RHEOLOGY AND FLOW OF MUCUS IN HUMAN BRONCHIAL EPITHELIAL CELL CULTURES

Public Deposited
Analytics

Downloadable Content

Download PDF
Request Version for Screen Reader
Last Modified
  • March 19, 2019
Creator
  • Jin, Yuan
    • Affiliation: College of Arts and Sciences, Department of Mathematics
Abstract
  • The propulsion of mucus in human airways toward the trachea by the collective and coordinated action of cilia, known as mucociliary clearance, remains an outstanding modeling and computational challenge. A model system for mucociliary clearance is provided by human bronchial epithelial (HBE) cell cultures that generate macroscopic mean rotational flow. We coarse grain the coordinated cilia propulsion into an imposed dynamic velocity condition on the flat base of a cylinder. A multi-mode Giseskus nonlinear viscoelastic constitutive model derived from rheological data of mucus is employed for the mucus layer. The full system of governing equations for the transient and stationary axisymmetric flow field and air-mucus interface is solved numerically. Our modeling is the first step toward a platform for several purposes: to test accuracy of the constitutive modeling of mucus; to build a faithful model of the cilia-mucus boundary condition; to simulate both the flow and stress fields throughout the mucus layer; to explore the linear and nonlinear viscoelastic behavior of the mucus flow; and to explore the advection-diffusion process of a drug concentration dropped at the surface of the cell culture, and illustrate how the absorption by the bottom plate varies versus the initial drop position and the diffusion coefficient.
Date of publication
Keyword
Subject
DOI
Identifier
Resource type
Rights statement
  • In Copyright
Advisor
  • Forest, M. Gregory
  • Huang, Jingfang
  • Hill, David
  • Vasquez, Paula
  • Miller, Laura
Degree
  • Doctor of Philosophy
Degree granting institution
  • University of North Carolina at Chapel Hill Graduate School
Graduation year
  • 2015
Language
Publisher
Place of publication
  • Chapel Hill, NC
Access right
  • There are no restrictions to this item.
Date uploaded
  • August 25, 2015

Relations

Parents:

This work has no parents.

Items

Thumbnail Title Date Uploaded Visibility Actions
file details Jin_unc_0153D_15644.pdf 2019-04-10 Public Download