A cohort study of in utero polychlorinated biphenyl (PCB) exposures in relation to secondary sex ratio
Public DepositedAdd to collection
You do not have access to any existing collections. You may create a new collection.
Downloadable Content
Download PDFCitation
MLA
Hertz Picciotto, Irva, et al. A Cohort Study of In Utero Polychlorinated Biphenyl (pcb) Exposures In Relation to Secondary Sex Ratio. BioMed Central Ltd, 2008. https://doi.org/10.17615/yxj9-c834APA
Hertz Picciotto, I., Jusko, T., Willman, E., Baker, R., Keller, J., Teplin, S., & Charles, M. (2008). A cohort study of in utero polychlorinated biphenyl (PCB) exposures in relation to secondary sex ratio. BioMed Central Ltd. https://doi.org/10.17615/yxj9-c834Chicago
Hertz Picciotto, Irva, Todd A Jusko, Eric J Willman, Rebecca J Baker, Jean A Keller, Stuart W Teplin, and M Judith Charles. 2008. A Cohort Study of In Utero Polychlorinated Biphenyl (pcb) Exposures In Relation to Secondary Sex Ratio. BioMed Central Ltd. https://doi.org/10.17615/yxj9-c834- Creator
-
Hertz-Picciotto, Irva
- Other Affiliation: Department of Public Health Sciences, School of Medicine, TB #168, University of California-Davis, Davis, CA, 95616, USA
-
Jusko, Todd A.
- Other Affiliation: Department of Epidemiology, School of Public Health and Community Medicine, University of Washington, Box 357236, Seattle, WA, 98195, USA
-
Willman, Eric J.
- Other Affiliation: Department of Environmental Toxicology, University of California-Davis, Davis, CA, 95616, USA; Ecolab, Eagen, MN, 55121, USA
-
Baker, Rebecca J.
- Affiliation: Gillings School of Global Public Health, Department of Epidemiology
-
Keller, Jean A.
- Affiliation: Gillings School of Global Public Health, Department of Epidemiology
- Other Affiliation: Quintiles, Inc, 5927 South Miami Blvd, Morrisville, NC, 27560, USA
-
Teplin, Stuart W.
- Affiliation: School of Medicine, Department of Pediatrics
- Other Affiliation: Clinical Center for the Study of Development and Learning
-
Charles, M Judith
- Other Affiliation: Department of Environmental Toxicology, University of California-Davis, Davis, CA, 95616, USA
- Abstract
- Abstract: Background: Polychlorinated biphenyls (PCBs) are ubiquitous industrial chemicals that persist in the environment and in human fatty tissue. PCBs are related to a class of compounds known as dioxins, specifically 2,3,7,8-TCDD (tetrachloro-dibenzodioxin), which has been implicated as a cause of altered sex ratio, especially in relation to paternal exposures. Methods: In the 1960's, serum specimens were collected from pregnant women participating in the Child Health and Development Study in the San Francisco Bay Area. The women were interviewed and their serum samples stored at -20°C. For this study, samples were thawed and a total of eleven PCBs were determined in 399 specimens. Secondary sex ratio, or sex ratio at birth, was evaluated as a function of maternal serum concentrations using log-binomial and logistic regression, controlling for hormonally active medications taken during pregnancy. Results: The relative risk of a male birth decreased by 33% comparing women at the 90th percentile of total PCBs with women at the 10th percentile (RR = 0.67; 95% CI, 0.48–0.94; p = 0.02), or by approximately 7% for each 1 μg/L increase in total PCB concentration. Although some congener-specific associations with sex ratio were only marginally statistically significant, all nine PCB congeners with < 30% of samples below the LOQ showed the same direction of association, an improbable finding under the null hypothesis. Conclusion: Maternal exposure to PCBs may be detrimental to the success of male sperm or to the survival of male embryos. Findings could be due to contaminants, metabolites or PCBs themselves.
- Date of publication
- July 15, 2008
- DOI
- Identifier
- Resource type
- Article
- Rights statement
- In Copyright
- Rights holder
- Irva Hertz-Picciotto et al.; licensee BioMed Central Ltd.
- License
- Journal title
- Environmental Health
- Journal volume
- 7
- Journal issue
- 1
- Page start
- 37
- Language
- English
- Is the article or chapter peer-reviewed?
- Yes
- ISSN
- 1476-069X
- Bibliographic citation
- Environmental Health. 2008 Jul 15;7(1):37
- Publisher
- BioMed Central Ltd
- Access right
- Open Access
- Date uploaded
- August 24, 2012
Relations
- Parents:
This work has no parents.
Items
Thumbnail | Title | Date Uploaded | Visibility | Actions |
---|---|---|---|---|
1476-069X-7-37.pdf | 2019-05-07 | Public | Download | |
1476-069X-7-37.xml | 2019-05-07 | Public | Download |