High rates of parkinsonism in adults with autism
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Starkstein, Sergio, et al. High Rates of Parkinsonism In Adults with Autism. BioMed Central, 2015. https://doi.org/10.17615/6zzg-tg91APA
Starkstein, S., Gellar, S., Parlier, M., Payne, L., & Piven, J. (2015). High rates of parkinsonism in adults with autism. BioMed Central. https://doi.org/10.17615/6zzg-tg91Chicago
Starkstein, Sergio, Scott Gellar, Morgan Parlier, Leslie Payne, and Joseph Piven. 2015. High Rates of Parkinsonism In Adults with Autism. BioMed Central. https://doi.org/10.17615/6zzg-tg91- Creator
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Starkstein, Sergio
- Other Affiliation: Fremantle Hospital, University of Western Australia, 35 Stirling Highway, Crawley, Western Australia, Australia; Autism Association of Western Australia, Western Australia, WA 6008, Australia; School of Psychiatry, University of Western Australia, 35 Stirling Highway, Crawley, Western Australia, Australia
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Gellar, Scott
- Other Affiliation: Fremantle Hospital, University of Western Australia, 35 Stirling Highway, Crawley, Western Australia, Australia
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Parlier, Morgan
- Affiliation: School of Medicine, Neurodevelopment Disorders Research Center, Carolina Institute for Developmental Disabilities
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Payne, Leslie
- Affiliation: School of Medicine, Neurodevelopment Disorders Research Center, Carolina Institute for Developmental Disabilities
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Piven, Joseph
- Affiliation: School of Medicine, Neurodevelopment Disorders Research Center, Carolina Institute for Developmental Disabilities
- Other Affiliation: Fremantle Hospital, University of Western Australia, 35 Stirling Highway, Crawley, Western Australia, Australia
- Abstract
- Abstract Background While it is now recognized that autism spectrum disorder (ASD) is typically a life-long condition, there exist only a handful of systematic studies on middle-aged and older adults with this condition. Methods We first performed a structured examination of parkinsonian motor signs in a hypothesis-generating, pilot study (study I) of 19 adults with ASD over 49 years of age. Observing high rates of parkinsonism in those off atypical neuroleptics (2/12, 17 %) in comparison to published population rates for Parkinson’s disease and parkinsonism, we examined a second sample of 37 adults with ASD, over 39 years of age, using a structured neurological assessment for parkinsonism. Results Twelve of the 37 subjects (32 %) met the diagnostic criteria for parkinsonism; however, of these, 29 subjects were on atypical neuroleptics, complicating interpretation of the findings. Two of eight (25 %) subjects not taking atypical neuroleptic medications met the criteria for parkinsonism. Combining subjects who were not currently taking atypical neuroleptic medications, across both studies, we conservatively classified 4/20 (20 %) with parkinsonism. Conclusions We find a high frequency of parkinsonism among ASD individuals older than 39 years. If high rates of parkinsonism and potentially Parkinson’s disease are confirmed in subsequent studies of ASD, this observation has important implications for understanding the neurobiology of autism and treatment of manifestations in older adults. Given the prevalence of autism in school-age children, the recognition of its life-long natural history, and the recognition of the aging of western societies, these findings also support the importance of further systematic study of other aspects of older adults with autism.
- Date of publication
- August 30, 2015
- DOI
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- Resource type
- Article
- Rights statement
- In Copyright
- Rights holder
- Starkstein et al.
- Language
- English
- Bibliographic citation
- Journal of Neurodevelopmental Disorders. 2015 Aug 30;7(1):29
- Publisher
- BioMed Central
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