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An RNAi screen of Rho signalling networks identifies RhoH as a regulator of Rac1 in prostate cancer cell migration

Creator: Tajadura-Ortega, Virginia, Garg, Ritu, Allen, Richard, Owczarek, Claudia, Bright, Michael D, Kean, Samuel, Mohd-Noor, Aisyah, Grigoriadis, Anita, Elston, Timothy, Hahn, Klaus, Ridley, Anne J

Abstract Background Cell migration is essential for development and tissue repair, but it also contributes to disease. Rho GTPases regulate cell migration, but a comprehensive analysis of how each Rho signalling component affects migration has not (more)

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pdf

12915_2018_article_489.pdf

Collection: BioMed Central

Date Deposited: 2018-03-10

Date Created: 2018-03-10

pdf  (3.7 MB)

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Additional file 1: Table S1. List of gene targets in siRNA library

Collection: BioMed Central

Date Deposited: 2018-03-10

Date Created: 2018-03-10

xlsx  (49.7 KB)

avi

Additional file 2: Movie S1. Random migration of PC3 cells transfected with siControl

Collection: BioMed Central

Date Deposited: 2018-03-10

Date Created: 2018-03-10

avi  (1 MB)

avi

Additional file 3: Movie S2. Random migration of PC3 cells transfected with siRhoH-1

Collection: BioMed Central

Date Deposited: 2018-03-10

Date Created: 2018-03-10

avi  (610.8 KB)

avi

Additional file 4: Movie S3. Random migration of PC3 cells transfected with siRhoH-2

Collection: BioMed Central

Date Deposited: 2018-03-10

Date Created: 2018-03-10

avi  (585.5 KB)

mp4

Additional file 5: Movie S4. Rac1 biosensor in PC3 cells transfected with siControl

Collection: BioMed Central

Date Deposited: 2018-03-10

Date Created: 2018-03-10

mp4  (4.7 MB)

mp4

Additional file 6: Movie S5. Rac1 biosensor in PC3 cells transfected with siRhoH-1

Collection: BioMed Central

Date Deposited: 2018-03-10

Date Created: 2018-03-10

mp4  (6.5 MB)

mp4

Additional file 7: Movie S6. Rac1 biosensor in PC3 cells transfected with siRhoH-2

Collection: BioMed Central

Date Deposited: 2018-03-10

Date Created: 2018-03-10

mp4  (6.4 MB)