Relationship between crown-like structures and sex-steroid hormones in breast adipose tissue and serum among postmenopausal breast cancer patients
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Mullooly, Maeve, et al. Relationship Between Crown-like Structures and Sex-steroid Hormones In Breast Adipose Tissue and Serum Among Postmenopausal Breast Cancer Patients. BioMed Central, 2017. https://doi.org/10.17615/np6t-r814APA
Mullooly, M., Yang, H., Falk, R., Nyante, S., Cora, R., Pfeiffer, R., Radisky, D., Visscher, D., Hartmann, L., Carter, J., Degnim, A., Stanczyk, F., Figueroa, J., Garcia Closas, M., Lissowska, J., Troester, M., Hewitt, S., Brinton, L., Sherman, M., & Gierach, G. (2017). Relationship between crown-like structures and sex-steroid hormones in breast adipose tissue and serum among postmenopausal breast cancer patients. BioMed Central. https://doi.org/10.17615/np6t-r814Chicago
Mullooly, Maeve, Hannah P Yang, Roni T Falk, Sarah Nyante, Renata Cora, Ruth M Pfeiffer, Derek C Radisky et al. 2017. Relationship Between Crown-Like Structures and Sex-Steroid Hormones In Breast Adipose Tissue and Serum Among Postmenopausal Breast Cancer Patients. BioMed Central. https://doi.org/10.17615/np6t-r814- Creator
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Mullooly, Maeve
- Other Affiliation: National Cancer Institute
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Yang, Hannah P
- Other Affiliation: National Cancer Institute
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Falk, Roni T
- Other Affiliation: National Cancer Institute
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Nyante, Sarah
- Affiliation: School of Medicine, Department of Radiology
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Cora, Renata
- Other Affiliation: Independent contractor, CT(ASCP)
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Pfeiffer, Ruth M
- Other Affiliation: National Cancer Institute
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Radisky, Derek C
- Other Affiliation: Mayo Clinic
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Visscher, Daniel W
- Other Affiliation: Mayo Clinic
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Hartmann, Lynn C
- Other Affiliation: Mayo Clinic
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Carter, Jodi M
- Other Affiliation: Mayo Clinic
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Degnim, Amy C
- Other Affiliation: Mayo Clinic
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Stanczyk, Frank Z
- Other Affiliation: University of Southern California
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Figueroa, Jonine D
- Other Affiliation: The University of Edinburgh
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Garcia-Closas, Montserrat
- Other Affiliation: National Cancer Institute
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Lissowska, Jolanta
- Other Affiliation: Cancer Center and M. Sklodowska-Curie Institute of Oncology
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Troester, Melissa
- Affiliation: Gillings School of Global Public Health, Department of Epidemiology
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Hewitt, Stephen M
- Other Affiliation: National Cancer Institute
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Brinton, Louise A
- Other Affiliation: National Cancer Institute
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Sherman, Mark E
- Other Affiliation: National Cancer Institute
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Gierach, Gretchen L
- Other Affiliation: National Cancer Institute
- Abstract
- Background Postmenopausal obesity is associated with increased circulating levels of androgens and estrogens and elevated breast cancer risk. Crown-like structures (CLS; microscopic foci of dying adipocytes surrounded by macrophages) are proposed to represent sites of increased aromatization of androgens to estrogens. Accordingly, we examined relationships between CLS and sex-steroid hormones in breast adipose tissue and serum from postmenopausal breast cancer patients. Methods Formalin-fixed paraffin embedded benign breast tissues collected for research from postmenopausal women (n = 83) diagnosed with invasive breast cancer in the Polish Breast Cancer Study (PBCS) were evaluated. Tissues were immunohistochemically stained for CD68 to determine the presence of CLS per unit area of adipose tissue. Relationships were assessed between CD68 density and CLS and previously reported sex-steroid hormones quantified using radioimmunoassays in serum taken at the time of diagnosis and in fresh frozen adipose tissue taken at the time of surgery. Logistic regression analysis was used to estimate odds ratios (ORs) and 95% confidence intervals (CIs) for the relationships between hormones (in tertiles) and CLS. Results CLS were observed in 36% of benign breast tissues, with a higher frequency among obese versus lean women (54% versus 17%, p = 0.03). Detection of CLS was not related to individual hormone levels or breast tumor pathology characteristics. However, detection of CLS was associated with hormone ratios. Compared with women in the highest tertile of estrone:androstenedione ratio in fat, those in the lowest tertile were less likely to have CLS (OR 0.12, 95% CI 0.03–0.59). A similar pattern was observed with estradiol:testosterone ratio in serum and CLS (lowest versus highest tertile, OR 0.18, 95% CI 0.04–0.72). Conclusions CLS were more frequently identified in the breast fat of obese women and were associated with increased ratios of select estrogens:androgens in the blood and tissues, but not with individual hormones. Additional studies on CLS, tissue and blood hormone levels, and breast cancer risk are needed to understand and confirm these findings.
- Date of publication
- January 19, 2017
- DOI
- Identifier
- Resource type
- Article
- Rights statement
- In Copyright
- Rights holder
- The Author(s).
- Journal title
- Breast Cancer Research
- Journal volume
- 19
- Journal issue
- 1
- Language
- English
- Bibliographic citation
- Breast Cancer Research. 2017 Jan 19;19(1):8
- Publisher
- BioMed Central
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