Integrated Genomic Analysis Identifies Clinically Relevant Subtypes of Glioblastoma Characterized by Abnormalities in PDGFRA, IDH1, EGFR, and NF1
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Verhaak, Roel G.W, et al. Integrated Genomic Analysis Identifies Clinically Relevant Subtypes of Glioblastoma Characterized by Abnormalities In Pdgfra, Idh1, Egfr, and Nf1. 2010. https://doi.org/10.17615/7tss-5e39APA
Verhaak, R., Hoadley, K., Purdom, E., Wang, V., Qi, Y., Wilkerson, M., Miller, C., Ding, L., Golub, T., Mesirov, J., Alexe, G., Lawrence, M., O'kelly, M., Tamayo, P., Weir, B., Gabriel, S., Winckler, W., Gupta, S., Jakkula, L., Feiler, H., Hodgson, J., James, C., Sarkaria, J., Brennan, C., Kahn, A., Spellman, P., Wilson, R., Speed, T., Gray, J., Meyerson, M., Getz, G., Perou, C., & Hayes, N. (2010). Integrated Genomic Analysis Identifies Clinically Relevant Subtypes of Glioblastoma Characterized by Abnormalities in PDGFRA, IDH1, EGFR, and NF1. https://doi.org/10.17615/7tss-5e39Chicago
Verhaak, Roel G.W., Katherine Hoadley, Elizabeth Purdom, Victoria Wang, Yuan Qi, Matthew D Wilkerson, C. Ryan Miller et al. 2010. Integrated Genomic Analysis Identifies Clinically Relevant Subtypes of Glioblastoma Characterized by Abnormalities In Pdgfra, Idh1, Egfr, and Nf1. https://doi.org/10.17615/7tss-5e39- Creator
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Verhaak, Roel G.W.
- Other Affiliation: The Eli and Edythe L. Broad Institute of Massachusetts Institute of Technology and Harvard University
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Hoadley, Katherine
- Affiliation: N.C. Cancer Hospital, UNC Lineberger Comprehensive Cancer Center
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Purdom, Elizabeth
- Other Affiliation: Department of Statistics, University of California, Berkeley
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Wang, Victoria
- Other Affiliation: Group in Biostatistics, University of California, Berkeley
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Qi, Yuan
- Affiliation: N.C. Cancer Hospital, UNC Lineberger Comprehensive Cancer Center
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Wilkerson, Matthew D
- Affiliation: N.C. Cancer Hospital, UNC Lineberger Comprehensive Cancer Center
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Miller, C. Ryan
- Affiliation: N.C. Cancer Hospital, UNC Lineberger Comprehensive Cancer Center
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Ding, Li
- Other Affiliation: The Genome Center at Washington University, Department of Genetics, Washington University School of Medicine
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Golub, Todd
- Other Affiliation: The Eli and Edythe L. Broad Institute of Massachusetts Institute of Technology and Harvard University
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Mesirov, Jill P.
- Other Affiliation: The Eli and Edythe L. Broad Institute of Massachusetts Institute of Technology and Harvard University
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Alexe, Gabriele
- Other Affiliation: The Eli and Edythe L. Broad Institute of Massachusetts Institute of Technology and Harvard University
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Lawrence, Michael
- Other Affiliation: The Eli and Edythe L. Broad Institute of Massachusetts Institute of Technology and Harvard University
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O'Kelly, Michael
- Other Affiliation: The Eli and Edythe L. Broad Institute of Massachusetts Institute of Technology and Harvard University
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Tamayo, Pablo
- Other Affiliation: The Eli and Edythe L. Broad Institute of Massachusetts Institute of Technology and Harvard University
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Weir, Barbara A.
- Other Affiliation: The Eli and Edythe L. Broad Institute of Massachusetts Institute of Technology and Harvard University
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Gabriel, Stacey
- Other Affiliation: The Eli and Edythe L. Broad Institute of Massachusetts Institute of Technology and Harvard University
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Winckler, Wendy
- Other Affiliation: The Eli and Edythe L. Broad Institute of Massachusetts Institute of Technology and Harvard University
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Gupta, Supriya
- Other Affiliation: The Eli and Edythe L. Broad Institute of Massachusetts Institute of Technology and Harvard University
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Jakkula, Lakshmi
- Other Affiliation: Life Sciences Division, Lawrence Berkeley National Laboratory
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Feiler, Heidi S.
- Other Affiliation: Life Sciences Division, Lawrence Berkeley National Laboratory
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Hodgson, J. Graeme
- Other Affiliation: Department of Neurological Surgery, University of California, San Francisco
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James, C. David
- Other Affiliation: Department of Neurological Surgery, University of California, San Francisco
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Sarkaria, Jann N.
- Other Affiliation: Department of Radiation Oncology, Mayo Clinic
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Brennan, Cameron
- Other Affiliation: Department of Neurosurgery, Memorial Sloan-Kettering Cancer Center
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Kahn, Ari
- Other Affiliation: SRA International
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Spellman, Paul T.
- Other Affiliation: Life Sciences Division, Lawrence Berkeley National Laboratory
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Wilson, Richard K.
- Other Affiliation: The Genome Center at Washington University, Department of Genetics, Washington University School of Medicine
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Speed, Terence P.
- Other Affiliation: Department of Statistics, University of California, Berkeley
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Gray, Joe W.
- Other Affiliation: Life Sciences Division, Lawrence Berkeley National Laboratory
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Meyerson, Matthew
- Other Affiliation: The Eli and Edythe L. Broad Institute of Massachusetts Institute of Technology and Harvard University
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Getz, Gad
- Other Affiliation: The Eli and Edythe L. Broad Institute of Massachusetts Institute of Technology and Harvard University
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Perou, Charles
- ORCID: https://orcid.org/0000-0001-9827-2247
- Affiliation: N.C. Cancer Hospital, UNC Lineberger Comprehensive Cancer Center
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Hayes, Neil
- Affiliation: N.C. Cancer Hospital, UNC Lineberger Comprehensive Cancer Center
- Abstract
- The Cancer Genome Atlas Network recently cataloged recurrent genomic abnormalities in glioblastoma multiforme (GBM). We describe a robust gene expression-based molecular classification of GBM into Proneural, Neural, Classical, and Mesenchymal subtypes and integrate multidimensional genomic data to establish patterns of somatic mutations and DNA copy number. Aberrations and gene expression of EGFR, NF1, and PDGFRA/IDH1 each define the Classical, Mesenchymal, and Proneural subtypes, respectively. Gene signatures of normal brain cell types show a strong relationship between subtypes and different neural lineages. Additionally, response to aggressive therapy differs by subtype, with the greatest benefit in the Classical subtype and no benefit in the Proneural subtype. We provide a framework that unifies transcriptomic and genomic dimensions for GBM molecular stratification with important implications for future studies.
- Date of publication
- 2010
- DOI
- Identifier
- 2-s2.0-73649123907
- https://doi.org/10.1016/j.ccr.2009.12.020
- Related resource URL
- Resource type
- Article
- Rights statement
- In Copyright
- Journal title
- Cancer Cell
- Journal volume
- 17
- Journal issue
- 1
- Page start
- 98
- Page end
- 110
- Language
- English
- Version
- Postprint
- ISSN
- 1535-6108
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- Parents:
This work has no parents.
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