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Tribbles homolog 3 denotes a poor prognosis in breast cancer and is involved in hypoxia response

Creator: Wennemers, Marloes, Bussink, Johan, Scheijen, Blanca, Nagtegaal, Iris D, van Laarhoven, Hanneke WM, Raleigh, James A, Varia, Mahesh A, Heuvel, Joop JTM, Rouschop, Kasper M, Sweep, Fred CGJ, Span, Paul N

Abstract Introduction Hypoxia in solid tumors is associated with treatment resistance, resulting in poor prognosis. Tribbles homolog 3 (TRIB3) is induced during hypoxia and is involved in multiple cellular pathways involved in cell survival. Here, we (more)

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13058_2011_article_2734.pdf

Collection: BioMed Central

Date Deposited: 2017-01-20

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Figure 1 TRIB3 expression is associated with poor prognosis in breast cancer

Collection: BioMed Central

Date Deposited: 2017-01-20

Date Created: 2017-01-20

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Figure 2 TRIB3 is induced by cell stress and is expressed in hypoxic areas

Collection: BioMed Central

Date Deposited: 2017-01-20

Date Created: 2017-01-20

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Figure 3 TRIB3 colocalizes with pimonidazole in human breast cancer tissue

Collection: BioMed Central

Date Deposited: 2017-01-20

Date Created: 2017-01-20

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Figure 5 Knockdown of TRIB3 results in lower cell survival under hypoxic conditions

Collection: BioMed Central

Date Deposited: 2017-01-20

Date Created: 2017-01-20

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