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Brian
Barkley
Author
Department of Biostatistics
Gillings School of Global Public Health
Causal Inference From Observational Studies in the Presence of Partial Interference
Analyzing data to estimate the effect of treatment on health outcomes can play a major role in the fields of personal and public health. Interference occurs when the treatment of one individual affects the outcome of another individual. This work aims to develop statistical methodology for inference about causal effects from observational studies in the presence of interference. We assume partial interference throughout: interference may exist within clusters of individuals, but not between distinct clusters. In each paper we propose estimators that are consistent and asymptotically Normal; estimators for the asymptotic variance are also proposed. Finite-sample performance of each estimator is investigated, and each method is illustrated by analyzing a cholera vaccine study in Matlab, Bangladesh.
In the first paper, we propose a method for inverse probability-weighted estimation of target estimands in the presence of partial interference that is more robust to model mis-specification than existing methods. This technique relies on an algorithm which combines machine learning and mixed effects methods to determine the relationship between treatment and covariates assuming a certain correlation structure. We employ the algorithm on a training sample as a data-adaptive model selection procedure. We recover the set of rules that the algorithm uses for prediction to transform the covariates in a testing sample. We proceed by fitting a model to the transformed covariates to estimate propensity scores for IPW estimation of target estimands.
We propose a matching technique for estimating causal effects in the presence of partial interference in the second paper. These estimators extend methods that are commonly employed when no interference is assumed. The proposed methods can be carried out without modeling treatment, and may outperform existing IPW estimators in certain scenarios. Extensions of these estimators are discussed.
In the third paper we propose new causal estimands for observational studies in the presence of partial interference. The proposed estimands describe counterfactual scenarios in which there may be within-cluster dependence in the individual treatment selections. These estimands may be more relevant for public health officials. These estimands are identifiable from observational data with parametric assumptions. Inverse probability-weighted estimators for these estimands are proposed.
Spring 2018
2018
Biostatistics
Statistics
Epidemiology
causal inference, interference, inverse probability weight, matching, observational study, spillover effects
eng
Doctor of Philosophy
Dissertation
University of North Carolina at Chapel Hill Graduate School
Degree granting institution
Biostatistics
Michael
Hudgens
Thesis advisor
Maurice
Brookhart
Thesis advisor
Michael
Emch
Thesis advisor
Michael
Kosorok
Thesis advisor
Donglin
Zeng
Thesis advisor
text
Brian
Barkley
Author
Department of Biostatistics
Gillings School of Global Public Health
Causal Inference From Observational Studies in the Presence of Partial Interference
Analyzing data to estimate the effect of treatment on health outcomes can play a major role in the fields of personal and public health. Interference occurs when the treatment of one individual affects the outcome of another individual. This work aims to develop statistical methodology for inference about causal effects from observational studies in the presence of interference. We assume partial interference throughout: interference may exist within clusters of individuals, but not between distinct clusters. In each paper we propose estimators that are consistent and asymptotically Normal; estimators for the asymptotic variance are also proposed. Finite-sample performance of each estimator is investigated, and each method is illustrated by analyzing a cholera vaccine study in Matlab, Bangladesh.
In the first paper, we propose a method for inverse probability-weighted estimation of target estimands in the presence of partial interference that is more robust to model mis-specification than existing methods. This technique relies on an algorithm which combines machine learning and mixed effects methods to determine the relationship between treatment and covariates assuming a certain correlation structure. We employ the algorithm on a training sample as a data-adaptive model selection procedure. We recover the set of rules that the algorithm uses for prediction to transform the covariates in a testing sample. We proceed by fitting a model to the transformed covariates to estimate propensity scores for IPW estimation of target estimands.
We propose a matching technique for estimating causal effects in the presence of partial interference in the second paper. These estimators extend methods that are commonly employed when no interference is assumed. The proposed methods can be carried out without modeling treatment, and may outperform existing IPW estimators in certain scenarios. Extensions of these estimators are discussed.
In the third paper we propose new causal estimands for observational studies in the presence of partial interference. The proposed estimands describe counterfactual scenarios in which there may be within-cluster dependence in the individual treatment selections. These estimands may be more relevant for public health officials. These estimands are identifiable from observational data with parametric assumptions. Inverse probability-weighted estimators for these estimands are proposed.
Spring 2018
2018
Biostatistics
Statistics
Epidemiology
causal inference, interference, inverse probability weight, matching, observational study, spillover effects
eng
Doctor of Philosophy
Dissertation
University of North Carolina at Chapel Hill Graduate School
Degree granting institution
Biostatistics
Michael
Hudgens
Thesis advisor
Maurice
Brookhart
Thesis advisor
Michael
Emch
Thesis advisor
Michael
Kosorok
Thesis advisor
Donglin
Zeng
Thesis advisor
text
Brian
Barkley
Author
Department of Biostatistics
Gillings School of Global Public Health
Causal Inference From Observational Studies in the Presence of Partial Interference
Analyzing data to estimate the effect of treatment on health outcomes can play a major role in the fields of personal and public health. Interference occurs when the treatment of one individual affects the outcome of another individual. This work aims to develop statistical methodology for inference about causal effects from observational studies in the presence of interference. We assume partial interference throughout: interference may exist within clusters of individuals, but not between distinct clusters. In each paper we propose estimators that are consistent and asymptotically Normal; estimators for the asymptotic variance are also proposed. Finite-sample performance of each estimator is investigated, and each method is illustrated by analyzing a cholera vaccine study in Matlab, Bangladesh.
In the first paper, we propose a method for inverse probability-weighted estimation of target estimands in the presence of partial interference that is more robust to model mis-specification than existing methods. This technique relies on an algorithm which combines machine learning and mixed effects methods to determine the relationship between treatment and covariates assuming a certain correlation structure. We employ the algorithm on a training sample as a data-adaptive model selection procedure. We recover the set of rules that the algorithm uses for prediction to transform the covariates in a testing sample. We proceed by fitting a model to the transformed covariates to estimate propensity scores for IPW estimation of target estimands.
We propose a matching technique for estimating causal effects in the presence of partial interference in the second paper. These estimators extend methods that are commonly employed when no interference is assumed. The proposed methods can be carried out without modeling treatment, and may outperform existing IPW estimators in certain scenarios. Extensions of these estimators are discussed.
In the third paper we propose new causal estimands for observational studies in the presence of partial interference. The proposed estimands describe counterfactual scenarios in which there may be within-cluster dependence in the individual treatment selections. These estimands may be more relevant for public health officials. These estimands are identifiable from observational data with parametric assumptions. Inverse probability-weighted estimators for these estimands are proposed.
Spring 2018
2018
Biostatistics
Statistics
Epidemiology
causal inference, interference, inverse probability weight, matching, observational study, spillover effects
eng
Doctor of Philosophy
Dissertation
University of North Carolina at Chapel Hill Graduate School
Degree granting institution
Biostatistics
Michael
Hudgens
Thesis advisor
Maurice
Brookhart
Thesis advisor
Michael
Emch
Thesis advisor
Michael
Kosorok
Thesis advisor
Donglin
Zeng
Thesis advisor
text
Brian
Barkley
Author
Department of Biostatistics
Gillings School of Global Public Health
Causal Inference From Observational Studies in the Presence of Partial Interference
Analyzing data to estimate the effect of treatment on health outcomes can play a major role in the fields of personal and public health. Interference occurs when the treatment of one individual affects the outcome of another individual. This work aims to develop statistical methodology for inference about causal effects from observational studies in the presence of interference. We assume partial interference throughout: interference may exist within clusters of individuals, but not between distinct clusters. In each paper we propose estimators that are consistent and asymptotically Normal; estimators for the asymptotic variance are also proposed. Finite-sample performance of each estimator is investigated, and each method is illustrated by analyzing a cholera vaccine study in Matlab, Bangladesh.
In the first paper, we propose a method for inverse probability-weighted estimation of target estimands in the presence of partial interference that is more robust to model mis-specification than existing methods. This technique relies on an algorithm which combines machine learning and mixed effects methods to determine the relationship between treatment and covariates assuming a certain correlation structure. We employ the algorithm on a training sample as a data-adaptive model selection procedure. We recover the set of rules that the algorithm uses for prediction to transform the covariates in a testing sample. We proceed by fitting a model to the transformed covariates to estimate propensity scores for IPW estimation of target estimands.
We propose a matching technique for estimating causal effects in the presence of partial interference in the second paper. These estimators extend methods that are commonly employed when no interference is assumed. The proposed methods can be carried out without modeling treatment, and may outperform existing IPW estimators in certain scenarios. Extensions of these estimators are discussed.
In the third paper we propose new causal estimands for observational studies in the presence of partial interference. The proposed estimands describe counterfactual scenarios in which there may be within-cluster dependence in the individual treatment selections. These estimands may be more relevant for public health officials. These estimands are identifiable from observational data with parametric assumptions. Inverse probability-weighted estimators for these estimands are proposed.
Spring 2018
2018
Biostatistics
Statistics
Epidemiology
causal inference, interference, inverse probability weight, matching, observational study, spillover effects
eng
Doctor of Philosophy
Dissertation
Biostatistics
Michael
Hudgens
Thesis advisor
Maurice
Brookhart
Thesis advisor
Michael
Emch
Thesis advisor
Michael
Kosorok
Thesis advisor
Donglin
Zeng
Thesis advisor
text
University of North Carolina at Chapel Hill
Degree granting institution
Brian
Barkley
Creator
Department of Biostatistics
Gillings School of Global Public Health
Causal Inference From Observational Studies in the Presence of Partial Interference
Analyzing data to estimate the effect of treatment on health outcomes can play a major role in the fields of personal and public health. Interference occurs when the treatment of one individual affects the outcome of another individual. This work aims to develop statistical methodology for inference about causal effects from observational studies in the presence of interference. We assume partial interference throughout: interference may exist within clusters of individuals, but not between distinct clusters. In each paper we propose estimators that are consistent and asymptotically Normal; estimators for the asymptotic variance are also proposed. Finite-sample performance of each estimator is investigated, and each method is illustrated by analyzing a cholera vaccine study in Matlab, Bangladesh.
In the first paper, we propose a method for inverse probability-weighted estimation of target estimands in the presence of partial interference that is more robust to model mis-specification than existing methods. This technique relies on an algorithm which combines machine learning and mixed effects methods to determine the relationship between treatment and covariates assuming a certain correlation structure. We employ the algorithm on a training sample as a data-adaptive model selection procedure. We recover the set of rules that the algorithm uses for prediction to transform the covariates in a testing sample. We proceed by fitting a model to the transformed covariates to estimate propensity scores for IPW estimation of target estimands.
We propose a matching technique for estimating causal effects in the presence of partial interference in the second paper. These estimators extend methods that are commonly employed when no interference is assumed. The proposed methods can be carried out without modeling treatment, and may outperform existing IPW estimators in certain scenarios. Extensions of these estimators are discussed.
In the third paper we propose new causal estimands for observational studies in the presence of partial interference. The proposed estimands describe counterfactual scenarios in which there may be within-cluster dependence in the individual treatment selections. These estimands may be more relevant for public health officials. These estimands are identifiable from observational data with parametric assumptions. Inverse probability-weighted estimators for these estimands are proposed.
Biostatistics
Statistics
Epidemiology
causal inference; interference; inverse probability weight; matching; observational study; spillover effects
eng
Doctor of Philosophy
Dissertation
Biostatistics
Michael
Hudgens
Thesis advisor
Maurice
Brookhart
Thesis advisor
Michael
Emch
Thesis advisor
Michael
Kosorok
Thesis advisor
Donglin
Zeng
Thesis advisor
text
University of North Carolina at Chapel Hill
Degree granting institution
2018
2018-05
Brian
Barkley
Author
Department of Biostatistics
Gillings School of Global Public Health
Causal Inference From Observational Studies in the Presence of Partial Interference
Analyzing data to estimate the effect of treatment on health outcomes can play a major role in the fields of personal and public health. Interference occurs when the treatment of one individual affects the outcome of another individual. This work aims to develop statistical methodology for inference about causal effects from observational studies in the presence of interference. We assume partial interference throughout: interference may exist within clusters of individuals, but not between distinct clusters. In each paper we propose estimators that are consistent and asymptotically Normal; estimators for the asymptotic variance are also proposed. Finite-sample performance of each estimator is investigated, and each method is illustrated by analyzing a cholera vaccine study in Matlab, Bangladesh.
In the first paper, we propose a method for inverse probability-weighted estimation of target estimands in the presence of partial interference that is more robust to model mis-specification than existing methods. This technique relies on an algorithm which combines machine learning and mixed effects methods to determine the relationship between treatment and covariates assuming a certain correlation structure. We employ the algorithm on a training sample as a data-adaptive model selection procedure. We recover the set of rules that the algorithm uses for prediction to transform the covariates in a testing sample. We proceed by fitting a model to the transformed covariates to estimate propensity scores for IPW estimation of target estimands.
We propose a matching technique for estimating causal effects in the presence of partial interference in the second paper. These estimators extend methods that are commonly employed when no interference is assumed. The proposed methods can be carried out without modeling treatment, and may outperform existing IPW estimators in certain scenarios. Extensions of these estimators are discussed.
In the third paper we propose new causal estimands for observational studies in the presence of partial interference. The proposed estimands describe counterfactual scenarios in which there may be within-cluster dependence in the individual treatment selections. These estimands may be more relevant for public health officials. These estimands are identifiable from observational data with parametric assumptions. Inverse probability-weighted estimators for these estimands are proposed.
Spring 2018
2018
Biostatistics
Statistics
Epidemiology
causal inference, interference, inverse probability weight, matching, observational study, spillover effects
eng
Doctor of Philosophy
Dissertation
University of North Carolina at Chapel Hill Graduate School
Degree granting institution
Biostatistics
Michael
Hudgens
Thesis advisor
Maurice
Brookhart
Thesis advisor
Michael
Emch
Thesis advisor
Michael
Kosorok
Thesis advisor
Donglin
Zeng
Thesis advisor
text
Brian
Barkley
Creator
Department of Biostatistics
Gillings School of Global Public Health
Causal Inference From Observational Studies in the Presence of Partial Interference
Analyzing data to estimate the effect of treatment on health outcomes can play a major role in the fields of personal and public health. Interference occurs when the treatment of one individual affects the outcome of another individual. This work aims to develop statistical methodology for inference about causal effects from observational studies in the presence of interference. We assume partial interference throughout: interference may exist within clusters of individuals, but not between distinct clusters. In each paper we propose estimators that are consistent and asymptotically Normal; estimators for the asymptotic variance are also proposed. Finite-sample performance of each estimator is investigated, and each method is illustrated by analyzing a cholera vaccine study in Matlab, Bangladesh.
In the first paper, we propose a method for inverse probability-weighted estimation of target estimands in the presence of partial interference that is more robust to model mis-specification than existing methods. This technique relies on an algorithm which combines machine learning and mixed effects methods to determine the relationship between treatment and covariates assuming a certain correlation structure. We employ the algorithm on a training sample as a data-adaptive model selection procedure. We recover the set of rules that the algorithm uses for prediction to transform the covariates in a testing sample. We proceed by fitting a model to the transformed covariates to estimate propensity scores for IPW estimation of target estimands.
We propose a matching technique for estimating causal effects in the presence of partial interference in the second paper. These estimators extend methods that are commonly employed when no interference is assumed. The proposed methods can be carried out without modeling treatment, and may outperform existing IPW estimators in certain scenarios. Extensions of these estimators are discussed.
In the third paper we propose new causal estimands for observational studies in the presence of partial interference. The proposed estimands describe counterfactual scenarios in which there may be within-cluster dependence in the individual treatment selections. These estimands may be more relevant for public health officials. These estimands are identifiable from observational data with parametric assumptions. Inverse probability-weighted estimators for these estimands are proposed.
2018-05
2018
Biostatistics
Statistics
Epidemiology
causal inference; interference; inverse probability weight; matching; observational study; spillover effects
eng
Doctor of Philosophy
Dissertation
University of North Carolina at Chapel Hill Graduate School
Degree granting institution
Michael
Hudgens
Thesis advisor
Maurice
Brookhart
Thesis advisor
Michael
Emch
Thesis advisor
Michael
Kosorok
Thesis advisor
Donglin
Zeng
Thesis advisor
text
Barkley_unc_0153D_17700.pdf
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