Multi-analyte profiling of ten cytokines in South African HIV-infected patients with Immune Reconstitution Inflammatory Syndrome (IRIS)

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  • Worsley, Catherine M
    • Other Affiliation: Department of Molecular Medicine and Haematology, Faculty of Health Sciences, University of the Witwatersrand and National Health Laboratory Services, Johannesburg, South Africa
  • Suchard, Melinda S
    • Other Affiliation: Department of Molecular Medicine and Haematology, Faculty of Health Sciences, University of the Witwatersrand and National Health Laboratory Services, Johannesburg, South Africa
  • Stevens, Wendy S
    • Other Affiliation: Department of Molecular Medicine and Haematology, Faculty of Health Sciences, University of the Witwatersrand and National Health Laboratory Services, Johannesburg, South Africa
  • Van Rie, Annelies
    • Affiliation: Gillings School of Global Public Health, Department of Epidemiology
  • Murdoch, David
    • Affiliation: Gillings School of Global Public Health, Department of Epidemiology
    • Other Affiliation: Department of Medicine, Duke University Medical Centre, Durham, North Carolina, USA
Abstract
  • Abstract Background Immune reconstitution inflammatory syndrome (IRIS) is an important complication of HAART in sub-Saharan Africa, where opportunistic infections (OIs) including mycobacteria and cryptococcus are common. The immune system's role in HIV infected patients is complex with cytokine expression strongly influencing HIV infection and replication. Methods We determined the expression patterns of 10 cytokines by Luminex multi-analyte profiling in 17 IRIS nested case-control pairs participating in a prospective South African cohort initiating anti-retroviral therapy. Results Interferon-gamma (IFN-γ) expression was significantly elevated in IRIS cases compared to controls (median 9.88 pg/ml versus 2.68 pg/ml, respectively, P = 0.0057), while other cytokines displayed non-significant differences in expression. Significant correlation was observed between IL-6, IL-10, and IFN-γ expression in the IRIS patients. Conclusions Significantly increased expression levels of IFN-γ suggest that this cytokine possibly plays a role in IRIS pathology and is a potential diagnostic marker.
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  • Article
Rights statement
  • In Copyright
Rights holder
  • Catherine M Worsley et al.; licensee BioMed Central Ltd.
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Journal title
  • AIDS Research and Therapy
Journal volume
  • 7
Journal issue
  • 1
Page start
  • 36
Language
  • English
Is the article or chapter peer-reviewed?
  • Yes
ISSN
  • 1742-6405
Bibliographic citation
  • AIDS Research and Therapy. 2010 Oct 07;7(1):36
Publisher
  • BioMed Central Ltd
Access right
  • Open Access
Date uploaded
  • August 23, 2012

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