Indoor air pollution exposure from use of indoor stoves and fireplaces in association with breast cancer: a case-control study

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  • White, Alexandra J
    • Affiliation: Gillings School of Global Public Health, Department of Epidemiology
  • Teitelbaum, Susan L
    • Other Affiliation: Department of Preventative Medicine, Mt. Sinai School of Medicine, New York, NY, USA
  • Stellman, Steven D
    • Other Affiliation: Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA
  • Beyea, Jan
    • Other Affiliation: Consulting in the Public Interest (CIPI), Lambertville, NJ, USA
  • Steck, Susan E
    • Other Affiliation: Department of Epidemiology and Biostatistics, University of South Carolina, Columbia, SC, USA
  • Mordukhovich, Irina
    • Other Affiliation: Exposure, Epidemiology and Risk Program, Department of Environmental Health, Harvard School of Public Health, Boston, MA, USA
  • McCarty, Kathleen M
    • Affiliation: Gillings School of Global Public Health, Department of Epidemiology
  • Ahn, Jiyoung
    • Other Affiliation: Department of Population Health, New York University School of Medicine, New York, NY, USA
  • Rossner, Pavel
    • Other Affiliation: Department of Genetic Ecotoxicology, Institute of Experimental Medicine ASCR, Prague, Czech Republic
  • Santella, Regina M
    • Other Affiliation: Department of Environmental Health Sciences, Columbia University, New York, NY, USA
  • Gammon, Marilie D.
    • Affiliation: Gillings School of Global Public Health, Department of Epidemiology
Abstract
  • Background Previous studies suggest that polycyclic aromatic hydrocarbons (PAHs) may adversely affect breast cancer risk. Indoor air pollution from use of indoor stoves and/or fireplaces is an important source of ambient PAH exposure. However, the association between indoor stove/fireplace use and breast cancer risk is unknown. We hypothesized that indoor stove/fireplace use in a Long Island, New York study population would be positively associated with breast cancer and differ by material burned, and the duration and timing of exposure. We also hypothesized that the association would vary by breast cancer subtype defined by p53 mutation status, and interact with glutathione S-transferases GSTM1, T1, A1 and P1 polymorphisms. Methods Population-based, case-control resources (1,508 cases/1,556 controls) were used to conduct unconditional logistic regression to estimate adjusted odds ratios (OR) and 95% confidence intervals (CI). Results Breast cancer risk was increased among women reporting ever burning synthetic logs (which may also contain wood) in their homes (OR = 1.42, 95% CI 1.11, 1.84), but not for ever burning wood alone (OR = 0.93, 95% CI 0.77, 1.12). For synthetic log use, longer duration >7 years, older age at exposure (>20 years; OR = 1.65, 95% CI 1.02, 2.67) and 2 or more variants in GSTM1, T1, A1 or P1 (OR = 1.71, 95% CI 1.09, 2.69) were associated with increased risk. Conclusions Burning wood or synthetic logs are both indoor PAH exposure sources; however, positive associations were only observed for burning synthetic logs, which was stronger for longer exposures, adult exposures, and those with multiple GST variant genotypes. Therefore, our results should be interpreted with care and require replication.
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  • Article
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  • In Copyright
Rights holder
  • White et al.; licensee BioMed Central.
Journal title
  • Environmental Health
Journal volume
  • 13
Journal issue
  • 1
Language
  • English
Bibliographic citation
  • Environmental Health. 2014 Dec 12;13(1):108
Publisher
  • BioMed Central

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