Diabetes Mellitus and Associated Risk Factors Among HIV Positive Patients At Parirenyatwa Hospital Family Care Centre
Public Deposited- Last Modified
- February 26, 2019
- Creator
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Matika, Tafadzwa
- Affiliation: Gillings School of Global Public Health, Department of Nutrition
- Abstract
- Type 2 Diabetes (T2DM) prevalence is increasing globally, particularly in resource-limited settings where infectious diseases are also highly prevalent. Little is known about prevalence of T2DM and prediabetes among HIV positive (HIV+) individuals in Africa. The aim of this study was to estimate T2DM and prediabetes prevalence and to describe T2DM and prediabetes risk factors among HIV+ patients receiving care at Parirenyatwa Hospital Family Care Center in Zimbabwe (PHFCC). Adult HIV+ patients attending visits for routine CD4 count testing between July-August 2015 were enrolled (n=244). Nearly all the participants (95.5%) were on anti-retroviral therapy (ART) with 18.4% having been on a protease inhibitor (PI)-based regimen. T2DM was defined by hemoglobin A1c (HbA1c) ≥ 6.5% or prior clinical records indicating T2D diagnosis while prediabetes was defined by HbA1c from 5.7 - 6.4%. Information on sex, age, BMI, reported history of family diabetes, ART medication history, CD4 count and full blood count reports was collected. Among the 244 HIV+ participants, 17 (7.0%) had T2DM and 111 (45.4%) had prediabetes. In models fully adjusted for age, BMI, anemia and protease inhibitor (PI) use, BMI was positively associated with prediabetes (OR 1.07, 95% CI 1.02- 1.12) and T2DM (OR 1.14, 95% CI 1.04-1.24). Age (OR 1.12, 95% CI 1.06-1.19) was only associated with T2DM but not prediabetes. The age adjusted prevalence of diabetes and prediabetes were 4.1% and 45.3% respectively while age the standardized prevalence were 10.2% and 42.6% respectively. These data indicate that HIV+ patients in Africa are experiencing a notable burden of T2DM. A better understanding of the influences associated with the risk for T2DM and its risk factors in HIV+ individuals in resource-limited settings is needed.
- Date of publication
- spring 2016
- Keyword
- DOI
- Resource type
- Rights statement
- In Copyright
- Note
- Funding: Robertson Scholars Leadership Program
- Advisor
- Mayer-Davis, Elizabeth
- Degree
- Bachelor of Science in Public Health
- Honors level
- Highest Honors
- Degree granting institution
- University of North Carolina at Chapel Hill
- Extent
- 67
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