Anemia in people on second line antiretroviral treatment in Lilongwe, Malawi: a cross-sectional study
Public DepositedAdd to collection
You do not have access to any existing collections. You may create a new collection.
Downloadable Content
Download PDFCitation
MLA
Ngongondo, Mc Neil, et al. Anemia In People On Second Line Antiretroviral Treatment In Lilongwe, Malawi: a Cross-sectional Study. BioMed Central, 2018. https://doi.org/10.17615/h0ed-bh71APA
Ngongondo, M., Rosenberg, N., Stanley, C., Lim, R., Ongubo, D., Broadhurst, R., Speight, C., Flick, R., Tembo, P., & Hosseinipour, M. (2018). Anemia in people on second line antiretroviral treatment in Lilongwe, Malawi: a cross-sectional study. BioMed Central. https://doi.org/10.17615/h0ed-bh71Chicago
Ngongondo, Mc Neil, Nora E Rosenberg, Christopher C Stanley, Robertino Lim, Dennis Ongubo, Richard Broadhurst, Colin Speight et al. 2018. Anemia In People On Second Line Antiretroviral Treatment In Lilongwe, Malawi: a Cross-Sectional Study. BioMed Central. https://doi.org/10.17615/h0ed-bh71- Creator
-
Ngongondo, McNeil
- Affiliation: School of Medicine, UNC Project-Malawi
-
Rosenberg, Nora E
- Affiliation: School of Medicine, UNC Project-Malawi
-
Stanley, Christopher C
- Affiliation: School of Medicine, UNC Project-Malawi
-
Lim, Robertino
- Affiliation: School of Medicine, UNC Project-Malawi
- Other Affiliation: Tufts University School of Medicine, Boston, USA
-
Ongubo, Dennis
- Other Affiliation: Tulane University School of Public Health and Tropical Medicine, New Orleans, Louisiana, USA
-
Broadhurst, Richard
- Affiliation: Gillings School of Global Public Health
-
Speight, Colin
- Other Affiliation: Lighthouse Trust, Lilongwe, Malawi
-
Flick, Robert
- Affiliation: School of Medicine, UNC Project-Malawi
-
Tembo, Petros
- Other Affiliation: Lighthouse Trust, Lilongwe, Malawi
-
Hosseinipour, Mina
- Affiliation: School of Medicine, UNC Project-Malawi
- Abstract
- Background Anemia is common among people living with HIV infection and is frequently associated with poor quality of life and poor prognosis. It has been well described in antiretroviral naïve individuals and those on non-nucleoside reverse transcriptase inhibitor-based first line antiretroviral therapy (ART) regimens. However there is limited information on anemia for ART experienced individuals on protease inhibitor-based second line ART regimens in resource limited settings. Our objective was to describe the prevalence and risk factors of anemia in this ART experienced population in Malawi. Methods We conducted a cross-sectional study using routine facility data at two HIV clinics in Lilongwe, Malawi. The analysis included individuals receiving protease inhibitor-based second line ART. Clinical and laboratory data were collected at routine clinic visits. We used descriptive statistics, two-sample t-tests and multivariate logistic regression for data analysis. Results Three hundred seventy-seven records were included in this analysis (37% male, median age 41 years, median CD4 count 415 cells/μL). The prevalence of anemia was 125/377 (33.2%) − mild, moderate and severe anemia was 17.5%, 13.8%, and 1.9% respectively. Female participants had a higher prevalence than male participants (43.6% vs. 15.7%, p < 0.001). In multivariate logistic regression, female sex (adjusted odds ratio (aOR) 5.3; 95% CI 2.9–9.5) and a CD4 count <200 cell/ul (aOR 3.1; 95%CI 1.6–6.0) were associated with increased risk of having anemia while a BMI ≥30 kg/m2 (aOR 0.8; 95% CI 0.6–1.0) and being on ART for more than 10 years (aOR 0.4; 95% CI 0.2–0.9) were associated with reduced risk of anemia. Being on a zidovudine- containing ART regimen was not associated with anemia. Conclusion Anemia is common in people on second line ART in Lilongwe, Malawi. Screening for anemia in this population would be a useful strategy; especially for female patients, those who are underweight and have a low CD4 cell counts.
- Date of publication
- January 15, 2018
- DOI
- Identifier
- Resource type
- Article
- Rights statement
- In Copyright
- Rights holder
- The Author(s).
- Journal title
- BMC Infectious Diseases
- Journal volume
- 18
- Journal issue
- 1
- Page start
- 39
- Language
- English
- Bibliographic citation
- BMC Infectious Diseases. 2018 Jan 15;18(1):39
- Publisher
- BioMed Central
Relations
- Parents:
This work has no parents.
Items
Thumbnail | Title | Date Uploaded | Visibility | Actions |
---|---|---|---|---|
12879_2018_article_2952.pdf | 2019-05-06 | Public | Download |