A prospective cohort study of biomarkers of prenatal tobacco smoke exposure: the correlation between serum and meconium and their association with infant birth weight
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Braun, Joe M, et al. A Prospective Cohort Study of Biomarkers of Prenatal Tobacco Smoke Exposure: the Correlation Between Serum and Meconium and Their Association with Infant Birth Weight. BioMed Central Ltd, 2010. https://doi.org/10.17615/zrv2-7217APA
Braun, J., Daniels, J., Poole, C., Olshan, A., Hornung, R., Bernert, J., Xia, Y., Bearer, C., Barr, D., & Lanphear, B. (2010). A prospective cohort study of biomarkers of prenatal tobacco smoke exposure: the correlation between serum and meconium and their association with infant birth weight. BioMed Central Ltd. https://doi.org/10.17615/zrv2-7217Chicago
Braun, Joe M., Julie Daniels, Charles Poole, Andrew Olshan, Richard Hornung, John T Bernert, Yang Xia et al. 2010. A Prospective Cohort Study of Biomarkers of Prenatal Tobacco Smoke Exposure: the Correlation Between Serum and Meconium and Their Association with Infant Birth Weight. BioMed Central Ltd. https://doi.org/10.17615/zrv2-7217- Creator
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Braun, Joe M.
- Affiliation: Gillings School of Global Public Health, Department of Epidemiology
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Daniels, Julie
- Affiliation: Gillings School of Global Public Health, Department of Epidemiology
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Poole, Charles
- Affiliation: Gillings School of Global Public Health, Department of Epidemiology
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Olshan, Andrew
- Affiliation: Gillings School of Global Public Health, Department of Epidemiology
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Hornung, Richard
- Other Affiliation: Department of Pediatrics, Division of General and Community Pediatrics, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH 45229, USA
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Bernert, John T.
- Other Affiliation: Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA 30341, USA
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Xia, Yang
- Other Affiliation: Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA 30341, USA
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Bearer, Cynthia
- Other Affiliation: Department of Pediatrics, University of Maryland School of Medicine, Baltimore, MD 21201, USA
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Barr, Dana
- Other Affiliation: Rollins School of Public Health, Emory University, Atlanta, GA 30322, USA
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Lanphear, Bruce P.
- Other Affiliation: Department of Pediatrics, Division of General and Community Pediatrics, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH 45229, USA; Child & Family Research Institute, British Columbia Children’s Hospital and the Faculty of Health Sciences, Simon Fraser University, Vancouver, British Columbia, CA
- Abstract
- Abstract Background The evaluation of infant meconium as a cumulative matrix of prenatal toxicant exposure requires comparison to established biomarkers of prenatal exposure. Methods We calculated the frequency of detection and concentration of tobacco smoke metabolites measured in meconium (nicotine, cotinine, and trans-3'-hydroxycotinine concentrations) and three serial serum cotinine concentrations taken during the latter two-thirds of pregnancy among 337 mother-infant dyads. We estimated the duration and intensity of prenatal tobacco smoke exposure using serial serum cotinine concentrations and calculated geometric mean meconium tobacco smoke metabolite concentrations according to prenatal exposure. We also compared the estimated associations between these prenatal biomarkers and infant birth weight using linear regression. Results We detected nicotine (80%), cotinine (69%), and trans-3'-hydroxycotinine (57%) in most meconium samples. Meconium tobacco smoke metabolite concentrations were positively associated with serum cotinine concentrations and increased with the number of serum cotinine measurements consistent with secondhand or active tobacco smoke exposure. Like serum cotinine, meconium tobacco smoke metabolites were inversely associated with birth weight. Conclusions Meconium is a useful biological matrix for measuring prenatal tobacco smoke exposure and could be used in epidemiological studies that enroll women and infants at birth. Meconium holds promise as a biological matrix for measuring the intensity and duration of environmental toxicant exposure and future studies should validate the utility of meconium using other environmental toxicants.
- Date of publication
- August 27, 2010
- DOI
- Identifier
- Resource type
- Article
- Rights statement
- In Copyright
- Rights holder
- Joe M Braun et al.; licensee BioMed Central Ltd.
- License
- Journal title
- Environmental Health
- Journal volume
- 9
- Journal issue
- 1
- Page start
- 53
- Language
- English
- Is the article or chapter peer-reviewed?
- Yes
- ISSN
- 1476-069X
- Bibliographic citation
- Environmental Health. 2010 Aug 27;9(1):53
- Publisher
- BioMed Central Ltd
- Access right
- Open Access
- Date uploaded
- August 23, 2012
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