Systemic LPS causes chronic neuroinflammation and progressive neurodegeneration
Public DepositedAdd to collection
You do not have access to any existing collections. You may create a new collection.
Downloadable Content
Download PDFCitation
MLA
Qin, Liya, et al. Systemic Lps Causes Chronic Neuroinflammation and Progressive Neurodegeneration. 2007. https://doi.org/10.17615/nrrm-df47APA
Qin, L., Wu, X., Block, M., Liu, Y., Breese, G., Hong, J., Knapp, D., & Crews, F. (2007). Systemic LPS causes chronic neuroinflammation and progressive neurodegeneration. https://doi.org/10.17615/nrrm-df47Chicago
Qin, Liya, Xuefei Wu, Michelle L Block, Yuxin Liu, George R Breese, Jau Shyong Hong, Darin Knapp et al. 2007. Systemic Lps Causes Chronic Neuroinflammation and Progressive Neurodegeneration. https://doi.org/10.17615/nrrm-df47- Creator
-
Qin, Liya
- Affiliation: School of Medicine, Bowles Center for Alcohol Studies
-
Wu, Xuefei
- Other Affiliation: Department of Physiology, Dalian Medical University, Dalian, China
-
Block, Michelle L.
- Other Affiliation: Neuropharmacology Section, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina
-
Liu, Yuxin
- Affiliation: School of Medicine, Bowles Center for Alcohol Studies
- Other Affiliation: North Carolina Neuropharmacology Section, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina
-
Breese, George R.
- Affiliation: School of Medicine, Department of Psychiatry, Bowles Center for Alcohol Studies
-
Hong, Jau-Shyong
- Other Affiliation: Neuropharmacology Section, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina
-
Knapp, Darin
- Affiliation: School of Medicine, Department of Psychiatry, Bowles Center for Alcohol Studies
-
Crews, Fulton
- Affiliation: School of Medicine, Department of Psychiatry, Bowles Center for Alcohol Studies
- Abstract
- Inflammation is implicated in the progressive nature of neurodegenerative diseases, such as Parkinson's disease, but the mechanisms are poorly understood. A single systemic lipopolysaccharide (LPS, 5 mg/kg, i.p.) or tumor necrosis factor alpha (TNFα, 0.25 mg/kg, i.p.) injection was administered in adult wild‐type mice and in mice lacking TNFα receptors (TNF R1/R2−/−) to discern the mechanisms of inflammation transfer from the periphery to the brain and the neurodegenerative consequences. Systemic LPS administration resulted in rapid brain TNFα increase that remained elevated for 10 months, while peripheral TNFα (serum and liver) had subsided by 9 h (serum) and 1 week (liver). Systemic TNFα and LPS administration activated microglia and increased expression of brain pro‐inflammatory factors (i.e., TNFα, MCP‐1, IL‐1β, and NF‐κB p65) in wild‐type mice, but not in TNF R1/R2−/− mice. Further, LPS reduced the number of tyrosine hydroxylase‐immunoreactive neurons in the substantia nigra (SN) by 23% at 7‐months post‐treatment, which progressed to 47% at 10 months. Together, these data demonstrate that through TNFα, peripheral inflammation in adult animals can: (1) activate brain microglia to produce chronically elevated pro‐inflammatory factors; (2) induce delayed and progressive loss of DA neurons in the SN. These findings provide valuable insight into the potential pathogenesis and self‐propelling nature of Parkinson's disease.
- Date of publication
- 2007
- Keyword
- DOI
- Identifier
- https://doi.org/10.1002/glia.20467
- 2-s2.0-33847759064
- Related resource URL
- Resource type
- Article
- Rights statement
- In Copyright
- Journal title
- GLIA
- Journal volume
- 55
- Journal issue
- 5
- Page start
- 453
- Page end
- 462
- Language
- English
- Version
- Postprint
- ISSN
- 1098-1136
Relations
- Parents:
This work has no parents.
Items
Thumbnail | Title | Date Uploaded | Visibility | Actions |
---|---|---|---|---|
Systemic LPS causes chronic neuroinflammation.pdf | 2019-05-03 | Public | Download |