Vertebral fractures among breast cancer survivors in China: a cross-sectional study of prevalence and health services gaps
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Hsieh, Evelyn, et al. Vertebral Fractures Among Breast Cancer Survivors In China: a Cross-sectional Study of Prevalence and Health Services Gaps. BioMed Central, 2018. https://doi.org/10.17615/d4h6-bz65APA
Hsieh, E., Wang, Q., Zhang, R., Niu, X., Xia, W., Fraenkel, L., Insogna, K., Li, J., Smith, J., Zhou, C., Qiao, Y., & Zhang, P. (2018). Vertebral fractures among breast cancer survivors in China: a cross-sectional study of prevalence and health services gaps. BioMed Central. https://doi.org/10.17615/d4h6-bz65Chicago
Hsieh, Evelyn, Qin Wang, Renzhi Zhang, Xin Niu, Weibo Xia, Liana Fraenkel, Karl L Insogna et al. 2018. Vertebral Fractures Among Breast Cancer Survivors In China: a Cross-Sectional Study of Prevalence and Health Services Gaps. BioMed Central. https://doi.org/10.17615/d4h6-bz65- Creator
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Hsieh, Evelyn
- Other Affiliation: Section of Rheumatology, Yale School of Medicine, New Haven, CT, USA
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Wang, Qin
- Other Affiliation: Department of Ultrasound, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China
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Zhang, Renzhi
- Other Affiliation: Department of Diagnostic Radiology, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China
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Niu, Xin
- Other Affiliation: Department of Cancer Epidemiology, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China
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Xia, Weibo
- Other Affiliation: Department of Endocrinology, Key Laboratory of Endocrinology, Peking Union Medical College Hospital, Beijing, China
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Fraenkel, Liana
- Other Affiliation: Section of Rheumatology, Yale School of Medicine, New Haven, CT, USA
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Insogna, Karl L
- Other Affiliation: Section of Endocrinology, Yale School of Medicine, New Haven, CT, USA
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Li, Jing
- Other Affiliation: Department of Diagnostic Radiology, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China
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Smith, Jennifer
- Affiliation: Gillings School of Global Public Health, Department of Epidemiology
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Zhou, Chunwu
- Other Affiliation: Department of Diagnostic Radiology, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China
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Qiao, You-lin
- Other Affiliation: Department of Cancer Epidemiology, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China
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Zhang, Pin
- Other Affiliation: Department of Medical Oncology, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China
- Abstract
- Abstract Background Breast cancer survivors are at high risk for fracture due to cancer treatment-induced bone loss, however, data is scarce regarding the scope of this problem from an epidemiologic and health services perspective among Chinese women with breast cancer. Methods We designed a cross-sectional study comparing prevalence of vertebral fractures among age- and BMI-matched women from two cohorts. Women in the Breast Cancer Survivors cohort were enrolled from a large cancer hospital in Beijing. Eligibility criteria included age 50–70 years, initiation of treatment for breast cancer at least 5 years prior to enrollment, and no history of metabolic bone disease or bone metastases. Data collected included sociodemographic characteristics; fracture-related risk factors, screening and preventive measures; breast cancer history; and thoracolumbar x-ray. The matched comparator group was selected from participants enrolled in the Peking Vertebral Fracture Study, an independent cohort of healthy community-dwelling postmenopausal women from Beijing. Results Two hundred breast cancer survivors were enrolled (mean age 57.5 ± 4.9 years), and compared with 200 matched healthy women. Twenty-two (11%) vertebral fractures were identified among breast cancer survivors compared with 7 (3.5%) vertebral fractures in the comparison group, yielding an adjusted odds ratio for vertebral fracture of 4.16 (95%CI 1.69–10.21, p < 0.01). The majority had early stage (85.3%) and estrogen and/or progesterone receptor positive (84.6%) breast cancer. Approximately half of breast cancer survivors reported taking calcium supplements, 6.1% reported taking vitamin D supplements, and only 27% reported having a bone density scan since being diagnosed with breast cancer. Conclusions Despite a four-fold increased odds of prevalent vertebral fracture among Chinese breast cancer survivors in our study, rates of screening for osteoporosis and fracture risk were low reflecting a lack of standardization of care regarding cancer-treatment induced bone loss.
- Date of publication
- January 30, 2018
- DOI
- Identifier
- Resource type
- Article
- Rights statement
- In Copyright
- Rights holder
- The Author(s).
- Language
- English
- Bibliographic citation
- BMC Cancer. 2018 Jan 30;18(1):104
- Publisher
- BioMed Central
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