Magic shotguns versus magic bullets: Selectively non-selective drugs for mood disorders and schizophrenia
Public Deposited- Creator
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Roth, Bryan L.
- ORCID: https://orcid.org/0000-0002-0561-6531
- Other Affiliation: Department of Biochemistry, School of Medicine, Case Western Reserve University
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Sheffler, Douglas J.
- Other Affiliation: Department of Biochemistry, School of Medicine, Case Western Reserve University
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Kroeze, Wesley K.
- Other Affiliation: Department of Biochemistry, School of Medicine, Case Western Reserve University
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Roth, Bryan L.
- Abstract
- Most common central nervous system disorders — such as depression, bipolar disorder and schizophrenia — seem to be polygenic in origin, and the most effective medications have exceedingly complex pharmacologies. Attempts to develop more effective treatments for diseases such as schizophrenia and depression by discovering drugs selective for single molecular targets (that is, 'magic bullets') have, not surprisingly, been largely unsuccessful. Here we propose that designing selectively non-selective drugs (that is, 'magic shotguns') that interact with several molecular targets will lead to new and more effective medications for a variety of central nervous system disorders.
- Date of publication
- 2004
- DOI
- Identifier
- https://doi.org/10.1038/nrd1346
- 2-s2.0-4644271084
- Related resource URL
- Resource type
- Journal Item
- Rights statement
- In Copyright
- Journal title
- Nature Reviews Drug Discovery
- Journal volume
- 3
- Journal issue
- 4
- Page start
- 353
- Page end
- 359
- Language
- English
- Version
- Postprint
- ISSN
- 1474-1776
- Date uploaded
- April 10, 2018
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