Periapical Microsurgery: The Effects of Locally Injected Dexamethasone on Post-operative Healing

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  • March 19, 2019
Creator
  • Kan, Elena
    • Affiliation: School of Dentistry, Department of Endodontics
Abstract
  • Substantial inflammation, bruising and pain have been an inevitable consequence of oral surgery. Objectives: To study a protocol to reduce these complications after periapical microsurgery. Hypothesis is that a single local submucosal injection of 4.0mg of dexamethasone at the time of periapical microsurgery can reduce the postoperative complications. Materials and Methods: Sixty patients received injections of either dexamethasone or a placebo solution at the conclusion of a standardized periapical microsurgery within a double-blind randomized controlled clinical trial. A self-administered survey provided data for analytical comparison. Data was analyzed at a significance level of 95% using Chi square and the Fisher Exact tests. Results: Subjects who received the dexamethasone injection reported less swelling 24 hours post-periapical microsurgery compared to the placebo at a statistical significant level of greater than 98%. Conclusion: A dexamethasone injection minimizes post-operative swelling 24 hours following periapical microsurgery.
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  • In Copyright
Advisor
  • Reside, Jonathan
  • Khan, Asma
  • Tawil, Peter
Degree
  • Master of Science
Degree granting institution
  • University of North Carolina at Chapel Hill Graduate School
Graduation year
  • 2015
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  • Chapel Hill, NC
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  • There are no restrictions to this item.
Date uploaded
  • June 23, 2015

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