ingest cdrApp 2018-06-13T21:16:31.741Z 51cd2fe2-3fd7-401f-a923-a97bc3db68a2 modifyDatastreamByValue RELS-EXT fedoraAdmin 2018-06-13T22:48:07.203Z Setting exclusive relation addDatastream MD_TECHNICAL fedoraAdmin 2018-06-13T22:48:18.707Z Adding technical metadata derived by FITS addDatastream MD_FULL_TEXT fedoraAdmin 2018-06-13T22:48:42.234Z Adding full text metadata extracted by Apache Tika modifyDatastreamByValue RELS-EXT fedoraAdmin 2018-06-13T22:49:04.395Z Setting exclusive relation modifyDatastreamByValue MD_DESCRIPTIVE cdrApp 2018-07-10T22:17:07.179Z modifyDatastreamByValue MD_DESCRIPTIVE cdrApp 2018-08-15T14:59:28.651Z modifyDatastreamByValue MD_DESCRIPTIVE cdrApp 2018-08-16T18:02:26.799Z modifyDatastreamByValue MD_DESCRIPTIVE cdrApp 2018-09-25T20:21:59.386Z modifyDatastreamByValue MD_DESCRIPTIVE cdrApp 2018-09-26T18:29:48.153Z modifyDatastreamByValue MD_DESCRIPTIVE cdrApp 2018-10-11T19:17:46.743Z modifyDatastreamByValue MD_DESCRIPTIVE cdrApp 2019-02-28T02:34:45.087Z modifyDatastreamByValue MD_DESCRIPTIVE cdrApp 2019-03-19T21:52:44.569Z Deirdre Rodeberg Author Department of Psychology and Neuroscience College of Arts and Sciences ROLE OF THE NUCLEUS ACCUMBENS AND ITS DOPAMINERGIC AND GLUTAMATERGIC AFFERENTS DURING DELAY DISCOUNTING Effective decision making depends on an organism’s ability to assess available resources and choose the best available option. Organisms must also assess changes to reward value and update their behavior accordingly to keep selecting the best option. Value-based decision making depends on neural pathways including the nucleus accumbens (NAc) and its dopaminergic input from the ventral tegmental area (VTA). A glutamatergic afferent to the NAc core, the prelimbic cortex (PrL), may also be implicated in value-based decision-making, such as delay discounting. However, it is unknown how these dopaminergic and glutamatergic afferents to the NAc mediate value-based decision-making behavior. First, I used optogenetic techniques to examine the causal role of dopaminergic input to the NAc during delay discounting decision making tasks. This experiment revealed that dopamine release in the NAc core does not mediate delay discounting. The next set of experiments shifted focus to the PrL’s glutamatergic ennervation of the NAc. Electrophysiological recording of the PrL during our delay discounting task revealed that PrL neurons track the predicted and eventual outcome of preferred rewards, as the value of that reward shifts across blocks. Further, this tracking differentially encoded preferred rewards depending on rats’ inherent impulsivity, such that high impulsive rats demonstrated preferential encoding of the small/immediate option. In the next experiment, optogenetic stimulation of the PrL-NAc core pathway revealed that glutamate signaling in the NAc core was not sufficient to mediate delay discounting. Together, these experiments help to characterize of the neural circuits and mechanisms by which delay discounting behavior is processed within the brain, providing insight into the potential role of the NAc and its dopaminergic and glutamatergic afferents in mediating appropriate decisions. Spring 2018 2018 Behavioral psychology behavior, decision making, electrophysiology, nucleus accumbens, optogenetics, rat eng Doctor of Philosophy Dissertation University of North Carolina at Chapel Hill Graduate School Degree granting institution Psychology Regina Carelli Thesis advisor Donald Lysle Thesis advisor Todd Thiele Thesis advisor Mark Hollins Thesis advisor Kathryn Reissner Thesis advisor text Deirdre Rodeberg Author Department of Psychology and Neuroscience College of Arts and Sciences ROLE OF THE NUCLEUS ACCUMBENS AND ITS DOPAMINERGIC AND GLUTAMATERGIC AFFERENTS DURING DELAY DISCOUNTING Effective decision making depends on an organism’s ability to assess available resources and choose the best available option. Organisms must also assess changes to reward value and update their behavior accordingly to keep selecting the best option. Value-based decision making depends on neural pathways including the nucleus accumbens (NAc) and its dopaminergic input from the ventral tegmental area (VTA). A glutamatergic afferent to the NAc core, the prelimbic cortex (PrL), may also be implicated in value-based decision-making, such as delay discounting. However, it is unknown how these dopaminergic and glutamatergic afferents to the NAc mediate value-based decision-making behavior. First, I used optogenetic techniques to examine the causal role of dopaminergic input to the NAc during delay discounting decision making tasks. This experiment revealed that dopamine release in the NAc core does not mediate delay discounting. The next set of experiments shifted focus to the PrL’s glutamatergic ennervation of the NAc. Electrophysiological recording of the PrL during our delay discounting task revealed that PrL neurons track the predicted and eventual outcome of preferred rewards, as the value of that reward shifts across blocks. Further, this tracking differentially encoded preferred rewards depending on rats’ inherent impulsivity, such that high impulsive rats demonstrated preferential encoding of the small/immediate option. In the next experiment, optogenetic stimulation of the PrL-NAc core pathway revealed that glutamate signaling in the NAc core was not sufficient to mediate delay discounting. Together, these experiments help to characterize of the neural circuits and mechanisms by which delay discounting behavior is processed within the brain, providing insight into the potential role of the NAc and its dopaminergic and glutamatergic afferents in mediating appropriate decisions. Spring 2018 2018 Behavioral psychology behavior, decision making, electrophysiology, nucleus accumbens, optogenetics, rat eng Doctor of Philosophy Dissertation University of North Carolina at Chapel Hill Graduate School Degree granting institution Psychology Regina Carelli Thesis advisor Donald Lysle Thesis advisor Todd Thiele Thesis advisor Mark Hollins Thesis advisor Kathryn Reissner Thesis advisor text Deirdre Rodeberg Author Department of Psychology and Neuroscience College of Arts and Sciences ROLE OF THE NUCLEUS ACCUMBENS AND ITS DOPAMINERGIC AND GLUTAMATERGIC AFFERENTS DURING DELAY DISCOUNTING Effective decision making depends on an organism’s ability to assess available resources and choose the best available option. Organisms must also assess changes to reward value and update their behavior accordingly to keep selecting the best option. Value-based decision making depends on neural pathways including the nucleus accumbens (NAc) and its dopaminergic input from the ventral tegmental area (VTA). A glutamatergic afferent to the NAc core, the prelimbic cortex (PrL), may also be implicated in value-based decision-making, such as delay discounting. However, it is unknown how these dopaminergic and glutamatergic afferents to the NAc mediate value-based decision-making behavior. First, I used optogenetic techniques to examine the causal role of dopaminergic input to the NAc during delay discounting decision making tasks. This experiment revealed that dopamine release in the NAc core does not mediate delay discounting. The next set of experiments shifted focus to the PrL’s glutamatergic ennervation of the NAc. Electrophysiological recording of the PrL during our delay discounting task revealed that PrL neurons track the predicted and eventual outcome of preferred rewards, as the value of that reward shifts across blocks. Further, this tracking differentially encoded preferred rewards depending on rats’ inherent impulsivity, such that high impulsive rats demonstrated preferential encoding of the small/immediate option. In the next experiment, optogenetic stimulation of the PrL-NAc core pathway revealed that glutamate signaling in the NAc core was not sufficient to mediate delay discounting. Together, these experiments help to characterize of the neural circuits and mechanisms by which delay discounting behavior is processed within the brain, providing insight into the potential role of the NAc and its dopaminergic and glutamatergic afferents in mediating appropriate decisions. Spring 2018 2018 Behavioral psychology behavior, decision making, electrophysiology, nucleus accumbens, optogenetics, rat eng Doctor of Philosophy Dissertation Psychology Regina Carelli Thesis advisor Donald Lysle Thesis advisor Todd Thiele Thesis advisor Mark Hollins Thesis advisor Kathryn Reissner Thesis advisor text University of North Carolina at Chapel Hill Degree granting institution Deirdre Rodeberg Author Department of Psychology and Neuroscience College of Arts and Sciences ROLE OF THE NUCLEUS ACCUMBENS AND ITS DOPAMINERGIC AND GLUTAMATERGIC AFFERENTS DURING DELAY DISCOUNTING Effective decision making depends on an organism’s ability to assess available resources and choose the best available option. Organisms must also assess changes to reward value and update their behavior accordingly to keep selecting the best option. Value-based decision making depends on neural pathways including the nucleus accumbens (NAc) and its dopaminergic input from the ventral tegmental area (VTA). A glutamatergic afferent to the NAc core, the prelimbic cortex (PrL), may also be implicated in value-based decision-making, such as delay discounting. However, it is unknown how these dopaminergic and glutamatergic afferents to the NAc mediate value-based decision-making behavior. First, I used optogenetic techniques to examine the causal role of dopaminergic input to the NAc during delay discounting decision making tasks. This experiment revealed that dopamine release in the NAc core does not mediate delay discounting. The next set of experiments shifted focus to the PrL’s glutamatergic ennervation of the NAc. Electrophysiological recording of the PrL during our delay discounting task revealed that PrL neurons track the predicted and eventual outcome of preferred rewards, as the value of that reward shifts across blocks. Further, this tracking differentially encoded preferred rewards depending on rats’ inherent impulsivity, such that high impulsive rats demonstrated preferential encoding of the small/immediate option. In the next experiment, optogenetic stimulation of the PrL-NAc core pathway revealed that glutamate signaling in the NAc core was not sufficient to mediate delay discounting. Together, these experiments help to characterize of the neural circuits and mechanisms by which delay discounting behavior is processed within the brain, providing insight into the potential role of the NAc and its dopaminergic and glutamatergic afferents in mediating appropriate decisions. Spring 2018 2018 Behavioral psychology behavior, decision making, electrophysiology, nucleus accumbens, optogenetics, rat eng Doctor of Philosophy Dissertation University of North Carolina at Chapel Hill Graduate School Degree granting institution Psychology Regina Carelli Thesis advisor Donald Lysle Thesis advisor Todd Thiele Thesis advisor Mark Hollins Thesis advisor Kathryn Reissner Thesis advisor text Deirdre Rodeberg Creator Department of Psychology and Neuroscience College of Arts and Sciences ROLE OF THE NUCLEUS ACCUMBENS AND ITS DOPAMINERGIC AND GLUTAMATERGIC AFFERENTS DURING DELAY DISCOUNTING Effective decision making depends on an organism’s ability to assess available resources and choose the best available option. Organisms must also assess changes to reward value and update their behavior accordingly to keep selecting the best option. Value-based decision making depends on neural pathways including the nucleus accumbens (NAc) and its dopaminergic input from the ventral tegmental area (VTA). A glutamatergic afferent to the NAc core, the prelimbic cortex (PrL), may also be implicated in value-based decision-making, such as delay discounting. However, it is unknown how these dopaminergic and glutamatergic afferents to the NAc mediate value-based decision-making behavior. First, I used optogenetic techniques to examine the causal role of dopaminergic input to the NAc during delay discounting decision making tasks. This experiment revealed that dopamine release in the NAc core does not mediate delay discounting. The next set of experiments shifted focus to the PrL’s glutamatergic ennervation of the NAc. Electrophysiological recording of the PrL during our delay discounting task revealed that PrL neurons track the predicted and eventual outcome of preferred rewards, as the value of that reward shifts across blocks. Further, this tracking differentially encoded preferred rewards depending on rats’ inherent impulsivity, such that high impulsive rats demonstrated preferential encoding of the small/immediate option. In the next experiment, optogenetic stimulation of the PrL-NAc core pathway revealed that glutamate signaling in the NAc core was not sufficient to mediate delay discounting. Together, these experiments help to characterize of the neural circuits and mechanisms by which delay discounting behavior is processed within the brain, providing insight into the potential role of the NAc and its dopaminergic and glutamatergic afferents in mediating appropriate decisions. Behavioral psychology behavior; decision making; electrophysiology; nucleus accumbens; optogenetics; rat eng Doctor of Philosophy Dissertation University of North Carolina at Chapel Hill Graduate School Degree granting institution Psychology Regina Carelli Thesis advisor Donald Lysle Thesis advisor Todd Thiele Thesis advisor Mark Hollins Thesis advisor Kathryn Reissner Thesis advisor text 2018 2018-05 Deirdre Rodeberg Creator Department of Psychology and Neuroscience College of Arts and Sciences ROLE OF THE NUCLEUS ACCUMBENS AND ITS DOPAMINERGIC AND GLUTAMATERGIC AFFERENTS DURING DELAY DISCOUNTING Effective decision making depends on an organism’s ability to assess available resources and choose the best available option. Organisms must also assess changes to reward value and update their behavior accordingly to keep selecting the best option. Value-based decision making depends on neural pathways including the nucleus accumbens (NAc) and its dopaminergic input from the ventral tegmental area (VTA). A glutamatergic afferent to the NAc core, the prelimbic cortex (PrL), may also be implicated in value-based decision-making, such as delay discounting. However, it is unknown how these dopaminergic and glutamatergic afferents to the NAc mediate value-based decision-making behavior. First, I used optogenetic techniques to examine the causal role of dopaminergic input to the NAc during delay discounting decision making tasks. This experiment revealed that dopamine release in the NAc core does not mediate delay discounting. The next set of experiments shifted focus to the PrL’s glutamatergic ennervation of the NAc. Electrophysiological recording of the PrL during our delay discounting task revealed that PrL neurons track the predicted and eventual outcome of preferred rewards, as the value of that reward shifts across blocks. Further, this tracking differentially encoded preferred rewards depending on rats’ inherent impulsivity, such that high impulsive rats demonstrated preferential encoding of the small/immediate option. In the next experiment, optogenetic stimulation of the PrL-NAc core pathway revealed that glutamate signaling in the NAc core was not sufficient to mediate delay discounting. Together, these experiments help to characterize of the neural circuits and mechanisms by which delay discounting behavior is processed within the brain, providing insight into the potential role of the NAc and its dopaminergic and glutamatergic afferents in mediating appropriate decisions. Behavioral psychology behavior; decision making; electrophysiology; nucleus accumbens; optogenetics; rat eng Doctor of Philosophy Dissertation University of North Carolina at Chapel Hill Graduate School Degree granting institution Psychology Regina Carelli Thesis advisor Donald Lysle Thesis advisor Todd Thiele Thesis advisor Mark Hollins Thesis advisor Kathryn Reissner Thesis advisor text 2018 2018-05 Deirdre Rodeberg Author Department of Psychology and Neuroscience College of Arts and Sciences ROLE OF THE NUCLEUS ACCUMBENS AND ITS DOPAMINERGIC AND GLUTAMATERGIC AFFERENTS DURING DELAY DISCOUNTING Effective decision making depends on an organism’s ability to assess available resources and choose the best available option. Organisms must also assess changes to reward value and update their behavior accordingly to keep selecting the best option. Value-based decision making depends on neural pathways including the nucleus accumbens (NAc) and its dopaminergic input from the ventral tegmental area (VTA). A glutamatergic afferent to the NAc core, the prelimbic cortex (PrL), may also be implicated in value-based decision-making, such as delay discounting. However, it is unknown how these dopaminergic and glutamatergic afferents to the NAc mediate value-based decision-making behavior. First, I used optogenetic techniques to examine the causal role of dopaminergic input to the NAc during delay discounting decision making tasks. This experiment revealed that dopamine release in the NAc core does not mediate delay discounting. The next set of experiments shifted focus to the PrL’s glutamatergic ennervation of the NAc. Electrophysiological recording of the PrL during our delay discounting task revealed that PrL neurons track the predicted and eventual outcome of preferred rewards, as the value of that reward shifts across blocks. Further, this tracking differentially encoded preferred rewards depending on rats’ inherent impulsivity, such that high impulsive rats demonstrated preferential encoding of the small/immediate option. In the next experiment, optogenetic stimulation of the PrL-NAc core pathway revealed that glutamate signaling in the NAc core was not sufficient to mediate delay discounting. Together, these experiments help to characterize of the neural circuits and mechanisms by which delay discounting behavior is processed within the brain, providing insight into the potential role of the NAc and its dopaminergic and glutamatergic afferents in mediating appropriate decisions. Spring 2018 2018 Behavioral psychology behavior, decision making, electrophysiology, nucleus accumbens, optogenetics, rat eng Doctor of Philosophy Dissertation University of North Carolina at Chapel Hill Graduate School Degree granting institution Psychology Regina Carelli Thesis advisor Donald Lysle Thesis advisor Todd Thiele Thesis advisor Mark Hollins Thesis advisor Kathryn Reissner Thesis advisor text Deirdre Rodeberg Creator Department of Psychology and Neuroscience College of Arts and Sciences Effective decision making depends on an organism’s ability to assess available resources and choose the best available option. Organisms must also assess changes to reward value and update their behavior accordingly to keep selecting the best option. Value-based decision making depends on neural pathways including the nucleus accumbens (NAc) and its dopaminergic input from the ventral tegmental area (VTA). A glutamatergic afferent to the NAc core, the prelimbic cortex (PrL), may also be implicated in value-based decision-making, such as delay discounting. However, it is unknown how these dopaminergic and glutamatergic afferents to the NAc mediate value-based decision-making behavior. First, I used optogenetic techniques to examine the causal role of dopaminergic input to the NAc during delay discounting decision making tasks. This experiment revealed that dopamine release in the NAc core does not mediate delay discounting. The next set of experiments shifted focus to the PrL’s glutamatergic ennervation of the NAc. Electrophysiological recording of the PrL during our delay discounting task revealed that PrL neurons track the predicted and eventual outcome of preferred rewards, as the value of that reward shifts across blocks. Further, this tracking differentially encoded preferred rewards depending on rats’ inherent impulsivity, such that high impulsive rats demonstrated preferential encoding of the small/immediate option. In the next experiment, optogenetic stimulation of the PrL-NAc core pathway revealed that glutamate signaling in the NAc core was not sufficient to mediate delay discounting. Together, these experiments help to characterize of the neural circuits and mechanisms by which delay discounting behavior is processed within the brain, providing insight into the potential role of the NAc and its dopaminergic and glutamatergic afferents in mediating appropriate decisions. 2018-05 2018 Behavioral psychology behavior; decision making; electrophysiology; nucleus accumbens; optogenetics; rat eng Doctor of Philosophy Dissertation University of North Carolina at Chapel Hill Graduate School Degree granting institution Psychology Regina Carelli Thesis advisor Donald Lysle Thesis advisor Todd Thiele Thesis advisor Mark Hollins Thesis advisor Kathryn Reissner Thesis advisor text Deirdre Rodeberg Creator Department of Psychology and Neuroscience College of Arts and Sciences Effective decision making depends on an organism’s ability to assess available resources and choose the best available option. Organisms must also assess changes to reward value and update their behavior accordingly to keep selecting the best option. Value-based decision making depends on neural pathways including the nucleus accumbens (NAc) and its dopaminergic input from the ventral tegmental area (VTA). A glutamatergic afferent to the NAc core, the prelimbic cortex (PrL), may also be implicated in value-based decision-making, such as delay discounting. However, it is unknown how these dopaminergic and glutamatergic afferents to the NAc mediate value-based decision-making behavior. First, I used optogenetic techniques to examine the causal role of dopaminergic input to the NAc during delay discounting decision making tasks. This experiment revealed that dopamine release in the NAc core does not mediate delay discounting. The next set of experiments shifted focus to the PrL’s glutamatergic ennervation of the NAc. Electrophysiological recording of the PrL during our delay discounting task revealed that PrL neurons track the predicted and eventual outcome of preferred rewards, as the value of that reward shifts across blocks. Further, this tracking differentially encoded preferred rewards depending on rats’ inherent impulsivity, such that high impulsive rats demonstrated preferential encoding of the small/immediate option. In the next experiment, optogenetic stimulation of the PrL-NAc core pathway revealed that glutamate signaling in the NAc core was not sufficient to mediate delay discounting. Together, these experiments help to characterize of the neural circuits and mechanisms by which delay discounting behavior is processed within the brain, providing insight into the potential role of the NAc and its dopaminergic and glutamatergic afferents in mediating appropriate decisions. 2018-05 2018 Behavioral psychology behavior; decision making; electrophysiology; nucleus accumbens; optogenetics; rat eng Doctor of Philosophy Dissertation University of North Carolina at Chapel Hill Graduate School Degree granting institution Regina Carelli Thesis advisor Donald Lysle Thesis advisor Todd Thiele Thesis advisor Mark Hollins Thesis advisor Kathryn Reissner Thesis advisor text Rodeberg_unc_0153D_17933.pdf uuid:b72a3852-c543-4444-b797-50d75889a694 2020-06-13T00:00:00 2018-06-10T13:04:20Z proquest application/pdf 1782772