Associations Between Biochemical Markers of Cartilage Metabolism and Gait Biomechanics in Healthy Participants

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  • March 20, 2019
Creator
  • Davis, Hope
    • Affiliation: College of Arts and Sciences, Department of Exercise and Sport Science
Abstract
  • Introduction: Mechanical loading is associated with cartilage breakdown in people with knee osteoarthritis (KOA); it is unknown if this association exists in healthy young individuals. Purpose: Determine associations between biomarkers of collagen turnover (synthesis:breakdown) and peak vertical ground reaction force (vGRF) in healthy young individuals. Methods: Resting serum samples and walking gait kinetics were collected from 24 healthy, young individuals. Type II collagen synthesis (Collagen type II C- propeptide; CPII) and breakdown (Collagen type II cleavage product; C2C) were examined via enzyme-linked immunosorbent assays (ELISA). Gait kinetics were assessed during walking trials. Pearson product (r) moment correlations were used to determine associations between transformed (base-10 log scale) collagen turnover and peak vGRF. Results: 24 subjects (age=20±2 years, BMI=23.4±3.0) completed this study. There was a moderate association between CPII:C2C ratios and peak vGRF approaching significance (r= 0.363, p=0.081). Discussion: Higher loading in gait may increase collagen synthesis-to-degradation ratio in healthy young subjects.
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  • In Copyright
Advisor
  • Harkey, Matthew
  • Hackney, Anthony
  • Pietrosimone, Brian
Degree
  • Master of Arts
Degree granting institution
  • University of North Carolina at Chapel Hill Graduate School
Graduation year
  • 2016
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