Longitudinal age-dependent effect on systolic blood pressure

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  • Joubert, Bonnie R
    • Affiliation: Gillings School of Global Public Health, Department of Epidemiology
  • Diao, Guoqing
    • Other Affiliation: Department of Statistics, George Mason University, 4400 University Drive, Fairfax, Virginia 22030, USA
  • Lin, Danyu
    • Affiliation: Gillings School of Global Public Health, Department of Biostatistics
  • North, Kari
    • Affiliation: Gillings School of Global Public Health, Department of Epidemiology
  • Franceschini, Nora
    • Affiliation: Gillings School of Global Public Health, Department of Epidemiology
Abstract
  • Abstract Age-dependent genetic effects on susceptibility to hypertension have been documented. We present a novel variance-component method for the estimation of age-dependent genetic effects on longitudinal systolic blood pressure using 57,827 Affymetrix single-nucleotide polymorphisms (SNPs) on chromosomes 17-22 genotyped in 2,475 members of the Offspring Cohort of the Framingham Heart Study. We used the likelihood-ratio test statistic to test the main genetic effect, genotype-by-age interaction, and simultaneously, main genetic effect and genotype-by-age interactions (2 degrees of freedom (df) test) for each SNP. Applying Bonferroni correction, three SNPs were significantly associated with longitudinal blood pressure in the analysis of main genetic effects or in combined 2-df analyses. For the associations detected using the simultaneous 2-df test, neither main effects nor genotype-by-age interaction p-values reached genome-wide statistical significance. The value of the 2-df test for screening genetic interaction effects could not be established in this study.
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  • Article
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  • In Copyright
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  • Bonnie R Joubert et al.; licensee BioMed Central Ltd.
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  • English
Is the article or chapter peer-reviewed?
  • Yes
Bibliographic citation
  • BMC Proceedings. 2009 Dec 15;3(Suppl 7):S87
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  • BioMed Central Ltd
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  • Open Access
Date uploaded
  • February 19, 2016

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