Parental exposures to occupational asthmagens and risk of autism spectrum disorder in a Danish population-based case-control study
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Singer, Alison B, et al. Parental Exposures to Occupational Asthmagens and Risk of Autism Spectrum Disorder In a Danish Population-based Case-control Study. BioMed Central, 2017. https://doi.org/10.17615/1gqs-b996APA
Singer, A., Burstyn, I., Thygesen, M., Mortensen, P., Fallin, M., & Schendel, D. (2017). Parental exposures to occupational asthmagens and risk of autism spectrum disorder in a Danish population-based case-control study. BioMed Central. https://doi.org/10.17615/1gqs-b996Chicago
Singer, Alison B, Igor Burstyn, Malene Thygesen, Preben B Mortensen, M. D Fallin, and Diana E Schendel. 2017. Parental Exposures to Occupational Asthmagens and Risk of Autism Spectrum Disorder In a Danish Population-Based Case-Control Study. BioMed Central. https://doi.org/10.17615/1gqs-b996- Creator
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Singer, Alison B
- Affiliation: Gillings School of Global Public Health, Department of Epidemiology
- Other Affiliation: Department of Epidemiology and Wendy Klag Center for Autism and Developmental Disabilities, Johns Hopkins University Bloomberg School of Public Health, 615 N. Wolfe St, Baltimore, MD 21205, USA; Centre for Integrated Register-based Research, Aarhus University, Aarhus, Denmark
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Burstyn, Igor
- Other Affiliation: Department of Environmental and Occupational Health, Department of Epidemiology and Biostatistics, the A.J. Drexel Autism Institute, Drexel University Dornsife School of Public Health, 3215 Market Street, Philadelphia, PA 19104, USA
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Thygesen, Malene
- Other Affiliation: Centre for Integrated Register-based Research, Aarhus University, Aarhus, Denmark; Department of Economics and Business, National Centre for Register-based Research, Aarhus University, Fuglesangs Allé 4, Building 2631, DK-8210 Aarhus V, Denmark
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Mortensen, Preben B
- Other Affiliation: Centre for Integrated Register-based Research, Aarhus University, Aarhus, Denmark; Department of Economics and Business, National Centre for Register-based Research, Aarhus University, Fuglesangs Allé 4, Building 2631, DK-8210 Aarhus V, Denmark; Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, Aarhus, Denmark
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Fallin, M. D
- Other Affiliation: Department of Epidemiology and Wendy Klag Center for Autism and Developmental Disabilities, Johns Hopkins University Bloomberg School of Public Health, 615 N. Wolfe St, Baltimore, MD 21205, USA; Department of Mental Health, Johns Hopkins University Bloomberg School of Public Health, 624 N. Broadway, Baltimore, MD 21205, USA
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Schendel, Diana E
- Other Affiliation: Centre for Integrated Register-based Research, Aarhus University, Aarhus, Denmark; Department of Economics and Business, National Centre for Register-based Research, Aarhus University, Fuglesangs Allé 4, Building 2631, DK-8210 Aarhus V, Denmark; Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, Aarhus, Denmark; Department of Public Health, Section for Epidemiology, Aarhus University, Bartholins Allé 2, Building 1260, DK-8000 Aarhus C, Denmark
- Abstract
- Abstract Background Environmental exposures and immune conditions during pregnancy could influence development of autism spectrum disorder (ASD) in offspring. However, few studies have examined immune-triggering exposures in relation to ASD. We evaluated the association between parental workplace exposures to risk factors for asthma (“asthmagens”) and ASD. Methods We conducted a population-based case-control study in the Danish population using register linkage. Our study population consisted of 11,869 ASD cases and 48,046 controls born from 1993 through 2007. Cases were identified by ICD-10 codes in the Danish Psychiatric Central Register. ASD cases and controls were linked to parental Danish International Standard Classification of Occupations (DISCO-88) job codes. Parental occupational asthmagen exposure was estimated by linking DISCO-88 codes to an asthma-specific job-exposure matrix. Results Our maternal analyses included 6706 case mothers and 29,359 control mothers employed during the pregnancy period. We found a weak inverse association between ASD and any maternal occupational asthmagen exposure, adjusting for sociodemographic covariates (adjusted OR: 0.92, 95% CI: 0.86–0.99). In adjusted analyses, including 7647 cases and 31,947 controls with employed fathers, paternal occupational asthmagen exposure was not associated with ASD (adjusted OR: 0.98, 95% CI: 0.92–1.05). Conclusions We found a weak inverse association between maternal occupational asthmagen exposure and ASD, and a null association between paternal occupational exposure and ASD. We suggest that unmeasured confounding negatively biased the estimate, but that this unmeasured confounding is likely not strong enough to bring the effect above the null. Overall, our results were consistent with no positive association between parental asthmagen exposure and ASD in the children.
- Date of publication
- March 31, 2017
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- Article
- Rights statement
- In Copyright
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- The Author(s).
- Language
- English
- Bibliographic citation
- Environmental Health. 2017 Mar 31;16(1):31
- Publisher
- BioMed Central
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