While aggressive chemotherapy is standard for promoting complete remission in newly diagnosed acute myelogenous leukemia patients, treatment side effects impair post-cancer quality of life due in part to negative changes in body composition and increases in cancer-related fatigue. This population would greatly benefit from an intervention which increases physical activity during treatment. Therefore, the primary purpose of this study was to examine the effects of aerobic and resistance exercise on muscle cross sectional area and fatigue before and after induction chemotherapy. One patient with acute myelogenous leukemia participated in this study. The exercise protocol included 30-40 minutes of aerobic and resistance exercise performed 2-4 days per week, twice a day for 4 weeks. While a decrease in vastus lateralis cross sectional area was present post-intervention, this decrease may have been much greater without the intervention. A decrease in self-reported fatigue was recorded. In conclusion, the results of this study suggest that an exercise intervention during induction chemotherapy may mitigate large losses in muscle cross sectional area and may potentially reduce fatigue.