Retrospectively Assigning Context of Observation for F-344 Rats Chronically Exposed to Formaldehyde
Public Deposited- Last Modified
- February 28, 2019
- Creator
-
Lowry, William H.
- Affiliation: Gillings School of Global Public Health, Department of Environmental Sciences and Engineering
- Abstract
- One approach to estimating age-specific tumor incidence rates using scheduled sacrifice information involves determining context of observation for each tumor bearing animal. Context of observation is defined as determination of whether the tumor of interest contributed directly or indirectly to the cause of death, or alternatively, the tumor was an incidental finding at necropsy, in an animal dying of an unrelated cause. The present study was undertaken to assign retrospectively the context of observation for nasal squamous cell carcinoma in F-344 rats exposed to 15 ppm of formaldehyde for up to 24 months. Results indicate that greater than 90% of the tumors were classifiable as definitely incidental (2%) or definitely fatal (88%) with a high degree of confidence. This study demonstrates that context of observation can be assigned even long after the bioassay has been completed, provided the data have been properly archived.
- Date of publication
- December 1988
- DOI
- Resource type
- Rights statement
- In Copyright
- Advisor
- Starr, Thomas B.
- Turner, Alvis G.
- Crawford-Brown, Douglas J.
- Degree
- Master of Science in Public Health
- Academic concentration
- Environmental Management and Policy
- Degree granting institution
- University of North Carolina at Chapel Hill
- Graduation year
- 1988
- Language
- Deposit record
- ad7e9272-7c4f-43e0-afeb-7a5f2526ad76
Relations
- Parents:
This work has no parents.