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Caiping
Wei
Author
Department of Sociology
College of Arts and Sciences
THE INFLUENCES OF SOCIOECONOMIC STATUS, LIFESTYLE, AND GENETIC INHERITANCE ON WAIST CIRCUMFERENCE
Waist circumference is a convenient measure of obesity, abdominal obesity and fat distribution and it is a more efficient predictor than BMI for diseases including type 2 diabetes and cardiovascular disease. In this study, we investigate the GxE interplay in influencing waist circumference among the elderly males using the data from the Health and Retirement Study (HRS) that includes 4,944 males whose waist circumferences are measured at five different time points, mostly aged 50 to 100. We generate “top-hits” polygenic scores using genetic variants associated with waist circumference from previous studies and whole-genome polygenic score using whole-genome genetic variants from GIANT consortium. By incorporating the polygenic scores, socioeconomic status (SES), and lifestyle, we found that the genetic influence on waist circumference for people who do less physical activity is higher than for those who do more physical activity.
Spring 2018
2018
Sociology
GWAS, GxE interaction, lifestyle, socioeconomic status, waist circumference
eng
Master of Arts
Thesis
University of North Carolina at Chapel Hill Graduate School
Degree granting institution
Sociology
Guang
Guo
Thesis advisor
Francois
Nielsen
Thesis advisor
Mike
Shanahan
Thesis advisor
text
Caiping
Wei
Author
Department of Sociology
College of Arts and Sciences
THE INFLUENCES OF SOCIOECONOMIC STATUS, LIFESTYLE, AND GENETIC INHERITANCE ON WAIST CIRCUMFERENCE
Waist circumference is a convenient measure of obesity, abdominal obesity and fat distribution and it is a more efficient predictor than BMI for diseases including type 2 diabetes and cardiovascular disease. In this study, we investigate the GxE interplay in influencing waist circumference among the elderly males using the data from the Health and Retirement Study (HRS) that includes 4,944 males whose waist circumferences are measured at five different time points, mostly aged 50 to 100. We generate “top-hits” polygenic scores using genetic variants associated with waist circumference from previous studies and whole-genome polygenic score using whole-genome genetic variants from GIANT consortium. By incorporating the polygenic scores, socioeconomic status (SES), and lifestyle, we found that the genetic influence on waist circumference for people who do less physical activity is higher than for those who do more physical activity.
Spring 2018
2018
Sociology
GWAS, GxE interaction, lifestyle, socioeconomic status, waist circumference
eng
Master of Arts
Thesis
University of North Carolina at Chapel Hill Graduate School
Degree granting institution
Sociology
Guang
Guo
Thesis advisor
Francois
Nielsen
Thesis advisor
Mike
Shanahan
Thesis advisor
text
Caiping
Wei
Author
Department of Sociology
College of Arts and Sciences
THE INFLUENCES OF SOCIOECONOMIC STATUS, LIFESTYLE, AND GENETIC INHERITANCE ON WAIST CIRCUMFERENCE
Waist circumference is a convenient measure of obesity, abdominal obesity and fat distribution and it is a more efficient predictor than BMI for diseases including type 2 diabetes and cardiovascular disease. In this study, we investigate the GxE interplay in influencing waist circumference among the elderly males using the data from the Health and Retirement Study (HRS) that includes 4,944 males whose waist circumferences are measured at five different time points, mostly aged 50 to 100. We generate “top-hits” polygenic scores using genetic variants associated with waist circumference from previous studies and whole-genome polygenic score using whole-genome genetic variants from GIANT consortium. By incorporating the polygenic scores, socioeconomic status (SES), and lifestyle, we found that the genetic influence on waist circumference for people who do less physical activity is higher than for those who do more physical activity.
Spring 2018
2018
Sociology
GWAS, GxE interaction, lifestyle, socioeconomic status, waist circumference
eng
Master of Arts
Thesis
Sociology
Guang
Guo
Thesis advisor
Francois
Nielsen
Thesis advisor
Michael
Shanahan
Thesis advisor
text
University of North Carolina at Chapel Hill
Degree granting institution
Caiping
Wei
Creator
Department of Sociology
College of Arts and Sciences
THE INFLUENCES OF SOCIOECONOMIC STATUS, LIFESTYLE, AND GENETIC INHERITANCE ON WAIST CIRCUMFERENCE
Waist circumference is a convenient measure of obesity, abdominal obesity and fat distribution and it is a more efficient predictor than BMI for diseases including type 2 diabetes and cardiovascular disease. In this study, we investigate the GxE interplay in influencing waist circumference among the elderly males using the data from the Health and Retirement Study (HRS) that includes 4,944 males whose waist circumferences are measured at five different time points, mostly aged 50 to 100. We generate “top-hits” polygenic scores using genetic variants associated with waist circumference from previous studies and whole-genome polygenic score using whole-genome genetic variants from GIANT consortium. By incorporating the polygenic scores, socioeconomic status (SES), and lifestyle, we found that the genetic influence on waist circumference for people who do less physical activity is higher than for those who do more physical activity.
Sociology
GWAS; GxE interaction; lifestyle; socioeconomic status; waist circumference
eng
Master of Arts
Masters Thesis
Sociology
Guang
Guo
Thesis advisor
Francois
Nielsen
Thesis advisor
Michael
Shanahan
Thesis advisor
text
University of North Carolina at Chapel Hill
Degree granting institution
2018
2018-05
Caiping
Wei
Author
Department of Sociology
College of Arts and Sciences
THE INFLUENCES OF SOCIOECONOMIC STATUS, LIFESTYLE, AND GENETIC INHERITANCE ON WAIST CIRCUMFERENCE
Waist circumference is a convenient measure of obesity, abdominal obesity and fat distribution and it is a more efficient predictor than BMI for diseases including type 2 diabetes and cardiovascular disease. In this study, we investigate the GxE interplay in influencing waist circumference among the elderly males using the data from the Health and Retirement Study (HRS) that includes 4,944 males whose waist circumferences are measured at five different time points, mostly aged 50 to 100. We generate “top-hits” polygenic scores using genetic variants associated with waist circumference from previous studies and whole-genome polygenic score using whole-genome genetic variants from GIANT consortium. By incorporating the polygenic scores, socioeconomic status (SES), and lifestyle, we found that the genetic influence on waist circumference for people who do less physical activity is higher than for those who do more physical activity.
Spring 2018
2018
Sociology
GWAS, GxE interaction, lifestyle, socioeconomic status, waist circumference
eng
Master of Arts
Thesis
University of North Carolina at Chapel Hill Graduate School
Degree granting institution
Sociology
Guang
Guo
Thesis advisor
Francois
Nielsen
Thesis advisor
Michael
Shanahan
Thesis advisor
text
Caiping
Wei
Creator
Department of Sociology
College of Arts and Sciences
THE INFLUENCES OF SOCIOECONOMIC STATUS, LIFESTYLE, AND GENETIC INHERITANCE ON WAIST CIRCUMFERENCE
Waist circumference is a convenient measure of obesity, abdominal obesity and fat distribution and it is a more efficient predictor than BMI for diseases including type 2 diabetes and cardiovascular disease. In this study, we investigate the GxE interplay in influencing waist circumference among the elderly males using the data from the Health and Retirement Study (HRS) that includes 4,944 males whose waist circumferences are measured at five different time points, mostly aged 50 to 100. We generate “top-hits” polygenic scores using genetic variants associated with waist circumference from previous studies and whole-genome polygenic score using whole-genome genetic variants from GIANT consortium. By incorporating the polygenic scores, socioeconomic status (SES), and lifestyle, we found that the genetic influence on waist circumference for people who do less physical activity is higher than for those who do more physical activity.
2018-05
2018
Sociology
GWAS; GxE interaction; lifestyle; socioeconomic status; waist circumference
eng
Master of Arts
Masters Thesis
University of North Carolina at Chapel Hill Graduate School
Degree granting institution
Guang
Guo
Thesis advisor
Francois
Nielsen
Thesis advisor
Michael
Shanahan
Thesis advisor
text
Wei_unc_0153M_17553.pdf
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2020-06-13T00:00:00
2018-04-03T17:09:14Z
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