The transcription factor NF-κB: Control of oncogenesis and cancer therapy resistance

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  • Baldwin, Albert
  • Mayo, Marty W.
    • Affiliation: N.C. Cancer Hospital, UNC Lineberger Comprehensive Cancer Center
Abstract
  • Discovered in 1986 as a DNA binding activity that recognized the immunoglobulin light chain intronic enhancer, NF-kappaB has been studied intensively for its role in controlling expression of genes involved in immune and inflammatory function. However, more recently, NF-kappaB has been implicated in controlling cell growth and oncogenesis. The link between NF-kappaB and cancer stems, in part, from the fact that this transcription factor is capable of inducing gene products that control proliferative responses and that suppress apoptotic cascades, such as those induced by tumor necrosis factor (TNF), expression of oncoproteins, and genotoxic stress. This latter observation is likely to be important in developing new approaches aimed at improving the efficacy of cancer chemotherapy.
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Resource type
  • Journal Item
Rights statement
  • In Copyright
Journal title
  • Biochimica et Biophysica Acta - Reviews on Cancer
Journal volume
  • 1470
Journal issue
  • 2
Page start
  • M55
Page end
  • M62
Language
  • English
Version
  • Postprint
ISSN
  • 0304-419X

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