The somatic genomic landscape of glioblastoma
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Brennan, Cameron W, et al. The Somatic Genomic Landscape of Glioblastoma. 2013. https://doi.org/10.17615/1c99-j777APA
Brennan, C., Verhaak, R., Mc Kenna, A., Campos, B., Noushmehr, H., Salama, S., Zheng, S., Chakravarty, D., Sanborn, J., Berman, S., Beroukhim, R., Bernard, B., Wu, C., Genovese, G., Shmulevich, I., Barnholtz Sloan, J., Zou, L., Vegesna, R., Shukla, S., Ciriello, G., Yung, W., Zhang, W., Sougnez, C., Mikkelsen, T., Aldape, K., Bigner, D., Van Meir, E., Prados, M., Sloan, A., Black, K., Eschbacher, J., Finocchiaro, G., Friedman, W., Andrews, D., Guha, A., Iacocca, M., O'neill, B., Foltz, G., Myers, J., Weisenberger, D., Penny, R., Kucherlapati, R., Perou, C., Hayes, N., Gibbs, R., Marra, M., Mills, G., Lander, E., Spellman, P., Wilson, R., Sander, C., Weinstein, J., Meyerson, M., Gabriel, S., Laird, P., Haussler, D., Getz, G., Chin, L., & Research Network, T. (2013). The somatic genomic landscape of glioblastoma. https://doi.org/10.17615/1c99-j777Chicago
Brennan, Cameron W., Roel G.W Verhaak, Aaron Mc Kenna, Benito Campos, Houtan Noushmehr, Sofie R Salama, Siyuan Zheng et al. 2013. The Somatic Genomic Landscape of Glioblastoma. https://doi.org/10.17615/1c99-j777- Creator
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Brennan, Cameron W.
- Other Affiliation: Human Oncology and Pathogenesis Program, Brain Tumor Center, Memorial Sloan-Kettering Cancer Center
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Verhaak, Roel G.W.
- Other Affiliation: Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center
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McKenna, Aaron
- Other Affiliation: Cancer Program, The Broad Institute of Harvard and MIT
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Campos, Benito
- Other Affiliation: Department of Medical Oncology, Dana-Farber Cancer Institute
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Noushmehr, Houtan
- Other Affiliation: University of Southern California Epigenome Center, University of Southern California
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Salama, Sofie R.
- Other Affiliation: Department of Biomolecular Engineering and Center for Biomolecular Science and Engineering, University of California Santa Cruz
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Zheng, Siyuan
- Other Affiliation: Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center
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Chakravarty, Debyani
- Other Affiliation: Human Oncology and Pathogenesis Program, Brain Tumor Center, Memorial Sloan-Kettering Cancer Center
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Sanborn, J. Zachary
- Other Affiliation: Department of Biomolecular Engineering and Center for Biomolecular Science and Engineering, University of California Santa Cruz
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Berman, Samuel H.
- Other Affiliation: Human Oncology and Pathogenesis Program, Brain Tumor Center, Memorial Sloan-Kettering Cancer Center
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Beroukhim, Rameen
- Other Affiliation: Cancer Program, The Broad Institute of Harvard and MIT
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Bernard, Brady
- Other Affiliation: Institute for Systems Biology
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Wu, Chang-Jiun
- Other Affiliation: Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center
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Genovese, Giannicola
- Other Affiliation: Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center
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Shmulevich, Ilya
- Other Affiliation: Institute for Systems Biology
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Barnholtz-Sloan, Jill
- Other Affiliation: Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine
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Zou, Lihua
- Other Affiliation: Cancer Program, The Broad Institute of Harvard and MIT
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Vegesna, Rahulsimham
- Other Affiliation: Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center
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Shukla, Sachet A.
- Other Affiliation: Department of Medical Oncology, Dana-Farber Cancer Institute
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Ciriello, Giovanni
- Other Affiliation: Computational Biology Center, Memorial Sloan-Kettering Cancer Center
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Yung, W.K.
- Other Affiliation: Department of Neuro-Oncology, The University of Texas MD Anderson Cancer Center
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Zhang, Wei
- Other Affiliation: Department of Pathology, The University of Texas MD Anderson Cancer Center
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Sougnez, Carrie
- Other Affiliation: Cancer Program, The Broad Institute of Harvard and MIT
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Mikkelsen, Tom
- Other Affiliation: Departments of Neurology and Neurosurgery, Henry Ford Hospital
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Aldape, Kenneth
- Other Affiliation: Department of Pathology, The University of Texas MD Anderson Cancer Center
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Bigner, Darell D.
- Other Affiliation: Department of Pathology, Duke University Medical Center
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Van Meir, Erwin G.
- Other Affiliation: Departments of Neurosurgery and Hematology and Medical Oncology, Winship Cancer Institute and School of Medicine, Emory University
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Prados, Michael
- Other Affiliation: Department of Neurosurgery, University of California, San Francisco
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Sloan, Andrew
- Other Affiliation: Department of Neurosurgery, University Hospitals-Case Medical Center, Seidman Cancer Center
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Black, Keith L.
- Other Affiliation: Department of Neurosurgery, Cedars-Sinai Medical Center
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Eschbacher, Jennifer
- Other Affiliation: Department of Pathology, St. Joseph’s Hospital and Medical Center
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Finocchiaro, Gaetano
- Other Affiliation: Istituto Neurologico Besta, Department of Neuro-Oncology
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Friedman, William
- Other Affiliation: Department of Neurosurgery, University of Florida
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Andrews, David W.
- Other Affiliation: Department of Neurological Surgery, Thomas Jefferson University
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Guha, Abhijit
- Other Affiliation: Department of Neurosurgery, Toronto Western Hospital
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Iacocca, Mary
- Other Affiliation: Department of Pathology, Christiana Care, Helen F. Graham Cancer Center
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O'Neill, Brian P.
- Other Affiliation: Department of Neurology, Mayo Clinic and Mayo Clinic Cancer Center
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Foltz, Greg
- Other Affiliation: Ivy Brain Tumor Center, Swedish Neuroscience Institute
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Myers, Jerome
- Other Affiliation: Department of Pathology, Penrose-St. Francis Health Services
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Weisenberger, Daniel J.
- Other Affiliation: University of Southern California Epigenome Center, University of Southern California
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Penny, Robert
- Other Affiliation: International Genomics Consortium
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Kucherlapati, Raju
- Other Affiliation: Brigham and Women’s Hospital and Harvard Medical School
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Perou, Charles
- ORCID: https://orcid.org/0000-0001-9827-2247
- Affiliation: School of Medicine, Department of Genetics
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Hayes, Neil
- Affiliation: School of Medicine, Department of Genetics
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Gibbs, Richard
- Other Affiliation: Human Genome Sequencing Center, Baylor College of Medicine
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Marra, Marco
- Other Affiliation: Canada’s Michael Smith Genome Sciences Centre, BC Cancer Agency
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Mills, Gordon B.
- Other Affiliation: Department of Systems Biology, The University of Texas MD Anderson Cancer Center
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Lander, Eric
- Other Affiliation: Cancer Program, The Broad Institute of Harvard and MIT
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Spellman, Paul
- Other Affiliation: Oregon Health and Science University, Department of Molecular and Medical Genetics
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Wilson, Richard
- Other Affiliation: The Genome Institute, Washington University
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Sander, Chris
- Other Affiliation: Computational Biology Center, Memorial Sloan-Kettering Cancer Center
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Weinstein, John
- Other Affiliation: Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center
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Meyerson, Matthew
- Other Affiliation: Cancer Program, The Broad Institute of Harvard and MIT
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Gabriel, Stacey
- Other Affiliation: Cancer Program, The Broad Institute of Harvard and MIT
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Laird, Peter W.
- Other Affiliation: University of Southern California Epigenome Center, University of Southern California
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Haussler, David
- Other Affiliation: Department of Biomolecular Engineering and Center for Biomolecular Science and Engineering, University of California Santa Cruz
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Getz, Gad
- Other Affiliation: Cancer Program, The Broad Institute of Harvard and MIT
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Chin, Lynda
- Other Affiliation: Cancer Program, The Broad Institute of Harvard and MIT
- TCGA Research Network
- Abstract
- We describe the landscape of somatic genomic alterations based on multidimensional and comprehensive characterization of more than 500 glioblastoma tumors (GBMs). We identify several novel mutated genes as well as complex rearrangements of signature receptors, including EGFR and PDGFRA. TERT promoter mutations are shown to correlate with elevated mRNA expression, supporting a role in telomerase reactivation. Correlative analyses confirm that the survival advantage of the proneural subtype is conferred by the G-CIMP phenotype, and MGMT DNA methylation may be a predictive biomarker for treatment response only in classical subtype GBM. Integrative analysis of genomic and proteomic profiles challenges the notion of therapeutic inhibition of a pathway as an alternative to inhibition of the target itself. These data will facilitate the discovery of therapeutic and diagnostic target candidates, the validation of research and clinical observations and the generation of unanticipated hypotheses that can advance our molecular understanding of this lethal cancer.
- Date of publication
- 2013
- DOI
- Identifier
- https://doi.org/10.1016/j.cell.2013.09.034
- 2-s2.0-84885074034
- Related resource URL
- Resource type
- Article
- Rights statement
- In Copyright
- Journal title
- Cell
- Journal volume
- 155
- Journal issue
- 2
- Page start
- 462
- Page end
- 477
- Language
- English
- Version
- Postprint
- ISSN
- 0092-8674
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