Genetic relatedness of hepatitis A virus strains recovered from different geographical regions
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Robertson, Betty H, et al. Genetic Relatedness of Hepatitis A Virus Strains Recovered From Different Geographical Regions. 1992. https://doi.org/10.17615/wvna-kg41APA
Robertson, B., Jansen, R., Khanna, B., Totsuka, A., Nainan, O., Siegl, G., Widell, A., Margolis, H., Isomura, S., Ito, K., Ishizu, T., Moritsugu, Y., & Lemon, S. (1992). Genetic relatedness of hepatitis A virus strains recovered from different geographical regions. https://doi.org/10.17615/wvna-kg41Chicago
Robertson, Betty H., Robert W Jansen, Bhawna Khanna, Atsuko Totsuka, Omana V Nainan, Gunter Siegl, Anders Widell et al. 1992. Genetic Relatedness of Hepatitis A Virus Strains Recovered From Different Geographical Regions. https://doi.org/10.17615/wvna-kg41- Creator
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Robertson, Betty H.
- Other Affiliation: Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control (Worm Health Organization Collaborating Centre for Research and Reference in Viral Hepatitis)
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Jansen, Robert W.
- Affiliation: School of Medicine, Division of Infectious Diseases
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Khanna, Bhawna
- Other Affiliation: Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control (Worm Health Organization Collaborating Centre for Research and Reference in Viral Hepatitis)
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Totsuka, Atsuko
- Other Affiliation: National Institute of Health
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Nainan, Omana V.
- Other Affiliation: Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control (Worm Health Organization Collaborating Centre for Research and Reference in Viral Hepatitis)
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Siegl, Gunter
- Other Affiliation: Institute for Clinical Microbiology and Immunology
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Widell, Anders
- Other Affiliation: Department of Medical Microbiology, University of Lund
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Margolis, Harold S.
- Other Affiliation: Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control (Worm Health Organization Collaborating Centre for Research and Reference in Viral Hepatitis)
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Isomura, Shin
- Other Affiliation: Aichi Prefectural Institute of Public Health
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Ito, Kiichi
- Other Affiliation: Shizuoka Prefectural Institute of Public and Environmental Health
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Ishizu, Tetsuya
- Other Affiliation: Mie Prefectural Institute of Public Health
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Moritsugu, Yasuo
- Other Affiliation: National Institute of Health
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Lemon, Stanley
- Affiliation: School of Medicine, Division of Infectious Diseases
- Abstract
- A pairwise comparison of the nucleic acid sequence of 168 bases from 152 wild-type or unique cell culture-adapted strains of hepatitis A virus (HAV) revealed that HAV strains can be differentiated genetically into seven unique genotypes (I to VII). In general, the nucleotide sequence of viruses in different genotypes differs at 15 to 25% of positions within this segment of the genome. Viruses from four of the genotypes (I, II, III and VII) were recovered from cases of hepatitis A in humans, whereas viruses from the other three genotypes (IV, V and VI) were isolated only from simian species developing a hepatitis A-like illness during captivity. Among non-epidemiologically related human HAV strains, 81 were characterized as genotype I, and 19 as genotype III. Within each of these major genotypes, there were two distinct groups (sub-genotypes), which differed in sequence at approximately 7.5% of base positions. Each genotype and sub-genotype has a characteristic amino acid sequence in this region of the polyprotein, with the most divergent genotypes differing at 10 of 56 residues. Strains recovered from some geographical regions belonged to a common (endemic) genotype, whereas strains from other regions belonged to several, probably imported, genotypes. Thus, HAV strains recovered in North America were for the most part closely related at the nucleotide sequence level, whereas in other regions, such as Japan and Western Europe, HAV strains were derived from multiple genotypes or sub-genotypes. These data indicate that patterns of endemic transmission can be differentiated from situations in which infections are imported due to travel.
- Date of publication
- 1992
- DOI
- Identifier
- 2-s2.0-0026631017
- https://doi.org/10.1099/0022-1317-73-6-1365
- Related resource URL
- Resource type
- Article
- Rights statement
- In Copyright
- Journal title
- Journal of General Virology
- Journal volume
- 73
- Journal issue
- 6
- Page start
- 1365
- Page end
- 1377
- Language
- English
- Version
- Postprint
- ISSN
- 0022-1317
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