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Molecular analysis reveals heterogeneity of mouse mammary tumors conditionally mutant for Brca1

Creator: Wright, Mollie H, Robles, Ana I, Herschkowitz, Jason I, Hollingshead, Melinda G, Anver, Miriam R, Perou, Charles M, Varticovski, Lyuba

Abstract Background Development of therapies for patients with BRCA1 mutations has been hampered by lack of readily available in vitro and in vivo models. We recently showed that transplantation of transgenic mammary tumors as cell suspensions into (more)

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1476-4598-7-29.pdf

Collection: BioMed Central

Date Deposited: 2012-09-06

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Additional file 1: Overall similarity of MMTV-driven tumor models

Collection: BioMed Central

Date Deposited: 2012-09-06

Date Created: 2012-09-06

ppt  (26.5 KB)

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Additional file 2: Heterogeneity of Brca1 tumors

Collection: BioMed Central

Date Deposited: 2012-09-06

Date Created: 2012-09-06

ppt  (1.4 MB)

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Additional file 5: Unsupervised Hierarchical Cluster

Collection: BioMed Central

Date Deposited: 2012-09-06

Date Created: 2012-09-06

ppt  (1 MB)

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Additional file 6: Genotyping of Brca1 cell lines by PCR

Collection: BioMed Central

Date Deposited: 2012-09-06

Date Created: 2012-09-06

ppt  (86 KB)

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Additional file 7: Characterization of Brca1 cell lines by Western blot

Collection: BioMed Central

Date Deposited: 2012-09-06

Date Created: 2012-09-06

ppt  (49.5 KB)

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Additional file 8: Characterization of Brca1 cell lines by flow cytometry

Collection: BioMed Central

Date Deposited: 2012-09-06

Date Created: 2012-09-06

ppt  (54.5 KB)