Opioid antinociception and antihyperalgesia in combination with metabotropic glutamate receptor antagonism

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  • March 21, 2019
Creator
  • Daugherty, Dana Elaine
    • Affiliation: College of Arts and Sciences, Department of Psychology and Neuroscience
Abstract
  • Research has shown that the analgesic effects of mu-opioids can be enhanced by concurrent administration of drugs that target various sites within the glutamate system. To explore these effects, the present study examined the effects of a metabotropic glutamate receptor subtype 1 (mGluR1) antagonist and a metabotropic glutamate receptor subtype 5 (mGluR5) antagonist in combination with morphine. These interactions were examined in two models of acute pain and one model of inflammatory pain. Selected doses of the mGluR1 antagonist JNJ16259685 (1.0 - 5.6 mg/kg) and the mGluR5 antagonist MPEP (30.0 mg/kg) enhanced morphine antinociception in both models of acute pain. Neither antagonist enhanced morphine-antihyperalgesia in the model of inflammatory pain; however, MPEP (10.0 mg/kg) did attenuate the antihyperalgesic effects of high doses of morphine. These results suggest that the interaction between the mGluR and opioid receptor systems depends on the assay used to examine these effects and the dose combinations examined.
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  • In Copyright
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  • "... in partial fulfillment for the requirements for the degree of Master of Arts in the Department of Psychology."
Advisor
  • Dykstra, Linda A.
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Place of publication
  • Chapel Hill, NC
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  • Open access
Date uploaded
  • March 18, 2013

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