Collections > Open Access Datasets > Metabolite data of mouse hearts in the early stages of the cardiac fuel switch

Purpose of Experiment: The goal of this study was to identify metabolic differences in mouse heart resulting from knockout of acyl-coenzyme A synthetase. A second component of this study was to examine these metabolic differences in the context of inhibition of mTOR via rapamycin treatment. Experimental design / Summary of Procedure: Global biochemical profiles were determined in 27 samples of mouse heart from WT or acyl coenzyme A synthetase KO animals left untreated or treated with rapamycin (an mTOR inhibitor).