alaska Fairbanks, United States AU - Cutcher-Gershenfeld, J. AU - Baker, K. S. AU - Berente, N. AU - Berkman, P. A. AU - Canavan, P. AU - Feltus, F. A. AU - Garmulewicz, A. AU - Hutchins, R. AU - King, J. L. AU - Kirkpatrick, C. AU - Lenhardt, C. AU - Lewis, S. AU - Maffe, M. AU - Mittleman, B. AU - Sampath, R. AU - Shin, N. AU - Stall, S. AU - Winter, S. AU - Veazey, P. DB - Scopus DO - 10.1111/nejo.12340 IS - 4 J2 - Negot. J. KW - alignment COVID-19 data forums institutions interests models negotiated order negotiations pandemic resources rules of the game stakeholders LA - English M3 - Article N1 - Cited By :1 Export Date: 4 May 2021 Correspondence Address: Cutcher-Gershenfeld, J.; Heller School for Social Policy and Management, United States; email: joelcg@brandeis.edu Funding details: National Center for Atmospheric Research, NCAR Funding text 1: We appreciate the additional contributions of Mathew Mayernik, National Center for Atmospheric Research. 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Available from PY - 2020 SN - 07484526 (ISSN) SP - 497-534 ST - Negotiated Sharing of Pandemic Data, Models, and Resources T2 - Negotiation Journal TI - Negotiated Sharing of Pandemic Data, Models, and Resources UR - https://www.scopus.com/inward/record.uri?eid=2-s2.0-85091826497&doi=10.1111%2fnejo.12340&partnerID=40&md5=4cac51137a78abc4e549c444fb6a7c68 VL - 36 ID - 370 ER - TY - JOUR AB - Background: SARS-CoV-2 infection among People Living With HIV (PLWH) is not well-described. Objective: To study COVID-19 symptoms and SARS-CoV-2 PCR-based swab testing among participants of the Multicenter AIDS Cohort Study (MACS) and Women’s Interagency HIV Study (WIHS). Methods: A telephone survey was collected April-June 30, 2020. Symptom and testing prevalence were explored. Multivariable logistic regression was used to examine the factors associated with SARS-CoV-2 positivity. Results: The survey was completed by 3411 participants, including 2078 (61%) PLWH and 1333 HIV-seronegative (SN) participants from across the US. Thirteen percent (n = 441) were tested for SARS-CoV-2 infection (13.4% of PLWH vs 12.2% of SN). Among those tested, positivity was higher in PLWH than SN (11.2% vs 6.1%, p = 0.08). Reasons for not being tested included testing not being available (30% of participants) and not knowing where to get tested (16% of participants). Most symptoms reported since January 2020 were similar in PLWH and SN, including headache (23% vs. 24%), myalgias (19% vs 18%), shortness of breath (14% vs 13%), chills (12% vs 10%), fever (6% vs 6%) and loss of taste or smell (6% vs 7%). Among PLWH who tested positive for SARS-CoV-2 DNA, the most common symptoms were headache (71%), myalgia (68%), cough (68%) and chills (65%). In multivariable analysis among those tested, the odds of SARS-CoV-2 positivity were higher among PLWH than SN (aOR = 2.22 95%CI = 01.01–4.85, p = 0.046) and among those living with others versus living alone (aOR = 2.95 95%CI = 1.18–7.40). Conclusion: Prevalence and type of COVID-19 symptoms were similar in PLWH and SN. SARS-CoV-2 infection may be elevated among PLWH. © 2020 Informa UK Limited, trading as Taylor & Francis Group. AD - Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, United States Department of Neurology, State of New York Downstate Health Sciences University, Brooklyn, NY, United States Department of Medicine, Division of Infectious Diseases, Georgetown University, Washington, DC, United States Department of Medicine, Division of Infectious Diseases, University of Miami Miller School of Medicine, Miami, Fl, United States Department of Medicine, UNC School Division of Medicine, The Infectious Diseases, University of North Carolina School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States Department of Medicine, Albert Einstein College of Medicine, Bronx, NY, United States Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, United States Department of Medicine, University of California, San Francisco and Department of Veterans Affairs, San Francisco, CA, United States Department of Epidemiology, Fielding School of Public Health, UCLA, Los Angeles, CA, United States Schools of Nursing, Public Health and Medicine, University of Alabama at Birmingham, Birmingham, AL, United States Department of Medicine, Division of Infectious Diseases, Emory University School of Medicine, Atlanta, GA, United States Department of Infectious Diseases and Microbiology, Department of Pathology, University of Pittsburgh, Pittsburgh, PA, United States Department of Medicine, CORE Center/Stroger Hospital of Cook County, Chicago, IL, United States Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, United States Department of Epidemiology, UNC Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States AU - D’Souza, G. AU - Springer, G. AU - Gustafson, D. AU - Kassaye, S. AU - Alcaide, M. L. AU - Ramirez, C. AU - Sharma, A. AU - Palella, F. J. AU - Tien, P. C. AU - Detels, R. AU - Kempf, M. C. AU - Lahiri, C. D. AU - Rinaldo, C. R. AU - French, A. L. AU - Margolick, J. B. AU - Adimora, A. A. C2 - 33211636 DB - Scopus DO - 10.1080/25787489.2020.1844521 J2 - HIV Res. Clin. Pract. KW - COVID-19 epidemiology HIV MWCCS PLWH SARS-CoV-2 symptoms testing acquired immune deficiency syndrome adult aged ageusia anosmia coughing dyspnea female fever headache human Human immunodeficiency virus infection induced hypothermia isolation and purification middle aged mixed infection pathophysiology prevalence United States very elderly virology Acquired Immunodeficiency Syndrome Aged, 80 and over Chills Coinfection Cough HIV Infections Humans LA - English M3 - Article N1 - Cited By :3 Export Date: 4 May 2021 Correspondence Address: D’Souza, G.; Johns Hopkins School of Public Health, 615 N Wolfe St, United States Correspondence Address: Adimora, A.A.; Johns Hopkins School of Public Health, 615 N Wolfe St, United States Funding details: P30-AI-050410 Funding details: K23AI124913 Funding details: National Institutes of Health, NIH Funding details: National Institute of Mental Health, NIMH Funding details: National Institute on Drug Abuse, NIDA Funding details: National Institute on Alcohol Abuse and Alcoholism, NIAAA Funding details: National Institute on Aging, NIA Funding details: National Heart, Lung, and Blood Institute, NHLBI Funding details: National Cancer Institute, NCI Funding details: National Institute on Deafness and Other Communication Disorders, NIDCD Funding details: National Institute of Nursing Research, NINR Funding details: National Institute of Allergy and Infectious Diseases, NIAID Funding details: National Institute of Diabetes and Digestive and Kidney Diseases, NIDDK Funding details: National Institute of Neurological Disorders and Stroke, NINDS Funding details: National Institute of Dental and Craniofacial Research, NIDCR Funding details: Merck Funding details: Gilead Sciences Funding details: Office of AIDS Research, OAR, UL1-TR000004 Funding details: National Institute on Minority Health and Health Disparities, NIMHD Funding details: University of California, San Francisco, UCSF, P30-AI-050409 Funding details: Eunice Kennedy Shriver National Institute of Child Health and Human Development, NICHD Funding details: Center for AIDS Research, University of North Carolina at Chapel Hill, UNC CFAR, P30-AI-027767 Funding text 1: The contents of this publication are solely the responsibility of the authors and do not represent the official views of the National Institutes of Health (NIH). MWCCS (Principal Investigators): Atlanta CRS (Ighovwerha Ofotokun, Anandi Sheth, and Gina Wingood), U01-HL146241; Baltimore CRS (Todd Brown and Joseph Margolick), U01-HL146201; Bronx CRS (Kathryn Anastos and Anjali Sharma), U01-HL146204; Brooklyn CRS (Deborah Gustafson and Tracey Wilson), U01-HL146202; Data Analysis and Coordination Center (Gypsyamber D’Souza, Stephen Gange and Elizabeth Golub), U01-HL146193; Chicago-Cook County CRS (Mardge Cohen and Audrey French), U01-HL146245; Chicago-Northwestern CRS (Steven Wolinsky), U01-HL146240; Northern California CRS (Bradley Aouizerat, Jennifer Price, and Phyllis Tien), U01-HL146242; Los Angeles CRS (Roger Detels), U01-HL146333; Metropolitan Washington CRS (Seble Kassaye and Daniel Merenstein), U01-HL146205; Miami CRS (Maria Alcaide, Margaret Fischl, and Deborah Jones), U01-HL146203; Pittsburgh CRS (Jeremy Martinson and Charles Rinaldo), U01-HL146208; UAB-MS CRS (Mirjam-Colette Kempf, Jodie Dionne-Odom, and Deborah Konkle-Parker), U01-HL146192; UNC CRS (Adaora Adimora), U01-HL146194. The MWCCS is funded primarily by the National Heart, Lung, and Blood Institute (NHLBI), with additional co-funding from the Eunice Kennedy Shriver National Institute Of Child Health & Human Development (NICHD), National Institute On Aging (NIA), National Institute Of Dental & Craniofacial Research (NIDCR), National Institute Of Allergy And Infectious Diseases (NIAID), National Institute Of Neurological Disorders And Stroke (NINDS), National Institute Of Mental Health (NIMH), National Institute On Drug Abuse (NIDA), National Institute Of Nursing Research (NINR), National Cancer Institute (NCI), National Institute on Alcohol Abuse and Alcoholism (NIAAA), National Institute on Deafness and Other Communication Disorders (NIDCD), National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), National Institute on Minority Health and Health Disparities (NIMHD), and in coordination and alignment with the research priorities of the National Institutes of Health, Office of AIDS Research (OAR). MWCCS data collection is also supported by UL1-TR000004 (UCSF CTSA), P30-AI-050409 (Atlanta CFAR), P30-AI-050410 (UNC CFAR), and P30-AI-027767 (UAB CFAR). Dr. Lahiri is also supported by NIH/NIAID K23AI124913. Funding text 2: Palella FJ has been a consultant and/or has provided lectures for the following: Gilead Sciences, Janssen Pharmaceuticals, ViiV Healthcare and Merck. Sharma A has received grant funding from Gilead Sciences, Inc. PCT has received grant support from Merck. Aadimora AA has received consulting fees from Viiv, and Gilead and her institution has received funding from Gilead for her research. All other authors have no conflicts to report. 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Accessed July 13, 2020; Masukume, G., Mapanga, W., Grinberg, S., van Zyl, D.S., COVID-19 and HIV co-infection an emerging consensus [Epub Ahead of Print] J Med Virol., , https://doi.org/10.1002/jmv.26270; Stokes, E.K., Zambrano, L.D., Anderson, K.N., Coronavirus disease 2019 case surveillance — United States, January 22–May 30, 2020 (2020) MMWR Morb Mortal Wkly Rep., 69 (24), pp. 759-765; Stawicki, S.P., Jeanmonod, R., Miller, A.C., The 2019-2020 novel coronavirus (severe acute respiratory syndrome coronavirus 2) pandemic: a Joint American College of Academic International Medicine-World Academic Council of Emergency Medicine Multidisciplinary COVID-19 Working Group Consensus Paper (2020) J Glob Infect Dis., 12 (2), pp. 47-93 PY - 2020 SN - 25787489 (ISSN) ST - COVID-19 symptoms and SARS-CoV-2 infection among people living with HIV in the US: the MACS/WIHS combined cohort study T2 - HIV Research and Clinical Practice TI - COVID-19 symptoms and SARS-CoV-2 infection among people living with HIV in the US: the MACS/WIHS combined cohort study UR - https://www.scopus.com/inward/record.uri?eid=2-s2.0-85096370608&doi=10.1080%2f25787489.2020.1844521&partnerID=40&md5=e2cf8fcb03e8484a9a1384d07a68d0ca ID - 541 ER - TY - JOUR AD - University of North Carolina School of Medicine, Chapel Hill, United States Yale New Haven Medical Center, Waterbury Hospital, Waterbury, CT, United States Division of Cardiology, Department of Medicine, University of North Carolina at Chapel Hill, 6033 Burnett-Womack Building, 160 Dental Cir, Chapel Hill, NC 27599, United States AU - Davari, D. AU - Mirzaei, M. AU - Simpson, R. J., Jr. C2 - 32628247 DB - Scopus DO - 10.1001/jamainternmed.2020.1912 32150242; Gan, Z.S.W., Choi, W., Lin, F.C., Factors underlying increased incidence of sudden unexpected death in rural counties in north carolina (2019) J Gen Intern Med, 34 (6), pp. 815-817. , http://dx.doi.org/10.1007/s11606-018-4771-5, doi: 30684197; Rural Hunger in America - SNAP: Get the Facts, , https://frac.org/research/resource-library/rural-hunger-america-snap-get-facts, Accessed March 26, 2020; Mounsey, L.A., Lin, F.C., Pursell, I., Relation of household income to incidence of sudden unexpected death in Wake County, North Carolina (2017) Am J Cardiol, 119 (7), pp. 1030-1035. , http://dx.doi.org/10.1016/j.amjcard.2016.11.061, doi: 28187864; Chart Book: SNAP Helps Struggling Families Put Food on the Table, , https://www.cbpp.org/research/food-assistance/chart-book-snap-helps-struggling-families-put-food-on-the-table, Accessed March 31, 2020 IS - 9 J2 - JAMA Intern. Med. KW - adverse outcome coronavirus disease 2019 demography family income food assistance health care access health care policy household income human incidence Letter mortality risk North Carolina pandemic priority journal social determinants of health sudden death catering service poverty Death, Sudden Food Supply Humans LA - English M3 - Letter N1 - Export Date: 4 May 2021 Correspondence Address: Simpson, R.J.; Division of Cardiology, 160 Dental Cir, United States; email: rsimpson@med.unc.edu PY - 2020 SN - 21686106 (ISSN) SP - 1259-1260 ST - Limiting Supplemental Nutrition Assistance Program Eligibility May Increase Sudden Death T2 - JAMA Internal Medicine TI - Limiting Supplemental Nutrition Assistance Program Eligibility May Increase Sudden Death UR - https://www.scopus.com/inward/record.uri?eid=2-s2.0-85088388495&doi=10.1001%2fjamainternmed.2020.1912&partnerID=40&md5=67a1bf74d8dc412e7a0f2a633ecccac0 VL - 180 ID - 396 ER - TY - JOUR AD - Center for Vaccine Development and Global Health, University of Maryland, School of Medicine, Baltimore, MD, United States Center for Infectious Diseases Research, Walter Reed Army Institute of Research, Silver Spring, MD, United States Henry Jackson Foundation, Bethesda, MD, United States Institute for Global Health and Infectious Diseases, School of Medicine, University of North Carolina, Chapel Hill, United States AU - Deming, M. E. AU - Michael, N. L. AU - Robb, M. AU - Cohen, M. S. AU - Neuzil, K. M. C2 - 32610006 C7 - e63 DB - Scopus DO - 10.1056/NEJMp2020076 IS - 10 J2 - New Engl. J. Med. KW - SARS-CoV-2 vaccine COVID-19 vaccine virus vaccine biosafety coronavirus disease 2019 disease model drug efficacy drug research drug safety drug screening economic recession good manufacturing practice human infection control infection risk materials handling morbidity mortality pandemic practice guideline priority journal proof of concept protocol compliance public health service randomized controlled trial (topic) reliability research ethics Review risk assessment risk reduction Severe acute respiratory syndrome coronavirus 2 treatment outcome United States virus immunity World Health Organization Betacoronavirus Coronavirus infection ethics human experiment patient safety risk virus pneumonia Coronavirus Infections Human Experimentation Humans Pandemics Pneumonia, Viral Viral Vaccines LA - English M3 - Review N1 - Cited By :27 Export Date: 4 May 2021 CODEN: NEJMA Chemicals/CAS: COVID-19 vaccine; Viral Vaccines References: Eyal, N., Lipsitch, M., Smith, P.G., Human challenge studies to accelerate coronavirus vaccine licensure (2020) J Infect Dis, 221, pp. 1752-1756; Shah, S.K., Miller, F.G., Darton, T.C., Ethics of controlled human infection to address COVID-19 (2020) Science, 368, pp. 832-834; Plotkin, S.A., Caplan, A., Extraordinary diseases require extraordinary solutions (2020) Vaccine, 38, pp. 3987-3988; (2020) Feasibility, Potential Value and Limitations of Establishing a Closely Monitored Challenge Model of Experimental COVID-19 Infection and Illness in Healthy Young Adult Volunteers, , https://www.who.int/publications/m/item/feasibility-potential-value-and-limitations-of-establishing-a-closely-monitored-challenge-model-of-experimental-covid-19-infection-and-illness-in-healthy-young-adult-volunteers, Geneva: World Health Organization; Bradburne, A.F., Bynoe, M.L., Tyrrell, D.A.J., Effects of a “new” human respiratory virus in volunteers (1967) Br Med J, 3, pp. 767-769 PY - 2020 SN - 00284793 (ISSN) ST - Accelerating development of SARS-CoV-2 vaccines - The role for controlled human infection models T2 - New England Journal of Medicine TI - Accelerating development of SARS-CoV-2 vaccines - The role for controlled human infection models UR - https://www.scopus.com/inward/record.uri?eid=2-s2.0-85089824400&doi=10.1056%2fNEJMp2020076&partnerID=40&md5=272582eb7d6fa656e083d35ab6bc0e44 VL - 383 ID - 368 ER - TY - JOUR AB - Coronaviruses are prone to transmission to new host species, as recently demonstrated by the spread to humans of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of the coronavirus disease 2019 (COVID-19) pandemic1. Small animal models that recapitulate SARS-CoV-2 disease are needed urgently for rapid evaluation of medical countermeasures2,3. SARS-CoV-2 cannot infect wild-type laboratory mice owing to inefficient interactions between the viral spike protein and the mouse orthologue of the human receptor, angiotensin-converting enzyme 2 (ACE2)4. Here we used reverse genetics5 to remodel the interaction between SARS-CoV-2 spike protein and mouse ACE2 and designed mouse-adapted SARS-CoV-2 (SARS-CoV-2 MA), a recombinant virus that can use mouse ACE2 for entry into cells. SARS-CoV-2 MA was able to replicate in the upper and lower airways of both young adult and aged BALB/c mice. SARS-CoV-2 MA caused more severe disease in aged mice, and exhibited more clinically relevant phenotypes than those seen in Hfh4-ACE2 transgenic mice, which express human ACE2 under the control of the Hfh4 (also known as Foxj1) promoter. We demonstrate the utility of this model using vaccine-challenge studies in immune-competent mice with native expression of mouse ACE2. Finally, we show that the clinical candidate interferon-λ1a (IFN-λ1a) potently inhibits SARS-CoV-2 replication in primary human airway epithelial cells in vitro—both prophylactic and therapeutic administration of IFN-λ1a diminished SARS-CoV-2 replication in mice. In summary, the mouse-adapted SARS-CoV-2 MA model demonstrates age-related disease pathogenesis and supports the clinical use of pegylated IFN-λ1a as a treatment for human COVID-196. © 2020, The Author(s), under exclusive licence to Springer Nature Limited. AD - Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States Department of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill, NC, United States Eiger BioPharmaceuticals, Palo Alto, CA, United States Departments of Medicine and Microbiology and Immunology, Stanford University, Stanford, CA, United States Palo Alto Veterans Administration, Palo Alto, CA, United States Rapidly Emerging Antiviral Drug Discovery Initiative, University of North Carolina, Chapel Hill, NC, United States AU - Dinnon, K. H., III AU - Leist, S. R. AU - Schäfer, A. AU - Edwards, C. E. AU - Martinez, D. R. AU - Montgomery, S. A. AU - West, A. AU - Yount, B. L., Jr. AU - Hou, Y. J. AU - Adams, L. E. AU - Gully, K. L. AU - Brown, A. J. AU - Huang, E. AU - Bryant, M. D. AU - Choong, I. C. AU - Glenn, J. S. AU - Gralinski, L. E. AU - Sheahan, T. P. AU - Baric, R. S. C2 - 32854108 DB - Scopus DO - 10.1038/s41586-020-2708-8 IS - 7830 J2 - Nature KW - angiotensin converting enzyme 2 peginterferon lambda virus spike protein alpha interferon COVID-19 vaccine dipeptidyl carboxypeptidase forkhead transcription factor FOXJ1 protein, mouse IFNL1 protein, human interferon interleukin derivative virus receptor virus vaccine disease control laboratory method numerical model parasite transmission severe acute respiratory syndrome testing method virus adult aged airway epithelium cell animal cell animal experiment animal model animal tissue Article controlled study coronavirus disease 2019 disease severity female gene gene control Hfh4 gene human human cell in vitro study infection prevention lower respiratory tract male mouse nonhuman pathogenesis priority journal promoter region protein expression protein protein interaction reverse genetics Severe acute respiratory syndrome coronavirus 2 virus entry virus inhibition virus replication young adult aging animal Bagg albino mouse Betacoronavirus Coronavirus infection disease model drug effect genetics immunology metabolism molecular model pandemic pathogenicity transgenic mouse virus pneumonia Animalia Coronavirus Mus Mus musculus SARS coronavirus Animals Coronavirus Infections Disease Models, Animal Forkhead Transcription Factors Humans Interferon-alpha Interferons Interleukins Mice Mice, Inbred BALB C Mice, Transgenic Models, Molecular Pandemics Peptidyl-Dipeptidase A Pneumonia, Viral Receptors, Virus Viral Vaccines LA - English M3 - Article N1 - Cited By :71 Export Date: 4 May 2021 CODEN: NATUA Correspondence Address: Baric, R.S.; Department of Microbiology and Immunology, United States; email: rbaric@email.unc.edu Chemicals/CAS: peginterferon lambda, 914617-98-4; dipeptidyl carboxypeptidase, 9015-82-1; angiotensin converting enzyme 2; COVID-19 vaccine; Forkhead Transcription Factors; FOXJ1 protein, mouse; IFNL1 protein, human; Interferon-alpha; Interferons; Interleukins; Peptidyl-Dipeptidase A; Receptors, Virus; Viral Vaccines Manufacturers: Eiger Funding details: 1U19 AI142759, 5R01AI132178 Funding details: T32 AI007151, T32 AI007419 Funding details: National Institutes of Health, NIH, HHSN272201700036I Funding details: National Cancer Institute, NCI, 5P30CA016086-41 Funding details: National Institute of Allergy and Infectious Diseases, NIAID Funding details: Burroughs Wellcome Fund, BWF, DK065988 Funding details: Cystic Fibrosis Foundation, BOUCHE15RO Funding details: University of North Carolina, UNC Funding details: University of North Carolina at Chapel Hill, UNC-CH Funding text 1: Acknowledgements This project was funded in part by the National Institute of Allergy and Infectious Diseases, National Institutes of Health, Department of Health and Human Service award: 1U19 AI142759 (Antiviral Drug Discovery and Development Center awarded to R.S.B.); 5R01AI132178 (partnership grant awarded to T.P.S. and R.S.B.) and an animal models contract from the NIH (HHSN272201700036I). This project was supported in part by the North Carolina Policy Collaboratory at the University of North Carolina at Chapel Hill with funding from the North Carolina Coronavirus Relief Fund established and appropriated by the North Carolina General Assembly. K.H.D. is funded by an NIH NIAID T32 AI007419. D.R.M. is funded by an NIH NIAID T32 AI007151 and a Burroughs Wellcome Fund Postdoctoral Enrichment Program Award. The Marsico Lung Institute Tissue Procurement and Cell Culture Core is supported by NIH grant DK065988 and Cystic Fibrosis Foundation grant BOUCHE15RO. Animal histopathology service was performed by D. Hilliard and L. Wang in the Animal Histopathology and Laboratory Medicine Core at the University of North Carolina, which is supported in part by an NCI Center Core Support Grant (5P30CA016086-41) to the UNC Lineberger Comprehensive Cancer Center. References: Li, Q., Early transmission dynamics in Wuhan, China, of novel coronavirus-infected pneumonia (2020) N. Engl. J. 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Med., 107, pp. 183-206; Davidson, S., IFNλ is a potent anti-influenza therapeutic without the inflammatory side effects of IFNα treatment (2016) EMBO Mol. Med., 8, pp. 1099-1112 PY - 2020 SN - 00280836 (ISSN) SP - 560-566 ST - A mouse-adapted model of SARS-CoV-2 to test COVID-19 countermeasures T2 - Nature TI - A mouse-adapted model of SARS-CoV-2 to test COVID-19 countermeasures UR - https://www.scopus.com/inward/record.uri?eid=2-s2.0-85089860081&doi=10.1038%2fs41586-020-2708-8&partnerID=40&md5=cd8cf074d70b47f70336200627dc5cbd VL - 586 ID - 319 ER - TY - JOUR AB - Purpose of Review: Coronavirus disease 2019 (COVID-19) has become a global health crisis of our time. The disease arises from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that binds to angiotensin-converting enzyme 2 (ACE2) receptors on host cells for its internalization. COVID-19 has a wide range of respiratory symptoms from mild to severe and affects several other organs, increasing the complexity of the treatment. There is accumulating evidence to suggest that SARS-CoV-2 can target the nervous system. In this review, we provide an account of the COVID-19 central nervous system (CNS) manifestations. Recent Findings: A broad spectrum of the CNS manifestations including headache, impaired consciousness, delirium, loss of smell and taste, encephalitis, seizures, strokes, myelitis, acute disseminated encephalomyelitis, neurogenic respiratory failure, encephalopathy, silent hypoxemia, generalized myoclonus, neuroleptic malignant syndrome and Kawasaki syndrome has been reported in patients with COVID-19. Summary: CNS manifestations associated with COVID-19 should be considered in clinical practice. There is a need for modification of current protocols and standing orders to provide better care for COVID-19 patients presenting with neurological symptoms. © 2020, Springer Science+Business Media, LLC, part of Springer Nature. AD - Department of Neurology, School of Medicine, University of New Mexico, Albuquerque, NM, United States Research Unit of Clinical Physiology and Nuclear Medicine, Department of Nuclear Medicine, Odense University Hospital, Faculty of Health Sciences, University of Southern Denmark, Odense, Denmark Neuroscience Research Center, Department of Neurosurgery, Poursina Hospital, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran Department of Neurology, Loyola University, Stritch School of Medicine, Maywood, IL, United States Department of Neurology and Stroke Unit, San Camillo de’ Lellis District General Hospital, Rieti, Italy Department of Neurology, University of North Carolina, Chapel Hill, NC, United States Department of Neurology, The University of Mississippi Medical Center, Jackson, MS, United States Sree Chitra Tirunal Institute for Medical Sciences and Technology, Trivandrum, India Department of Neurology, Mayo Clinic, Rochester, MN, United States Neurological Clinic, Department of Experimental and Clinical Medicine, Marche Polytechnic University, Ancona, Italy Department of Neurology, McGovern Medical School, The University of Texas at Houston, Houston, TX, United States Neurology Department, Texas Tech Health University, Health Sciences Center, El Paso, El Paso, TX, United States Departments of Clinical Neurological sciences, Western University, London, Canada AU - Divani, A. 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(2020) Neurol(R) Neuroimmunol Neuroinflamm, 7 (4) IS - 12 J2 - Curr. Neurol. Neurosci. Rep. KW - CNS manifestations COVID-19 Neurological manifestations Pandemic SARS-CoV-2 Stroke angiotensin converting enzyme 2 benzodiazepine carbamazepine D dimer haloperidol lacosamide levetiracetam lorazepam nonsteroid antiinflammatory agent olanzapine phenobarbital phenytoin primidone quetiapine risperidone thiopental topiramate troponin valproic acid acute disseminated encephalomyelitis ageusia anosmia brain disease central nervous system disease cerebrovascular accident consciousness disorder coronavirus disease 2019 delirium disease association electroencephalography encephalitis headache human hypoxemia leukoencephalopathy mucocutaneous lymph node syndrome myelitis myoclonus neuroleptic malignant syndrome neurotropism respiratory failure Review seizure Severe acute respiratory syndrome coronavirus 2 virus cell interaction virus entry Betacoronavirus Coronavirinae Coronavirus infection virus pneumonia Coronavirus Coronavirus Infections Humans Pandemics Pneumonia, Viral LA - English M3 - Review N1 - Cited By :8 Export Date: 4 May 2021 CODEN: CNNRB Correspondence Address: Divani, A.A.; Department of Neurology, United States; email: adivani@gmail.com Chemicals/CAS: benzodiazepine, 12794-10-4; carbamazepine, 298-46-4, 8047-84-5; haloperidol, 52-86-8, 1511-16-6; lacosamide, 175481-36-4; levetiracetam, 102767-28-2; lorazepam, 846-49-1; olanzapine, 132539-06-1; phenobarbital, 50-06-6, 57-30-7, 8028-68-0; phenytoin, 57-41-0, 630-93-3; primidone, 125-33-7; quetiapine, 111974-72-2; risperidone, 106266-06-2; thiopental, 71-73-8, 76-75-5; topiramate, 97240-79-4; valproic acid, 1069-66-5, 99-66-1 PY - 2020 SN - 15284042 (ISSN) ST - Central Nervous System Manifestations Associated with COVID-19 T2 - Current Neurology and Neuroscience Reports TI - Central Nervous System Manifestations Associated with COVID-19 UR - https://www.scopus.com/inward/record.uri?eid=2-s2.0-85094672613&doi=10.1007%2fs11910-020-01079-7&partnerID=40&md5=030af21f74c325d80d5daf42fec470f9 VL - 20 ID - 269 ER - TY - JOUR AB - The novel coronavirus disease (COVID-19) pandemic has significantly impacted the field of rheumatology, in both the delivery of clinical care and didactic education for our trainees. These changes have generated significant strain for program directors and clinical educators who have had to leverage technology and develop new systems to ensure continued trainee education and assessment. We aim to outline the impacts on formal education programs presented by these unprecedented disruptions, describe the development and deployment of online teaching, reflect on the challenges and opportunities for technology-enabled learning and use of social media for education, and give some international perspectives on impacts on postgraduate rheumatology training outside the USA. With the rapid dissolution of barriers in place during the pre-COVID-19 era, we have the opportunity to assess the efficacy of new methods of care and further integrate technology into teaching and assessment. We propose that a hybrid in-person and technology-enabled learning approach, so-called blended learning, is likely to remain the most desirable future model for supporting trainee learning. © 2020, International League of Associations for Rheumatology (ILAR). AD - Department of Medicine, Division of Rheumatology, Northwestern University Feinberg School of Medicine, Galter Pavilion, 675 N St Clair St Ste 14-100, Chicago, IL 60611, United States Department of Medicine, Division of Rheumatology, George Washington University Medical Center, Washington, DC, United States Department of Medicine, University of Otago Wellington, Wellington, New Zealand Division of Rheumatology, Allergy, and Immunology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, United States Charité University Medicine, Department of Rheumatology and Clinical Immunology, Berlin, Germany Department of Medicine, Division of Rheumatology, Allergy, and Immunology, University of North Carolina School of Medicine, Chapel Hill, NC, United States AU - Dua, A. B. AU - Kilian, A. AU - Grainger, R. AU - Fantus, S. A. AU - Wallace, Z. S. AU - Buttgereit, F. AU - Jonas, B. L. C2 - 33067772 DB - Scopus DO - 10.1007/s10067-020-05449-x IS - 12 J2 - Clin. Rheumatol. KW - COVID19 Fellowship Medical education Technology-enabled education Virtual learning blended learning clinical assessment clinical effectiveness collaborative learning coronavirus disease 2019 education program human hybrid knowledge learning medical information medical technology online system pandemic postgraduate education postgraduate student priority journal Review rheumatic disease rheumatology social media teaching United States virtual learning environment Coronavirus infection curriculum education information dissemination procedures virus pneumonia Coronavirus Infections Education, Distance Education, Medical, Graduate Humans Pandemics Pneumonia, Viral LA - English M3 - Review N1 - Cited By :2 Export Date: 4 May 2021 CODEN: CLRHD Correspondence Address: Dua, A.B.; Department of Medicine, Galter Pavilion, 675 N St Clair St Ste 14-100, United States; email: Anisha.dua@northwestern.edu References: Wood, P.R., Caplan, L., Outcomes, satisfaction, and costs of a rheumatology telemedicine program: a longitudinal evaluation (2019) JCR: J Clin Rheumatol, 25 (1), pp. 41-44. , PID: 30461466; Kulcsar, Z., Albert, D., Ercolano, E., Mecchella, J.N., Telerheumatology: a technology appropriate for virtually all (2016) Semin Arthritis Rheum, 46 (3), pp. 380-385; Kilian, A., Upton, L.A., Battafarano, D.F., Monrad, S.U., Workforce trends in rheumatology (2019) Rheum Dis Clin N Am, 45 (1), pp. 13-26; Piga, M., Cangemi, I., Mathieu, A., Cauli, A., Telemedicine for patients with rheumatic diseases: systematic review and proposal for research agenda (2017) Semin Arthritis Rheum, 47 (1), pp. 121-128; Shaw, S.C.K., Hopelessness, helplessness and resilience: the importance of safeguarding our trainees' mental wellbeing during the COVID-19 pandemic (2020) Nurse Educ Pract, 44, p. 102780; Isaza-Restrepo, A., Gómez, M.T., Cifuentes, G., Argüello, A., The virtual patient as a learning tool: a mixed quantitative qualitative study (2018) BMC Med Educ, 18 (1), p. 297; Frenk, J., Chen, L., Bhutta, Z.A., Cohen, J., Crisp, N., Evans, T., Fineberg, H., Zurayk, H., Health professionals for a new century: transforming education to strengthen health systems in an interdependent world (2010) Lancet, 376 (9756), pp. 1923-1958; West, C.P., Shanafelt, T.D., Kolars, J.C., Quality of life, burnout, educational debt, and medical knowledge among internal medicine residents (2011) Jama, 306 (9), pp. 952-960. , COI: 1:CAS:528:DC%2BC3MXhtFyrsb7E; Mayer, R.E., Applying the science of learning to medical education (2010) Med Educ, 44 (6), pp. 543-549; Hodges, C., M, S., Lockee, B., Trust, T., Bond, A., The difference between emergency remote teaching and online learning (2020) Educause Review, , https://er.educause.edu/articles/2020/3/the-difference-between-emergency-remote-teaching-and-online-learning, Retrieved from; Kirkley, S.E., Kirkley, J.R., Creating next generation blended learning environments using mixed reality (2005) Video Games and Simulations TechTrends, 49 (3), pp. 42-53; Grainger, R., Liu, Q., Geertshuis, S., Learning technologies: a medium for the transformation of medical education? 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S2213–2198(20)30481–5 PY - 2020 SN - 07703198 (ISSN) SP - 3535-3541 ST - Challenges, collaboration, and innovation in rheumatology education during the COVID-19 pandemic: leveraging new ways to teach T2 - Clinical Rheumatology TI - Challenges, collaboration, and innovation in rheumatology education during the COVID-19 pandemic: leveraging new ways to teach UR - https://www.scopus.com/inward/record.uri?eid=2-s2.0-85092601968&doi=10.1007%2fs10067-020-05449-x&partnerID=40&md5=18b7ee6b8feff4c971785b5dae0bf696 VL - 39 ID - 270 ER - TY - JOUR AD - School of Nursing, Boston College, Boston, MA, United States School of Nursing, The University of North Carolina at Chapel Hill, Chapel Hill, NC, United States School of Nursing, Texas Tech University Health Sciences Center, San Antonio, TX, United States AU - Edmonds, J. K. AU - Kneipp, S. M. AU - Campbell, L. C2 - 32281160 DB - Scopus DO - 10.1111/phn.12733 IS - 3 J2 - Public Health Nurs. KW - chronic disease contact examination coronavirus disease 2019 disease surveillance Editorial emergency care epidemic financial management health care cost health workforce human infant mortality infection prevention laboratory test maternal care maternal mortality nondiscrimination policy nurse pandemic practice guideline public health public health service quarantine socioeconomics vaccination Betacoronavirus Coronavirinae Coronavirus infection virus pneumonia Coronavirus Coronavirus Infections Humans Nurses, Public Health Pandemics Pneumonia, Viral LA - English M3 - Editorial N1 - Cited By :10 Export Date: 4 May 2021 CODEN: PHNUE Correspondence Address: Edmonds, J.K.; School of Nursing, United States; email: joyce.edmonds@bc.edu References: (1946) Public health nurses lauded by Truman, , New York Times; (2008) Report on a public health nurse to population ratio, , http://www.quadcouncilphn.org/documents-3/2008-astdn-report-on-a-public-health-nurse-to-population-ratio/, Retrieved from; Campbell, L.A., Harmon, M.J., Joyce, B.L., Little, S.H., Quad Council Coalition community/public health nursing competencies: Building consensus through collaboration (2020) Public Health Nursing, 37 (96-112). , https://onlinelibrary.wiley.com/doi/full/10.1111/phn.12666; (2020) Immediate plans for Coronavirus disease 2019 supplemental funding to jurisdictions, , https://www.cdc.gov/coronavirus/2019-ncov/downloads/supplemental-funding-to-jurisdictions.pdf, Retrieved from; (2017) The public health system & the 10 essential public health services, , https://www.cdc.gov/stltpublichealth/publichealthservices/essentialhealthservices.html, Retrieved from; (2020), H.R.748, U.S. Congress; (2018) Developing a financing system to support public health infrastructure, , https://www.resolve.ngo/docs/phlf_developingafinancingsystemtosupportpublichealth636869439688663025.pdf, Retrieved from; Spetz, J., (2020) There are not nearly enough nurses to handle the surge of Coronavirus patients: Here's how to close the gap quickly, , https://www.healthaffairs.org/do/10.1377/hblog20200327.714037/full/, Retrieved from; (2019) The impact of chronic underfunding of America's public health system: Trends, risks, and recommendations, 2019 PY - 2020 SN - 07371209 (ISSN) SP - 323-324 ST - A call to action for public health nurses during the COVID-19 pandemic T2 - Public Health Nursing TI - A call to action for public health nurses during the COVID-19 pandemic UR - https://www.scopus.com/inward/record.uri?eid=2-s2.0-85083485534&doi=10.1111%2fphn.12733&partnerID=40&md5=615262242ee074e3daeecc5afaa0881c VL - 37 ID - 511 ER - TY - JOUR AB - Zoonotic coronaviruses represent an ongoing threat, yet the myriads of circulating animal viruses complicate the identification of higher-risk isolates that threaten human health. Swine acute diarrhea syndrome coronavirus (SADS-CoV) is a newly discovered, highly pathogenic virus that likely evolved from closely related HKU2 bat coronaviruses, circulating in Rhinolophus spp. bats in China and elsewhere. As coronaviruses cause severe economic losses in the pork industry and swine are key intermediate hosts of human disease outbreaks, we synthetically resurrected a recombinant virus (rSADS-CoV) as well as a derivative encoding tomato red fluorescent protein (tRFP) in place of ORF3. rSADS-CoV replicated efficiently in a variety of continuous animal and primate cell lines, including human liver and rectal carcinoma cell lines. Of concern, rSADS-CoV also replicated efficiently in several different primary human lung cell types, as well as primary human intestinal cells. rSADS-CoV did not use human coronavirus ACE-2, DPP4, or CD13 receptors for docking and entry. Contemporary human donor sera neutralized the group I human coronavirus NL63, but not rSADS-CoV, suggesting limited human group I coronavirus cross protective herd immunity. Importantly, remdesivir, a broad-spectrum nucleoside analog that is effective against other group 1 and 2 coronaviruses, efficiently blocked rSADS-CoV replication in vitro. rSADS-CoV demonstrated little, if any, replicative capacity in either immune-competent or immunodeficient mice, indicating a critical need for improved animal models. Efficient growth in primary human lung and intestinal cells implicate SADS-CoV as a potential higher-risk emerging coronavirus pathogen that could negatively impact the global economy and human health. © 2020 National Academy of Sciences. All rights reserved. AD - Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, United States Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, United States Chemical and Biological Signatures Division, Pacific Northwest National Laboratory, Richland, WA 99354, United States Department of Comparative Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, United States Marsico Lung Institute, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, United States Rapidly Emerging Antiviral Drug Discovery Initiative, University of North Carolina, Chapel Hill, NC 27599, United States AU - Edwards, C. E. AU - Yount, B. L. AU - Graham, R. L. AU - Leist, S. R. AU - Hou, Y. J. AU - Dinnon, K. H., III AU - Sims, A. C. AU - Swanstrom, J. AU - Gully, K. AU - Scobey, T. D. AU - Cooley, M. R. AU - Currie, C. G. AU - Randell, S. H. AU - Baric, R. S. C2 - 33046644 DB - Scopus DO - 10.1073/pnas.2001046117 IS - 43 J2 - Proc. Natl. Acad. Sci. U. S. A. KW - Coronavirus Emerging infectious disease One Health SADS angiotensin converting enzyme 2 dipeptidyl peptidase IV microsomal aminopeptidase red fluorescent protein remdesivir adenosine phosphate alanine photoprotein animal cell animal experiment animal model animal tissue Article cells by body anatomy controlled study drug efficacy drug mechanism hepatocellular carcinoma cell line herd immunity human human cell immunocompetence in vitro study infection risk infection sensitivity intestine cell lung alveolus cell molecular docking mouse nonhuman open reading frame primate priority journal rectum carcinoma swine acute diarrhea syndrome Swine acute diarrhea syndrome coronavirus virus cell interaction virus entry virus inhibition virus neutralization virus recombinant virus replication virus strain virus transmission Alphacoronavirus animal cell culture Chlorocebus aethiops Coronavirus infection disease predisposition drug effect gene expression genetics growth, development and aging host range physiology Vero cell line virology Adenosine Monophosphate Animals Cells, Cultured Coronavirus Infections Disease Susceptibility Host Specificity Humans Luminescent Proteins Mice Vero Cells LA - English M3 - Article N1 - Cited By :8 Export Date: 4 May 2021 CODEN: PNASA Correspondence Address: Baric, R.S.; Department of Epidemiology, United States; email: rbaric@email.unc.edu Chemicals/CAS: dipeptidyl peptidase IV, 54249-88-6; microsomal aminopeptidase, 9054-63-1; red fluorescent protein, 251925-26-5; remdesivir, 1809249-37-3; adenosine phosphate, 61-19-8, 8063-98-7; alanine, 56-41-7, 6898-94-8; Adenosine Monophosphate; Alanine; Luminescent Proteins; remdesivir Funding details: AI089728, AI132178, AI142759, AI151797 Funding details: National Institutes of Health, NIH, DK065988 Funding details: Cystic Fibrosis Foundation, BOUCHE19R0 Funding details: University of North Carolina at Chapel Hill, UNC-CH Funding text 1: ACKNOWLEDGMENTS. Provision of primary human lung cells by Dr. Randell was supported by grants from the Cystic Fibrosis Foundation (BOUCHE19R0) and NIH (DK065988). We thank Dr. Camille Ehre for providing the primary human intestinal cells for this study. This project was supported by the North Carolina Policy Collaboratory at the University of North Carolina at Chapel Hill with funding from the North Carolina Coronavirus Relief Fund established and appropriated by the North Carolina General Assembly. This work was also supported by NIH Grants AI089728, AI142759, AI132178, and AI151797 (to R.S.B.). The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH. References: Mackenzie, J. S., Jeggo, M., The One Health approach—Why is it so important? (2019) Trop. Med. Infect. Dis, 4, p. 88; Wang, Q., Vlasova, A. N., Kenney, S. P., Saif, L. J., Emerging and re-emerging coronaviruses in pigs (2019) Curr. Opin. Virol, 34, pp. 39-49; Corman, V. 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E., Mutant Swine acute diarrhea syndrome coronavirus strain icSADS-tRFP, complete genome GenBank, , https://www.ncbi.nlm.nih.gov/nuccore/MT039232, Deposited on 10 June 2020 PY - 2020 SN - 00278424 (ISSN) SP - 26915-26925 ST - Swine acute diarrhea syndrome coronavirus replication in primary human cells reveals potential susceptibility to infection T2 - Proceedings of the National Academy of Sciences of the United States of America TI - Swine acute diarrhea syndrome coronavirus replication in primary human cells reveals potential susceptibility to infection UR - https://www.scopus.com/inward/record.uri?eid=2-s2.0-85094805497&doi=10.1073%2fpnas.2001046117&partnerID=40&md5=0d79250387ad612f11ecbfd36ff7ca7b VL - 117 ID - 316 ER - TY - JOUR AD - Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, United States School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, United States AU - Edwards, J. K. AU - Cole, S. R. AU - Adimora, A. A. C2 - 33010832 DB - Scopus DO - 10.1016/S0140-6736(20)32020-1 IS - 10256 J2 - Lancet KW - chloroquine cytochrome P450 2D6 remdesivir viral protein adenosine phosphate alanine African American China Chinese coronavirus disease 2019 CYP2D6 gene disease severity drug approval drug efficacy drug targeting ethnic difference European Food and Drug Administration gene genetic difference genetic variability genetic variation heredity Hispanic human Japan Letter medical research methodology mutation rate pharmacogenetics pharmacogenomics priority journal Severe acute respiratory syndrome coronavirus 2 treatment outcome United States adult Betacoronavirus Coronavirus infection double blind procedure pandemic virus pneumonia Adenosine Monophosphate Coronavirus Infections Double-Blind Method Humans Pandemics Pneumonia, Viral LA - English M3 - Letter N1 - Cited By :1 Export Date: 4 May 2021 CODEN: LANCA Chemicals/CAS: chloroquine, 132-73-0, 3545-67-3, 50-63-5, 54-05-7; remdesivir, 1809249-37-3; adenosine phosphate, 61-19-8, 8063-98-7; alanine, 56-41-7, 6898-94-8; Adenosine Monophosphate; Alanine; remdesivir References: Wang, Y., Zhang, D., Du, G., Remdesivir in adults with severe COVID-19: a randomised, double-blind, placebo-controlled, multicentre trial (2020) Lancet, 395, pp. 1569-1578; Cao, B., Wang, Y., Wen, D., A trial of lopinavir-ritonavir in adults hospitalized with severe Covid-19 (2020) N Engl J Med, 382, pp. 1787-1799; Edwards, J.K., Cole, S.R., Westreich, D., Age at entry into care, timing of antiretroviral therapy initiation, and 10-year mortality among HIV-seropositive adults in the United States (2015) Clin Infect Dis, 61, pp. 1189-1195 PY - 2020 SN - 01406736 (ISSN) SP - 953 ST - Remdesivir and COVID-19 T2 - The Lancet TI - Remdesivir and COVID-19 UR - https://www.scopus.com/inward/record.uri?eid=2-s2.0-85091935453&doi=10.1016%2fS0140-6736%2820%2932020-1&partnerID=40&md5=7c3124b74f993a17d63c350ecd578f88 VL - 396 ID - 329 ER - TY - JOUR AD - Baric and Boucher Laboratories, University of North Carolina, School of Medicine, Chapel Hill, NC, United States AU - Ehre, C. C2 - 32877585 DB - Scopus DO - 10.1056/NEJMicm2023328 IS - 10 J2 - New Engl. J. Med. KW - airway cell biosafety coronavirus disease 2019 HBEC cell line (bronchial epithelium) health care facility human inoculation laboratory test nonhuman Note priority journal scanning electron microscopy Severe acute respiratory syndrome coronavirus 2 Betacoronavirus bronchus cell culture Coronavirus infection cytology epithelium cell pandemic pathology ultrastructure virology virus culture virus pneumonia Bronchi Cells, Cultured Coronavirus Infections Epithelial Cells Humans Microscopy, Electron, Scanning Pandemics Pneumonia, Viral Virus Cultivation LA - English M3 - Note N1 - Cited By :4 Export Date: 4 May 2021 CODEN: NEJMA Correspondence Address: Ehre, C.; Baric and Boucher Laboratories, United States; email: cehre@med.unc.edu PY - 2020 SN - 00284793 (ISSN) SP - 969 ST - SARS-CoV-2 infection of airway cells T2 - New England Journal of Medicine TI - SARS-CoV-2 infection of airway cells UR - https://www.scopus.com/inward/record.uri?eid=2-s2.0-85090261665&doi=10.1056%2fNEJMicm2023328&partnerID=40&md5=9c5265402baea9e2163281e77227f241 VL - 383 ID - 367 ER - TY - JOUR AD - University of Cincinnati, 234, Goodman Street, Cincinnati, OH 45267, United States Staten Island University hospital, New York, NY, United States Mayo Clinic, Phoenix, AZ, United States Ochsner Health System, New Orleans, LA, United States UNC School of Medicine, Chapel Hill, NC, United States AU - England, E. AU - Kanfi, A. AU - Flink, C. AU - Vagal, A. AU - Sarkany, D. AU - Patel, M. D. AU - Milburn, J. AU - Chadalavada, S. AU - Jordan, S. C2 - 32417034 DB - Scopus DO - 10.1016/j.acra.2020.05.001 . PubMed PMID:32216719; Cavallo, J.J., Forman, H.P., The economic impact of the COVID-19 pandemic on radiology practices (2020) Radiology, , 32293225 Epub 2020/04/16PubMed PMID:; https://radiologyresidentcorelectures.com/, Radiologists AoU. Radiology resident core curriculum lecture series. 2020[cited 04/05/2020]. Available from:; (2020) APDR virtual noon conference series, , https://apdr.org/uploadedFiles/Content/Residents_Students/APDR_Noon_Conference_Schedule.pdf, [cited 04/05/2020]. Available from:; https://apdr.org/template.aspx?id=1677, Radiology AoPDI. Online education resources. 2020[cited 04/05/2020]. Available from:; Hammer, M.M., Shetty, A.S., Cizman, Z., Results of the 2015 survey of the American alliance of academic chief residents in radiology (2015) Acad Radiol, 22 (10), pp. 1308-1316. , 26297641 Epub 2015/08/25PubMed PMID:; Vagal, A., Reeder, S.B., Sodickson, D.K., The impact of the COVID-19 pandemic on the radiology research enterprise: radiology scientific expert panel. Radiology.0(0):201393. doi:. PubMed PMID:32293224; https://www.acgme.org/COVID-19/Specialty-Letters-to-the-Community.%20Accessed%20April%2028, ACGME. ACGME response to pandemic crisis2020[cited 05/01/2020]. Available from:; https://www.rsna.org/covid-19, RSNA. COVID-19 resources. 2020[cited 05/01/2020]. 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(2014) Organ Stud, 35 (12), pp. 1867-1892; Clinic, M., (2016), Make the difference: preventing medical trainee suicide; https://www.acgme.org/Portals/0/PFAssets/ProgramRequirements/CPRResidency2019.pdf, ACGME. ACGME common program requirements (Residency). 2018[cited 05/01/2020]. Available from:; England, E., Patel, M.D., Jordan, S., Promoting well-being in radiology residency: a primer for program directors. Acad Radiol. doi:; (2020), Radiology TACo. Combating the COVID-19 pandemic: a collection of well-being resources for radiologists; https://www.acgme.org/Portals/0/PDFs/Milestones/DiagnosticRadiologyMilestones.pdf?ver=2015-11-06-120532-380, ABR Aa. The diagnostic radiology milestone project. 2015[cited 04/05/2020]. Available from:; https://www.acgme.org/Portals/0/PDFs/Milestones/DiagnosticRadiologyMilestones2.0.pdf?ver=2020-03-10-155615-320, ACGME. Diagnostic radiology milestones. 2012[updated 12/2019; cited 04/05/2020]. Available from:; https://www.ncdhhs.gov/divisions/public-health/covid19/child-care, Department of Health & Human Services. Available from:UR - https://www.scopus.com/inward/record.uri?eid=2-s2.0-85086324719&doi=10.1016%2fj.acra.2020.05.001&partnerID=40&md5=2dcb16e476b10bcd6660128659c01909 IS - 8 J2 - Acad. Radiol. KW - COVID-19 Education Radiology Residency program management Well-being adaptation coronavirus disease 2019 education program experience health care system human Note pandemic priority journal residency education wellbeing LA - English M3 - Note N1 - Cited By :18 Export Date: 4 May 2021 CODEN: ARADF Correspondence Address: England, E.; University of Cincinnati, 234, Goodman Street, United States; email: englanec@ucmail.uc.edu Funding text 1: Human centered design grant, ACR Innovation Fund. PY - 2020 SN - 10766332 (ISSN) SP - 1140-1146 ST - Radiology Residency Program Management in the COVID Era – Strategy and Reality T2 - Academic Radiology TI - Radiology Residency Program Management in the COVID Era – Strategy and Reality VL - 27 ID - 432 ER - TY - JOUR AB - The COVID-19 pandemic has challenged our ability to provide timely surgical care for our patients. In response, the U.S. Surgeon General, the American College of Srugeons, and other surgical professional societies recommended postponing elective surgical procedures and proceeding cautiously with cancer procedures that may require significant hospital resources and expose vulnerable patients to the virus. These challenges have particularly distressing for women with a gynecologic cancer diagnosis and their providers. Currently, circumstances vary greatly by region and by hospital, depending on COVID-19 prevalence, case mix, hospital type, and available resources. Therefore, COVID-19-related modifications to surgical practice guidelines must be individualized. Special consideration is necessary to evaluate the appropriateness of procedural interventions, recognizing the significant resources and personnel they require. Additionally, the pandemic may occur in waves, with patient demand for surgery ebbing and flowing accordingly. Hospitals, cancer centers and providers must prepare themselves to meet this demand. The purpose of this white paper is to highlight all phases of gynecologic cancer surgical care during the COVID-19 pandemic and to illustrate when it is best to operate, to hestitate, and reintegrate surgery. Triage and prioritization of surgical cases, preoperative COVID-19 testing, peri-operative safety principles, and preparations for the post-COVID-19 peak and surgical reintegration are reviewed. © 2020 Elsevier Inc. AD - Kelly Gynecologic Oncology Service, Department of Gynecology and Obstetrics, Johns Hopkins Hospital, Baltimore, MD, United States Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Alabama, Birmingham, AL, United States Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Penn State Hershey Medical Center, Hershey, PA, United States Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, New York University, New York City, NY, United States Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Columbia University, New York City, NY, United States Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Mayo Clinic, Rochester, MN, United States Department of Gynecologic Oncology and Reproductive Medicine, MD Anderson Cancer Center, Houston, TX, United States Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Miami Medical Center, Miami, FL, United States Department of Gynecologic Oncology, Memorial Sloan Kettering Cancer Center, New York City, NY, United States Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Lehigh Valley Health Network, Lancaster, PA, United States Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Stanford University Medical Center, Palo Alto, CA, United States Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of North Carolina, Chapel Hill, NC, United States Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Atrium Health, Levine Cancer Institute, Charlotte, NC, United States Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Mt Sinai University, NYC, NY, United States Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, StonyBrookNY, United States Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Washington Medical Center, Seattle, WA, United States Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Michigan Ann ArborMI, United States Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Chicago Medical Center, Chicago, IL, United States AU - Fader, A. N. AU - Huh, W. K. AU - Kesterson, J. AU - Pothuri, B. AU - Wethington, S. AU - Wright, J. D. AU - Bakkum-Gamez, J. N. AU - Soliman, P. T. AU - Sinno, A. K. AU - Leitao, M. AU - Martino, M. A. AU - Karam, A. AU - Rossi, E. AU - Brown, J. AU - Blank, S. AU - Burke, W. AU - Goff, B. AU - Yamada, S. D. AU - Uppal, S. AU - Dowdy, S. C. C2 - 32532460 DB - Scopus DO - 10.1016/j.ygyno.2020.06.001 IS - 2 J2 - Gynecol. Oncol. KW - burnout cancer surgery coronavirus disease 2019 female genital tract cancer gynecologic oncologist human job stress laparoscopy medical society pandemic perioperative period preoperative evaluation priority journal Review telemedicine virtual reality Betacoronavirus Coronavirus infection decision making disease transmission female female genital tract tumor gynecologic surgery infection control isolation and purification laboratory technique prevention and control procedures surgical oncology virology virus pneumonia Clinical Laboratory Techniques Coronavirus Infections Genital Neoplasms, Female Gynecologic Surgical Procedures Humans Infectious Disease Transmission, Patient-to-Professional Pandemics Pneumonia, Viral LA - English M3 - Review N1 - Cited By :9 Export Date: 4 May 2021 CODEN: GYNOA Correspondence Address: Fader, A.N.600 N. Wolfe St, Phipps 287, United States; email: afader1@jhmi.edu Funding details: AstraZeneca Funding details: Merck Funding details: Clovis Oncology Funding text 1: Dr. Bhavana Pothuri reports grants, personal fees and non-financial support outside the submitted work; institutional PI for industry sponsored trials from Tesaro/GSK, AstraZeneca, Merck, Genentech/Roche, and Clovis Oncology. Compensated advisory boards include Tesaro/GSK, AstraZeneca, and Eisai. 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Dis., 12, pp. 1924-1932; https://www.cdc.gov/coronavirus/2019-ncov/need-extra-precautions/racial-ethnic-minorities.htmlUR - https://www.scopus.com/inward/record.uri?eid=2-s2.0-85086153195&doi=10.1016%2fj.ygyno.2020.06.001&partnerID=40&md5=1da5ebf101a10b5dbe8added5e26ce9a PY - 2020 SN - 00908258 (ISSN) SP - 236-243 ST - When to Operate, Hesitate and Reintegrate: Society of Gynecologic Oncology Surgical Considerations during the COVID-19 Pandemic T2 - Gynecologic Oncology TI - When to Operate, Hesitate and Reintegrate: Society of Gynecologic Oncology Surgical Considerations during the COVID-19 Pandemic VL - 158 ID - 433 ER - TY - CONF A4 - Acm, Sigarch A2 - Acm, Sigbed A2 - Acm, Sigcomm A2 - Acm, Sigmetrics A2 - Acm, Sigmobile A2 - Acm, Sigops AB - Human sensing, motion trajectory estimation, and identification are crucial to applications such as customer analysis, public safety, smart homes and cities, and access control. In the wake of the global COVID-19 pandemic, the ability to perform contact tracing effectively is vital to limit the spread of infectious diseases. Although vision-based solutions such as facial recognition can potentially scale to millions of people for identification, the privacy implications and laws to banning such a technology limit its applicability in the real world. Other techniques may require installations and maintenance of multiple units, and/or lack long-Term re-identification capability. We present a dataset to fuse WiFi Channel State Information (CSI) and camera-based location information for person identification and tracking. While previous works focused on collecting WiFi CSI from stationary transmitters and receivers (laptop, desktop, or router), our WiFi CSI data are generated from a smartphone that is carried while someone is moving. In addition, we collect camera-generated real-world coordinate for each WiFi packet that can serve as ground truth location. The dataset is collected in different environments and with various numbers of persons in the scene at several days to capture real-world variations. © 2020 ACM. AD - Unc Chapel Hill, United States Bosch Research and Technology AU - Fang, S. AU - Munir, S. AU - Nirjon, S. C3 - DATA 2020 - Proceedings of the 3rd Workshop on Data Acquisition To Analysis, Part of SenSys 2020, BuildSys 2020 DB - Scopus DO - 10.1145/3419016.3431488 KW - Access control Automation Cameras Data acquisition Face recognition Intelligent buildings Smartphones Wireless local area networks (WLAN) Customer analysis Facial recognition Infectious disease Location information Motion trajectories Person identification Re identifications Vision-based solutions Channel state information LA - English N1 - Conference code: 164626 Cited By :1 Export Date: 4 May 2021 References: San Francisco Banned Facial Recognition, , https://www.nytimes.com/2019/07/01/us/facial-recognition-san-francisco.html; SpotFi Matlab Implementation, , https://bitbucket.org/mkotaru/spotfimusicaoaestimation/src/master/; Alazrai, R., Awad, A., BahaA, A., Hababeh, M., Daoud, M.I., A dataset for Wi-Fi-based human-To-human interaction recognition (2020) Data in Brief, 2020, p. 105668; Bagave, P., Linssen, J., Teeuw, W., Klein Brinke, J., Meratnia, N., 2019. 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Occupancy Sensing and Activity Recognition with Cameras and Wireless Sensors Proceedings of the 2nd Workshop on Data Acquisition to Analysis, pp. 1-6 PB - Association for Computing Machinery, Inc PY - 2020 SN - 9781450381369 (ISBN) SP - 26-30 ST - Person tracking and identification using cameras and wi-fi channel state information (CSI) from smartphones: Dataset T2 - 3rd Workshop on Data Acquisition To Analysis, DATA 2020 - Part of SenSys 2020, BuildSys 2020 TI - Person tracking and identification using cameras and wi-fi channel state information (CSI) from smartphones: Dataset UR - https://www.scopus.com/inward/record.uri?eid=2-s2.0-85097349900&doi=10.1145%2f3419016.3431488&partnerID=40&md5=d766cc19b58cbf2e88551769b790e487 Y2 - 16 November 2020 through 19 November 2020 ID - 287 ER - TY - JOUR AD - Peers for Progress, Department of Health Behavior, Gillings School of Global Public Health, University of North Carolina-Chapel Hill, Chapel Hill, NC 27599-7440, United States Cancer Prevention and Control Program, Fox Chase Cancer Center/Temple University Health System, Philadelphia, PA 19140, United States Rutgers University Behavioral Health Care, Department of Psychiatry, Rutgers University Medical School, Piscataway, NJ 08854, United States AU - Fisher, E. B. AU - Miller, S. M. AU - Evans, M. AU - Luu, S. L. AU - Tang, P. Y. AU - Valovcin, D. D. AU - Castellano, C. C2 - 32569372 DB - Scopus DO - 10.1093/tbm/ibaa056 IS - 3 J2 - Transl. Behav. Med. KW - behavioral medicine caregiver child abuse child protection coping behavior coronavirus disease 2019 dementia disaster disease exacerbation Editorial human peer group police priority journal public health Betacoronavirus Coronavirus infection pandemic virus pneumonia Coronavirus Infections Humans Pandemics Pneumonia, Viral LA - English M3 - Editorial N1 - Cited By :3 Export Date: 4 May 2021 Correspondence Address: Fisher, E.B.; Peers for Progress, United States; email: fishere@email.unc.edu Funding details: P30 DK092926 Funding details: American Cancer Society, ACS, RSG-15-02101CPPB Funding details: National Cancer Institute, NCI, P30 CA006927, R01 CA224918 Funding details: Healthcare Foundation of New Jersey, HFNJ Funding text 1: The project described was supported by a grant from the Healthcare Foundation of New Jersey to Rutgers University Behavioral Health Care, Department of Psychiatry, Rutgers University Medical School and also from the UNC-Michigan Peer Support Core of the Michigan Center for Diabetes Translational Research (P30 DK092926, William Herman, PI). Support also from the American Cancer Society (grant RSG-15-02101CPPB) and National Cancer Institute (grants R01 CA224918 and P30 CA006927). References: Pfefferbaum, B, North, CS., Mental health and the Covid-19 pandemic (2020) N Engl J Med; Bayefsky, MJ, Bartz, D, Watson, KL., Abortion during the Covid-19 pandemic—Ensuring access to an essential health service (2020) N Engl J Med, 382 (19), p. e47; Akiyama, MJ, Spaulding, AC, Rich, JD., Flattening the curve for incarcerated populations—Covid-19 in jails and prisons (2020) N Engl J Med, 382 (22), pp. 2075-2077; Dunn, CG, Kenney, E, Fleischhacker, SE, Bleich, SN., Feeding low-income children during the Covid-19 pandemic (2020) N Engl J Med, 382 (18), p. e40; Fontanarosa, PB, Bauchner, H., COVID-19-looking beyond tomorrow for health care and society (2020) JAMA, 323 (19), pp. 1907-1908. , 2020; Yancy, CW., COVID-19 and African Americans (2020) JAMA, 323 (19), pp. 1891-1892; Gostin, LO, Hodge, JG, Wiley, LF., Presidential powers and response to COVID-19 (2020) JAMA, 323 (16), pp. 1547-1548; Fisher, EB, Coufal, MM, Parada, H, Peer support in health care and prevention: cultural, organizational and dissemination issues (2014) Annual Review of Public Health, 35, pp. 363-383. , Fielding J, Brownson RC, Green L, eds, Palo Alto, CA: Annual Reviews; Fisher, EB, Bhushan, N, Coufal, MM, Peer support in prevention, chronic disease management, and well being (2018) Principles and Concepts of Behavioral Medicine: A Global Handbook, pp. 643-677. , Fisher EB, Cameron LD, Christensen AJ, Ehlert U, Guo Y, Oldenburg B, Snoek FJ, eds, New York, NY: Springer; Rosenthal, EL, Macinko, J., JACM special issue on community health workers and community health worker practice (2011) J Ambul Care Manage, 34 (3), pp. 208-209; Rosenthal, EL, Wiggins, N., Community health workers: Advocating for a just community and workplace (2015) J Ambul Care Manage, 38 (3), pp. 204-205; Perry, HB, Zulliger, R, Rogers, MM., Community health workers in low-, middle-, and high-income countries: An overview of their history, recent evolution, and current effectiveness (2014) Annu Rev Public Health, 35, pp. 399-421; Evans, M, Tang, PY, Bhushan, N, Fisher, EB, Dreyer Valovicin, D, Castellano, C., Standardization and adaptability for scale up of telephone peer support for high risk groups: general evaluation and lessons learned (2020) Transl Behav Med, , press; Kowitt, SD, Urlaub, D, Guzman-Corrales, L, Emotional support for diabetes management: An international cross-cultural study (2015) Diabetes Educ, 41 (3), pp. 291-300; Holt-Lunstad, J, Smith, TB, Layton, JB., Social relationships and mortality risk: A meta-analytic review (2010) PLoS Med, 7 (7), p. e1000316; Cohen, S, Doyle, WJ, Skoner, DP, Rabin, BS, Gwaltney, JM, Social ties and susceptibility to the common cold (1997) JAMA, 277 (24), pp. 1940-1944; House, JS, Landis, KR, Umberson, D., Social relationships and health (1988) Science, 241 (4865), pp. 540-545 PY - 2020 SN - 18696716 (ISSN) SP - 503-505 ST - COVID-19, stress, trauma, and peer support—observations from the field T2 - Translational Behavioral Medicine TI - COVID-19, stress, trauma, and peer support—observations from the field UR - https://www.scopus.com/inward/record.uri?eid=2-s2.0-85089294174&doi=10.1093%2ftbm%2fibaa056&partnerID=40&md5=059ea9ff7373151538f8160e84d71665 VL - 10 ID - 483 ER - TY - JOUR AB - With the current national opioid crisis, it is critical to examine the mechanisms underlying pathophysiologic interactions between human immunodeficiency virus (HIV) and opioids in the central nervous system (CNS). Recent advances in experimental models, methodology, and our understanding of disease processes at the molecular and cellular levels reveal opioid-HIV interactions with increasing clarity. However, despite the substantial new insight, the unique impact of opioids on the severity, progression, and prognosis of neuroHIV and HIV-associated neurocognitive disorders (HAND) are not fully understood. In this review, we explore, in detail, what is currently known about mechanisms underlying opioid interactions with HIV, with emphasis on individual HIV-1-expressed gene products at the molecular, cellular and systems levels. Furthermore, we review preclinical and clinical studies with a focus on key considerations when addressing questions of whether opioid-HIV interactive pathogenesis results in unique structural or functional deficits not seen with either disease alone. These considerations include, understanding the combined consequences of HIV-1 genetic variants, host variants, and μ-opioid receptor (MOR) and HIV chemokine co-receptor interactions on the comorbidity. Lastly, we present topics that need to be considered in the future to better understand the unique contributions of opioids to the pathophysiology of neuroHIV. [Figure not available: see fulltext.] © 2020, The Author(s). AD - Department of Psychology and Neuroscience, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-3270, United States Department of Pharmacotherapy and Outcomes Science, School of Pharmacy, Virginia Commonwealth University, Richmond, VA 23298, United States Department of Pharmacology and Toxicology, School of Medicine, Virginia Commonwealth University, 1217 East Marshall Street, Richmond, VA 23298-0613, United States Department of Anatomy and Neurobiology, School of Medicine, Virginia Commonwealth University, Richmond, VA 23298-0709, United States Institute for Drug and Alcohol Studies, Virginia Commonwealth University, 203 East Cary Street, Richmond, VA 23298-0059, United States AU - Fitting, S. AU - McRae, M. P. AU - Hauser, K. F. C2 - 32876803 DB - Scopus DO - 10.1007/s11481-020-09941-8 IS - 4 J2 - J. Neuroimmune Pharmacol. KW - Antiretroviral therapy Astrocyte Blood-brain barrier Buprenorphine C-C motif chemokine receptor 5 (CCR5) COVID-19 Cytochrome P450 3A4 (CYP 3A4) Endogenous opioid system of peptides and receptors Functional selectivity/biased agonism HIV-associated neurocognitive disorders Maladaptive neuroplasticity Methadone Microglia neuroHIV Oligodendroglia P-glycoprotein Pro-brain-derived neurotrophic factor (pro-BDNF) Synaptodendritic degeneration μ-Opioid receptor (OPRM1) complication HIV associated dementia human Human immunodeficiency virus 1 Human immunodeficiency virus infection immunology opiate addiction AIDS Dementia Complex HIV Infections HIV-1 Humans Opioid Epidemic Opioid-Related Disorders LA - English M3 - Review N1 - Cited By :3 Export Date: 4 May 2021 Correspondence Address: Hauser, K.F.; Department of Pharmacology and Toxicology, 1217 East Marshall Street, United States; email: kurt.hauser@vcuhealth.org Funding details: National Institute on Drug Abuse, NIDA, R01 DA018633, R01 DA034231, R01 DA044855, R01 DA045588, R01 DA045596, R21 DA045630 Funding text 1: This work was supported by the National Institute on Drug Abuse: R01 DA034231 (KFH), R01 DA044855 (KFH), R01 DA045588 (KFH), R01 DA018633 (KFH), R21 DA045630 (MM), and R01 DA045596 (SF). Acknowledgements Funding text 2: Portions of this review were initially presented at the Satellite Symposium of the 25th SNIP Scientific Conference entitled, ?Unraveling NeuroAIDS in the Presence of Substance Use Disorder? that was sponsored and organized by NIH/NIDA. 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Sheps Center for Health Services Research, Department of Family Medicine, University of North Carolina at Chapel Hill, Chapel Hill, United States Department of Health Policy and Management, Fitzhugh Mullan Institute for Health Workforce Equity, Milken Institute School of Public Health, George Washington University, Washington, DC, United States Department of Family Medicine, Center for Health Workforce Studies, School of Medicine, University of Washington, Seattle, United States Health Workforce Research Center on Long-Term Care, Philip R. Lee Institute for Health Policy Studies, University of California, San Francisco, San Francisco, United States New York Center for Health Workforce Studies, Rensselaer, United States Health Workforce Technical Assistance Center, Rensselaer, United States SUNY School of Public Health, Rensselaer, United States Behavioral Health Workforce Research Center, Department of Health Behavior and Health Education, University of Michigan School of Public Health, Ann Arbor, United States Center for Interdisciplinary Health Workforce Studies, College of Nursing, Montana State University, Bozeman, United States AU - Fraher, E. P. AU - Pittman, P. AU - Frogner, B. K. AU - Spetz, J. AU - Moore, J. AU - Beck, A. J. AU - Armstrong, D. AU - Buerhaus, P. I. C2 - 32268021 DB - Scopus DO - 10.1056/NEJMp2006376 IS - 23 J2 - New Engl. J. Med. KW - coronavirus disease 2019 critically ill patient government health care delivery health educator health workforce human infection prevention life threat medicare mental health pandemic priority journal protocol compliance public-private partnership Review sustainable development United States work capacity workflow Betacoronavirus Coronavirus infection health care personnel organization and management personnel management virus pneumonia Coronavirus Infections Delivery of Health Care Health Personnel Humans Pandemics Personnel Staffing and Scheduling Pneumonia, Viral Workforce LA - English M3 - Review N1 - Cited By :31 Export Date: 4 May 2021 CODEN: NEJMA References: 1135 Waiver — At A Glance, , https://www.cms.gov/Medicare/Provider-Enrollment-and-Certification/SurveyCertEmergPrep/Downloads/1135-Waivers-At-A-Glance.pdf; Medicare Telemedicine Health Care Provider Fact Sheet, , https://www.cms.gov/newsroom/fact-sheets/medicare-telemedicine-health-care-provider-fact-sheet; Marsh, J., In one day, 1,000 NYC doctors and nurses enlist to battle coronavirus New York Post, p. 2020. , https://nypost.com/2020/03/18/in-one-day-1000-nyc-doctors-and-nurses-enlist-to-battle-coronavirus/, March 18; Frogner, B.K., Fraher, E.P., Spetz, J., Modernizing scope-of-practice regulations — Time to prioritize patients (2020) N Engl J Med, 382, pp. 591-593 PY - 2020 SN - 00284793 (ISSN) SP - 2181-2183 ST - Ensuring and sustaining a pandemic workforce T2 - New England Journal of Medicine TI - Ensuring and sustaining a pandemic workforce UR - https://www.scopus.com/inward/record.uri?eid=2-s2.0-85083777835&doi=10.1056%2fNEJMp2006376&partnerID=40&md5=3c21833688d0056ca3da1a13b77905dc VL - 382 ID - 482 ER - TY - JOUR AB - We describe 2 hospitalized patients with confirmed coronavirus 19 (COVID-19) infection in whom brain imaging showed hemorrhagic posterior reversible encephalopathy syndrome, and we discuss the possible reasons for these findings and their relationship to the infection. © The Author(s), 2020. AD - Neuroradiology Section, Department of Radiology, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell Health, 300 Community Dr, Manhasset, NY 11030-3816, United States Department of Neurology, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell Health, Manhasset, NY, United States Department of Radiology, Stony Brook University Hospital, Stony Brook, NY, United States Neuroradiology Section, Department of Radiology, University of North Carolina School of Medicine, Chapel Hill, NC, United States AU - Franceschi, A. M. AU - Ahmed, O. AU - Giliberto, L. AU - Castillo, M. C2 - 32439646 DB - Scopus DO - 10.3174/AJNR.A6595 IS - 7 J2 - Am. J. Neuroradiol. KW - C reactive protein creatinine D dimer ferritin lactate dehydrogenase lactic acid nitrogen urea adult aged airplane pilot Article artificial ventilation asthma blood pressure case report clinical article confusion coronary artery disease coronavirus disease 2019 corpus callosum coughing cytokine release syndrome diabetes mellitus dyspnea female fever gout human hypertension hyponatremia lactate blood level lethargy male medical history mental health middle aged nuclear magnetic resonance imaging obesity petechia polymerase chain reaction posterior reversible encephalopathy syndrome quarantine shock thorax pain urea nitrogen blood level Betacoronavirus brain hemorrhage complication Coronavirus infection diagnostic imaging pandemic virus pneumonia Coronavirus Infections Humans Intracranial Hemorrhages Magnetic Resonance Imaging Pandemics Pneumonia, Viral Posterior Leukoencephalopathy Syndrome LA - English M3 - Article N1 - Cited By :51 Export Date: 4 May 2021 CODEN: AAJND Correspondence Address: Franceschi, A.M.; Neuroradiology Section, 300 Community Dr, United States; email: afranceschi@northwell.edu Chemicals/CAS: C reactive protein, 9007-41-4; creatinine, 19230-81-0, 60-27-5; ferritin, 9007-73-2; lactate dehydrogenase, 9001-60-9; lactate dehydrogenase A; lactic acid, 113-21-3, 50-21-5; nitrogen, 7727-37-9; urea, 57-13-6 References: Coronavirus disease (COVID-19) Pandemic, , https://www.who.int/emergencies/diseases/novelcoronavirus-2019, Geneva: World Health Organization. 2020. 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All rights reserved. AD - Neuroradiology Section, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell Health, Manhasset, NY, United States Departments of Radiology and Neurology, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell Health, Manhasset, NY, United States Neuroradiology Section, Department of Radiology, University of North Carolina, School of Medicine, Chapel Hill, NC, United States Department of Radiology, 300 Community Dr, Manhasset, NY 11030-3816, United States AU - Franceschi, A. M. AU - Arora, R. AU - Wilson, R. AU - Giliberto, L. AU - Libman, R. B. AU - Castillo, M. C2 - 32527844 DB - Scopus DO - 10.3174/ajnr.A6655 IS - 9 J2 - Am. J. Neuroradiol. KW - anticoagulant agent argatroban C reactive protein cytokine receptor antagonist D dimer enoxaparin ferritin hydroxychloroquine hypertensive factor interleukin 6 antibody lactate dehydrogenase methylprednisolone sodium chloride tissue plasminogen activator troponin abnormal value acute brain disease acute kidney failure acute respiratory failure adult arm weakness Article artificial ventilation basal ganglion brain edema brain hemorrhage brain hernia brain infarction case report cerebellum hemorrhage cerebrovascular disease clinical article coronavirus disease 2019 coughing drug megadose dyspnea extracorporeal oxygenation female ferritin blood level fever frontal lobe gaze paralysis headache hemiparesis hemisphere hospital admission hospital patient hospitalization human hypoglycemia hypotension hypoxia influenza intensive care unit internal carotid artery internal carotid artery occlusion intubation lactate dehydrogenase blood level left common carotid artery leukocytosis limb weakness lung edema lung parenchyma male middle aged middle cerebral artery occlusion multiple organ failure neuroimaging neurological complication nuclear magnetic resonance imaging occipital lobe oxygen therapy paresthesia parietal lobe patient transport pneumonia polydipsia polymerase chain reaction protein blood level respiratory acidosis respiratory distress respiratory failure self care septic shock slurred speech temporal lobe thorax radiography x-ray computed tomography aged Betacoronavirus complication Coronavirus infection diagnostic imaging pandemic virus pneumonia Cerebrovascular Disorders Coronavirus Infections Humans Pandemics Pneumonia, Viral Tomography, X-Ray Computed LA - English M3 - Article N1 - Cited By :9 Export Date: 4 May 2021 CODEN: AAJND Correspondence Address: Franceschi, A.M.; Neuroradiology Section, United States; email: afranceschi@northwell.edu Chemicals/CAS: argatroban, 74863-84-6, 141396-28-3; C reactive protein, 9007-41-4; enoxaparin, 679809-58-6; ferritin, 9007-73-2; hydroxychloroquine, 118-42-3, 525-31-5; lactate dehydrogenase, 9001-60-9; lactate dehydrogenase A; methylprednisolone, 6923-42-8, 83-43-2; sodium chloride, 7647-14-5; tissue plasminogen activator, 105913-11-9 References: Coronavirus disease (COVID-19) pandemic, , https://www.who.int/emergencies/diseases/novelcoronavirus-2019, Geneva: World Health Organization. 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Clinicians trace a ferocious rampage through the body, from brain to toes (2020) Science, , April 17 CrossRef; Poor, HD, Ventetuolo, CE, Tolbert, T, COVID-19 critical illness pathophysiology driven by diffuse pulmonary thrombi and pulmonary endothelial dysfunction responsive to thrombolysis https://onlinelibrary.wiley.com/doi/abs/10.1002/ctm2.44, Clinical and Translational Medicine May 13, 2020. Accessed May 15, 2020; Fox, SE, Akmatbekov, A, Harbert, JL, Pulmonary and cardiac pathology in Covid-19: the first autopsy series from New Orleans https://www.researchgate.net/publication/340563942_Pulmonary_and_Cardiac_Pathology_in_Covid-19_The_First_Autopsy_Series_from_New_Orleans, Research Gate April 2020. 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[Epub ahead of print] CrossRef Medline PY - 2020 SN - 01956108 (ISSN) SP - 1632-1640 ST - Neurovascular complications in COVID-19 infection: Case series T2 - American Journal of Neuroradiology TI - Neurovascular complications in COVID-19 infection: Case series UR - https://www.scopus.com/inward/record.uri?eid=2-s2.0-85089737790&doi=10.3174%2fajnr.A6655&partnerID=40&md5=6784e9ad7345403a436a0ec8164767cd VL - 41 ID - 387 ER - TY - JOUR AD - Department of Dermatology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States Medical Practice Evaluation Center, Mongan Institute, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States Department of Dermatology, Saint Louis University School of Medicine, Saint Louis, MO, United States Clinical Medicine, Trinity College Dublin, Dublin, Ireland Department of Dermatology, Public Health and Epidemiology; Immunity and Infections, Amsterdam University Medical Centers, location Academic Medical Center, Amsterdam, Netherlands St John's Institute of Dermatology, King's College London and Guy's & St Thomas' National Health Service Foundation Trust, London, United Kingdom Section of Pediatric Dermatology, Children's Hospital of Philadelphia, Philadelphia, PA, United States Department of Dermatology, University of California, San Francisco, San Francisco, CA, United States Section of Pediatric Dermatology, Hospital for Sick Children, Toronto, ON, Canada Sunnybrook Research Institute, Dermatology Division, Department of Medicine, University of Toronto, Toronto, ON, Canada Division of Infection and Immunity, Department of Dermatology & Academic Wound Healing, Cardiff University, Cardiff, United Kingdom Center for Dermatology Research, Department of Dermatology, Wake Forest School of Medicine, Winston-Salem, NC, United States Department of Pediatrics, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States Hair Restoration Blackrock, Dublin, Ireland National and International Skin Registry Solutions (NISR), Charles Institute of Dermatology, Dublin, Ireland Sinclair Dermatology, East Melbourne, Victoria, Australia French Society of Dermatology and Department of Dermatology, University Hospital of Bordeaux, Bordeaux, France American Academy of Dermatology, Rosemont, IL, United States Department of Dermatology, University Hospital, Munich University of Ludwig Maximilian, Munich, Germany Department of Dermatology, Henry Ford Health System, Detroit, MI, United States Dermatology Centre, Salford Royal Hospital, National Institute for Health Research, Manchester Biomedical Research Centre, University of Manchester, Manchester, United Kingdom Unit for Population-Based Dermatology Research, St John's Institute of Dermatology, King's College London and Guy's & St Thomas' National Health Service Foundation Trust, London, United Kingdom AU - Freeman, E. E. AU - McMahon, D. E. AU - Hruza, G. J. AU - Irvine, A. D. AU - Spuls, P. I. AU - Smith, C. H. AU - Mahil, S. K. AU - Castelo-Soccio, L. AU - Cordoro, K. M. AU - Lara-Corrales, I. AU - Naik, H. B. AU - Alhusayen, R. AU - Ingram, J. R. AU - Feldman, S. R. AU - Balogh, E. A. AU - Kappelman, M. D. AU - Wall, D. AU - Meah, N. AU - Sinclair, R. AU - Beylot-Barry, M. AU - Fitzgerald, M. AU - French, L. E. AU - Lim, H. W. AU - Griffiths, C. E. M. AU - Flohr, C. C2 - 32562840 DB - Scopus DO - 10.1016/j.jaad.2020.06.050 IS - 3 J2 - J. Am. Acad. Dermatol. KW - consensus coronavirus disease 2019 data processing dermatologist dermatology health service human Letter medical society priority journal register Betacoronavirus complication Coronavirus infection epidemiological monitoring international cooperation isolation and purification organization and management pandemic practice guideline skin disease virology virus pneumonia Coronavirus Infections Humans Pandemics Pneumonia, Viral Practice Guidelines as Topic Registries Skin Diseases LA - English M3 - Letter N1 - Cited By :5 Export Date: 4 May 2021 CODEN: JAADD Correspondence Address: Freeman, E.E.; Massachusetts General Hospital, 55 Fruit St, United States; email: efreeman@mgh.harvard.edu Funding details: American Academy of Dermatology, AAD Funding details: National Psoriasis Foundation, NPF Funding details: Pfizer Funding details: Merck Funding details: Novartis Funding details: Samsung Funding details: Janssen Biotech Funding details: AbbVie Funding details: British Society for Pediatric Dermatology, BSPD Funding details: Psoriasis Association Funding details: NIHR Biomedical Research Centre, Royal Marsden NHS Foundation Trust/Institute of Cancer Research, BRC Funding details: Manchester Biomedical Research Centre, BRC Funding details: British Paediatric Respiratory Society, BPRS, ISRCTN11210918 Funding details: National Institute for Health Research, NIHR Funding details: King's College London Funding details: Guy's and St Thomas' NHS Foundation Trust Funding details: Société Française de Dermatologie et de Pathologie Sexuellement Transmissible, SFD Funding details: Galderma Funding details: National Institute for Health Research Biomedical Research Centre at Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology Funding text 1: Conflicts of interest and disclosures: Drs Freeman and Hruza are part of the American Academy of Dermatology (AAD) COVID-19 Ad Hoc Task Force. Drs Smith and Mahil are supported by the National Institute for Health Research (NIHR) Biomedical Research Centre at Guy's and St Thomas' National Health Service Foundation Trust and King's College, London, United Kingdom, and the Psoriasis Association, United Kingdom. Drs Castelo-Soccio, Cordoro, and Lara-Corrales are part of the Pediatric Dermatology Research Alliance COVID-19 Response Task Force, a collaboration between the Society for Pediatric Dermatology (SPD) and the Pediatric Dermatology Research Alliance (PeDRA). Dr Naik is a board member of the Hidradenitis Suppurativa Foundation. Raed Alhusayen is a member of the Canadian Dermatology Association (CDA) COVID-19 Task-Force and president of the Canadian Hidradenitis Suppurativa Foundation. Dr Feldman has received research, speaking, and/or consulting support from a variety of companies, including Galderma, GSK/Stiefel, Almirall, Alvotech, LEO Pharma, BMS, Boehringer Ingelheim, Mylan, Celgene, Pfizer, Ortho Dermatology, AbbVie, Samsung, Janssen, Lilly, Menlo, Merck, Novartis, Regeneron, Sanofi, Novan, Qurient, National Biological Corporation, Caremark, Advance Medical, Sun Pharma, Suncare Research, Informa, UpToDate, and the National Psoriasis Foundation. Dr Feldman also consults for others through Guidepoint Global, Gerson Lehrman, and other consulting organizations. Dr Feldman is founder and majority owner of www.DrScore.com and is founder and part owner of Causa Research, a company dedicated to enhancing patients' adherence to treatment. Dr Kappelman has consulted for AbbVie, Janssen, and Takeda, is a shareholder in Johnson & Johnson, and has received research support from AbbVie and Janssen. Dr Beylot-Barry is president of the French Society of Dermatology. Dr French is president and Dr Lim is a board member of the International League of Dermatological Societies (ILDS). Dr Griffiths is president of the European Society for Dermatological Research and is funded in part by the National Institute for Health Research Manchester Biomedical Research Centre. Dr Flohr is president of the British Society for Paediatric Dermatology and chief investigator of the UK-Irish Atopic eczema Systemic TherApy Register (A-STAR; ISRCTN11210918). Dr Flohr and the patient-facing part of the SECURE-AD registry are supported by the National Institute for Health Research Biomedical Research Centre at Guy's and St Thomas' National Health Service Foundation Trust, London, United Kingdom. Devon McMahon and Drs Irvine, Spuls, Ingram, Balogh, Wall, Meah, Sinclair, and Fitzgerald have no conflicts of interest to disclose. Funding text 2: Conflicts of interest and disclosures: Drs Freeman and Hruza are part of the American Academy of Dermatology (AAD) COVID-19 Ad Hoc Task Force. Drs Smith and Mahil are supported by the National Institute for Health Research (NIHR) Biomedical Research Centre at Guy's and St Thomas' National Health Service Foundation Trust and King's College , London, United Kingdom, and the Psoriasis Association , United Kingdom. Drs Castelo-Soccio, Cordoro, and Lara-Corrales are part of the Pediatric Dermatology Research Alliance COVID-19 Response Task Force, a collaboration between the Society for Pediatric Dermatology (SPD) and the Pediatric Dermatology Research Alliance (PeDRA). Dr Naik is a board member of the Hidradenitis Suppurativa Foundation. Raed Alhusayen is a member of the Canadian Dermatology Association (CDA) COVID-19 Task-Force and president of the Canadian Hidradenitis Suppurativa Foundation. Dr Feldman has received research, speaking, and/or consulting support from a variety of companies, including Galderma, GSK/Stiefel, Almirall, Alvotech, LEO Pharma, BMS, Boehringer Ingelheim, Mylan, Celgene, Pfizer, Ortho Dermatology, AbbVie, Samsung, Janssen, Lilly, Menlo, Merck, Novartis, Regeneron, Sanofi, Novan, Qurient, National Biological Corporation, Caremark, Advance Medical, Sun Pharma, Suncare Research, Informa, UpToDate, and the National Psoriasis Foundation. Dr Feldman also consults for others through Guidepoint Global, Gerson Lehrman, and other consulting organizations. Dr Feldman is founder and majority owner of www.DrScore.com and is founder and part owner of Causa Research, a company dedicated to enhancing patients' adherence to treatment. Dr Kappelman has consulted for AbbVie, Janssen, and Takeda, is a shareholder in Johnson & Johnson, and has received research support from AbbVie and Janssen . Dr Beylot-Barry is president of the French Society of Dermatology. Dr French is president and Dr Lim is a board member of the International League of Dermatological Societies (ILDS). Dr Griffiths is president of the European Society for Dermatological Research and is funded in part by the National Institute for Health Research Manchester Biomedical Research Centre . Dr Flohr is president of the British Society for Paediatric Dermatology and chief investigator of the UK-Irish Atopic eczema Systemic TherApy Register (A-STAR; ISRCTN11210918). Dr Flohr and the patient-facing part of the SECURE-AD registry are supported by the National Institute for Health Research Biomedical Research Centre at Guy's and St Thomas' National Health Service Foundation Trust, London, United Kingdom. Devon McMahon and Drs Irvine, Spuls, Ingram, Balogh, Wall, Meah, Sinclair, and Fitzgerald have no conflicts of interest to disclose. References: Freeman, E.E., McMahon, D.E., Fitzgerald, M.E., The AAD COVID-19 Registry: crowdsourcing dermatology in the age of COVID-19 (2020) J Am Acad Dermatol, 83 (2), pp. 509-510; Mahil, S.K., Yiu, Z.Z.N., Mason, K.J., Global reporting of cases of COVID-19 in psoriasis and atopic dermatitis: an opportunity to inform care during a pandemic (2020), [e-pub ahead of print]. Br J Dermatol (Accessed 26 May 2020); Balogh, E.A., Heron, C., Feldman, S.R., Huang, W.W., SECURE-Psoriasis: a de-identified registry of psoriasis patients diagnosed with COVID-19 (2020) J Dermatolog Treat, 31 (4), p. 327; Bauchner, H., Golub, R.M., Zylke, J., Editorial concern–possible reporting of the same patients with COVID-19 in different reports (2020) JAMA, 323 (13), p. 1256; Khunti, K., Singh, A.K., Pareek, M., Hanif, W., Is ethnicity linked to incidence or outcomes of COVID-19? (2020) BMJ, 369, p. m1548 PY - 2020 SN - 01909622 (ISSN) SP - e261-e266 ST - International collaboration and rapid harmonization across dermatologic COVID-19 registries T2 - Journal of the American Academy of Dermatology TI - International collaboration and rapid harmonization across dermatologic COVID-19 registries UR - https://www.scopus.com/inward/record.uri?eid=2-s2.0-85089007567&doi=10.1016%2fj.jaad.2020.06.050&partnerID=40&md5=3b5ffad319d19bb6aa5dcd1d0f00341a VL - 83 ID - 393 ER - TY - JOUR AB - We are currently in the midst of a global pandemic with the spread of Coronavirus Disease 2019 (COVID-19). While we do not know how this situation will unfold or resolve, we do have insight into how it fits within existing patterns and relations, particularly those pertaining to sociocultural constructions of (in)security, vulnerability, and risk. We can see evidence of surveillance dynamics at play with how bodies and pathogens are being measured, tracked, predicted, and regulated. We can grasp how threat is being racialized, how and why institutions are flailing, and how social media might be fueling social divisions. There is, in other words, a lot that our scholarly community could add to the conversation. In this rapid-response editorial, we provide an introduction to the framing devices of disease surveillance and discuss how a surveillance studies orientation could help us think critically about the present crisis and its possible aftermath. © The author(s), 2020. AD - Concordia University, Canada University of North Carolina at Chapel Hill, United States AU - French, M. AU - Monahan, T. DB - Scopus DO - 10.24908/ss.v18i1.13985 IS - 1 J2 - Surveill. Soc. 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Cnn.Com, , https://www.cnn.com/2020/02/20/us/coronavirus-racist-attacks-against-asian-americans/index.html, February 21. Available from , accessed March 11, 2020 PY - 2020 SN - 14777487 (ISSN) SP - 1-11 ST - Disease surveillance: how might surveillance studies address covid-19? T2 - Surveillance and Society TI - Disease surveillance: how might surveillance studies address covid-19? UR - https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082177573&doi=10.24908%2fss.v18i1.13985&partnerID=40&md5=fe66b6374d2d42ad88d03a9214aa1890 VL - 18 ID - 574 ER - TY - JOUR AD - Cellular Immunotherapy Program, Massachusetts General Hospital, Boston, MA, United States Division of Hematologic Malignancies, Department of Medicine, Dana-Farber Cancer Institute, Boston, MA, United States Division of Infectious Diseases, Department of Medicine, Massachusetts General Hospital, Boston, MA, United States Center for International Blood and Marrow Transplant Research, Medical College of Wisconsin, Milwaukee, WI, United States Blood and Marrow Transplant and Cellular Therapy Program, Medical College of Wisconsin, Milwaukee, WI, United States Division of Hematology/Oncology, Department of Medicine, University of North Carolina, Chapel Hill, NC, United States Division of Hematology/Oncology/Bone Marrow Transplantation, Department of Medicine, University of Wisconsin, Madison, WI, United States Department of Medicine, University of Washington, Seattle, WA, United States Adult Blood and Marrow Transplant Service, Memorial Sloan Kettering Cancer Center, New York, NY, United States AU - Frigault, M. J. AU - Nikiforow, S. AU - Mansour, M. K. AU - Hu, Z. H. AU - Horowitz, M. M. AU - Riches, M. L. AU - Hematti, P. AU - Turtle, C. J. AU - Zhang, M. J. AU - Perales, M. A. AU - Pasquini, M. C. C2 - 32457999 DB - Scopus DO - 10.1182/BLOOD.2020006216 IS - 1 J2 - Blood KW - corticosteroid cyclophosphamide fludarabine immunosuppressive agent tocilizumab monoclonal antibody aged bacterial infection bk virus infection cancer chemotherapy chimeric antigen receptor T-cell immunotherapy confounding variable controlled study coronavirus disease 2019 Coronavirus infection corticosteroid therapy cytokine release syndrome cytomegalovirus infection cytopenia drug fatality Enterovirus infection Epstein Barr virus infection erythema infectiosum female hematologic malignancy hemophagocytic syndrome hepatitis A hepatitis B herpes simplex human Human metapneumovirus infection immune effector cell associated neurotoxicity syndrome immunocompromised patient immunopathology immunosuppressive treatment incidence infection risk infectious complication influenza A influenza B Letter macrophage activation syndrome major clinical study male mycosis neurotoxicity overall survival Parainfluenza virus infection phase 3 clinical trial (topic) priority journal respiratory syncytial virus infection T cell depletion viral respiratory tract infection virus infection adoptive immunotherapy adverse event Betacoronavirus complication drug effect hematologic disease middle aged pandemic risk factor very elderly virus pneumonia Aged, 80 and over Antibodies, Monoclonal, Humanized Coronavirus Infections Hematologic Neoplasms Humans Immunotherapy, Adoptive Pandemics Pneumonia, Viral Risk Factors LA - English M3 - Letter N1 - Cited By :16 Export Date: 4 May 2021 CODEN: BLOOA Correspondence Address: Pasquini, M.C.; Center for International Blood and Marrow Transplant Research, 9200 West Wisconsin Ave, United States; email: mpasquini@mcw.edu Chemicals/CAS: cyclophosphamide, 50-18-0; fludarabine, 21679-14-1; tocilizumab, 375823-41-9; Antibodies, Monoclonal, Humanized; tocilizumab Funding details: K12CA087723 Funding details: National Institutes of Health, NIH Funding details: National Heart, Lung, and Blood Institute, NHLBI Funding details: National Cancer Institute, NCI, U24CA233032 Funding details: National Institute of Allergy and Infectious Diseases, NIAID Funding details: AstraZeneca Funding details: Novartis Funding details: Gilead Sciences Funding details: U.S. Public Health Service, USPHS, U24CA076518 Funding details: Miltenyi Biotec Funding text 1: The authors acknowledge all centers that report CAR T-cell data to the Center for International Blood and Marrow Transplant Research. The Center for International Blood and Marrow Transplant Research cellular therapy registry receives research support from the National Cancer Institute (Cellular Immunotherapy Data Resource, U24CA233032), Novartis, and Kite Pharma. The Center for International Blood and Marrow Transplant Research is also supported by Public Health Service U24CA076518 from the National Institutes of Health, National Cancer Institute, National Heart, Lung, and Blood Institute, and National Institute of Allergy and Infectious Diseases. M.J.F. is supported by Dana-Farber/Harvard Cancer Consortium National Institutes of Health project K12CA087723. Funding text 2: M.J.F. is supported by Dana-Farber/Harvard Cancer Consortium National Institutes of Health project K12CA087723. Funding text 3: Conflict-of-interest disclosure: M.J.F. has acted as a consultant for Novartis, Gilead, Celgene, and Arcellx. S.N. has acted as a consultant for Novartis and Kite Pharma. M.K.M. has acted as a consultant for Celularity, GenMark Diagnostics, SmartPharm Therapeutics, Pulsethera, Vericel Corporation, and Globe Life Sciences and has received research support from Thermo Fisher Scientific and Genentech. C.J.T. has received research funding from Juno Therapeutics, Nektar Therapeutics, AstraZeneca, and TCR2 Therapeutics; serves on scientific advisory boards for Precision Biosciences, Eureka Therapeutics, Caribou Biosciences, T-CURX, Myeloid Therapeutics, ArsenalBio, and Century Therapeutics; serves on ad hoc advisory boards (last 12 months) for Nektar Therapeutics, Allogene, PACT Pharma, and Astra Zeneca; has stock options for Precision Biosciences, Eureka Therapeutics, Caribou Biosciences, Myeloid Therapeutics, ArsenalBio; and has a patent licensed to Juno Therapeutics; M.-A.P. reports honoraria from Abbvie, Bellicum, Bristol-Myers Squibb, Incyte, Merck, Novartis, Nektar Therapeutics, Omeros, and Takeda; serves on DSMBs for Servier and Medigene, and the scientific advisory boards of MolMed and NexImmune; and has received research support for clinical trials from Incyte, Kite/ Gilead, and Miltenyi Biotec. M.C.P. has acted as a consultant for Bristol-Myers Squibb and Amgen and has received research support from Novartis, Kite Pharma, and Bristol-Myers Squibb. The remaining authors declare no competing financial interests. Funding text 4: The authors acknowledge all centers that report CAR T-cell data to the Center for International Blood and Marrow Transplant Research. The Center for International Blood and Marrow Transplant Research cellular therapy registry receives research support from the National Cancer Institute (Cellular Immunotherapy Data Resource, U24CA233032), Novartis, and Kite Pharma. The Center for International Blood and Marrow Transplant Research is also supported by Public Health Service U24CA076518 from the National Institutes of Health, National Cancer Institute, National Heart, Lung, and Blood Institute, and National Institute of Allergy and Infectious Diseases. 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T2 - Blood TI - Tocilizumab not associated with increased infection risk after CAR T-cell therapy: Implications for COVID-19? UR - https://www.scopus.com/inward/record.uri?eid=2-s2.0-85087529450&doi=10.1182%2fBLOOD.2020006216&partnerID=40&md5=f82cae4f7bb2d68d839c254f159a6d1a VL - 136 ID - 451 ER - TY - JOUR AB - The coronavirus identified in 2019 (COVID-19) has caused dramatic disruptions in pharmacy experiential education. Administrators and programs have worked to help external preceptors, faculty members, and students cope with the new realities of virtual or remote experiences and new or increased use of telemedicine. Clear and effective lines of communication as well as well-reasoned and resourced alternative plans are necessary to help manage the current issues and prepare for future challenges. Doctor of Pharmacy programs should enhance their focus not just on the physical health and well-being of students, faculty members, and external preceptors, but also on their mental and emotional health. The full scope of the impact of the pandemic on experiential education in pharmacy is still unclear, but this situation should serve as a stimulus for innovation and rethinking the paradigm of how pharmacy programs educate and prepare students for pharmacy practice. © 2020 American Association of Colleges of Pharmacy. AD - University of North Carolina, Eshelman School of Pharmacy, Chapel Hill, NC, United States University of Arkansas for Medical Sciences, College of Pharmacy, Little Rock, AR, United States Presbyterian College, School of Pharmacy, Clinton, SC, United States Sullivan University, College of Pharmacy and Health Sciences, Louisville, KY, United States American Journal of Pharmaceutical Education, Arlington, VA, United States AU - Fuller, K. A. AU - Heldenbrand, S. D. AU - Smith, M. D. AU - Malcom, D. R. C2 - 32665722 C7 - 8149 DB - Scopus DO - 10.5688/ajpe8149 IS - 6 J2 - Am. J. Pharm. Educ. KW - Change COVID-19 Education Experiential education Betacoronavirus coping behavior Coronavirus infection human interpersonal communication organization and management pandemic pharmacy school pharmacy student problem based learning psychology videoconferencing virus pneumonia Adaptation, Psychological Communication Coronavirus Infections Education, Distance Education, Pharmacy Faculty, Pharmacy Humans Pandemics Pneumonia, Viral Problem-Based Learning Schools, Pharmacy Students, Pharmacy LA - English M3 - Article N1 - Cited By :6 Export Date: 4 May 2021 Correspondence Address: Malcom, D.R.; Sullivan University, United States; email: dmalcom@sullivan.edu Correspondence Address: Malcom, D.R.; American Journal of Pharmaceutical EducationUnited States; email: dmalcom@sullivan.edu References: Brazeau, G, Romanelli, F., Navigating the unchartered waters in the time of COVID-19 (2020) Am J Pharm Educ, 84 (3), p. 8063. , Article; Kuhn, TS., (1962) The Structure of Scientific Revolutions, , 1st edition. 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KW - Corona virus COVID-19 chloroquine remdesivir virus antibody adult respiratory distress syndrome antiviral therapy cardiotoxicity convalescence coronavirus disease 2019 evidence based practice experimental therapy herd immunity human Letter pandemic patient care plasma transfusion practice guideline priority journal vaccination virus transmission Betacoronavirus Coronavirus infection virus pneumonia Coronavirus Infections Humans Pandemics Pneumonia, Viral LA - English M3 - Letter N1 - Export Date: 4 May 2021 Correspondence Address: Charles, A.; UNC School of Medicine, 4008 Burnett Womack Building, CB, 7228, United States; email: anthony_charles@med.unc.edu Chemicals/CAS: chloroquine, 132-73-0, 3545-67-3, 50-63-5, 54-05-7; remdesivir, 1809249-37-3 References: Nicola, M., O'Neill, N., Sohrabi, C., Khan, M., Agha, R., Evidence based management guideline for the COVID-19 pandemic - review article (2020) Int. J. Surg.; Greenhalgh, T., Schmid, M.B., Czypionka, T., Bassler, D., Gruer, L., Face masks for the public during the covid-19 crisis (2020) BMJ, p. 369; Jaffe, S., Regulators split on antimalarials for COVID-19 (2020) Lancet, 395 (10231), p. 1179; Casadevall, A., Pirofski, L., The convalescent sera option for containing COVID-19 (2020) J. Clin. Invest., 130 (4); Sutton, D., Fuchs, K., D'Alton, M., Goffman, D., Universal screening for SARS-CoV-2 in women admitted for delivery (2020) NEJM PY - 2020 SN - 17439191 (ISSN) SP - 42 ST - Developing guidelines for COVID-19 management: A moving target. An invited commentary on “Evidence based management guideline for the COVID-19 pandemic - Review article” T2 - International Journal of Surgery TI - Developing guidelines for COVID-19 management: A moving target. An invited commentary on “Evidence based management guideline for the COVID-19 pandemic - Review article” UR - https://www.scopus.com/inward/record.uri?eid=2-s2.0-85083469481&doi=10.1016%2fj.ijsu.2020.04.030&partnerID=40&md5=2d6013516bf559bbaa4a9f2066f1ee5b VL - 78 ID - 495 ER - TY - JOUR AD - The African Research Network, Kumasi, Ghana Université de Paris, Integrative Epidemiology of Cardiovascular Diseases, Paris Cardiovascular Research Center-INSERM U970, Paris, France Department of Medicine, Division of General Internal Medicine, University of North Carolina at Chapel Hill, Chapel Hill School of Medicine, Chapel Hill, NC, United States Cecil G. Sheps Center for Health Services Research, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC, United States University of Yaoundé, Ministry of Public Health, Yaoundé, Cameroon Institute of Cardiology of Abidjan, Abidjan, Cote d'Ivoire CIBER of Pathophysiology of Obesity and Nutrition, Instituto de Salud Carlos III, Madrid, Spain Department of Cardiology, University Hospital of Conakry, Conakry, Guinea Cardiology Department, University Hospital of Fann, Dakar, Senegal Leverhulme Centre for Demographic Science, Nuffield College, University of Oxford, Oxford, United Kingdom Cardiology Department, Georges-Pompidou European Hospital, Paris, France AU - Gaye, B. AU - Khoury, S. AU - Cene, C. W. AU - Kingue, S. AU - N’Guetta, R. AU - Lassale, C. AU - Baldé, D. AU - Diop, I. B. AU - Dowd, J. B. AU - Mills, M. C. AU - Jouven, X. C2 - 32528153 DB - Scopus DO - 10.1038/s41591-020-0960-y IS - 7 J2 - Nat. Med. KW - Africa comorbidity coronavirus disease 2019 human infection control Note pandemic priority journal Betacoronavirus climate community care Coronavirus infection demography mortality organization and management socioeconomics virus pneumonia Community Networks Coronavirus Infections Humans Pandemics Pneumonia, Viral Socioeconomic Factors LA - English M3 - Note N1 - Cited By :5 Export Date: 4 May 2021 CODEN: NAMEF Correspondence Address: Gaye, B.; The African Research NetworkGhana; email: bamba.gaye@inserm.fr References: Nkengasong, J.N., Mankoula, W., (2020) Lancet, 395, pp. 841-842. , COI: 1:CAS:528:DC%2BB3cXktFCit7w%3D; Fanidi, A., Jouven, X., Gaye, B., (2020) Eur. Heart J., , https://doi.org/10.1093/eurheartj/ehaa278; (2020) Time, , https://time.com/5822461/coronavirus-tests-africa/; https://www.bsg.ox.ac.uk/research/research-projects/coronavirus-government-response-tracker, (accessed 26 April 2020); Dowd, J.B., (2020) Proc. Natl Acad. Sci. 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Health, 7, pp. e1375-e1387; Kearney, P.M., (2005) Lancet, 365, pp. 217-223; (2020) World Health Organization, , https://www.who.int/publications-detail/the-potential-impact-of-health-service-disruptions-on-the-burden-of-malaria; (2020), https://www.people-press.org/2020/03/18/u-s-public-sees-multiple-threats-from-the-coronavirus-and-concerns-are-growing/; Fasina, F.O., (2014) Euro Surveill., 19, p. 20920. , COI: 1:STN:280:DC%2BC2M3hsVelsQ%3D%3D; (2020), https://population.un.org/wpp/; (2020), https://www.epicentro.iss.it/coronavirus/bollettino/Bollettino-sorveglianza-integrata-COVID-19_30-marzo-2020.pdfUR - https://www.scopus.com/inward/record.uri?eid=2-s2.0-85086340609&doi=10.1038%2fs41591-020-0960-y&partnerID=40&md5=b74752e35d61ddfce00694dbbde8e813 PY - 2020 SN - 10788956 (ISSN) SP - 996-999 ST - Socio-demographic and epidemiological consideration of Africa’s COVID-19 response: what is the possible pandemic course? T2 - Nature Medicine TI - Socio-demographic and epidemiological consideration of Africa’s COVID-19 response: what is the possible pandemic course? VL - 26 ID - 463 ER - TY - JOUR AB - COVID-19 caused by SARS-CoV-2, is an international concern. This infection requires urgent efforts to develop new antiviral compounds. To date, no specific drug in controlling this disease has been identified. Developing the new treatment is usually time consuming, therefore using the repurposing broad-spectrum antiviral drugs could be an effective strategy to respond immediately. In this review, a number of broad-spectrum antivirals with potential efficacy to inhibit the virus replication via targeting the virus spike protein (S protein), RNA-dependent RNA polymerase (RdRp), 3-chymotrypsin-like protease (3CLpro) and papain-like protease (PLpro) that are critical in the pathogenesis and life cycle of coronavirus, have been evaluated as possible treatment options against SARS-CoV-2 in COVID-19 patients. © 2021 Future Medicine Ltd AD - Digestive Oncology Research Center, Digestive Diseases Research Institute, Tehran University of Medical Science, Tehran, 1411713135, Iran Department of Virology, Faculty of Medicine, Hamadan University of Medical Sciences, Hamadan, 65178-38678, Iran Foodborne and Waterborne Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, 1985717411, Iran Department of Veterinary Biomedical Sciences, University of Saskatchewan, Saskatoon, SK S7N 5B4, Canada Pharmaceutical Analysis Research Center and Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, 5166/1573, Iran Department of Nutrition, Nutrition Research Institute, University of North Carolina at Chapel Hill, Chapel Hill, NC 28081, United States AU - Ghanbari, R. AU - Teimoori, A. AU - Sadeghi, A. AU - Mohamadkhani, A. AU - Rezasoltani, S. AU - Asadi, E. AU - Jouyban, A. AU - Sumner, S. C. J. C2 - 33404263 DB - Scopus DO - 10.2217/fmb-2020-0120 IS - 18 J2 - Future Microbiol. KW - antiviral drugs COVID-19 drug repurposing SARS-CoV-2 antivirus agent coronavirus 3C protease danoprevir disulfiram favipiravir galidesivir griffithsin lopinavir plus ritonavir nafamstat nelfinavir papain-like protease remdesivir ribavirin RNA directed RNA polymerase viral protease virus spike protein chymase NSP12 protein, SARS-CoV-2 papain-like protease, SARS-CoV-2 antiviral activity coronavirus disease 2019 drug efficacy drug potency human life cycle nonhuman pathogenesis priority journal protein targeting Review Severe acute respiratory syndrome coronavirus 2 virus characterization virus replication drug effect drug repositioning drug therapy virus entry Antiviral Agents Chymases Coronavirus Papain-Like Proteases Coronavirus RNA-Dependent RNA Polymerase Humans Virus Internalization LA - English M3 - Review N1 - Cited By :1 Export Date: 4 May 2021 Correspondence Address: Ghanbari, R.; Digestive Oncology Research Center, Iran; email: r.ghanbari98@gmail.com Chemicals/CAS: 3C viral protease; coronavirus 3C protease; coronavirus RNA dependent RNA polymerase; cysteine proteinase; danoprevir, 916881-67-9, 1001913-18-3, 1225266-12-5, 850876-88-9, 916826-48-7; disulfiram, 97-77-8; favipiravir, 259793-96-9; galidesivir, 222631-44-9, 249503-25-1; gingipain cysteine endopeptidase; mucosa associated lymphoid tissue lymphoma translocation protein 1; nafamstat, 81525-10-2; nelfinavir, 159989-64-7, 159989-65-8; papain-like protease; peptide hydrolase; remdesivir, 1809249-37-3; ribavirin, 36791-04-5; RNA directed RNA polymerase, 9026-28-2; viral papain-like protease; viral protease; chymase, 75496-62-7, 97501-92-3; Antiviral Agents; Chymases; Coronavirus Papain-Like Proteases; Coronavirus RNA-Dependent RNA Polymerase; NSP12 protein, SARS-CoV-2; papain-like protease, SARS-CoV-2 Tradenames: avigan; kaletra References: Guo, Y.R., Cao, Q.D., Hong, Z.S., The origin, transmission and clinical therapies on coronavirus disease 2019 (COVID-19) outbreak-an update on the status (2020) Mil. 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Unlocked., 19, p. 100345; Calligari, P., Bobone, S., Ricci, G., Bocedi, A., Molecular investigation of SARS-CoV-2 proteins and their interactions with antiviral drugs (2020) Viruses, 12 (4), p. 445 PY - 2020 SN - 17460913 (ISSN) SP - 1747-1758 ST - Existing antiviral options against SARS-CoV-2 replication in COVID-19 patients T2 - Future Microbiology TI - Existing antiviral options against SARS-CoV-2 replication in COVID-19 patients UR - https://www.scopus.com/inward/record.uri?eid=2-s2.0-85099147054&doi=10.2217%2ffmb-2020-0120&partnerID=40&md5=f9719c5ca795d7d1a5278e04b770122f VL - 15 ID - 252 ER - TY - JOUR AB - Background: The emergence of the COVID-19 pandemic has significantly impacted global healthcare systems and this may affect stroke care and outcomes. This study examines the changes in stroke epidemiology and care during the COVID-19 pandemic in Zanjan Province, Iran. Methods: This study is part of the CASCADE international initiative. From February 18, 2019, to July 18, 2020, we followed ischemic and hemorrhagic stroke hospitalization rates and outcomes in Valiasr Hospital, Zanjan, Iran. We used a Bayesian hierarchical model and an interrupted time series analysis (ITS) to identify changes in stroke hospitalization rate, baseline stroke severity [measured by the National Institutes of Health Stroke Scale (NIHSS)], disability [measured by the modified Rankin Scale (mRS)], presentation time (last seen normal to hospital presentation), thrombolytic therapy rate, median door-to-needle time, length of hospital stay, and in-hospital mortality. We compared in-hospital mortality between study periods using Cox-regression model. Results: During the study period, 1,026 stroke patients were hospitalized. Stroke hospitalization rates per 100,000 population decreased from 68.09 before the pandemic to 44.50 during the pandemic, with a significant decline in both Bayesian [Beta: -1.034; Standard Error (SE): 0.22, 95% CrI: -1.48, -0.59] and ITS analysis (estimate: -1.03, SE = 0.24, p < 0.0001). Furthermore, we observed lower admission rates for patients with mild (NIHSS < 5) ischemic stroke (p < 0.0001). Although, the presentation time and door-to-needle time did not change during the pandemic, a lower proportion of patients received thrombolysis (-10.1%; p = 0.004). We did not see significant changes in admission rate to the stroke unit and in-hospital mortality rate; however, disability at discharge increased (p < 0.0001). Conclusion: In Zanjan, Iran, the COVID-19 pandemic has significantly impacted stroke outcomes and altered the delivery of stroke care. Observed lower admission rates for milder stroke may possibly be due to fear of exposure related to COVID-19. The decrease in patients treated with thrombolysis and the increased disability at discharge may indicate changes in the delivery of stroke care and increased pressure on existing stroke acute and subacute services. The results of this research will contribute to a similar analysis of the larger CASCADE dataset in order to confirm findings at a global scale and improve measures to ensure the best quality of care for stroke patients during the COVID-19 pandemic. © 2020 Elsevier Inc. AD - Stroke Research Group, Department of Neurology and Stroke Unit, Vali-e-Asr hospital, School of Medicine, Zanjan University of Medical SciencesZanjan, Iran Department of Biostatistics and Epidemiology, School of Medicine, Zanjan University of Medical SciencesZanjan, Iran Stroke Prevention and Atherosclerosis Research Centre, Robarts Research Institute, Western University, London, ON, Canada Schulich School of Medicine and Dentistry, Western University, London, ON, Canada Department of Medicine and Neurology, Melbourne Brain Centre at The Royal Melbourne Hospital, University of Melbourne, Australia Population Health and Immunity Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, Australia Comprehensive Stroke Care Program, Sree Chitra Tirunal Institute for Medical Sciences and Technology (SCTIMST), Trivandrum, Kerala, India Departments of Neurology, Neurological Surgery, and Anatomy & Neurobiology, Beckman Laser Institute & Medical Clinic, University of California, Irvine, CA, United States Department of Neurology, School of Medicine, University of New Mexico, Albuquerque, NM, United States Department of Neurology, Loyola University, Stritch School of Medicine, Chicago, IL, United States Department of Neurology, Monash Health and Department of Medicine, School of Clinical Sciences, Monash University, Australia Health Information Science, Western University, London, ON, Canada Regional Stroke Prevention, Southwestern Ontario Stroke Network, London Health Sciences, London, ON, Canada Department of Neurology, University of Massachusetts Medical School, Worcester, MA, United States Department of Neurology, Neuroscience Institute, Geisinger Medical Center, Danville, PA, United States Department of Medicine, Faculty of Medicine and Health Sciences, UPM, Serdang, Malaysia Department of Pathology and Ophthalmology, Center for Translational Research & Education, Loyola University Stritch School of Medicine, Maywood, IL, United States Department of Medicine and Neurology, University of Otago and Wellington Hospital, Wellington, New Zealand Boston Medical Center, Boston University School of Medicine, Boston, MA, United States Dr. Everett Chalmers Regional Hospital, Dalhousie University, New Brunswick, Canada Vascular Neurology Division, Department of Neurology, Fleni, Buenos Aires, Argentina Neurological Clinic, Department of Experimental and Clinical Medicine, Marche Polytechnic University, Via Conca, Ancona, Italy Department of Neurology, University of Oklahoma Health Science Center, Oklahoma City, OK, United States Neurology Department, Santa Casa of Sao Paulo Medical School, Sao Paulo, Brazil Department of Cerebrovascular Medicine/Division of Stroke Care Unit, National Cerebral and Cardiovascular Center, Suita, Osaka, Japan Hospital Dr. Arturo Oñativia, Rafael CalzadaAlte Brown, Pcia de Bs As, Argentina Westchester Medical Center Health Network, Director of Neurocritical Care and Emergency Neurological Services, Valhalla, NY, United States Westchester Medical Center Health Network, New York Medical College, Valhalla, NY, United States Clinical Research Development Unit, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran Siriraj Stroke Center, Department of Medicine, Siriraj Hospital, Mahidol UniversityBangkok, Thailand Departments of Neurology and Neurosurgery, Division of Neuroscience Critical Care, University of Mississippi Medical Center, Jackson, MS, United States Wayne State University, Detroit, MI, United States Department of Medicine, Al-Farabi Kazakh National University, Almaty, Kazakhstan Department of Neurology, Asfendiyarov Kazakh National Medical University, Almaty, Kazakhstan Department of Neurology, Hospital Universitari MutuaTerrassa, Terrassa, Barcelona, Spain Department of Life Sciences, CBS, Manchester Metropolitan UniversityManchester, United Kingdom Department of Neurology, Cooper University Hospital, Camden, NJ, United States Department of Epidemiology and Biostatistics, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada Department of Family Medicine, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada Department of Population Health, Luxembourg Institute of Health, Strassen, Luxembourg Department of Neurology, British HospitalMontevideo, Uruguay Department of Neurology, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina Department of Neurology, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States UCSD Stroke center, Department of Neurosciences, University of California, San Diego, United States Clinical Neurology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran Department of Neurology and Stroke Unit, San Camillo de’ Lellis General District Hospital, Rieti, Italy Neurological Section, Neuro-epidemiology Unit, SMDN-Centre for Cardiovascular Medicine and Cerebrovascular Disease Prevention, Sulmona, L'Aquila, Italy Department of Clinical Neurological Sciences, Western University, London, ON, Canada Department of Neurology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran AU - Ghoreishi, A. AU - Arsang-Jang, S. AU - Sabaa-Ayoun, Z. AU - Yassi, N. AU - Sylaja, P. N. AU - Akbari, Y. AU - Divani, A. A. AU - Biller, J. AU - Phan, T. AU - Steinwender, S. AU - Silver, B. AU - Zand, R. AU - Basri, H. B. AU - Iqbal, O. M. AU - Ranta, A. AU - Ruland, S. AU - Macri, E. AU - Ma, H. AU - Nguyen, T. N. AU - Abootalebi, S. AU - Gupta, A. AU - Alet, M. AU - Lattanzi, S. AU - Desai, M. AU - Gagliardi, R. J. AU - Girotra, T. AU - Inoue, M. AU - Yoshimoto, T. AU - Isaac, C. F. AU - Mayer, S. A. AU - Morovatdar, N. AU - Nilanont, Y. AU - Nobleza, C. O. S. AU - Saber, H. AU - Kamenova, S. AU - Kondybayeva, A. AU - Krupinski, J. AU - Siegler, J. E. AU - Stranges, S. AU - Torbey, M. T. AU - Yorio, D. AU - Zurrú, M. C. AU - Rubinos, C. A. AU - Shahripour, R. B. AU - Borhani-Haghighi, A. AU - Napoli, M. D. AU - Azarpazhooh, M. R. C2 - 33069086 C7 - 105321 DB - Scopus DO - 10.1016/j.jstrokecerebrovasdis.2020.105321 IS - 12 J2 - J. Stroke Cerebrovasc. Dis. KW - COVID-19 Disability Epidemiology Mortality Outcome Stroke Stroke care fibrinolytic agent aged Article blood clot lysis brain hemorrhage brain ischemia cerebrovascular accident coronavirus disease 2019 female fibrinolytic therapy hospital mortality hospital patient hospitalization human length of stay major clinical study male National Institutes of Health Stroke Scale outcome assessment pandemic preliminary data priority journal Rankin scale stroke patient stroke unit trend study Bayes theorem clinical trial convalescence Iran middle aged multicenter study time factor time to treatment treatment outcome very elderly Aged, 80 and over Humans Interrupted Time Series Analysis Intracranial Hemorrhages Outcome and Process Assessment, Health Care Recovery of Function Thrombolytic Therapy Time Factors Time-to-Treatment LA - English M3 - Article N1 - Cited By :1 Export Date: 4 May 2021 CODEN: JSCDF Correspondence Address: Azarpazhooh, M.R.; Stroke Prevention and Atherosclerosis Research Centre, Canada; email: reza.azarpazhooh@lhsc.on.ca Funding text 1: The authors have no conflict of interest related to this paper to declare. We would like to sincerely thank all centers participating in the CASCADE study during this extremely difficult period. The authors have not received any compensation for the current study. Valiasr Hospital is an active participating center in the Safe Implementation of Treatments in Stroke (SITS) registry, and we would like to thank SITS for its support. References: Adhanom Ghebreyesus, T., We now have a name for the disease caused by the novel coronavirus: COVID-19 [Internet]. twitter (2020), https://twitter.com/DrTedros/status/1227297754499764230, [cited 2020 Jul 22]. 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From the CASCADE Initiative: Statistical Analysis Plan and Preliminary Results T2 - Journal of Stroke and Cerebrovascular Diseases TI - Stroke Care Trends During COVID-19 Pandemic in Zanjan Province, Iran. From the CASCADE Initiative: Statistical Analysis Plan and Preliminary Results UR - https://www.scopus.com/inward/record.uri?eid=2-s2.0-85092513322&doi=10.1016%2fj.jstrokecerebrovasdis.2020.105321&partnerID=40&md5=cdf782f466001d837257ce5b69ff2eed VL - 29 ID - 271 ER - TY - JOUR AB - Purpose: The purpose of this article is to provide a follow up to “Libraries on the Frontlines: Neutrality and Social Justice,” which was published here in 2017. It addresses institutional responses to protests and uprising in the spring and summer of 2020 after the deaths of Ahmaud Arbery, Breonna Taylor and George Floyd, all of which occurred in the context of the global COVID-19 pandemic. The article expands the previous call for libraries to take a stand for Black lives. Design/methodology/approach: The authors describe the events of 2020 (a global pandemic, multiple murders of unarmed Black people and the consequent global protests) and responses from within library and information science (LIS), from the perspectives as women of color faculty and library professionals. Findings: The authors comment on how libraries are responding to current events, as well as the possibilities for panethnic solidarity. The authors also consider specifically how libraries and other institutions are responding to the racial uprisings through statements on social media and call for concrete action to ensure that their organizations and information practices are actively antiracist. In so doing, the authors update the claims and expand the appeals they made in 2017,that Black Lives Matter and that librarianship must not remain neutral. Originality/value: This paper addresses recent institutional and governmental reactions to the COVID-19 pandemic and the racial uprisings of spring and summer 2020. It is original, current and timely as it interrogates ongoing events in a LIS context. © 2020, Emerald Publishing Limited. AD - School of Library and Information Science, University of North Carolina at Chapel Hill, Carrboro, NC, United States Department of Library and Information Science, Catholic University of America, Washington, DC, United States College of Information and Communications, University of South Carolina ColumbiaSC, United States Master of Library and Information Science Program, St. Catherine University, St. Paul, MN, United States School of Information Studies, Syracuse University, Syracuse, NY, United States Department of Libraries and Educational Technologies, James Madison University, Harrisonburg, VA, United States AU - Gibson, A. N. AU - Chancellor, R. L. AU - Cooke, N. A. AU - Dahlen, S. P. AU - Patin, B. AU - Shorish, Y. L. DB - Scopus DO - 10.1108/EDI-07-2020-0178 IS - 1 J2 - Equal. Diversity Incl. KW - Black people Ethnic minorities Libraries Occupational health and safety Protest Public sector organizations LA - English M3 - Article N1 - Cited By :8 Export Date: 4 May 2021 Correspondence Address: Gibson, A.N.; School of Library and Information Science, United States; email: angibson@email.unc.edu References: (2018) Are Libraries Neutral?: Highlights from the Midwinter President's Program [WWW Document], , https://americanlibrariesmagazine.org/2018/06/01/are-libraries-neutral/, American Libraries Magazine: (accessed 28 June 2020; (2020) Moving Forward: Key Findings from New Libraries' COVID-19 Response Survey: Re-opening and Financial Results, , American Library Association, Chicago, IL; (2020), Armed Lockdown ProtestersMichigan Statehouse, BBC News, Lansing, MI; (2020) ‘Our Country Wasn't Built to Be Shut Down,’ Trump Says, , Washington, DC; (2020) COVID-19 in racial and ethnic minority groups, , https://www.cdc.gov/coronavirus/2019-ncov/need-extra-precautions/racial-ethnic-minorities.html, CDC, [WWW Document]: accessed, 30 June 2020; Cooke, N.A., Impolite hostilities and vague sympathies: academia as a site of cyclical abuse (2019) Journal of Education for Library and Information Science, 60, pp. 223-230; Cooke, N., (2020) Reading is only a step on the path to anti-racism, , https://www.publishersweekly.com/pw/by-topic/industry-news/libraries/article/83626-reading-is-only-a-step-on-the-path-to-anti-racism.html, [WWW Document], PublishersWeekly.com: accessed, 30 June 2020; Dalton, J., (2020) Black Lives Matter protest held in London, , https://www.independent.co.uk/news/uk/home-news/black-lives-matter-london-george-floyd-protest-demonstration-a9541066.html?fbclid=IwAR0oVWo5ryc0n1yWM41MOIWFRYt_TM39iBVpfEdePIpcz7XWzBauAOzbBAM, The Independent, [WWW Document]: accessed, 30 June 2020; Fausset, R., (2020) What We Know about the Shooting Death of Ahmaud Arbery, , The New York Times, Atlanta, GA; Fernandez, M., Montgomery, D., (2020) Businesses Chafing under Covid-19 Lockdowns Turn to Armed Defiance, , The New York Times, Shepherd, TX; Garcia-Febo, L., (2020) Black Lives Matter: statements and resources, , http://blogs.ifla.org/cpdwl/2020/06/16/black-lives-matter-statements-resources/, IFLA CPDWL Blog: accessed, 30 June 2020; Gibson, A.N., Hughes-Hassell, S., We will not Be silent: amplifying marginalized voices in LIS education and research (2017) The Library Quarterly, 87, pp. 317-329; Gibson, A.N., Chancellor, R.L., Cooke, N.A., Park Dahlen, S., Lee, S.A., Shorish, Y.L., Libraries on the frontlines: neutrality and social justice (2017) Equality, Diversity and Inclusion: International Journal, 36, pp. 751-766; Graves, J., Jarvis, E., (2020) An open letter: scientists and racial justice, , https://www.the-scientist.com/news-opinion/an-open-letter-scientists-and-racial-justice-67648, [WWW Document], The Scientist Magazine®: accessed, 30 June 2020; Harris, E.A., (2020) Libraries Strive to Stay ‘Community Living Rooms’ as They Reopen, , The New York Times, New York; Hathcock, A., (2015) White librarianship in blackface: diversity initiatives in LIS – in the library with the lead pipe, , 2015/lis-diversity/, accessed, 30 June 2020; Hlywak, S., (2020) ALA executive board stands with BCALA in condemning violence and racism towards black people and all people of color, , http://www.ala.org/news/press-releases/2020/06/ala-executive-board-stands-bcala-condemning-violence-and-racism-towards-0, [WWW Document], News and Press Center: accessed, 30 June 2020; Hlywak, S., (2020) ALA takes responsibility for past racism, pledges a more equitable association, , http://www.ala.org/news/press-releases/2020/06/ala-takes-responsibility-past-racism-pledges-more-equitable-association, [WWW Document], News and Press Center: accessed, 30 June 2020; Honma, T., Trippin' over the color line: the invisibility of race in library and information studies (2005) InterActions: UCLA Journal of Education and Information Studies, 1, pp. 1-27; (2020) A Pledge: self-examination and concrete action in the JMU libraries, , https://www.lib.jmu.edu/a-pledge-self-examination-and-concrete-action-in-the-jmu-libraries/, JMU Libraries, [WWW Document]: accessed, 30 June 2020; Oppel, R.A., Taylor, D.B., (2020) Here's what You Need to Know about Breonna Taylor's Death, , The New York Times, New York; Kang, J., (2020) Tou Thao and the myths of asian American solidarity. 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B. AU - Bednarczyk, R. A. AU - Gerend, M. A. AU - Kornides, M. L. AU - Perkins, R. B. AU - Saslow, D. AU - Sienko, J. AU - Zimet, G. D. AU - Brewer, N. T. C2 - 32933839 DB - Scopus DO - 10.1016/j.jadohealth.2020.08.013 IS - 5 J2 - J. Adolesc. Health KW - Wart virus vaccine adolescent health anticipatory guidance Article childhood clinical evaluation coronavirus disease 2019 evidence based practice family medicine health care delivery health care system human investment pandemic physical examination priority journal school health service social distancing spring summer telehealth total quality management uterine cervix cancer vaccination vaccination coverage vaccine hesitancy Wart virus adolescent Betacoronavirus Coronavirus infection papillomavirus infection United States virus pneumonia Coronavirus Infections Humans Pandemics Papillomavirus Infections Papillomavirus Vaccines Pneumonia, Viral LA - English M3 - Article N1 - Cited By :5 Export Date: 4 May 2021 CODEN: JADHE Correspondence Address: Gilkey, M.B.; Department of Health Behavior, CB 7440, United States; email: gilkey@email.unc.edu Chemicals/CAS: Papillomavirus Vaccines Funding details: Centers for Disease Control and Prevention, CDC Funding details: Pfizer Funding details: Merck Funding text 1: The National HPV Vaccination Roundtable is supported by the Grant Number 5 NH23IP22551-05-00 funded by the Centers for Disease Control and Prevention . Funding text 2: Conflicts of interest: G.D.Z. has received consultation fees from Sanofi Pasteur for work on the Adolescent Immunization Initiative and from Merck for consultation related to human papillomavirus vaccination. N.T.B. has served on paid advisory boards for Merck and received research grants from Merck and Pfizer. The remaining authors have no conflicts of interest to disclose. 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Radiology departments should implement strict infection control measures and robust operational plans to minimize disease transmission and mitigate potential impact of possible staff infection. In this article, the authors share several operational guidelines and strategies implemented in our practice to reduce spread of COVID-19 and maintain clinical and educational needs of a teaching hospital. © 2020 American College of Radiology AD - Department of Diagnostic Imaging, National University Hospital, Singapore Department of Radiology, The University of North Carolina, Chapel Hill, NC, United States AU - Goh, Y. AU - Chua, W. AU - Lee, J. K. T. AU - Ang, B. W. L. AU - Liang, C. R. AU - Tan, C. A. AU - Choong, D. A. W. AU - Hoon, H. X. AU - Ong, M. K. L. AU - Quek, S. T. C2 - 32298643 DB - Scopus DO - 10.1016/j.jacr.2020.03.027 IS - 6 J2 - J. Am. Coll. Radiol. KW - COVID-19 operational strategies radiology Article cleaning coronavirus disease 2019 high risk patient human hygiene infection control nuclear magnetic resonance imaging practice guideline protocol compliance radiology department severe acute respiratory syndrome Singapore teaching hospital workforce x-ray computed tomography communicable disease control Coronavirus infection cross infection diagnostic imaging disease transmission epidemic female male occupational health organization organization and management pandemic prevention and control procedures virus pneumonia Coronavirus Infections Disease Outbreaks Humans Infectious Disease Transmission, Patient-to-Professional Magnetic Resonance Imaging Organizational Innovation Outcome Assessment, Health Care Pandemics Pneumonia, Viral Radiology Department, Hospital Tomography, X-Ray Computed LA - English M3 - Article N1 - Cited By :29 Export Date: 4 May 2021 Correspondence Address: Quek, S.T.5 Lower Kent Ridge Rd, Singapore; email: swee_tian_quek@nuhs.edu.sg Correspondence Address: Goh, Y.5 Lower Kent Ridge Rd, Singapore; email: yong_geng_goh@nuhs.edu.sg References: Rolling updates on coronavirus disease (COVID-19) https://www.who.int/emergencies/diseases/novel-coronavirus-2019/events-as-they-happen, Available at: Published 2020. 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ChannelNewsAsia on July 20UR - https://www.scopus.com/inward/record.uri?eid=2-s2.0-85083663410&doi=10.1016%2fj.jacr.2020.03.027&partnerID=40&md5=9b1b33a31a32527f944c334ca349c53d PY - 2020 SN - 15461440 (ISSN) SP - 717-723 ST - Operational Strategies to Prevent Coronavirus Disease 2019 (COVID-19) Spread in Radiology: Experience From a Singapore Radiology Department After Severe Acute Respiratory Syndrome T2 - Journal of the American College of Radiology TI - Operational Strategies to Prevent Coronavirus Disease 2019 (COVID-19) Spread in Radiology: Experience From a Singapore Radiology Department After Severe Acute Respiratory Syndrome VL - 17 ID - 494 ER - TY - JOUR AD - Yale University School of Medicine, CT, New Haven, United States University of North Carolina School of Medicine, Chapel Hill, United States AU - Goldenberg, M. N. AU - Gerkin, J. S. AU - Penaskovic, K. M. C2 - 32761314 DB - Scopus DO - 10.1007/s40596-020-01293-y IS - 6 J2 - Acad Psychiatry KW - affect doctor patient relationship facial expression human mask nonverbal communication prevention and control psychiatry telemedicine telephone trust videoconferencing COVID-19 Humans Masks Physician-Patient Relations SARS-CoV-2 LA - English M3 - Letter N1 - Export Date: 4 May 2021 Funding text 1: On behalf of all authors, the corresponding author states that there is no conflict of interest. PY - 2020 SN - 15457230 (ISSN) SP - 682 ST - Being Reactive: Assessing Affect in the COVID-19 Era T2 - Academic psychiatry : the journal of the American Association of Directors of Psychiatric Residency Training and the Association for Academic Psychiatry TI - Being Reactive: Assessing Affect in the COVID-19 Era UR - https://www.scopus.com/inward/record.uri?eid=2-s2.0-85089018680&doi=10.1007%2fs40596-020-01293-y&partnerID=40&md5=a88778db7bc1fc13edb4c2d8f892e94d VL - 44 ID - 279 ER - TY - JOUR AD - Davidoff Center, Rabin Medical Center, Jabotinsky Street, Petach Tikvah, Israel Department of Health Policy and Management, Gillings School of Public Health, University of North Carolina, Chapel Hill, United States Department of Medicine, University of Chicago, Chicago, IL, United States Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, United States AU - Goldstein, D. A. AU - Ratain, M. J. AU - Saltz, L. B. C2 - 32459313 DB - Scopus DO - 10.1001/jamaoncol.2020.2493 29059432; Canadian Agency for Drugs and Technologies in Health. CADTH Technology Review: Optimal Use 360 Report: Dosing and Timing of Immuno-oncology Drugs, , https://www.cadth.ca/sites/default/files/ou-tr/ho0008-dosing-timing-immuno-oncology-drugs.pdf, Published online November 2019 Accessed May 19, 2020; Goldstein, D.A., Hirsch, A., A policy that encourages wastage of expensive medications - The JW modifier (2018) JAMA Oncol, 4 (2), pp. 155-156. , http://jamanetwork.com/article.aspx?doi=10.1001/jamaoncol.2017.3997, doi: 29222558; Lala, M., Li, M., Sinha, V., De Alwis, D., Chartash, E., Jain, L., A six-weekly (Q6W) dosing schedule for pembrolizumab based on an exposure-response (E-R) evaluation using modeling and simulation (2018) J Clin Oncol, , http://dx.doi.org/10.1200/JCO.2018.36.15_suppl.3062, 36(15, supp):3062. doi; National Comprehensive Cancer Network. Coronavirus Disease 2019 (COVID-19) Resources for the Cancer Care Community, , https://www.nccn.org/covid-19/, Accessed May 19, 2020; Elassaiss-Schaap, J., Rossenu, S., Lindauer, A., Using model-based "learn and confirm" to reveal the pharmacokinetics-pharmacodynamics relationship of pembrolizumab in the KEYNOTE-001 trial (2017) CPT Pharmacometrics Syst Pharmacol, 6 (1), pp. 21-28. , http://dx.doi.org/10.1002/psp4.12132, doi: 27863143; Merck Announces Fourth-quarter and Full-year 2019 Financial Results. News Release, , https://s21.q4cdn.com/488056881/files/doc_financials/2019/q4/Merck-4QFY19-Earnings-News-Release.pdf, Merck; February 5, 2020. Accessed May 19, 2020 IS - 11 J2 - JAMA Oncol. KW - pembrolizumab programmed death 1 ligand 1 coronavirus disease 2019 cost control drug approval drug cost drug dose regimen drug efficacy drug use health care cost health care policy health care system human medicaid medicare melanoma monotherapy non small cell lung cancer nonhuman Note pandemic pharmacokinetic parameters phase 3 clinical trial (topic) prescription Severe acute respiratory syndrome coronavirus 2 treatment indication treatment outcome LA - English M3 - Note N1 - Cited By :7 Export Date: 4 May 2021 Correspondence Address: Goldstein, D.A.; Davidoff Center, Jabotinsky Street, Israel; email: danielg3@tauex.tau.ac.il Chemicals/CAS: pembrolizumab, 1374853-91-4 Funding details: Merck Funding text 1: reported institutional research funding from Merck and personal fees from VIVIO Health. Dr Ratain reported personal fees from Aurobindo Pharma, Apotex, Ascentage Pharma, Teva Pharmaceutical Industries, Cyclacel Pharmaceuticals, Celltrion, Breckenridge Pharmaceutical, Par Pharmaceuticals, Roxane Laboratories, Aptevo Therapeutics, Accord Healthcare, Actavis, Amerigen Pharmaceuticals, Argentum Pharmaceuticals, BPI Labs, Belcher Pharmaceuticals, Dr Reddy’s Laboratories, Fresenius Kabi, Glenmark Pharmaceuticals, Hetero, Mylan, Sandoz, Pneuma Respiratory, and Shionogi; grants from AbbVie, Dicerna Pharmaceuticals, Genentech, and Xencor; and other fees from BeiGene; has a patent to US6395481B1 issued, licensed, and with royalties paid, a patent to EP1629111B1 issued, licensed, and with royalties paid, a patent to US8877723B2 issued, and a patent to US9617583B2 issued; and is director and treasurer of the Value in Cancer Care Consortium. No other disclosures were reported. PY - 2020 SN - 23742437 (ISSN) SP - 1694-1695 ST - Weight-Based Dosing of Pembrolizumab Every 6 Weeks in the Time of COVID-19 T2 - JAMA Oncology TI - Weight-Based Dosing of Pembrolizumab Every 6 Weeks in the Time of COVID-19 UR - https://www.scopus.com/inward/record.uri?eid=2-s2.0-85085762124&doi=10.1001%2fjamaoncol.2020.2493&partnerID=40&md5=dc6ed0880ead6ac95fcfff5a666db2c4 VL - 6 ID - 571 ER - TY - JOUR AD - Department of Radiation Oncology, Northwestern University, Feinberg School of Medicine, Chicago, IL, United States Department of Radiation Oncology, Cleveland Clinic, Cleveland, OH, United States Department of Radiation Oncology, Mayo Clinic, Rochester, MN, United States Department of Radiation Oncology, University of North Carolina, Chapel Hill, NC, United States Department of Radiation Oncology, University of California, San Diego, La Jolla, CA, United States Department of Radiation Medicine, Oregon Health Sciences University, Portland, OR, United States AU - Goodman, C. R. AU - Campbell, S. R. AU - Jeans, E. B. AU - Agarwal, A. AU - Tye, K. AU - Kahn, J. M. C2 - 32890532 DB - Scopus DO - 10.1016/j.ijrobp.2020.06.039 IS - 2 J2 - Int. J. Radiat. Oncol. Biol. Phys. KW - certification clinical practice coronavirus disease 2019 Editorial employment contract health care access human leadership medical examination nonhuman overall response rate pandemic priority journal quality control radiation oncologist radiation oncology radiodiagnosis residency education Severe acute respiratory syndrome coronavirus 2 social distancing Betacoronavirus computer interface Coronavirus infection education health care quality social change virus pneumonia Coronavirus Infections Humans Pandemics Pneumonia, Viral Quality Assurance, Health Care Specialty Boards User-Computer Interface LA - English M3 - Editorial N1 - Export Date: 4 May 2021 CODEN: IOBPD Correspondence Address: Kahn, J.M.; Department of Radiation Medicine, United States; email: kahnje@ohsu.edu References: ABMS and ACGME Joint Principles: Physician Training During the COVID-2019 Pandemic. American Board of Medical Specialties and American College of Graduate Medical Education https://www.abms.org/news-events/abms-and-acgme-joint-principles-physician-training-during-the-covid-2019-pandemic/, Available at: Published 2020. Accessed June 10, 2020; Letter to the American Board of Radiology from the Association of Residents in Radiation Oncology Executive Committee, April 7 2020 https://www.astro.org/ASTRO/media/ASTRO/AffiliatePages/arro/PDFs/ARROLettertoABR_Oral-Exams.pdf, Available at: Published 2020. Accessed June 10, 2020; Letter to the American Board of Radiology from the Association of Residents in Radiation Oncology Executive Committee, May 27 2020 https://www.astro.org/ASTRO/media/ASTRO/AffiliatePages/arro/PDFs/ARROLettertoABR_WrittenExams.pdf, Available at: Published 2020. Accessed June 10, 2020; Letter from the American College of Radiology to the American Board of Radiology https://www.acr.org/-/media/ACR/Files/RFS/ACR-Letter-to-ABR-in-support-of-RFS-YPS.pdf?la=en, Available at: Published 2020. Accessed June 12, 2020; Letter to the American Board of Radiology from the American Society for Radiation Oncology https://www.astro.org/ASTRO/media/ASTRO/AffiliatePages/arro/PDFs/ASTROLettertoABR.pdf, Available at: Published 2020. Accessed June 10, 2020; Letter to the American Board of Radiology from the Society of Chairs of Radiation Oncology Programs https://www.astro.org/ASTRO/media/ASTRO/AffiliatePages/SCAROP/PDFs/SCAROPlettertoABR.pdf, Available at: Published 2020. Accessed June 10, 2020; Coronavirus Information: June 22nd - ABR Moving to Virtual Exams. American Board of Radiology https://www.theabr.org/announcements/coronavirus-updates, Available at: Accessed; Bartley, G.B., COVID-19 and the American Board of Ophthalmology: When the Best-Laid Plans Go Awry (2020) Ophthalmology; The American Board of Surgery http://www.absurgery.org/default.jsp?news_covid19_gsqe, Available at: Published 2020. Accessed May 7, 2020; Candidate Communication Web site https://abop.org/covid19, Available at: Updated May 8, 2020. Accessed May 10, 2020; American Board of Orthopedic Surgery https://www.abos.org/2194-2/, Available at: Published 2020. Accessed June 10, 2020; 2020 Certification Exam Postponed Until October Due to COVID-19. American Board of Dermatology https://www.abderm.org/public/announcements/2020-certification-exam-postponed-until-october-due-to-covid-19.aspx, Available at: Published 2020. Accessed June 10, 2020; ABPMR Moves Part II Examination To Virtual Administrations This Fall. American Board of Physical Medicine and Rehabilitation https://www.abpmr.org/NewsCenter/Detail/part-ii-exam-virtual-2020, Available at: Published 2020. Accessed June 10, 2020; ABA Cancels June BASIC Exam, Offers August Administration. American Board of Anesthesiology http://aba-news.org/2020/04/aba-cancels-june-2020-basic-exam/, Available at: Published 2020. Accessed June 10, 2020; Zheng, J., Hundeyin, M., He, K., General surgery chief residents' perspective on surgical education during the coronavirus disease 2019 (COVID-19) pandemic (2020) Surgery; Guss, Z.D., Chen, Q., Hu, C., Guss, L.G., DeWeese, T.L., Terezakis, S.A., Differences in Physician Compensation Between Men and Women at United States Public Academic Radiation Oncology Departments (2019) Int J Radiat Oncol Biol Phys, 103, pp. 314-319; Lee, W.R., Amdur, R.J., A Call for Change in the ABR Initial Certification Examination in Radiation Oncology (2019) Int J Radiat Oncol Biol Phys, 104, pp. 17-20; Jackson, V.P., Balfe, D.M., Guiberteau, M.J., Counterpoint: Why Things Are Going Right With the ABR Examinations (2016) J Am Coll Radiol, 13, pp. 1361-1362 PY - 2020 SN - 03603016 (ISSN) SP - 458-461 ST - Modernization of Board Certification in Radiation Oncology: Opportunities Following COVID-19 T2 - International Journal of Radiation Oncology Biology Physics TI - Modernization of Board Certification in Radiation Oncology: Opportunities Following COVID-19 UR - https://www.scopus.com/inward/record.uri?eid=2-s2.0-85090003742&doi=10.1016%2fj.ijrobp.2020.06.039&partnerID=40&md5=13f0d84954784269aba6160ad529b792 VL - 108 ID - 349 ER - TY - JOUR AD - Department of Medical Microbiology, Leiden University Medical Center, Leiden, Netherlands Faculty of Bioengineering and Bioinformatics and Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Moscow, Russian Federation Department of Microbiology and Immunology, Loyola University of Chicago, Stritch School of Medicine, Maywood, IL, United States Department of Epidemiology, University of North Carolina, Chapel Hill, NC, United States Division of Virology, Department of Biomolecular Health Sciences, Faculty of Veterinary Medicine, Utrecht University, Utrecht, Netherlands Institute of Virology, Charité – Universitätsmedizin Berlin, Berlin, Germany Viroscience Lab, Erasmus MC, Rotterdam, Netherlands Texas A&M University-Texarkana, Texarkana, TX, United States Department of Microbiology and Immunology, University of Iowa, Iowa City, IA, United States Centre of Influenza Research & School of Public Health, The University of Hong Kong, Hong Kong, China Department of Molecular and Cell Biology, National Center of Biotechnology (CNB-CSIC), Campus de Cantoblanco, Madrid, Spain Institute of Medical Virology, Justus Liebig University Giessen, Giessen, Germany Department of Biomedical Data Sciences, Leiden University Medical Center, Leiden, Netherlands AU - Gorbalenya, A. E. AU - Baker, S. C. AU - Baric, R. S. AU - de Groot, R. J. AU - Drosten, C. AU - Gulyaeva, A. A. AU - Haagmans, B. L. AU - Lauber, C. AU - Leontovich, A. M. AU - Neuman, B. W. AU - Penzar, D. AU - Perlman, S. AU - Poon, L. L. M. AU - Samborskiy, D. V. AU - Sidorov, I. A. AU - Sola, I. AU - Ziebuhr, J. AU - Coronaviridae Study Group of the International Committee on Taxonomy of, Viruses C2 - 32123347 DB - Scopus DO - 10.1038/s41564-020-0695-z IS - 4 J2 - Nat. Microbiol. KW - Coronaviridae epidemic gene sequence human nonhuman phenotype phylogeny priority journal Review SARS-related coronavirus Severe acute respiratory syndrome coronavirus 2 virus cell interaction virus classification virus identification virus nomenclature virus replication virus transmission virus virulence animal Betacoronavirus classification consensus development Coronavirus infection genetic variation genetics Nidovirales nomenclature open reading frame pandemic procedures SARS coronavirus severe acute respiratory syndrome virology virus genome virus pneumonia World Health Organization zoonosis Animals Coronavirus Infections Genome, Viral Humans Open Reading Frames Pandemics Pneumonia, Viral SARS Virus Terminology as Topic Zoonoses LA - English M3 - Review N1 - Cited By :1832 Export Date: 4 May 2021 Correspondence Address: Gorbalenya, A.E.; Department of Biomedical Data Sciences, Netherlands Funding details: 653316 Funding details: Deutsche Forschungsgemeinschaft, DFG, SFB1021 Funding text 1: Work on DEmARC advancement and coronavirus and nidovirus taxonomies was supported by the EU Horizon 2020 EVAg 653316 project and the LUMC MoBiLe program (to A.E.G.), and on coronavirus and nidovirus taxonomies by a Mercator Fellowship by the Deutsche Forschungsgemeinschaft (to A.E.G.) in the context of the SFB1021 (A01 to J.Z.). 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Virol., 82, pp. 1819-1826 PY - 2020 SN - 20585276 (ISSN) SP - 536-544 ST - The species Severe acute respiratory syndrome-related coronavirus: classifying 2019-nCoV and naming it SARS-CoV-2 T2 - Nature Microbiology TI - The species Severe acute respiratory syndrome-related coronavirus: classifying 2019-nCoV and naming it SARS-CoV-2 UR - https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082561475&doi=10.1038%2fs41564-020-0695-z&partnerID=40&md5=e936cafbf9bb740e00087fa694e421ed VL - 5 ID - 519 ER - TY - JOUR AB - A newly described coronavirus named severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which is the causative agent of coronavirus disease 2019 (COVID-19), has infected over 2.3 million people, led to the death of more than 160,000 individuals and caused worldwide social and economic disruption1,2. There are no antiviral drugs with proven clinical efficacy for the treatment of COVID-19, nor are there any vaccines that prevent infection with SARS-CoV-2, and efforts to develop drugs and vaccines are hampered by the limited knowledge of the molecular details of how SARS-CoV-2 infects cells. Here we cloned, tagged and expressed 26 of the 29 SARS-CoV-2 proteins in human cells and identified the human proteins that physically associated with each of the SARS-CoV-2 proteins using affinity-purification mass spectrometry, identifying 332 high-confidence protein–protein interactions between SARS-CoV-2 and human proteins. Among these, we identify 66 druggable human proteins or host factors targeted by 69 compounds (of which, 29 drugs are approved by the US Food and Drug Administration, 12 are in clinical trials and 28 are preclinical compounds). We screened a subset of these in multiple viral assays and found two sets of pharmacological agents that displayed antiviral activity: inhibitors of mRNA translation and predicted regulators of the sigma-1 and sigma-2 receptors. Further studies of these host-factor-targeting agents, including their combination with drugs that directly target viral enzymes, could lead to a therapeutic regimen to treat COVID-19. © 2020, The Author(s), under exclusive licence to Springer Nature Limited. AD - QBI COVID-19 Research Group (QCRG), San Francisco, CA, United States Quantitative Biosciences Institute (QBI), University of California San Francisco, San Francisco, CA, United States J. David Gladstone Institutes, San Francisco, CA, United States Department of Cellular and Molecular Pharmacology, University of California San Francisco, San Francisco, CA, United States Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, United States Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, United States Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, United States Viral Populations and Pathogenesis Unit, CNRS UMR 3569, Institut Pasteur, Paris, France Department of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, CA, United States Howard Hughes Medical Institute, University of California San Francisco, San Francisco, CA, United States European Molecular Biology Laboratory (EMBL), European Bioinformatics Institute, Wellcome Genome Campus, Cambridge, United Kingdom Department of Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, CA, United States The UC Berkeley-UCSF Graduate Program in Bioengineering, University of California San Francisco, San Francisco, CA, United States Center for Computational Biology and Bioinformatics, Department of Medicine, University of California San Diego, San Diego, CA, United States Department of Cell and Tissue Biology, University of California San Francisco, San Francisco, CA, United States Department of Pharmacology, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC, United States Biophysics Graduate Program, University of California San Francisco, San Francisco, CA, United States Department of Biochemistry and Biophysics, University of California San Francisco, San Francisco, CA, United States Zoic Labs, Culver City, CA, United States Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, CA, United States Department of Urology, University of California San Francisco, San Francisco, CA, United States Cardiovascular Research Institute, University of California San Francisco, San Francisco, CA, United States Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, United States George William Hooper Foundation, Department of Microbiology and Immunology, University of California San Francisco, San Francisco, CA, United States Medical Scientist Training Program, University of California San Francisco, San Francisco, CA, United States Virus and Immunity Unit, Institut Pasteur, Paris, France Department of Medicine, University of California San Francisco, San Francisco, CA, United States Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, WA, United States Department of Psychiatry, University of California San Francisco, San Francisco, CA, United States Buck Institute for Research on Aging, Novato, CA, United States Direction Scientifique, Institut Pasteur, Paris, France Division of Genetics, Department of Medicine, University of California San Diego, San Diego, CA, United States Department of Medicine, Division of Infectious Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, United States The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, United States AU - Gordon, D. 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AU - Gross, J. D. AU - Sali, A. AU - Roth, B. L. AU - Ruggero, D. AU - Taunton, J. AU - Kortemme, T. AU - Beltrao, P. AU - Vignuzzi, M. AU - García-Sastre, A. AU - Shokat, K. M. AU - Shoichet, B. K. AU - Krogan, N. J. C2 - 32353859 DB - Scopus DO - 10.1038/s41586-020-2286-9 IS - 7816 J2 - Nature KW - 1 cyclohexyl 4 [3 (1,2,3,4 tetrahydro 5 methoxy 1 naphthyl)propyl]piperazine antihistaminic agent antivirus agent bromodomain protein clemastine cloperastine cullin haloperidol hydroxychloroquine messenger RNA pd 144418 progesterone ps 3061 sigma 1 opiate receptor sigma 2 opiate receptor siramesine ternatin 4 unclassified drug viral protein virus enzyme zotatifin protein binding sigma opiate receptor ubiquitin protein ligase alternative agriculture antimicrobial activity cell drug development protein RNA viral disease virus antiviral activity Article binding affinity controlled study coronavirus disease 2019 drug identification drug repositioning drug screening drug targeting human human cell IC50 innate immunity mass spectrometry molecular cloning nonhuman priority journal protein analysis protein expression protein protein interaction protein purification RNA translation Severe acute respiratory syndrome coronavirus 2 animal Betacoronavirus Chlorocebus aethiops classification Coronavirus infection drug effect genetics HEK293 cell line host pathogen interaction immunology metabolism molecularly targeted therapy pandemic pathogenicity preclinical study protein domain protein synthesis Vero cell line virology virus pneumonia Coronavirus SARS coronavirus Animals Antiviral Agents Cloning, Molecular Coronavirus Infections Drug Evaluation, Preclinical HEK293 Cells Host-Pathogen Interactions Humans Immunity, Innate Molecular Targeted Therapy Pandemics Pneumonia, Viral Protein Biosynthesis Protein Domains Protein Interaction Mapping Protein Interaction Maps Receptors, sigma SKP Cullin F-Box Protein Ligases Vero Cells Viral Proteins LA - English M3 - Article N1 - Cited By :783 Export Date: 4 May 2021 CODEN: NATUA Correspondence Address: Shokat, K.M.; QBI COVID-19 Research Group (QCRG)United States; email: Kevan.Shokat@ucsf.edu Correspondence Address: Shoichet, B.K.; QBI COVID-19 Research Group (QCRG)United States; email: shoichet@cgl.ucsf.edu Correspondence Address: Krogan, N.J.; QBI COVID-19 Research Group (QCRG)United States; email: nevan.krogan@ucsf.edu Correspondence Address: García-Sastre, A.; Department of Microbiology, United States; email: Adolfo.Garcia-Sastre@mssm.edu Correspondence Address: Vignuzzi, M.; Viral Populations and Pathogenesis Unit, France; email: marco.vignuzzi@pasteur.fr Chemicals/CAS: 1 cyclohexyl 4 [3 (1,2,3,4 tetrahydro 5 methoxy 1 naphthyl)propyl]piperazine, 172906-90-0, 172907-03-8; clemastine, 15686-51-8; haloperidol, 52-86-8, 1511-16-6; hydroxychloroquine, 118-42-3, 525-31-5; progesterone, 57-83-0; siramesine, 147817-50-3; zotatifin, 2098191-53-6; ubiquitin protein ligase, 134549-57-8; Antiviral Agents; Receptors, sigma; SKP Cullin F-Box Protein Ligases; Viral Proteins Tradenames: pb 28; pd 144418; ps 3061 References: Wu, F., A new coronavirus associated with human respiratory disease in China (2020) Nature, 579, pp. 265-269. , COI: 1:CAS:528:DC%2BB3cXksFKlsLc%3D, PID: 7094943; (2020) Coronavirus Disease (COVID-2019) Situation Reports, , https://www.who.int/emergencies/diseases/novel-coronavirus-2019/situation-reports; Wang, C., Horby, P.W., Hayden, F.G., Gao, G.F., A novel coronavirus outbreak of global health concern (2020) Lancet, 395, pp. 470-473. , COI: 1:CAS:528:DC%2BB3cXnsVaisLg%3D, PID: 31986257; Zhu, N., A novel coronavirus from patients with pneumonia in China, 2019 (2020) N. 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O. AU - Habibi, R. AU - Meier, B. M. C2 - 32631189 DB - Scopus DO - 10.1177/1073110520935354 IS - 2 J2 - J. Law Med. 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The Report of the Harvard-LSHTM Independent Panel on the Global Response to Ebola (2015) The Lancet, 386, pp. 2204-2221. , http://apps.who.int/gb/ebwha/pdf_files/WHA68/A68_22Add1-en.pdf, WHO, Implementation of the International Health Regulations (2005): Report of the Review Committee on Second Extensions for Establishing National Public Health Capacities and on IHR Implementation: Report by the director-general, para. 17 (Mar. 27, 2015), <, > (,); Fidler, D.P., (1999) International Law and Infectious Disease PY - 2020 SN - 10731105 (ISSN) SP - 376-381 ST - Has Global Health Law Risen to Meet the COVID-19 Challenge? Revisiting the International Health Regulations to Prepare for Future Threats T2 - Journal of Law, Medicine and Ethics TI - Has Global Health Law Risen to Meet the COVID-19 Challenge? Revisiting the International Health Regulations to Prepare for Future Threats UR - https://www.scopus.com/inward/record.uri?eid=2-s2.0-85087663579&doi=10.1177%2f1073110520935354&partnerID=40&md5=f31d6c35cd18bf3e41a27f257ee4bd0a VL - 48 ID - 484 ER - TY - JOUR AD - The O'Neill Institute for National and Global Health Law, Georgetown University Law Center, Washington, DC, United States The Global Health Centre, Graduate Institute of International and Development Studies, Geneva, Switzerland The Department of Public Policy, University of North Carolina, Chapel Hill, United States AU - Gostin, L. O. AU - Moon, S. AU - Meier, B. M. C2 - 33026872 DB - Scopus DO - 10.2105/AJPH.2020.305933 IS - 11 J2 - Am. J. Public Health KW - Betacoronavirus Coronavirus infection global health health care policy human international cooperation leadership organization and management pandemic politics United Nations virus pneumonia World Health Organization Coronavirus Infections Health Policy Humans Pandemics Pneumonia, Viral LA - English M3 - Article N1 - Cited By :3 Export Date: 4 May 2021 CODEN: AJPEA Correspondence Address: Gostin, L.O.; University Professor, 600 New Jersey Ave, NW, United States; email: gostin@georgetown.edu Funding text 1: The authors are grateful for the research assistance of Caitlin R. Williams, Meredith Dockery, and Victoria Matus, whose inspiring work gives us hope for the future of global health governance. 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(2020) Lancet, 395 (10240), pp. 1822-1823. , https://doi.org/10.1016/S0140-6736(20)31354-4; Chorev, N., (2012) The World Health Organization Between North and South, , https://doi.org/10.7591/cornell/9780801450655.001.0001, Ithaca, NY: Cornell University Press; Clinton, C, Sridhar, D., (2017) Governing Global Health: Who Runs the World and Why?, , New York, NY: Oxford University Press; Gostin, LO, Sridhar, D, Hougendobler, D., The normative authority of the World Health Organization (2015) Public Health, 129 (7), pp. 854-863. , https://doi.org/10.1016/j.puhe.2015.05.002; Global coalition to accelerate COVID-19 clinical research in resource-limited settings (2020) Lancet, 395 (10233), pp. 1322-1325. , https://doi.org/10.1016/S0140-6736(20)30798-4, COVID-19 Clinical Research Coalition PY - 2020 SN - 00900036 (ISSN) SP - 1615-1619 ST - Reimagining global health governance in the age of COVID-19 T2 - American Journal of Public Health TI - Reimagining global health governance in the age of COVID-19 UR - https://www.scopus.com/inward/record.uri?eid=2-s2.0-85092683015&doi=10.2105%2fAJPH.2020.305933&partnerID=40&md5=6e3e787e033da4a66c25d6ddbb9fae5f VL - 110 ID - 301 ER - TY - JOUR AB - Background: Virus infections result in a range of clinical outcomes for the host, from asymptomatic to severe or even lethal disease. Despite global efforts to prevent and treat virus infections to limit morbidity and mortality, the continued emergence and re-emergence of new outbreaks as well as common infections such as influenza persist as a health threat. Challenges to the prevention of severe disease after virus infection include both a paucity of protective vaccines as well as the early identification of individuals with the highest risk that may require supportive treatment. Methods: We completed a screen of mice from the Collaborative Cross (CC) that we infected with influenza, severe acute respiratory syndrome-coronavirus, and West Nile virus. Results: The CC mice exhibited a range of disease manifestations upon infections, and we used this natural variation to identify strains with mortality after infection and strains exhibiting no mortality. We then used comprehensive preinfection immunophenotyping to identify global baseline immune correlates of protection from mortality to virus infection. Conclusions: These data suggest that immune phenotypes might be leveraged to identify humans at highest risk of adverse clinical outcomes upon infection, who may most benefit from intensive clinical interventions, in addition to providing insight for rational vaccine design. © 2019 The Author(s) 2019. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. AD - Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA, United States Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States Department of Microbiology and Immunology, University of Texas Medical Center, Galveston, TX, United States Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States Center for Innate Immunity and Immune Disease, Department of Immunology, University of Washington School of Medicine, Seattle, WA, United States Division of Bioinformatics and Computational Biology, Department of Medical Informatics and Clinical Epidemiology, Oregon Health and Science University, Portland, OR, United States OHSU Knight Cancer Institute, Oregon Health and Science University, Portland, OR, United States Oregon Clinical and Translational Research Institute, Oregon Health and Science University, Portland, OR, United States Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States Department of Global Health, University of Washington, Seattle, WA, United States AU - Graham, J. B. AU - Swarts, J. L. AU - Menachery, V. D. AU - Gralinski, L. E. AU - Schäfer, A. AU - Plante, K. S. AU - Morrison, C. R. AU - Voss, K. M. AU - Green, R. AU - Choonoo, G. AU - Jeng, S. AU - Miller, D. R. AU - Mooney, M. A. AU - McWeeney, S. K. AU - Ferris, M. T. AU - De Villena, F. P. M. AU - Gale, M. AU - Heise, M. T. AU - Baric, R. S. AU - Lund, J. M. C2 - 31621854 DB - Scopus DO - 10.1093/infdis/jiz531 IS - 6 J2 - J. Infect. Dis. KW - Collaborative Cross Immune correlates of mortality RNA virus infection animal cell animal experiment animal model animal tissue Article CD4+ T lymphocyte CD8+ T lymphocyte controlled study flow cytometry haplotype immunophenotyping inoculation male mortality mouse nonhuman phenotype priority journal SARS coronavirus severe acute respiratory syndrome spleen steady state virus pathogenesis virus strain West Nile fever West Nile virus animal disease model female human immunology influenza Influenza A virus metabolism orthomyxovirus infection T lymphocyte virology cytokine RNA virus vaccine Animals Collaborative Cross Mice Cytokines Disease Models, Animal Humans Influenza, Human Mice Orthomyxoviridae Infections RNA Virus Infections SARS Virus T-Lymphocytes Viral Vaccines LA - English M3 - Article N1 - Cited By :2 Export Date: 4 May 2021 CODEN: JIDIA Correspondence Address: Lund, J.M.; Fred Hutchinson Cancer Research Center, 1100 Fairview Ave. N., E5-110, United States; email: jlund@fredhutch.org Chemicals/CAS: RNA, 63231-63-0; Cytokines; RNA; Viral Vaccines Funding details: National Institutes of Health, NIH, U19AI100625 Funding text 1: Financial support. Funding for this study was provided by National Institutes of Health Grant U19AI100625. 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As noted by Andersen et al. (Nature Medicine), the sequencing of proximal zoonotic ancestors to SARS-CoV-2 has aided in the identification of alleles that may contribute to the virus’ virulence in humans. © 2020 Elsevier Inc. AD - Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States AU - Graham, R. L. AU - Baric, R. S. C2 - 32392464 DB - Scopus DO - 10.1016/j.immuni.2020.04.016 IS - 5 J2 - Immunity KW - angiotensin converting enzyme 2 viral protein Article coronavirus disease 2019 high throughput sequencing human medical countermeasure natural selection nonhuman pandemic priority journal protein domain Severe acute respiratory syndrome coronavirus 2 viral genetics virus virus genome virus identification virus infectivity virus virulence Betacoronavirus Coronavirinae Coronavirus infection SARS coronavirus virus pneumonia Coronavirus Coronavirus Infections Humans Pandemics Pneumonia, Viral SARS Virus LA - English M3 - Article N1 - Cited By :7 Export Date: 4 May 2021 CODEN: IUNIE Correspondence Address: Baric, R.S.; Department of Epidemiology, United States; email: rbaric@email.unc.edu References: Andersen, K.G., Rambaut, A., Lipkin, W.I., Holmes, E.C., Garry, R.F., The proximal origin of SARS-CoV-2 (2020) Nat. 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AD - Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC 27514, United States Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX 77555, United States Institute for Human Infections and Immunity, University of Texas Medical Branch, Galveston, TX 77555, United States AU - Gralinski, L. E. AU - Menachery, V. D. C2 - 31991541 C7 - v12020135 DB - Scopus DO - 10.3390/v12020135 IS - 2 J2 - Viruses KW - 2019-nCoV Coronavirus Emerging viruses MERS-CoV Novel CoV SARS-CoV Wuhan Wuhan pneumonia virus RNA coronavirus spike glycoprotein COVID-19 nucleocapsid protein severe acute respiratory syndrome coronavirus 2 2019 novel coronavirus antiviral susceptibility biodiversity coronavirus disease 2019 diagnostic test disease association disease severity disease surveillance environmental protection epidemic extracorporeal oxygenation fever government health care health care personnel human immune response kidney function Middle East respiratory syndrome coronavirus mortality rate nucleotide sequence pneumonia public health respiratory tract disease Review SARS coronavirus sea food social media virus attachment virus nucleocapsid virus transmission animal Betacoronavirus chemistry China communicable disease Coronavirus infection disease carrier disease predisposition genetics isolation and purification metabolism severe acute respiratory syndrome virology virus genome virus pneumonia zoonosis Animals Communicable Diseases, Emerging Coronavirus Infections Disease Outbreaks Disease Reservoirs Disease Susceptibility Genome, Viral Humans Nucleocapsid Proteins Pneumonia, Viral SARS Virus Spike Glycoprotein, Coronavirus Zoonoses LA - English M3 - Review N1 - Cited By :395 Export Date: 4 May 2021 Correspondence Address: Menachery, V.D.; Department of Microbiology and Immunology, United States; email: Vimenach@utmb.edu Chemicals/CAS: COVID-19; Nucleocapsid Proteins; severe acute respiratory syndrome coronavirus 2; Spike Glycoprotein, Coronavirus References: Wuhan Municipal Health and Health Commission's Briefing on the Current Pneumonia Epidemic Situation in Our City, , http://wjw.wuhan.gov.cn/front/web/showDetail/2019123108989, Wuhan Municipal Health Commision. 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Case Stud., 2, p. a001214. , [CrossRef] [PubMed] PY - 2020 SN - 19994915 (ISSN) ST - Return of the coronavirus: 2019-nCoV T2 - Viruses TI - Return of the coronavirus: 2019-nCoV UR - https://www.scopus.com/inward/record.uri?eid=2-s2.0-85078688361&doi=10.3390%2fv12020135&partnerID=40&md5=3dbf1e6430096abfd7676f32b2158359 VL - 12 ID - 577 ER - TY - JOUR AB - Understanding adaptive immunity to SARS-CoV-2 is important for vaccine development, interpreting coronavirus disease 2019 (COVID-19) pathogenesis, and calibration of pandemic control measures. Using HLA class I and II predicted peptide “megapools,” circulating SARS-CoV-2-specific CD8+ and CD4+ T cells were identified in ∼70% and 100% of COVID-19 convalescent patients, respectively. CD4+ T cell responses to spike, the main target of most vaccine efforts, were robust and correlated with the magnitude of the anti-SARS-CoV-2 IgG and IgA titers. The M, spike, and N proteins each accounted for 11%–27% of the total CD4+ response, with additional responses commonly targeting nsp3, nsp4, ORF3a, and ORF8, among others. For CD8+ T cells, spike and M were recognized, with at least eight SARS-CoV-2 ORFs targeted. Importantly, we detected SARS-CoV-2-reactive CD4+ T cells in ∼40%–60% of unexposed individuals, suggesting cross-reactive T cell recognition between circulating “common cold” coronaviruses and SARS-CoV-2. © 2020 Elsevier Inc. An analysis of immune cell responses to SARS-CoV-2 from recovered patients identifies the regions of the virus that is targeted and also reveals cross-reactivity with other common circulating coronaviruses © 2020 Elsevier Inc. AD - Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, La Jolla, CA 92037, United States Department of Medicine, Division of Infectious Diseases and Global Public Health, University of California, San Diego, La Jolla, CA 92037, United States Department of Microbiology and Immunology, University of North Carolina School of Medicine, Chapel Hill, NC 27599-7290, United States Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, United States AU - Grifoni, A. AU - Weiskopf, D. AU - Ramirez, S. I. AU - Mateus, J. AU - Dan, J. M. AU - Moderbacher, C. R. AU - Rawlings, S. A. AU - Sutherland, A. AU - Premkumar, L. AU - Jadi, R. S. AU - Marrama, D. AU - de Silva, A. M. AU - Frazier, A. AU - Carlin, A. F. AU - Greenbaum, J. A. AU - Peters, B. AU - Krammer, F. AU - Smith, D. M. AU - Crotty, S. AU - Sette, A. C2 - 32473127 DB - Scopus DO - 10.1016/j.cell.2020.05.015 IS - 7 J2 - Cell KW - CD4 CD8 coronavirus COVID-19 cross-reactivity epitopes SARS-CoV-2 T cells coronavirus spike glycoprotein epitope HLA antigen class 1 HLA antigen class 2 immunoglobulin A immunoglobulin G nonstructural protein 3 nonstructural protein 4 severe acute respiratory syndrome vaccine unclassified drug viral protein virus M protein virus N protein COVID-19 vaccine spike protein, SARS-CoV-2 virus vaccine adaptive immunity adult aged antibody titer antigen recognition Article CD4+ T lymphocyte CD8+ T lymphocyte clinical article controlled study convalescence coronavirus disease 2019 cross reaction drug research drug targeting female human human cell immune response immunopathogenesis male open reading frame priority journal Severe acute respiratory syndrome coronavirus 2 Betacoronavirus blood Coronavirus infection genetics immunology metabolism mononuclear cell pandemic physiology virology virus pneumonia CD4-Positive T-Lymphocytes CD8-Positive T-Lymphocytes Coronavirus Infections Cross Reactions Epitopes, T-Lymphocyte Humans Leukocytes, Mononuclear Pandemics Pneumonia, Viral Spike Glycoprotein, Coronavirus Viral Proteins Viral Vaccines LA - English M3 - Article N1 - Cited By :723 Export Date: 4 May 2021 CODEN: CELLB Correspondence Address: Crotty, S.; Center for Infectious Disease and Vaccine Research, United States; email: shane@lji.org Correspondence Address: Sette, A.; Center for Infectious Disease and Vaccine Research, United States; email: alex@lji.org Chemicals/CAS: immunoglobulin G, 97794-27-9; COVID-19 vaccine; Epitopes, T-Lymphocyte; Spike Glycoprotein, Coronavirus; spike protein, SARS-CoV-2; Viral Proteins; Viral Vaccines Funding details: National Institutes of Health, NIH, 75N9301900065, U19 AI118626 Funding details: National Institute of Allergy and Infectious Diseases, NIAID, AI135078, AI42742 Funding details: Bill and Melinda Gates Foundation, BMGF Funding details: Departamento Administrativo de Ciencia, Tecnología e Innovación (COLCIENCIAS) Funding details: University of California, San Diego, UCSD, AI007036, AI007384 Funding details: Pontificia Universidad Javeriana Funding text 1: We would like to thank Cheryl Kim, director of the LJI flow cytometry core facility for outstanding expertise. We thank Prof. Peter Kim, Abigail Powell, PhD, and colleagues (Stanford) for RBD protein synthesized from Prof. Florian Krammer (Mt. Sinai) constructs. J.M. was supported by PhD student fellowships from the Departamento Administrativo de Ciencia , Tecnología e Innovación (COLCIENCIAS) , and Pontificia Universidad Javeriana . This work was funded by the NIH NIAID under awards AI42742 ( Cooperative Centers for Human Immunology ) (S.C. and A.S.), National Institutes of Health contract Nr. 75N9301900065 (A.S. and D.W.), and U19 AI118626 (A.S. and B.P.). The BD FACSymphony purchase was partially funded by the Bill and Melinda Gates Foundation and LJI Institutional Funds (S.C. and A.S.). This work was additionally supported in part by the Johnathan and Mary Tu Foundation (D.M.S.), the NIAID under K08 award AI135078 (J.D.), and UCSD T32s AI007036 and AI007384 Infectious Diseases Division (S.I.R. and S.A.R.). Funding text 2: We would like to thank Cheryl Kim, director of the LJI flow cytometry core facility for outstanding expertise. We thank Prof. Peter Kim, Abigail Powell, PhD, and colleagues (Stanford) for RBD protein synthesized from Prof. Florian Krammer (Mt. Sinai) constructs. J.M. was supported by PhD student fellowships from the Departamento Administrativo de Ciencia, Tecnologi?a e Innovacio?n (COLCIENCIAS), and Pontificia Universidad Javeriana. This work was funded by the NIH NIAID under awards AI42742 (Cooperative Centers for Human Immunology) (S.C. and A.S.), National Institutes of Health contract Nr. 75N9301900065 (A.S. and D.W.), and U19 AI118626 (A.S. and B.P.). The BD FACSymphony purchase was partially funded by the Bill and Melinda Gates Foundation and LJI Institutional Funds (S.C. and A.S.). This work was additionally supported in part by the Johnathan and Mary Tu Foundation (D.M.S.), the NIAID under K08 award AI135078 (J.D.), and UCSD T32s AI007036 and AI007384 Infectious Diseases Division (S.I.R. and S.A.R.). Conceptualization, A.G. D.W. S.C. and A.S.; Investigation, A.G. D.W. J.M. C.R.M. J.M.D. D.M. L.P. R.S.J. A.S. and D.W.; Formal Analysis, A.G. D.W. C.R.M. J.M.D. J.M. and S.C.; Resources, S.I.R. S.A.R. D.M.S. A.F.C. F.K. S.C. and A.S.; Data Curation, J.A.G. and B.P.; Writing, S.C. A.S. A.G. and D.W.; Supervision, B.P. A.M.d.S. S.C. and A.S.; Project Administration, A.F.; Funding Acquisition, S.C. A.S. D.W. D.S. and J.D. The authors declare no competing interests. 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Immunol., 2, p. eaan5393; Zhou, F., Yu, T., Du, R., Fan, G., Liu, Y., Liu, Z., Xiang, J., Gu, X., Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study (2020) Lancet, 395, pp. 1054-1062 PY - 2020 SN - 00928674 (ISSN) SP - 1489-1501.e15 ST - Targets of T Cell Responses to SARS-CoV-2 Coronavirus in Humans with COVID-19 Disease and Unexposed Individuals T2 - Cell TI - Targets of T Cell Responses to SARS-CoV-2 Coronavirus in Humans with COVID-19 Disease and Unexposed Individuals UR - https://www.scopus.com/inward/record.uri?eid=2-s2.0-85085363958&doi=10.1016%2fj.cell.2020.05.015&partnerID=40&md5=1c36ba012a64cfa0608c32b24dcfb4cf VL - 181 ID - 477 ER - TY - JOUR AB - The novel coronavirus (COVID-19) pandemic has had a major impact on how patients are evaluated and treated for diseases and conditions in normal patient care. Due to lack of effective treatments for this virus or vaccines to prevent infection, focus is placed on infection prevention through use of social distancing, quarantine, and face masks. To prevent COVID-19 infections in healthcare settings, the Centers for Disease Control and Prevention has recommended decreasing or eliminating nonurgent office visits. Telehealth has emerged as an alternative way to deliver effective patient care, while reducing patient and physician exposure to the virus. Telehealth is any remote healthcare process, including provider training or team meetings, whereas telemedicine refers to use of specific technology to connect a patient to a provider. High quality of care can and must be provided by Female Pelvic Medicine and Reconstructive Surgeons (FPMRS) as well as other specialists and health professionals using telemedicine. Because of the health care emergency during the pandemic, the Centers for Medicare and Medicaid Services have broadened access to and reimbursement for telemedicine services. Rapid advances in communications technology and widespread wireless access in many modern households have allowed the adoption and integration of telemedicine into urogynecology and other health practices. There are no clear guidelines for the use of telemedicine in FPMRS. The aim of this study was to conduct an expedited review of the evidence and to provide guidance for managing common outpatient FPRMS conditions during the COVID pandemic using telemedicine. FPMRS conditions were grouped into those that likely to require different treatment with virtual management compared with in-person visits, and those that could use accepted behavioral counseling and not deviate from current management paradigms. Rapid systematic review methodology was used to screen for articles related to 4 topics: (1) telemedicine in FPMRS, (2) pessary management, (3) urinary tract infections, and (4) urinary retention. In addition, 4 other topics were addressed (based on past systematic reviews and national or international society guidelines): (1) urinary incontinence, (2) vaginal prolapse, (3) fecal incontinence, and (4) defecatory dysfunction. Finally, clinical experience and expertise were pooled to reach consensus on 4 remaining areas: (1) FPMRS conditions amenable to virtual management, (2) urgent care scenarios requiring in-person visits, (3) symptoms that should alert providers to a possible COVID infection, and (4) special consideration for managing patients with known or suspected COVID-19. Overall, behavioral, medical, and conservative management provided in a virtual setting (via phone or Internet communication) will be valuable as first-line treatments. Certain situations were identified that require different treatments in the virtual setting than in person, whereas others were shown to require an in-person visit despite risks of COVID-19 exposure and spread of infection. This study presents guidance for treating FPMRS conditions via telemedicine in a format that can be actively referenced. The strengths of the study include use of an expedited review method, extensive experience of the authors in conducting systematic reviews, as well as being seasoned FPMRS practitioners. Main limitations include the rapid methodology, lack of data regarding many of the pertinent questions, and missed salient studies, because of the expedited evidence methods. © 2020 Lippincott Williams and Wilkins. All rights reserved. AD - Departments of Obstetrics and Gynecology and Urology, New York Medical College, Valhalla, NY, United States Center for Evidence Synthesis in Health, Brown School of Public Health, Brown University, Providence, RI, United States Department of Obstetrics and Gynecology, Division of Female Pelvic Medicine and Reconstructive Surgery, TriHealth, Cincinnati, OH, United States Department of Obstetrics and Gynecology, Division of Urogynecology, Houston Methodist Hospital, Houston, TX, United States Department of Obstetrics and Gynecology, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA, United States Department of Women's Health, Dell Medical School, University of Texas Austin, Austin, TX, United States Division of Female Pelvic Medicine and Reconstructive Surgery, Department of Obstetrics and Gynecology, University of New Mexico, Albuquerque, NM, United States Division of Female Pelvic Medicine and Reconstructive Surgery, Department of Obstetrics and Gynecology, University of Florida, Gainesville, FL, United States Department of Women's Health, Female Pelvic Medicine and Reconstructive Surgery, St Elizabeth Healthcare, Fort Thomas, KY, United States Section of Pelvic Medicine and Reconstructive Surgery, Department of Obstetrics and Gynecology, University of Calgary, Calgary, Alberta, Canada Department of Obstetrics and Gynecology, Georgetown University School of Medicine, Washington, DC, United States Division of Urogynecology and Reconstructive Pelvic Surgery, Department of Obstetrics and Gynecology, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States Department of Obstetrics and Gynecology, Columbia University Irving Medical Center, New York, NY, United States AU - Grimes, C. L. AU - Balk, E. M. AU - Crisp, C. C. AU - Antosh, D. D. AU - Murphy, M. AU - Halder, G. E. AU - Jeppson, P. C. AU - Lebrun, E. E. W. AU - Raman, S. AU - Kim-Fine, S. AU - Iglesia, C. AU - Dieter, A. A. AU - Yurteri-Kaplan, L. AU - Adam, G. AU - Meriwether, K. V. DB - Scopus DO - 10.1097/OGX.0000000000000825 IS - 8 J2 - Obstet. Gynecol. Surv. KW - coronavirus disease 2019 defecation disorder feces incontinence health care access health care quality health care utilization human infection prevention pandemic patient care patient counseling pelvic organ prolapse quarantine reimbursement Review social distancing telemedicine urine incontinence urine retention LA - English M3 - Review N1 - Export Date: 4 May 2021 CODEN: OGSUA PY - 2020 SN - 00297828 (ISSN) SP - 469-470 ST - A Guide for Urogynecologic Patient Care Utilizing Telemedicine during the COVID-19 Pandemic: Review of Existing Evidence T2 - Obstetrical and Gynecological Survey TI - A Guide for Urogynecologic Patient Care Utilizing Telemedicine during the COVID-19 Pandemic: Review of Existing Evidence UR - https://www.scopus.com/inward/record.uri?eid=2-s2.0-85092218867&doi=10.1097%2fOGX.0000000000000825&partnerID=40&md5=2dcbfbbb0dbf8fa5fef988f2af08177a VL - 75 ID - 419 ER - TY - JOUR AB - Introduction and hypothesis: The COVID-19 pandemic and the desire to “flatten the curve” of transmission have significantly affected the way providers care for patients. Female Pelvic Medicine and Reconstructive Surgeons (FPMRS) must provide high quality of care through remote access such as telemedicine. No clear guidelines exist on the use of telemedicine in FPMRS. Using expedited literature review methodology, we provide guidance regarding management of common outpatient urogynecology scenarios during the pandemic. Methods: We grouped FPMRS conditions into those in which virtual management differs from direct in-person visits and conditions in which treatment would emphasize behavioral and conservative counseling but not deviate from current management paradigms. We conducted expedited literature review on four topics (telemedicine in FPMRS, pessary management, urinary tract infections, urinary retention) and addressed four other topics (urinary incontinence, prolapse, fecal incontinence, defecatory dysfunction) based on existing systematic reviews and guidelines. We further compiled expert consensus regarding management of FPMRS patients in the virtual setting, scenarios when in-person visits are necessary, symptoms that should alert providers, and specific considerations for FPMRS patients with suspected or confirmed COVID-19. Results: Behavioral, medical, and conservative management will be valuable as first-line virtual treatments. Certain situations will require different treatments in the virtual setting while others will require an in-person visit despite the risks of COVID-19 transmission. Conclusions: We have presented guidance for treating FPMRS conditions via telemedicine based on rapid literature review and expert consensus and presented it in a format that can be actively referenced. © 2020, The International Urogynecological Association. AD - Departments of Obstetrics and Gynecology and Urology, New York Medical College, 19 Bradhurst Avenue, Suite 2700 South Hawthorne, Valhalla, NY 10532, United States Center for Evidence Synthesis in Health, Brown School of Public Health, Brown University, Providence, RI, United States Department of Obstetrics and Gynecology, Division of Female Pelvic Medicine and Reconstructive Surgery, TriHealth, Cincinnati, OH, United States Department of Obstetrics and Gynecology, Division of Urogynecology, Houston Methodist Hospital, Houston, TX, United States Department of Obstetrics and Gynecology, Sidney Kimmel Medical College of Thomas Jefferson University, Philadelphia, PA, United States Department of Women’s Health, Dell Medical School, University of Texas Austin, Austin, TX, United States Division of Female Pelvic Medicine and Reconstructive Surgery, Department of Obstetrics and Gynecology, University of New Mexico, Albuquerque, NM, United States Division of Female Pelvic Medicine and Reconstructive Surgery, Department of Obstetrics and Gynecology, University of Florida, Gainesville, FL, United States Department of Women’s Health, Female Pelvic Medicine and Reconstructive Surgery, St. Elizabeth Healthcare, Fort Thomas, KY, United States Section of Pelvic Medicine and Reconstructive Surgery, Department of Obstetrics and Gynecology, University of Calgary, Calgary, AB, Canada Department of Obstetrics and Gynecology, Georgetown University School of Medicine, Washington, DC, United States Division of Urogynecology and Reconstructive Pelvic Surgery, Department of Obstetrics and Gynecology, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States Department of Obstetrics and Gynecology, Columbia University Irving Medical Center, New York, NY, United States AU - Grimes, C. L. AU - Balk, E. M. AU - Crisp, C. C. AU - Antosh, D. D. AU - Murphy, M. AU - Halder, G. E. AU - Jeppson, P. C. AU - Weber LeBrun, E. E. AU - Raman, S. AU - Kim-Fine, S. AU - Iglesia, C. AU - Dieter, A. A. AU - Yurteri-Kaplan, L. AU - Adam, G. AU - Meriwether, K. V. C2 - 32342112 DB - Scopus DO - 10.1007/s00192-020-04314-4 IS - 6 J2 - Int. Urogynecol. J. KW - COVID-19 FPMRS Pandemic Systematic review Telemedicine Urogynecology Virtual visit antibiotic agent quinolone derivative antibiotic prophylaxis antibiotic resistance Article bladder emptying conservative treatment coronavirus disease 2019 defecation disorder diabetes mellitus feces incontinence follow up gynecologic disease health care utilization human infection complication meta analysis micturition disorder mixed incontinence nursing home patient care patient counseling patient satisfaction pelvic organ prolapse postoperative care priority journal recurrent infection stress incontinence telehealth urinary tract disease urinary tract infection urinary urgency urine incontinence urine retention Betacoronavirus Coronavirus infection female gynecology infection control procedures urogenital tract disease virology virus pneumonia Coronavirus Infections Female Urogenital Diseases Humans Pandemics Pneumonia, Viral LA - English M3 - Article N1 - Cited By :16 Export Date: 4 May 2021 CODEN: IUFDF Correspondence Address: Grimes, C.L.; Departments of Obstetrics and Gynecology and Urology, 19 Bradhurst Avenue, Suite 2700 South Hawthorne, United States; email: caragrimesmd@gmail.com Funding text 1: This work was conducted by the Society of Gynecologic Surgeons Collaborative Research in Pelvic Surgery Consortium (SGS CoRPS) and Systematic Review Group (SRG). Funding provided by the Society of Gynecologic Surgeons (SGS) supports assistance by methods experts in systematic reviews and other logistics. 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