Treatment-seeking patients with binge-eating disorder in the Swedish national registers: clinical course and psychiatric comorbidity
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Welch, Elisabeth, et al. Treatment-seeking Patients with Binge-eating Disorder In the Swedish National Registers: Clinical Course and Psychiatric Comorbidity. BioMed Central, 2016. https://doi.org/10.17615/23nv-7606APA
Welch, E., Jangmo, A., Thornton, L., Norring, C., Von Hausswolff Juhlin, Y., Herman, B., Pawaskar, M., Larsson, H., & Bulik, C. (2016). Treatment-seeking patients with binge-eating disorder in the Swedish national registers: clinical course and psychiatric comorbidity. BioMed Central. https://doi.org/10.17615/23nv-7606Chicago
Welch, Elisabeth, Andreas Jangmo, Laura M Thornton, Claes Norring, Yvonne Von Hausswolff Juhlin, Barry K Herman, Manjiri Pawaskar et al. 2016. Treatment-Seeking Patients with Binge-Eating Disorder In the Swedish National Registers: Clinical Course and Psychiatric Comorbidity. BioMed Central. https://doi.org/10.17615/23nv-7606- Creator
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Welch, Elisabeth
- Other Affiliation: Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
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Jangmo, Andreas
- Other Affiliation: Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
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Thornton, Laura M
- Affiliation: School of Medicine, Department of Psychiatry
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Norring, Claes
- Other Affiliation: Stockholm Centre for Eating Disorders, Stockholm, Sweden; Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden
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von Hausswolff-Juhlin, Yvonne
- Other Affiliation: Stockholm Centre for Eating Disorders, Stockholm, Sweden; Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden
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Herman, Barry K
- Other Affiliation: Shire, Wayne, PA, USA
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Pawaskar, Manjiri
- Other Affiliation: Shire, Wayne, PA, USA
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Larsson, Henrik
- Other Affiliation: Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
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Bulik, Cynthia
- Affiliation: Gillings School of Global Public Health, Department of Nutrition
- Other Affiliation: Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
- Abstract
- Background We linked extensive longitudinal data from the Swedish national eating disorders quality registers and patient registers to explore clinical characteristics at diagnosis, diagnostic flux, psychiatric comorbidity, and suicide attempts in 850 individuals diagnosed with binge-eating disorder (BED). Method Cases were all individuals who met criteria for BED in the quality registers (N = 850). We identified 10 controls for each identified case from the Multi-Generation Register matched on sex, and year, month, and county of birth. We evaluated characteristics of individuals with BED at evaluation and explored diagnostic flux across eating disorders presentations between evaluation and one-year follow-up. We applied conditional logistic regression models to assess the association of BED with each comorbid psychiatric disorder and with suicide attempts and explored whether risk for depression and suicide were differentially elevated in individuals with BED with or without comorbid obesity. Results BED shows considerable diagnostic flux with other eating disorders over time, carries high psychiatric comorbidity burden with other eating disorders (OR 85.8; 95 % CI: 61.6, 119.4), major depressive disorder (OR 7.6; 95 % CI: 6.2, 9.3), bipolar disorder (OR 7.5; 95 % CI: 4.8, 11.9), anxiety disorders (OR 5.2; 95 % CI: 4.2, 6.4), and post-traumatic stress disorder (OR 4.3; 95 % CI: 3.2, 5.7) and is associated with elevated risk for suicide attempts (OR 1.8; 95 % CI: 1.2, 2.7). Depression and suicide attempt risk were elevated in individuals with BED with and without comorbid obesity. Conclusions Considerable flux occurs across BED and other eating disorder diagnoses. The high psychiatric comorbidity and suicide risk underscore the severity and clinical complexity of BED.
- Date of publication
- May 26, 2016
- DOI
- Identifier
- Resource type
- Article
- Rights statement
- In Copyright
- Rights holder
- Welch et al.
- Journal title
- BMC Psychiatry
- Journal volume
- 16
- Journal issue
- 1
- Page start
- 163
- Language
- English
- Bibliographic citation
- BMC Psychiatry. 2016 May 26;16(1):163
- Publisher
- BioMed Central
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