Investigation of the Methylation Status of FGF2 gene in Periodontal Tissues as Determinants of Healing Response after Implant Surgery

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  • March 20, 2019
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  • Whitley, Travis
    • Affiliation: School of Dentistry, Department of Periodontology
Abstract
  • Periodontal wound healing is a complex process involving a series of interactions of growth factors, including FGF-2. Previous studies have suggested that the FGF2 gene may be down-regulated in diseased periodontal tissues. Aberrant gene expression in smokers and diabetics has also been reported. The aims of this study were to determine the association of FGF2 methylation level with wound healing after implant surgery and the association of smoking and diabetes with FGF2 methylation. Thirty-four included subjects were distributed into control, smoking and diabetic groups. During the implant surgery, gingival tissue biopsies were collected for real-time PCR analysis. This study demonstrated that FGF-2 hyper-methylation and associated gene down-regulation were associated with smoking status and diabetes.
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  • In Copyright
Advisor
  • Morelli, Thiago
  • Reside, Jonathan
  • Barros, Silvana
Degree
  • Master of Science
Degree granting institution
  • University of North Carolina at Chapel Hill Graduate School
Graduation year
  • 2016
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