TNF- and cancer therapy-induced apoptosis: Potentiation by inhibition of NF-κB

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  • Wang, Cun-Yu
    • Affiliation: School of Medicine, Curriculum in Genetics and Molecular Biology
  • Mayo, Marty W.
  • Baldwin, Albert
    • Affiliation: N.C. Cancer Hospital, UNC Lineberger Comprehensive Cancer Center
Abstract
  • Many cells are resistant to stimuli that can induce apoptosis, but the mechanisms involved are not fully understood. The activation of the transcription factor nuclear factor-kappa B (NF-kappaB) by tumor necrosis factor (TNF), ionizing radiation, or daunorubicin (a cancer chemotherapeutic compound), was found to protect from cell killing. Inhibition of NF-kappaB nuclear translocation enhanced apoptotic killing by these reagents but not by apoptotic stimuli that do not activate NF-kappaB. These results provide a mechanism of cellular resistance to killing by some apoptotic reagents, offer insight into a new role for NF-kappaB, and have potential for improvement of the efficacy of cancer therapies.
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  • Article
Rights statement
  • In Copyright
Journal title
  • Science
Journal volume
  • 274
Journal issue
  • 5288
Page start
  • 784
Page end
  • 787
Language
  • English
Version
  • Postprint
ISSN
  • 0036-8075

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