Identification of a CpG Island Methylator Phenotype that Defines a Distinct Subgroup of Glioma
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Noushmehr, Houtan, et al. Identification of a Cpg Island Methylator Phenotype That Defines a Distinct Subgroup of Glioma. 2010. https://doi.org/10.17615/bcyk-kr86APA
Noushmehr, H., Weisenberger, D., Diefes, K., Phillips, H., Pujara, K., Berman, B., Pan, F., Pelloski, C., Sulman, E., Bhat, K., Verhaak, R., Hoadley, K., Hayes, D., Perou, C., Schmidt, H., Ding, L., Wilson, R., Van Den Berg, D., Shen, H., Bengtsson, H., Neuvial, P., Cope, L., Buckley, J., Herman, J., Baylin, S., Laird, P., Aldape, K., & Cancer Genome Atlas Research Network, T. (2010). Identification of a CpG Island Methylator Phenotype that Defines a Distinct Subgroup of Glioma. https://doi.org/10.17615/bcyk-kr86Chicago
Noushmehr, Houtan, Daniel J Weisenberger, Kristin Diefes, Heidi S Phillips, Kanan Pujara, Benjamin P Berman, Fei Pan et al. 2010. Identification of a Cpg Island Methylator Phenotype That Defines a Distinct Subgroup of Glioma. https://doi.org/10.17615/bcyk-kr86- Creator
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Noushmehr, Houtan
- Other Affiliation: USC Epigenome Center, University of Southern California
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Weisenberger, Daniel J.
- Other Affiliation: USC Epigenome Center, University of Southern California
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Diefes, Kristin
- Other Affiliation: Department of Pathology, The University of Texas MD Anderson Cancer Center
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Phillips, Heidi S.
- Other Affiliation: Department of Tumor Biology and Angiogenesis, Genentech, Inc.
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Pujara, Kanan
- Other Affiliation: Department of Tumor Biology and Angiogenesis, Genentech, Inc.
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Berman, Benjamin P.
- Other Affiliation: USC Epigenome Center, University of Southern California
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Pan, Fei
- Other Affiliation: USC Epigenome Center, University of Southern California
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Pelloski, Christopher E.
- Other Affiliation: Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center
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Sulman, Erik P.
- Other Affiliation: Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center
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Bhat, Krishna P.
- Other Affiliation: Department of Pathology, The University of Texas MD Anderson Cancer Center
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Verhaak, Roel G.W.
- Other Affiliation: The Eli and Edythe L. Broad Institute of Massachusetts Institute of Technology and Harvard University
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Hoadley, Katherine
- Affiliation: School of Medicine, Department of Genetics
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Hayes, D. Neil
- Affiliation: School of Medicine, Department of Genetics
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Perou, Charles
- ORCID: https://orcid.org/0000-0001-9827-2247
- Affiliation: School of Medicine, Department of Genetics
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Schmidt, Heather K.
- Other Affiliation: The Genome Center at Washington University, Department of Genetics, Washington University School of Medicine
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Ding, Li
- Other Affiliation: The Genome Center at Washington University, Department of Genetics, Washington University School of Medicine
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Wilson, Richard K.
- Other Affiliation: The Genome Center at Washington University, Department of Genetics, Washington University School of Medicine
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Van Den Berg, David
- Other Affiliation: USC Epigenome Center, University of Southern California
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Shen, Hui
- Other Affiliation: USC Epigenome Center, University of Southern California
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Bengtsson, Henrik
- Other Affiliation: Department of Statistics, University of California, Berkeley
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Neuvial, Pierre
- Other Affiliation: Department of Statistics, University of California, Berkeley
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Cope, Leslie M.
- Other Affiliation: Department on Oncology, Johns Hopkins School of Medicine
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Buckley, Jonathan
- Other Affiliation: USC Epigenome Center, University of Southern California
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Herman, James G.
- Other Affiliation: Department on Oncology, Johns Hopkins School of Medicine
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Baylin, Stephen B.
- Other Affiliation: Department on Oncology, Johns Hopkins School of Medicine
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Laird, Peter W.
- Other Affiliation: USC Epigenome Center, University of Southern California
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Aldape, Kenneth
- Other Affiliation: Department of Pathology, The University of Texas MD Anderson Cancer Center
- The Cancer Genome Atlas Research Network
- Abstract
- We have profiled promoter DNA methylation alterations in 272 glioblastoma tumors in the context of The Cancer Genome Atlas (TCGA). We found that a distinct subset of samples displays concerted hypermethylation at a large number of loci, indicating the existence of a glioma-CpG island methylator phenotype (G-CIMP). We validated G-CIMP in a set of non-TCGA glioblastomas and low-grade gliomas. G-CIMP tumors belong to the proneural subgroup, are more prevalent among lower-grade gliomas, display distinct copynumber alterations, and are tightly associated with IDH1 somatic mutations. Patients with G-CIMP tumors are younger at the time of diagnosis and experience significantly improved outcome. These findings identify G-CIMP as a distinct subset of human gliomas on molecular and clinical grounds.
- Date of publication
- 2010
- DOI
- Identifier
- 2-s2.0-77952108366
- https://doi.org/10.1016/j.ccr.2010.03.017
- Related resource URL
- Resource type
- Article
- Rights statement
- In Copyright
- Journal title
- Cancer Cell
- Journal volume
- 17
- Journal issue
- 5
- Page start
- 510
- Page end
- 522
- Language
- English
- Version
- Postprint
- ISSN
- 1535-6108
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- Parents:
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