Neural mechanisms of negative reinforcement in children and adolescents with autism spectrum disorders
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Damiano, Cara R, et al. Neural Mechanisms of Negative Reinforcement In Children and Adolescents with Autism Spectrum Disorders. BioMed Central, 2015. https://doi.org/10.17615/x79e-qm73APA
Damiano, C., Cockrell, D., Dunlap, K., Hanna, E., Miller, S., Bizzell, J., Kovac, M., Turner Brown, L., Sideris, J., Kinard, J., & Dichter, G. (2015). Neural mechanisms of negative reinforcement in children and adolescents with autism spectrum disorders. BioMed Central. https://doi.org/10.17615/x79e-qm73Chicago
Damiano, Cara R, Dillon C Cockrell, Kaitlyn Dunlap, Eleanor K Hanna, Stephanie Miller, Joshua Bizzell, Megan Kovac et al. 2015. Neural Mechanisms of Negative Reinforcement In Children and Adolescents with Autism Spectrum Disorders. BioMed Central. https://doi.org/10.17615/x79e-qm73- Creator
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Damiano, Cara R
- Affiliation: School of Medicine, Neurodevelopment Disorders Research Center, Carolina Institute for Developmental Disabilities
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Cockrell, Dillon C
- Affiliation: College of Arts and Sciences, Department of Psychology and Neuroscience
- Other Affiliation: Virginia Tech Carilion School of Medicine and Research Institute
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Dunlap, Kaitlyn
- Other Affiliation: Brain Imaging and Analysis Center (BIAC), Duke University Medical Center
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Hanna, Eleanor K
- Affiliation: School of Medicine, Neurodevelopment Disorders Research Center, Carolina Institute for Developmental Disabilities
- Other Affiliation: Center for Cognitive Neuroscience, Duke University
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Miller, Stephanie
- Affiliation: School of Social Work
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Bizzell, Joshua
- Affiliation: School of Medicine, Department of Psychiatry
- Other Affiliation: Brain Imaging and Analysis Center (BIAC), Duke University Medical Center
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Kovac, Megan
- Affiliation: School of Education
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Turner-Brown, Lauren
- Affiliation: School of Medicine, Neurodevelopment Disorders Research Center, Carolina Institute for Developmental Disabilities
- Other Affiliation: TEACCH Autism Program
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Sideris, John
- Affiliation: Frank Porter Graham Child Development Institute
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Kinard, Jessica
- Affiliation: School of Medicine, Neurodevelopment Disorders Research Center, Carolina Institute for Developmental Disabilities
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Dichter, Gabriel
- Affiliation: School of Medicine, Neurodevelopment Disorders Research Center, Carolina Institute for Developmental Disabilities
- Other Affiliation: Brain Imaging and Analysis Center (BIAC), Duke University Medical Center
- Abstract
- Background Previous research has found accumulating evidence for atypical reward processing in autism spectrum disorders (ASD), particularly in the context of social rewards. Yet, this line of research has focused largely on positive social reinforcement, while little is known about the processing of negative reinforcement in individuals with ASD. Methods The present study examined neural responses to social negative reinforcement (a face displaying negative affect) and non-social negative reinforcement (monetary loss) in children with ASD relative to typically developing children, using functional magnetic resonance imaging (fMRI). Results We found that children with ASD demonstrated hypoactivation of the right caudate nucleus while anticipating non-social negative reinforcement and hypoactivation of a network of frontostriatal regions (including the nucleus accumbens, caudate nucleus, and putamen) while anticipating social negative reinforcement. In addition, activation of the right caudate nucleus during non-social negative reinforcement was associated with individual differences in social motivation. Conclusions These results suggest that atypical responding to negative reinforcement in children with ASD may contribute to social motivational deficits in this population.
- Date of publication
- March 25, 2015
- DOI
- Identifier
- Resource type
- Article
- Rights statement
- In Copyright
- Rights holder
- Damiano et al.; licensee BioMed Central.
- Journal title
- Journal of Neurodevelopmental Disorders
- Journal volume
- 7
- Journal issue
- 1
- Page start
- 12
- Language
- English
- Bibliographic citation
- Journal of Neurodevelopmental Disorders. 2015 Mar 25;7(1):12
- Publisher
- BioMed Central
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