Transcranial electrical stimulation (tES) is a novel noninvasive brain stimulation method which has been proposed to interact with and alter endogenous brain oscillations. This stimulation delivers a weak electric current to the brain via sponge electrodes placed on the skull. The tES has behavioral and cognitive effects on healthy populations and improves mood symptoms in several drug-resistant forms of psychiatric disorders including major depression and schizophrenia. The cellular level mechanism of the effect of tES is an active research topic in neuroscience. This study aims to study the effects of tES at the neural population level using mouse cortical slices in vitro.