Shape (but not volume) changes in the thalami in Parkinson disease

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  • McKeown, Martin J
    • Other Affiliation: Pacific Parkinson's Research Center, Brain Research Centre, Department of Medicine (Neurology), Biomedical Signal and Image Computing Lab, Department of Electrical and Computer Engineering, University of British Columbia, Vancouver, Canada
  • Uthama, Ashish
    • Other Affiliation: Biomedical Signal and Image Computing Lab, Department of Electrical and Computer Engineering, University of British Columbia, Vancouver, Canada
  • Abugharbieh, Rafeef
    • Other Affiliation: Brain Research Centre, Biomedical Signal and Image Computing Lab, Department of Electrical and Computer Engineering, University of British Columbia, Vancouver, Canada
  • Palmer, Samantha
    • Other Affiliation: Pacific Parkinson's Research Center, University of British Columbia, Vancouver, Canada
  • Lewis, Mechelle
    • Affiliation: School of Medicine, Department of Neurology
  • Huang, Xuemei
    • Affiliation: School of Medicine, Department of Neurology
Abstract
  • Abstract Background Recent pathological studies have suggested that thalamic degeneration may represent a site of non-dopaminergic degeneration in Parkinson's Disease (PD). Our objective was to determine if changes in the thalami could be non-invasively detected in structural MRI images obtained from subjects with Parkinson disease (PD), compared to age-matched controls. Results No significant differences in volume were detected in the thalami between eighteen normal subjects and eighteen PD subjects groups. However significant (p < 0.03) shape differences were detected between the Left vs. Right thalami in PD, between the left thalami in PD and controls, and between the right thalami in PD and controls using a recently-developed, spherical harmonic-based representation. Conclusion Systematic changes in thalamic shape can be non-invasively assessed in PD in vivo. Shape changes, in addition to volume changes, may represent a new avenue to assess the progress of neurodegenerative processes. Although not directly discernable at the resolution of standard MRI, previous pathological studies would suggest that the shape changes detected in this study represent degeneration in the centre median-parafascicular (CM-Pf) complex, an area known to represent selective non-dopaminergic degeneration in PD.
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  • Article
Rights statement
  • In Copyright
Rights holder
  • Martin J McKeown et al.; licensee BioMed Central Ltd.
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Journal title
  • BMC Neurology
Journal volume
  • 8
Journal issue
  • 1
Page start
  • 8
Language
  • English
Is the article or chapter peer-reviewed?
  • Yes
ISSN
  • 1471-2377
Bibliographic citation
  • BMC Neurology. 2008 Apr 16;8(1):8
Publisher
  • BioMed Central Ltd
Access right
  • Open Access
Date uploaded
  • July 15, 2016

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