Evaluation of population impact of candidate polymorphisms for coronary heart disease in the Framingham Heart Study Offspring Cohort
Public Deposited- Creator
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Yan, Yu
- Affiliation: Gillings School of Global Public Health, Department of Epidemiology
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Hu, Yijuan
- Affiliation: Gillings School of Global Public Health, Department of Biostatistics
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North, Kari
- Affiliation: Gillings School of Global Public Health, Department of Epidemiology
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Franceschini, Nora
- Affiliation: Gillings School of Global Public Health, Department of Epidemiology
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Lin, Danyu
- Affiliation: Gillings School of Global Public Health, Department of Biostatistics
- Abstract
- In order to evaluate the population impact of putative causal genetic variants over the life course of disease, we extended the static estimation of population-attributable risk fraction and developed a novel tool to evaluate how the population impact changes over time using the Framingham Heart Study Offspring Cohort data provided to the Genetic Analysis Workshop 16, Problem 2. A set of population-attributable risk fractions based on survival functions were estimated under the proportional hazards models. The development of this novel measure of population impact creates a more comprehensive estimate of population impact over the life course of disease, which may help us to better understand genetic susceptibility at the population level.
- Date of publication
- December 15, 2009
- DOI
- Identifier
- Resource type
- Article
- Rights statement
- In Copyright
- Rights holder
- Yu Yan et al.; licensee BioMed Central Ltd.
- License
- Journal title
- BMC Proceedings
- Journal volume
- 3
- Journal issue
- Suppl 7
- Page start
- S118
- Language
- English
- Is the article or chapter peer-reviewed?
- Yes
- Bibliographic citation
- BMC Proceedings. 2009 Dec 15;3(Suppl 7):S118
- Publisher
- BioMed Central Ltd
- Access right
- Open Access
- Date uploaded
- February 19, 2016
Relations
- Parents:
This work has no parents.
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