Engineering the Size of DNA Repair Inhibitor-Encapsulated Polymeric Nanoparticles to Improve the Therapeutic Index of Chemoradiotherapy

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  • February 26, 2019
Creator
  • Yu, Stephanie
    • Affiliation: Gillings School of Global Public Health, Department of Environmental Sciences and Engineering
Abstract
  • Nanoparticle (NP) delivery of chemotherapeutic drugs can be used to both improve tumor toxicity and reduce toxicity to normal tissue in chemo and chemoradiotherapy (CRT). However, various properties of nanoparticles with respect to CRT are yet to be explored. For instance, it is unknown how particle size may affect the therapeutic index of CRT. Exploration of this topic may provide invaluable insight on how NP-based CRT could be administered clinically in the future, as there is currently no set standard on an optimal particle size.
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  • In Copyright
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  • Funding: None
Advisor
  • Wang, Andrew
Degree
  • Bachelor of Arts
Academic concentration
  • Environmental Health Sciences
Honors level
  • Honors
Degree granting institution
  • University of North Carolina at Chapel Hill
Graduation year
  • 2017
Language
  • English

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