Promising insights into the health related quality of life for children with severe obesity

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  • Selewski, David T
    • Other Affiliation: Division of Nephrology, Department of Pediatrics, University of Michigan
  • Collier, David N
    • Other Affiliation: Department of Pediatrics and Pediatric Healthy Weight Research and Treatment Center, Brody School of Medicine, East Carolina University
  • MacHardy, Jacqueline
    • Affiliation: University of North Carolina at Chapel Hill
  • Gross, Heather E
    • Affiliation: University of North Carolina at Chapel Hill
  • Pickens, Edward M
    • Other Affiliation: University Pediatrics at Highgate
  • Cooper, Alan W
    • Other Affiliation: Carolina Pediatrics of the Triad
  • Bullock, Selam
    • Other Affiliation: Kids First Pediatrics of Raleigh
  • Earls, Marian F
    • Other Affiliation: Guilford Child Health
  • Pratt, Keeley J
    • Other Affiliation: Department of Human Services, The Ohio State University
  • Scanlon, Kelli
    • Affiliation: University of North Carolina at Chapel Hill
  • McNeill, Jonathan D
    • Affiliation: University of North Carolina at Chapel Hill
  • Messer, Kassandra L
    • Other Affiliation: Department of Biostatistics, School of Public Health, University of Michigan
  • Lu, Yee
    • Other Affiliation: Division of Nephrology, Department of Pediatrics, University of Michigan
  • Thissen, David
    • Affiliation: College of Arts and Sciences, Department of Psychology and Neuroscience
  • DeWalt, Darren A
    • Affiliation: School of Medicine, Department of Medicine, Division of General Medicine and Clinical Epidemiology
  • Gipson, Debbie S
    • Other Affiliation: Division of Nephrology, Department of Pediatrics, University of Michigan
Abstract
  • Background Childhood obesity is a growing health concern known to adversely affect quality of life in children and adolescents. The Patient Reported Outcomes Measurement Information System (PROMIS) pediatric measures were developed to capture child self-reports across a variety of health conditions experienced by children and adolescents. The purpose of this study is to begin the process of validation of the PROMIS pediatric measures in children and adolescents affected by obesity. Methods The pediatric PROMIS instruments were administered to 138 children and adolescents in a cross-sectional study of patient reported outcomes in children aged 8–17 years with age-adjusted body mass index (BMI) greater than the 85th percentile in a design to establish known-group validity. The children completed the depressive symptoms, anxiety, anger, peer relationships, pain interference, fatigue, upper extremity, and mobility PROMIS domains utilizing a computer interface. PROMIS domains and individual items were administered in random order and included a total of 95 items. Patient responses were compared between patients with BMI 85 to < 99th percentile versus ≥ 99th percentile. Results 136 participants were recruited and had all necessary clinical data for analysis. Of the 136 participants, 5% ended the survey early resulting in missing domain scores at the end of survey administration. In multivariate analysis, patients with BMI ≥ 99th percentile had worse scores for depressive symptoms, anger, fatigue, and mobility (p < 0.05). Parent-reported exercise was associated with better scores for depressive symptoms, anxiety, and fatigue (p < 0.05). Conclusions Children and adolescents ranging from overweight to severely obese can complete multiple PROMIS pediatric measures using a computer interface in the outpatient setting. In the 5% with missing domain scores, the missing scores were consistently found in the domains administered last, suggesting the length of the assessment is important. The differences in domain scores found in this study are consistent with previous reports investigating the quality of life in children and adolescents with obesity. We show that the PROMIS instrument represents a feasible and potentially valuable instrument for the future study of the effect of pediatric obesity on quality of life.
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Resource type
  • Article
Rights statement
  • In Copyright
Rights holder
  • David T Selewski et al.; licensee BioMed Central Ltd.
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Journal title
  • Health and Quality of Life Outcomes
Journal volume
  • 11
Journal issue
  • 1
Page start
  • 29
Language
  • English
Is the article or chapter peer-reviewed?
  • Yes
ISSN
  • 1477-7525
Bibliographic citation
  • Health and Quality of Life Outcomes. 2013 Mar 01;11(1):29
Publisher
  • BioMed Central Ltd
Access right
  • Open Access
Date uploaded
  • November 6, 2015

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